MX351590B - Antibioticos de oxazolidinona. - Google Patents
Antibioticos de oxazolidinona.Info
- Publication number
- MX351590B MX351590B MX2011010275A MX2011010275A MX351590B MX 351590 B MX351590 B MX 351590B MX 2011010275 A MX2011010275 A MX 2011010275A MX 2011010275 A MX2011010275 A MX 2011010275A MX 351590 B MX351590 B MX 351590B
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- oxazolidinone antibiotics
- formula
- oxazolidinone
- antibiotics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención se relaciona con los compuestos de fórmula (I) (ver fórmula (I)) en la cual U, y, X, R1, R2, R3, R4, R5, R6, A, B, D, E, G, m y n son tal como se define en la memoria descriptiva, con sales farmacéuticamente aceptables de tales compuestos para su empleo en la producción de un medicamento para la prevención o el tratamiento de una infección bacteriana. Ciertos compuestos de fórmula (I) son nuevos y también son parte de esta invención.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2007051290 | 2007-04-11 | ||
IB2007054587 | 2007-11-12 | ||
IB2007054768 | 2007-11-23 | ||
PCT/IB2008/051374 WO2008126034A2 (en) | 2007-04-11 | 2008-04-11 | Oxazolidinone antibiotics |
Publications (1)
Publication Number | Publication Date |
---|---|
MX351590B true MX351590B (es) | 2017-10-20 |
Family
ID=39682545
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011010274A MX351589B (es) | 2007-04-11 | 2008-04-11 | Antibioticos de oxazolidinona. |
MX2009010642A MX2009010642A (es) | 2007-04-11 | 2008-04-11 | Antibioticos de oxazolidinona. |
MX2011010275A MX351590B (es) | 2007-04-11 | 2008-04-11 | Antibioticos de oxazolidinona. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011010274A MX351589B (es) | 2007-04-11 | 2008-04-11 | Antibioticos de oxazolidinona. |
MX2009010642A MX2009010642A (es) | 2007-04-11 | 2008-04-11 | Antibioticos de oxazolidinona. |
Country Status (16)
Country | Link |
---|---|
US (1) | US8217029B2 (es) |
EP (3) | EP2915813B1 (es) |
JP (1) | JP5427770B2 (es) |
KR (1) | KR101495269B1 (es) |
CN (3) | CN102746297B (es) |
AR (1) | AR066013A1 (es) |
AU (1) | AU2008238904B2 (es) |
BR (1) | BRPI0809977A8 (es) |
CA (3) | CA2876879C (es) |
CL (1) | CL2008001002A1 (es) |
ES (3) | ES2618492T3 (es) |
MX (3) | MX351589B (es) |
PL (3) | PL2905283T3 (es) |
RU (1) | RU2470022C2 (es) |
TW (1) | TWI411434B (es) |
WO (1) | WO2008126034A2 (es) |
Families Citing this family (44)
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---|---|---|---|---|
US9505750B2 (en) * | 2007-12-18 | 2016-11-29 | Actelion Pharmaceuticals Ltd. | 5-aminocyclylmethyl-oxazolidin-2-one derivatives |
MX2010008922A (es) | 2008-02-20 | 2010-09-07 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos azatriciclicos. |
WO2009104159A1 (en) | 2008-02-22 | 2009-08-27 | Actelion Pharmaceuticals Ltd | Oxazolidinone derivatives |
CN102105467A (zh) | 2008-08-04 | 2011-06-22 | 埃科特莱茵药品有限公司 | 三环烷氨基甲基噁唑烷酮衍生物 |
AR073774A1 (es) | 2008-10-07 | 2010-12-01 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos oxazolidinona triciclicos |
JP2012505201A (ja) * | 2008-10-10 | 2012-03-01 | アクテリオン ファーマシューティカルズ リミテッド | 2−ベンゾチオフェニル−及び2−ナフチル−オキサゾリジノン、並びにそれらのアザアイソスター(azaisostere)類似体 |
FR2945533B1 (fr) * | 2009-05-12 | 2011-05-27 | Sanofi Aventis | Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
EP2388260A1 (de) * | 2010-05-21 | 2011-11-23 | Archimica GmbH | Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors |
EP2674430A4 (en) | 2011-02-07 | 2014-07-02 | Daiichi Sankyo Co Ltd | AMINO-GROUP-PYRROLIDINONE DERIVATIVES |
AU2012293329A1 (en) | 2011-08-11 | 2014-03-27 | Actelion Pharmaceuticals Ltd | Quinazoline-2,4-dione derivatives |
EP2776431B1 (en) * | 2011-11-08 | 2016-05-04 | Actelion Pharmaceuticals Ltd. | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
