DE602004014361D1 - Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen - Google Patents

Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen

Info

Publication number
DE602004014361D1
DE602004014361D1 DE602004014361T DE602004014361T DE602004014361D1 DE 602004014361 D1 DE602004014361 D1 DE 602004014361D1 DE 602004014361 T DE602004014361 T DE 602004014361T DE 602004014361 T DE602004014361 T DE 602004014361T DE 602004014361 D1 DE602004014361 D1 DE 602004014361D1
Authority
DE
Germany
Prior art keywords
oxazolidinone
anthrax
infections
treatment
chinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004014361T
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Luc Specklin
Daniel K Baeschlin
Hans Locher
Christine Sigwalt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphochem AG fuer Kombinatorische Chemie
Original Assignee
Morphochem AG fuer Kombinatorische Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem AG fuer Kombinatorische Chemie filed Critical Morphochem AG fuer Kombinatorische Chemie
Publication of DE602004014361D1 publication Critical patent/DE602004014361D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE602004014361T 2003-04-30 2004-04-06 Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen Expired - Lifetime DE602004014361D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46694503P 2003-04-30 2003-04-30
US53082203P 2003-12-18 2003-12-18
PCT/EP2004/003650 WO2004096221A1 (en) 2003-04-30 2004-04-06 Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections

Publications (1)

Publication Number Publication Date
DE602004014361D1 true DE602004014361D1 (de) 2008-07-24

Family

ID=33423632

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004014361T Expired - Lifetime DE602004014361D1 (de) 2003-04-30 2004-04-06 Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen

Country Status (16)

Country Link
US (3) US20070155714A1 (de)
EP (1) EP1620098B1 (de)
JP (2) JP4805139B2 (de)
KR (1) KR101101982B1 (de)
AT (1) ATE397930T1 (de)
AU (2) AU2004233557B2 (de)
BR (1) BRPI0409955A (de)
CA (1) CA2529347C (de)
DE (1) DE602004014361D1 (de)
ES (1) ES2308171T3 (de)
HK (1) HK1078806A1 (de)
IL (1) IL171546A (de)
MX (1) MXPA05011654A (de)
NZ (1) NZ543757A (de)
RU (1) RU2351335C2 (de)
WO (1) WO2004096221A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (de) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
JP4805139B2 (ja) 2003-04-30 2011-11-02 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
AU2004299278C9 (en) 2003-12-18 2013-10-24 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1723159B1 (de) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Makrozyklische verbindungen, deren herstellung und verwendung
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
PL2383271T3 (pl) 2006-03-13 2013-12-31 Kyorin Seiyaku Kk Aminochinolony jako inhibitory GSK-3
KR20080110877A (ko) 2006-03-31 2008-12-19 재단법인 이쯔우 연구소 헤테로환을 갖는 신규 화합물
BRPI0718862B8 (pt) * 2006-11-10 2021-05-25 Actelion Pharmaceuticals Ltd composto, composição farmacêutica que o contém e uso do composto
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
EP2203458B1 (de) 2007-09-11 2011-11-02 Kyorin Pharmaceutical Co., Ltd. Cyanoaminochinolone als gsk-3-inhibitoren
CA2699152C (en) 2007-09-12 2015-11-24 Activx Biosciences, Inc. Spirocyclic aminoquinolones as gsk-3 inhibitors
EP2208729A4 (de) 2007-10-02 2011-04-27 Res Found Itsuu Lab Oxazolidinonderivat mit 7-gliedrigem heteroring
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
US7666864B2 (en) * 2008-03-26 2010-02-23 Global Alliance For Tb Drug Development Bicyclic nitroimidazole-substituted phenyl oxazolidinones
ES2390405T3 (es) * 2008-05-09 2012-11-12 Actelion Pharmaceuticals Ltd. Derivados de 5-hidroximetil-oxazolidin-2-ona para el tratamiento de enfermedades intestinales bacterianas
EP2145891A1 (de) * 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substierte 5-Carboxy-Oxadiazin-Chinolon-Derivate, ihre Herstellung und ihre Anwendung als antibakterielle Mittel
AU2009310952B2 (en) * 2008-10-27 2015-04-30 Mitsubishi Tanabe Pharma Corporation Novel amide derivative and use thereof as medicine
JP5502889B2 (ja) 2009-03-11 2014-05-28 杏林製薬株式会社 ｇｓｋ−３阻害剤としての７−シクロアルキルアミノキノロン
JP5796412B2 (ja) 2011-08-26 2015-10-21 三菱電機株式会社 半導体素子の製造方法
SG11201401710PA (en) * 2011-11-08 2014-09-26 Actelion Pharmaceuticals Ltd 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives
AU2014225743A1 (en) 2013-03-08 2015-09-24 Allergan, Inc. Antibiotic conjugates directly linked with steroid drugs
EP2964268A1 (de) 2013-03-08 2016-01-13 Allergan, Inc. Antibiotische konjugate
ES2726828T3 (es) 2013-05-28 2019-10-09 Morphochem Gmbh Administración de antibacterianos híbridos de oxazolidinona-quinolona
WO2014191109A1 (en) * 2013-05-28 2014-12-04 Morphochem Aktiengesellschaft für kombinatorische Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
CN104725330B (zh) * 2013-12-18 2017-06-13 四川好医生药业集团有限公司 噁唑烷酮类化合物及其制备方法和用途
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840956A (en) 1986-02-18 1989-06-20 Warner-Lambert Company Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH0269478A (ja) 1988-09-05 1990-03-08 Sagami Chem Res Center キノロンカルボン酸誘導体
US5491139A (en) 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
ATE123494T1 (de) 1989-03-30 1995-06-15 Wakunaga Seiyaku Kk Chinolon-derivate und deren salze, verfahren zu deren herstellung und diese enthaltende antibakterielle wirkstoffe.
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
KR100257418B1 (ko) 1991-11-01 2000-05-15 로렌스 티. 마이젠헬더 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논
US5221676A (en) 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
JP3103380B2 (ja) 1995-09-22 2000-10-30 湧永製薬株式会社 新規ピリドンカルボン酸誘導体又はその塩並びに該物質を有効成分とする抗菌剤
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
DE19633480A1 (de) * 1996-08-20 1998-02-26 Bayer Ag Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
AU764184B2 (en) 1998-01-23 2003-08-14 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
TW572757B (en) 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
AU773359B2 (en) 1999-07-28 2004-05-20 Pharmacia & Upjohn Company Oxazolidinones and their use as antiinfectives
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
EP1349853B1 (de) * 2000-12-21 2006-03-08 Pharmacia & Upjohn Company LLC Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
ES2186550B2 (es) * 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
WO2003031443A1 (de) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
WO2003031441A1 (en) * 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
EP1594852A1 (de) 2003-02-07 2005-11-16 Ranbaxy Laboratories, Ltd. Oxazolidinonderivate als antimikrobielle mittel
JP4805139B2 (ja) 2003-04-30 2011-11-02 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
AU2004299278C9 (en) 2003-12-18 2013-10-24 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR200430712Y1 (ko) 2006-08-30 2006-11-13 명 식 신 천장등
BRPI0718862B8 (pt) 2006-11-10 2021-05-25 Actelion Pharmaceuticals Ltd composto, composição farmacêutica que o contém e uso do composto
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
ES2390405T3 (es) 2008-05-09 2012-11-12 Actelion Pharmaceuticals Ltd. Derivados de 5-hidroximetil-oxazolidin-2-ona para el tratamiento de enfermedades intestinales bacterianas

Also Published As

Publication number Publication date
JP2006526577A (ja) 2006-11-24
EP1620098A1 (de) 2006-02-01
EP1620098B1 (de) 2008-06-11
US8268812B2 (en) 2012-09-18
JP2011184441A (ja) 2011-09-22
WO2004096221A1 (en) 2004-11-11
BRPI0409955A (pt) 2006-04-25
US20120135961A1 (en) 2012-05-31
RU2005137032A (ru) 2007-06-10
US8513231B2 (en) 2013-08-20
NZ543757A (en) 2009-02-28
CA2529347C (en) 2011-09-06
ES2308171T3 (es) 2008-12-01
JP5536706B2 (ja) 2014-07-02
HK1078806A1 (en) 2006-03-24
US20070155714A1 (en) 2007-07-05
ATE397930T1 (de) 2008-07-15
AU2004233557A1 (en) 2004-11-11
IL171546A (en) 2014-06-30
AU2004233557B2 (en) 2010-02-18
RU2351335C2 (ru) 2009-04-10
AU2010201659A1 (en) 2010-05-20
KR20060025525A (ko) 2006-03-21
CA2529347A1 (en) 2004-11-11
JP4805139B2 (ja) 2011-11-02
MXPA05011654A (es) 2005-12-15
US20120322766A1 (en) 2012-12-20
KR101101982B1 (ko) 2012-01-02

Similar Documents

Publication Publication Date Title
DE602004014361D1 (de) Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen
EA200870569A1 (ru) Соединения и способы модуляции fxr
ATE526991T1 (de) Zusammensetzungen und ihre verwendungen für die gentherapeutische behandlung von knochenerkrankungen
ATE414089T1 (de) Verwendung von rapamycin und dessen derivaten zur behandlung von knochenverlust
ATE415968T1 (de) 3,11b-cis-dihydrotetrabanezin zur behandlung von schizophrenie und anderen psychosen
EA200700489A1 (ru) Новые бензоконденсированные гетероарилсульфамидные производные, полезные в качестве противоконвульсивных средств
ATE402180T1 (de) Verbindungen zur behandlung von dyslipidemie
NO20076413L (no) Multisykliske forbindelser og fremgangsmater for deres anvendelse
ATE502633T1 (de) Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
ATE449604T1 (de) Pyrazolamid-derivate, diese verbindungen enthaltende zusammensetzungen und anwendungsverfahren
ATE433447T1 (de) Pyrimiidinverbindungen
EP1841426A4 (de) Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer-krankheit
NO20055026L (no) Indolonacetamid-derivater, fremgangsmate for fremstilling og anvendelse av disse
EA200700202A1 (ru) Гетероарильные соединения в качестве бетамиметиков для лечения заболеваний дыхательных путей
NO20055741L (no) Nye kjemiske forbindelser
ATE410430T1 (de) 2,3-dihydro-6-nitroimidazoä2,1- büoxazolverbindungen zur behandlung von tuberkulose
EA201170571A1 (ru) Способы и композиции для улучшения когнитивной функции
EA200801580A1 (ru) Новые производные пирониндола и способ их получения
CR7195A (es) Nuevos derivados de oxazolidinonas como antibacterianos
UY29999A1 (es) "n-pirazinil-fenilsulfonamidas, procedimientos y compuestos intemedios utilizados en su preparacion, composiciones farmaceuticas que las contienen y aplicaciones"
ATE459600T1 (de) Substituierte pyrrolidin-2-one
DE60326069D1 (de) 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen
EA200900269A1 (ru) Лекарственные комбинации для лечения заболеваний дыхательных путей
DE602004021363D1 (de) Imidazotriazin verbindungen zur behandlung von krebserkrankungen
CY1109803T1 (el) Φαρμακευτικες συνθεσεις που βασιζονται σε ανταγωνιστες νκ2 για παιδιατρικη χρηση

Legal Events

Date Code Title Description
8364 No opposition during term of opposition