BRPI0809977A2 - Uso de um composto, compostos e composição farmacêutica que o contém - Google Patents

Uso de um composto, compostos e composição farmacêutica que o contém

Info

Publication number
BRPI0809977A2
BRPI0809977A2 BRPI0809977-4A2A BRPI0809977A BRPI0809977A2 BR PI0809977 A2 BRPI0809977 A2 BR PI0809977A2 BR PI0809977 A BRPI0809977 A BR PI0809977A BR PI0809977 A2 BRPI0809977 A2 BR PI0809977A2
Authority
BR
Brazil
Prior art keywords
compounds
compound
pharmaceutical composition
composition containing
pharmaceutical
Prior art date
Application number
BRPI0809977-4A2A
Other languages
English (en)
Inventor
Daniel Bur
Christian Hubschwerlen
Georg Rueedi
Jean-Philippe Surivet
Cornelia Zumbrunn-Acklin
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0809977A2 publication Critical patent/BRPI0809977A2/pt
Publication of BRPI0809977A8 publication Critical patent/BRPI0809977A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0809977A 2007-04-11 2008-04-11 Uso de um composto, compostos e composição farmacêutica que o contém BRPI0809977A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IB2007051290 2007-04-11
IB2007054587 2007-11-12
IB2007054768 2007-11-23
PCT/IB2008/051374 WO2008126034A2 (en) 2007-04-11 2008-04-11 Oxazolidinone antibiotics

Publications (2)

Publication Number Publication Date
BRPI0809977A2 true BRPI0809977A2 (pt) 2014-10-07
BRPI0809977A8 BRPI0809977A8 (pt) 2017-12-26

Family

ID=39682545

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809977A BRPI0809977A8 (pt) 2007-04-11 2008-04-11 Uso de um composto, compostos e composição farmacêutica que o contém

Country Status (16)

