BRPI0409955A - uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções - Google Patents

uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções

Info

Publication number
BRPI0409955A
BRPI0409955A BRPI0409955-9A BRPI0409955A BRPI0409955A BR PI0409955 A BRPI0409955 A BR PI0409955A BR PI0409955 A BRPI0409955 A BR PI0409955A BR PI0409955 A BRPI0409955 A BR PI0409955A
Authority
BR
Brazil
Prior art keywords
oxazolidinone
infections
hybrid
anthrax
treat anthrax
Prior art date
Application number
BRPI0409955-9A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Luc Specklin
Daniel K Baeschlin
Hans Locher
Christine Schmitt
Original Assignee
Morphochem Ag Komb Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem Ag Komb Chemie filed Critical Morphochem Ag Komb Chemie
Publication of BRPI0409955A publication Critical patent/BRPI0409955A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"USO DE ANTIBIóTICOS HìBRIDOS DE OXAZOLIDINONA - QUINOLINA PARA O TRATAMENTO DE ANTRAX E OUTRAS INFECçõES". A presente invenção refere-se ao uso de compostos, nos quais os farmacóforos de quinolona e oxazolidinona são ligados quimicamente através de um ligador que é estável sob condições fisiológicas, para o tratamento de antrax e outras infecções.
BRPI0409955-9A 2003-04-30 2004-04-06 uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções BRPI0409955A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46694503P 2003-04-30 2003-04-30
US53082203P 2003-12-18 2003-12-18
PCT/EP2004/003650 WO2004096221A1 (en) 2003-04-30 2004-04-06 Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections

Publications (1)

Publication Number Publication Date
BRPI0409955A true BRPI0409955A (pt) 2006-04-25

Family

ID=33423632

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409955-9A BRPI0409955A (pt) 2003-04-30 2004-04-06 uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções

Country Status (16)

Country Link
US (3) US20070155714A1 (pt)
EP (1) EP1620098B1 (pt)
JP (2) JP4805139B2 (pt)
KR (1) KR101101982B1 (pt)
AT (1) ATE397930T1 (pt)
AU (2) AU2004233557B2 (pt)
BR (1) BRPI0409955A (pt)
CA (1) CA2529347C (pt)
DE (1) DE602004014361D1 (pt)
ES (1) ES2308171T3 (pt)
HK (1) HK1078806A1 (pt)
IL (1) IL171546A (pt)
MX (1) MXPA05011654A (pt)
NZ (1) NZ543757A (pt)
RU (1) RU2351335C2 (pt)
WO (1) WO2004096221A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
BRPI0409955A (pt) 2003-04-30 2006-04-25 Morphochem Ag Komb Chemie uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
MXPA06006769A (es) * 2003-12-18 2006-12-19 Morphochem Ag Komb Chemie Antibioticos hibridos de oxazolidinona-quinolona.
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
PT2383271E (pt) 2006-03-13 2013-10-10 Kyorin Seiyaku Kk Aminoquinolonas como inibidores de gsk-3
EP2181993A1 (en) * 2006-03-31 2010-05-05 Research Foundation Itsuu Laboratory Antimicrobial oxazolidinone derivatives
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
JP4484965B2 (ja) * 2006-11-10 2010-06-16 アクテリオン ファーマシューティカルズ リミテッド ５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
US8389514B2 (en) 2007-09-11 2013-03-05 Kyorin Pharmaceutical Co., Ltd. Cyanoaminoquinolones and tetrazoloaminoquinolones as GSK-3 inhibitors
CN101855229A (zh) 2007-09-12 2010-10-06 埃迪威克斯生物科学公司 作为gsk-3抑制剂的螺环状氨基喹诺酮
WO2009044777A1 (ja) 2007-10-02 2009-04-09 Research Foundation Itsuu Laboratory ７員ヘテロ環を有するオキサゾリジノン誘導体
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
WO2009120789A1 (en) * 2008-03-26 2009-10-01 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
NZ589734A (en) * 2008-05-09 2012-11-30 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases
EP2145891A1 (en) * 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
WO2010050461A1 (ja) * 2008-10-27 2010-05-06 田辺三菱製薬株式会社 新規アミド誘導体およびその医薬としての用途
US8071591B2 (en) 2009-03-11 2011-12-06 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminoquinolones as GSK-3 inhibitors
JP5796412B2 (ja) 2011-08-26 2015-10-21 三菱電機株式会社 半導体素子の製造方法
AR088691A1 (es) * 2011-11-08 2014-06-25 Actelion Pharmaceuticals Ltd Derivados antibioticos de 2-oxo-oxazolidin-3,5-diilo
SG11201507244TA (en) 2013-03-08 2015-10-29 Allergan Inc Antibiotic conjugates directly linked with steroid drugs
US20140256694A1 (en) 2013-03-08 2014-09-11 Allergan, Inc. Steroid antibiotic conjugates
KR102242998B1 (ko) * 2013-05-28 2021-04-21 모르포켐 게엠베하 박테리아 감염 치료의 용도를 위한 옥사졸리디논-퀴놀론을 포함하는 병용 용법
SI3003289T1 (sl) * 2013-05-28 2019-08-30 Morphochem Gmbh Dajanje antibakterijskih oksazolidinon-kinolonskih hibridnih sredstev
CN104725330B (zh) * 2013-12-18 2017-06-13 四川好医生药业集团有限公司 噁唑烷酮类化合物及其制备方法和用途
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840956A (en) 1986-02-18 1989-06-20 Warner-Lambert Company Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH0269478A (ja) 1988-09-05 1990-03-08 Sagami Chem Res Center キノロンカルボン酸誘導体
US5491139A (en) 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
EP0390215B1 (en) 1989-03-30 1995-06-07 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivatives and salts thereof, preparation process es thereof, and antibacterial agents containing the same
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
DE69216251T2 (de) 1991-11-01 1997-05-15 Upjohn Co Substituierte aryl- und heteroaryl-phenyloxazolidinone
US5221676A (en) 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
PT992501E (pt) 1995-09-22 2003-01-31 Wakunaga Pharma Co Ltd Derivados de acido piridonacarboxilico como agentes antibacterianos
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
DE19633480A1 (de) * 1996-08-20 1998-02-26 Bayer Ag Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
CN1288462A (zh) 1998-01-23 2001-03-21 法玛西雅厄普约翰美国公司 噁唑烷酮组合库、组合物和制备方法
TW572757B (en) 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
MXPA02000985A (es) 1999-07-28 2002-07-30 Upjohn Co Oxazolidinonas y su uso como antiinfecciosos.
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
EP1349853B1 (en) * 2000-12-21 2006-03-08 Pharmacia & Upjohn Company LLC Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
ES2186550B2 (es) 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
WO2003031441A1 (en) * 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
WO2003031443A1 (en) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
AU2003202753A1 (en) 2003-02-07 2004-08-30 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
BRPI0409955A (pt) * 2003-04-30 2006-04-25 Morphochem Ag Komb Chemie uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
MXPA06006769A (es) 2003-12-18 2006-12-19 Morphochem Ag Komb Chemie Antibioticos hibridos de oxazolidinona-quinolona.
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR200430712Y1 (ko) 2006-08-30 2006-11-13 명 식 신 천장등
JP4484965B2 (ja) 2006-11-10 2010-06-16 アクテリオン ファーマシューティカルズ リミテッド ５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
NZ589734A (en) 2008-05-09 2012-11-30 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases

Also Published As

Publication number Publication date
NZ543757A (en) 2009-02-28
DE602004014361D1 (de) 2008-07-24
US20070155714A1 (en) 2007-07-05
IL171546A (en) 2014-06-30
WO2004096221A1 (en) 2004-11-11
US20120135961A1 (en) 2012-05-31
US8513231B2 (en) 2013-08-20
MXPA05011654A (es) 2005-12-15
ATE397930T1 (de) 2008-07-15
HK1078806A1 (en) 2006-03-24
JP4805139B2 (ja) 2011-11-02
ES2308171T3 (es) 2008-12-01
EP1620098A1 (en) 2006-02-01
KR101101982B1 (ko) 2012-01-02
US8268812B2 (en) 2012-09-18
US20120322766A1 (en) 2012-12-20
JP2006526577A (ja) 2006-11-24
AU2010201659A1 (en) 2010-05-20
CA2529347C (en) 2011-09-06
JP2011184441A (ja) 2011-09-22
RU2005137032A (ru) 2007-06-10
AU2004233557B2 (en) 2010-02-18
EP1620098B1 (en) 2008-06-11
JP5536706B2 (ja) 2014-07-02
CA2529347A1 (en) 2004-11-11
KR20060025525A (ko) 2006-03-21
RU2351335C2 (ru) 2009-04-10
AU2004233557A1 (en) 2004-11-11

Similar Documents

Publication Publication Date Title
BRPI0409955A (pt) uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções
SE0301700D0 (sv) Novel compounds
MY145647A (en) (4-hydroxy-2-oxo-3h-benzothiazol-7-yl)ethylamine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy (for example in the treatment of respiratory disease states)
EA200801997A1 (ru) Новые соединения
ES2422557T3 (es) Compuestos y composiciones como moduladores de la ruta Hedgehog
EA200870193A1 (ru) Цитотоксические агенты, включающие новые производные томаймицина, и их терапевтическое применение
BRPI0510177B8 (pt) composto, composição farmacêutica e uso do mesmo
ECSP066886A (es) Compuestos y métodos para el tratamiento de dislipidemia
ATE488232T1 (de) P53 aktivierende benzoylharnstoff- und benzoylthioharnstoff-verbindungen
EA200800564A1 (ru) Производные ксантина как селективные агонисты нм74а
MX2010007936A (es) Anticuerpo anti-nr-10 y su uso.
ATE534378T1 (de) Titrierung von tapentadol
ATE448232T1 (de) Substituierte heterozyklen
SE0301653D0 (sv) Novel compounds
EA200601777A1 (ru) Новое применение пептидных соединений для лечения боли при болезненной диабетической нейропатии
CL2011002925A1 (es) Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1.
RS51069B (sr) Upotreba oksikodona za tretiranje visceralnog bola
TR201901390T4 (tr) Demodikoza karşı madde.
CR7195A (es) Nuevos derivados de oxazolidinonas como antibacterianos
EA200970529A1 (ru) Антивирусная композиция и способ ее применения
CY1110130T1 (el) Παραγωγα μορφολινης για χρηση ως αγωνιστες ντοπαμινης στην θεραπευτικη αγωγη σεξουαλικης δυσλειτουργιας i.α.
SE0303541D0 (sv) New compounds
AR061446A1 (es) Utilizacion de la 1,7 -dimetilxantina para la fabricacion de un medicamento psicoanaleptico no ansiogeno destinado al tratamiento de un trastorno neuropsiquiatrico
SE0302546D0 (sv) New compounds
CY1109187T1 (el) Νεα μακρολιδια

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8, 13, 24 E 25 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]