DE102012006884A1 (de) * | 2012-04-04 | 2013-10-10 | Merck Patent Gmbh | Cyclische Amide als MetAP-2 Inhibitoren |
LT2861566T (lt) | 2012-06-13 | 2017-02-10 | F. Hoffmann-La Roche Ag | Nauji diazaspirocikloalkanai ir azaspirocikloalkanai |
AU2013277154A1 (en) | 2012-06-20 | 2014-12-18 | Jonathan E. Grob | Complement pathway modulators and uses thereof |
WO2014024056A1 (en) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Pyrrolidine derivatives with antibacterial properties |
CA2878442A1 (en) | 2012-09-25 | 2014-04-03 | F. Hoffmann-La Roche Ag | Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases |
CN103012389A (zh) * | 2013-01-24 | 2013-04-03 | 中国药科大学 | 一种利伐沙班中间体的制备方法 |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
SI3074400T1 (en) | 2013-11-26 | 2018-03-30 | F. Hoffmann-La Roche Ag | Octahydro-cyclobut (1,2-c, 3,4-cy) dipyrrole derivatives as autoantaxine inhibitors |
CN106029667B (zh) | 2014-03-26 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物 |
UA118582C2 (uk) | 2014-03-26 | 2019-02-11 | Ф. Хоффманн-Ля Рош Аг | Біциклічні сполуки як інгібітори продукції аутотаксину (atx) і лізофосфатидилової кислоти (lpa) |
AR102256A1 (es) * | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
MA41168A (fr) | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
MX2020004504A (es) | 2015-09-04 | 2021-11-10 | Hoffmann La Roche | Derivados de fenoximetilo. |
JP6846414B2 (ja) | 2015-09-24 | 2021-03-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Atx阻害剤としての二環式化合物 |
MX2017015034A (es) | 2015-09-24 | 2018-04-13 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca). |
BR112018006080A2 (pt) | 2015-09-24 | 2018-10-09 | F. Hoffmann-La Roche Ag | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
CA2991615A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
DK3386954T3 (da) | 2015-12-10 | 2021-02-15 | Bracco Imaging Spa | Dimere kontrastmidler |
SG11201804415QA (en) | 2015-12-10 | 2018-06-28 | Bracco Imaging Spa | Contrast agents |
SG10202001146PA (en) | 2015-12-17 | 2020-03-30 | Merck Patent Gmbh | Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders |
GB201602235D0 (en) * | 2016-02-08 | 2016-03-23 | Redx Pharma Plc | Antibacterial compounds |
JP2019504850A (ja) | 2016-02-08 | 2019-02-21 | レデックス ファーマ ピーエルシーRedx Pharma Plc | 複素環式化合物、特に2−オキソ−4,4,5,5,6,6,7,7−オクタヒドロベンズオキサゾール誘導体、および抗菌化合物としてのこれらの使用 |
EP3414246A1 (en) * | 2016-02-08 | 2018-12-19 | Redx Pharma PLC | Antibacterial compounds |
CN108779082B (zh) | 2016-04-13 | 2022-08-02 | 伯拉考成像股份公司 | 造影剂 |
RU2758686C2 (ru) | 2016-08-08 | 2021-11-01 | Мерк Патент Гмбх | Антагонисты tlr7/8 и их применение |
US10793533B2 (en) | 2016-12-12 | 2020-10-06 | Bracco Imaging S.P.A. | Dimeric contrast agents |
TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
WO2018167001A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual atx/ca inhibitors |
CA3070171A1 (en) * | 2017-07-18 | 2019-01-24 | Merck Patent Gmbh | Tlr7/8 antagonists and uses thereof |
WO2019106693A1 (en) * | 2017-11-29 | 2019-06-06 | Bugworks Research India Pvt Ltd | Anti-bacterial heterocyclic compounds and their synthesis |
CN109265389B (zh) * | 2018-08-31 | 2020-08-18 | 南京富润凯德生物医药有限公司 | 2-(氨基甲基)-1-氧杂-7-氮杂螺[3.5]壬烷衍生物、中间体及其制备方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3723797A1 (de) | 1987-07-18 | 1989-01-26 | Merck Patent Gmbh | Oxazolidinone |
KR950014567B1 (ko) | 1991-08-01 | 1995-12-08 | 주식회사대웅제약 | 신규한 퀴놀론 카르복실산 유도체 |
DE19707628A1 (de) * | 1997-02-26 | 1998-08-27 | Merck Patent Gmbh | Oxazolidinone |
HUP0200309A3 (en) | 1999-01-07 | 2003-05-28 | Wyeth Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression, process for their preparation and pharmaceutical compositions containing them |
KR20030019621A (ko) | 2000-07-26 | 2003-03-06 | 스미스클라인비이참피이엘시이 | 항균 활성을 갖는 아미노피페리딘 퀴놀린 및 그의아자이소스테릭 유사체 |
GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0112836D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
DE10247233A1 (de) * | 2002-10-10 | 2004-06-17 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Topoisomerase IV inhibieren |
ES2312839T3 (es) * | 2002-12-04 | 2009-03-01 | Glaxo Group Limited | Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos. |
DE10316081A1 (de) | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
FR2872164B1 (fr) * | 2004-06-29 | 2006-11-17 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
CA2572442A1 (fr) * | 2004-07-30 | 2006-03-09 | Palumed S.A. | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
CA2580621A1 (en) | 2004-09-24 | 2006-03-30 | Actelion Pharmaceuticals Ltd | New bicyclic antibiotics |
EP1846411A4 (en) * | 2005-01-25 | 2010-08-04 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
AR054608A1 (es) | 2005-08-08 | 2007-06-27 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidinona enlazados a quinolonas como antibacterianos |
DK1954697T3 (da) | 2005-10-21 | 2010-06-14 | Glaxo Group Ltd | Peri-kondenserede tricykliske forbindelser, der er anvendelige som antibakterielle midler |
WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
EP1963324B1 (en) | 2005-12-22 | 2010-04-21 | Glaxo Group Limited | Heterocyclic compounds, their preparation and their use as antibacterials |
DE602007006927D1 (en) | 2006-03-23 | 2010-07-15 | Actelion Pharmaceuticals Ltd | Antibiotische cyclohexyl- oder piperidinylcarboxamid-derivate |
WO2007118130A2 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Antibacterial agents |
GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
-
2008
- 2008-04-09 CL CL200801002A patent/CL2008001002A1/es unknown
- 2008-04-10 AR ARP080101486A patent/AR066013A1/es not_active Application Discontinuation
- 2008-04-10 TW TW097113021A patent/TWI411434B/zh not_active IP Right Cessation
- 2008-04-11 CA CA2876879A patent/CA2876879C/en not_active Expired - Fee Related
- 2008-04-11 CN CN201210209094.4A patent/CN102746297B/zh not_active Expired - Fee Related
- 2008-04-11 CA CA2679071A patent/CA2679071C/en not_active Expired - Fee Related
- 2008-04-11 CA CA2876878A patent/CA2876878C/en not_active Expired - Fee Related
- 2008-04-11 ES ES15154003.6T patent/ES2618492T3/es active Active
- 2008-04-11 ES ES08737800.6T patent/ES2557172T3/es active Active
- 2008-04-11 PL PL15154003T patent/PL2905283T3/pl unknown
- 2008-04-11 CN CN2008800118148A patent/CN101679415B/zh not_active Expired - Fee Related
- 2008-04-11 RU RU2009141311/04A patent/RU2470022C2/ru not_active IP Right Cessation
- 2008-04-11 WO PCT/IB2008/051374 patent/WO2008126034A2/en active Application Filing
- 2008-04-11 ES ES15154086.1T patent/ES2622961T3/es active Active
- 2008-04-11 US US12/595,720 patent/US8217029B2/en not_active Expired - Fee Related
- 2008-04-11 EP EP15154086.1A patent/EP2915813B1/en active Active
- 2008-04-11 EP EP08737800.6A patent/EP2144910B1/en not_active Not-in-force
- 2008-04-11 MX MX2011010274A patent/MX351589B/es unknown
- 2008-04-11 PL PL08737800T patent/PL2144910T3/pl unknown
- 2008-04-11 EP EP15154003.6A patent/EP2905283B1/en not_active Not-in-force
- 2008-04-11 CN CN201210209027.2A patent/CN102746296B/zh not_active Expired - Fee Related
- 2008-04-11 MX MX2009010642A patent/MX2009010642A/es active IP Right Grant
- 2008-04-11 KR KR1020097022518A patent/KR101495269B1/ko active IP Right Grant
- 2008-04-11 JP JP2010502628A patent/JP5427770B2/ja not_active Expired - Fee Related
- 2008-04-11 PL PL15154086T patent/PL2915813T3/pl unknown
- 2008-04-11 BR BRPI0809977A patent/BRPI0809977A8/pt not_active Application Discontinuation
- 2008-04-11 AU AU2008238904A patent/AU2008238904B2/en not_active Ceased
- 2008-04-11 MX MX2011010275A patent/MX351590B/es unknown
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