Country Link
US (1) US8217029B2 (pt)
EP (3) EP2905283B1 (pt)
JP (1) JP5427770B2 (pt)
KR (1) KR101495269B1 (pt)
CN (3) CN101679415B (pt)
AR (1) AR066013A1 (pt)
AU (1) AU2008238904B2 (pt)
BR (1) BRPI0809977A8 (pt)
CA (3) CA2876878C (pt)
CL (1) CL2008001002A1 (pt)
ES (3) ES2618492T3 (pt)
MX (3) MX2009010642A (pt)
PL (3) PL2905283T3 (pt)
RU (1) RU2470022C2 (pt)
TW (1) TWI411434B (pt)
WO (1) WO2008126034A2 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0820985A2 (pt) 2007-12-18 2015-06-16 Actelion Pharmaceuticals Ltd Composto derivado de 5-aminociclometil-oxazondin-2-ona, medicamento e composição farmacêutica que os contém e uso dos mesmos
BRPI0907892A2 (pt) 2008-02-20 2015-07-28 Actelion Pharmaceuticals Ltd Composto antibiótico azatricíclico, medicamento, composição farmacêutica que o contém e uso do mesmo
EP2254887B9 (en) 2008-02-22 2013-05-29 Actelion Pharmaceuticals Ltd. Oxazolidinone derivatives
ES2399499T3 (es) 2008-08-04 2013-04-01 Actelion Pharmaceuticals Ltd. Derivados de alquilaminometiloxazolidinona tricíclicos
BRPI0920895A8 (pt) 2008-10-07 2017-12-26 Actelion Pharmaceuticals Ltd Compostos antibióticos de oxazolidinona tricíclica
US20110195949A1 (en) * 2008-10-10 2011-08-11 Actelion Pharmaceuticals Ltd. 2-benzothiophenyl- and 2-naphthyl-oxazolidinones and their azaisostere analogues as antibacterial agents
FR2945533B1 (fr) * 2009-05-12 2011-05-27 Sanofi Aventis Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
EP2388260A1 (de) * 2010-05-21 2011-11-23 Archimica GmbH Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors
JPWO2012108376A1 (ja) 2011-02-07 2014-07-03 第一三共株式会社 アミノ基含有ピロリジノン誘導体
US8916573B2 (en) 2011-08-11 2014-12-23 Actelion Pharmaceuticals Ltd. Quinazoline-2,4-dione derivatives
BR112014011064A8 (pt) * 2011-11-08 2017-12-26 Actelion Pharmaceuticals Ltd derivados de antibióticos 2-oxo-oxazolidin-3,5-diila
DE102012006884A1 (de) 2012-04-04 2013-10-10 Merck Patent Gmbh Cyclische Amide als MetAP-2 Inhibitoren
JP6258928B2 (ja) 2012-06-13 2018-01-10 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規ジアザスピロシクロアルカンおよびアザスピロシクロアルカン
EA201590053A1 (ru) 2012-06-20 2015-08-31 Новартис Аг Модуляторы пути системы комплемента и их применение
WO2014024056A1 (en) 2012-08-06 2014-02-13 Daiichi Sankyo Company, Limited Pyrrolidine derivatives with antibacterial properties
AR092645A1 (es) 2012-09-25 2015-04-29 Hoffmann La Roche Derivados biciclicos inhibidores de autotaxina (atx)
CN103012389A (zh) * 2013-01-24 2013-04-03 中国药科大学 一种利伐沙班中间体的制备方法
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
PE20160845A1 (es) 2013-11-26 2016-09-10 Hoffmann La Roche Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo
PL3122750T3 (pl) 2014-03-26 2020-03-31 F.Hoffmann-La Roche Ag Związki bicykliczne jako inhibitory wytwarzania autotaksyny (ATX) i kwasu lizofosfatydowego (LPA)
EP3122751B1 (en) 2014-03-26 2019-10-30 F.Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
MA41168A (fr) * 2014-12-17 2017-10-24 Acraf Nouveaux composés antibactériens
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
UA123362C2 (uk) 2015-09-04 2021-03-24 Ф. Хоффманн-Ля Рош Аг Феноксиметильні похідні
MX2018002217A (es) 2015-09-24 2018-03-23 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de autotaxina (atx).
WO2017050747A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
WO2017050791A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
AU2016328437A1 (en) 2015-09-24 2018-01-25 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
SG11201804412SA (en) 2015-12-10 2018-06-28 Bracco Imaging Spa Dimeric contrast agents
CN108290849B (zh) 2015-12-10 2022-03-22 伯拉考成像股份公司 造影剂
EP3889146A1 (en) 2015-12-17 2021-10-06 Merck Patent GmbH Polyheterocyclic tlr7/8 antagonists and their uses for treating immune disorders
US20210179636A1 (en) * 2016-02-08 2021-06-17 Redx Pharma Plc Antibacterial compounds
GB201602235D0 (en) * 2016-02-08 2016-03-23 Redx Pharma Plc Antibacterial compounds
WO2017137744A1 (en) * 2016-02-08 2017-08-17 Redx Pharma Plc Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds
WO2017178301A1 (en) 2016-04-13 2017-10-19 Bracco Imaging Spa Contrast agents
KR102635885B1 (ko) 2016-08-08 2024-02-14 메르크 파텐트 게엠베하 Tlr7/8 안타고니스트 및 이의 용도
WO2018108780A1 (en) 2016-12-12 2018-06-21 Bracco Imaging Spa Dimeric contrast agents
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
SG11201908560SA (en) 2017-03-16 2019-10-30 Hoffmann La Roche Heterocyclic compounds useful as dual atx/ca inhibitors
US10793553B2 (en) * 2017-07-18 2020-10-06 Merck Patent Gmbh TLR7/8 antagonists and uses thereof
ES2952989T3 (es) * 2017-11-29 2023-11-07 Bugworks Res Inc Compuestos heterocíclicos antibacterianos y su síntesis
CN109265389B (zh) * 2018-08-31 2020-08-18 南京富润凯德生物医药有限公司 2-(氨基甲基)-1-氧杂-7-氮杂螺[3.5]壬烷衍生物、中间体及其制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3723797A1 (de) 1987-07-18 1989-01-26 Merck Patent Gmbh Oxazolidinone
KR950014567B1 (ko) 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체
DE19707628A1 (de) * 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
HUP0200309A3 (en) 1999-01-07 2003-05-28 Wyeth Corp Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression, process for their preparation and pharmaceutical compositions containing them
IL154107A0 (en) 2000-07-26 2003-07-31 Smithkline Beecham Plc Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
DE10247233A1 (de) * 2002-10-10 2004-06-17 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Topoisomerase IV inhibieren
ES2312839T3 (es) * 2002-12-04 2009-03-01 Glaxo Group Limited Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos.
DE10316081A1 (de) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
FR2872164B1 (fr) * 2004-06-29 2006-11-17 Aventis Pharma Sa Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
WO2006024741A2 (fr) * 2004-07-30 2006-03-09 Palumed S.A. Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
CA2580621A1 (en) 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
US7511035B2 (en) * 2005-01-25 2009-03-31 Glaxo Group Limited Antibacterial agents
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR20080064173A (ko) 2005-10-21 2008-07-08 글락소 그룹 리미티드 항균제로서 유용한 페리 축합 트리시클릭 화합물
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
DE602006013878D1 (de) 2005-12-22 2010-06-02 Glaxo Group Ltd Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
ES2345166T3 (es) 2006-03-23 2010-09-16 Actelion Pharmaceuticals Ltd. Derivados antibioticos del tipo de ciclohexil- o piperidinilcarboxamida.
JP2009532504A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌薬
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
WO2008126034A3 (en) 2008-12-31
ES2557172T3 (es) 2016-01-22
AR066013A1 (es) 2009-07-15
BRPI0809977A8 (pt) 2017-12-26
MX351590B (es) 2017-10-20
TWI411434B (zh) 2013-10-11
PL2144910T3 (pl) 2016-04-29
CL2008001002A1 (es) 2008-10-17
CN102746297A (zh) 2012-10-24
CA2679071A1 (en) 2008-10-23
JP2010523646A (ja) 2010-07-15
US8217029B2 (en) 2012-07-10
US20110039823A1 (en) 2011-02-17
CA2876878A1 (en) 2008-10-23
RU2009141311A (ru) 2011-05-20
PL2905283T3 (pl) 2017-06-30
TW200848031A (en) 2008-12-16
ES2618492T3 (es) 2017-06-21
KR101495269B1 (ko) 2015-02-26
MX351589B (es) 2017-10-20
CN102746297B (zh) 2015-08-26
EP2905283A1 (en) 2015-08-12
CA2876878C (en) 2017-07-11
PL2915813T3 (pl) 2017-07-31
WO2008126034A2 (en) 2008-10-23
EP2915813A1 (en) 2015-09-09
CN102746296A (zh) 2012-10-24
AU2008238904A1 (en) 2008-10-23
CA2876879A1 (en) 2008-10-23
KR20090130086A (ko) 2009-12-17
CA2679071C (en) 2016-06-07
EP2144910A2 (en) 2010-01-20
RU2470022C2 (ru) 2012-12-20
MX2009010642A (es) 2009-10-22
CN102746296B (zh) 2015-10-28
EP2905283B1 (en) 2016-12-14
JP5427770B2 (ja) 2014-02-26
EP2144910B1 (en) 2015-10-28
CN101679415A (zh) 2010-03-24
ES2622961T3 (es) 2017-07-10
CN101679415B (zh) 2013-07-31
EP2915813B1 (en) 2017-02-01
AU2008238904B2 (en) 2013-11-28
CA2876879C (en) 2017-11-28

Similar Documents

Publication Publication Date Title
BRPI0809977A2 (pt) Uso de um composto, compostos e composição farmacêutica que o contém
BRPI0810696A2 (pt) Composto, composição farmacêutica, e, uso de um composto
BRPI0919942A2 (pt) Composto, composição farmacêutica, e, uso de um composto
BRPI0907562A2 (pt) composto, composição farmacêutica, e, uso de um composto
BRPI0921375A2 (pt) composto, composição farmacêutica, e, uso de um composto
BRPI0810161A2 (pt) Composto, preparação farmacêutica, composição farmacêutica, e, uso de um composto
BRPI0815709A2 (pt) composro, composição farmacêutica, e, uso de um composto.
BRPI0814593A2 (pt) Composto, composição farmacêutica que o contém e uso do composto.
BRPI0819696A2 (pt) Compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto
BRPI0921879A2 (pt) composto, composição farmacêutica , e, uso de um composto
BRPI0716171A2 (pt) composto, composiÇço farmacÊutica e uso de um composto.
BRPI0815079A2 (pt) Composto dericado de 1,2-diamido-etileno, composição farmacêutica que contém e uso desse composto
BRPI0609802A2 (pt) composto, composição farmacêutica e uso de um composto
BRPI0810019A2 (pt) Composto, composição farmacêutica, e, uso de um composto
BRPI0812942A2 (pt) Composto, composição farmacêutica e uso de um composto
BRPI0917579A2 (pt) composto, composição farmacêutica, métodos, e, uso de um composto
BRPI0809667A2 (pt) Composto, medicamento e composição farmacêutica que o contém e uso do composto
BRPI0716698A2 (pt) Composto, composição farmacêutica e uso de um composto
BRPI0917001A2 (pt) composto, composição farmacêutica, e, uso de um composto ou uma composição farmacêutica
BRPI1016219A2 (pt) composto, composição farmacêutica, e, uso de um composto
BRPI1008793A2 (pt) composto, uso de um composto, e, composição farmacêutica
BRPI0906937A2 (pt) composto, composição farmacêutica, e, uso de um composto
BRPI0821115A2 (pt) Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto
BRPI0908208A2 (pt) Composto derivado de oxazolidinona, medicamento, composição farmacêutica que o contém e uso desse composto.
BRPI0907892A2 (pt) Composto antibiótico azatricíclico, medicamento, composição farmacêutica que o contém e uso do mesmo

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B25C Requirement related to requested transfer of rights

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements