BRPI0809977A2 - Uso de um composto, compostos e composição farmacêutica que o contém - Google Patents

Uso de um composto, compostos e composição farmacêutica que o contém

Info

Publication number
BRPI0809977A2
BRPI0809977A2 BRPI0809977-4A2A BRPI0809977A BRPI0809977A2 BR PI0809977 A2 BRPI0809977 A2 BR PI0809977A2 BR PI0809977 A BRPI0809977 A BR PI0809977A BR PI0809977 A2 BRPI0809977 A2 BR PI0809977A2
Authority
BR
Brazil
Prior art keywords
compounds
compound
pharmaceutical composition
composition containing
pharmaceutical
Prior art date
Application number
BRPI0809977-4A2A
Other languages
English (en)
Inventor
Daniel Bur
Christian Hubschwerlen
Georg Rueedi
Jean-Philippe Surivet
Cornelia Zumbrunn-Acklin
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0809977A2 publication Critical patent/BRPI0809977A2/pt
Publication of BRPI0809977A8 publication Critical patent/BRPI0809977A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0809977A 2007-04-11 2008-04-11 Uso de um composto, compostos e composição farmacêutica que o contém BRPI0809977A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IB2007051290 2007-04-11
IB2007054587 2007-11-12
IB2007054768 2007-11-23
PCT/IB2008/051374 WO2008126034A2 (en) 2007-04-11 2008-04-11 Oxazolidinone antibiotics

Publications (2)

Publication Number Publication Date
BRPI0809977A2 true BRPI0809977A2 (pt) 2014-10-07
BRPI0809977A8 BRPI0809977A8 (pt) 2017-12-26

Family

ID=39682545

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809977A BRPI0809977A8 (pt) 2007-04-11 2008-04-11 Uso de um composto, compostos e composição farmacêutica que o contém

Country Status (16)

Country Link
US (1) US8217029B2 (pt)
EP (3) EP2905283B1 (pt)
JP (1) JP5427770B2 (pt)
KR (1) KR101495269B1 (pt)
CN (3) CN102746297B (pt)
AR (1) AR066013A1 (pt)
AU (1) AU2008238904B2 (pt)
BR (1) BRPI0809977A8 (pt)
CA (3) CA2876879C (pt)
CL (1) CL2008001002A1 (pt)
ES (3) ES2618492T3 (pt)
MX (3) MX351590B (pt)
PL (3) PL2144910T3 (pt)
RU (1) RU2470022C2 (pt)
TW (1) TWI411434B (pt)
WO (1) WO2008126034A2 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101903380B (zh) 2007-12-18 2013-04-17 埃科特莱茵药品有限公司 5-氨基环甲基-噁唑啶-2-酮衍生物
ES2411930T3 (es) 2008-02-20 2013-07-09 Actelion Pharmaceuticals Ltd. Compuestos antibióticos azatricíclicos
RU2501799C2 (ru) 2008-02-22 2013-12-20 Актелион Фармасьютикалз Лтд Поизводные оксазолидинона
US8466168B2 (en) 2008-08-04 2013-06-18 Actellon Pharmaceuticals Ltd. Tricyclic alkylaminomethyloxazolidinone derivatives
ES2533217T3 (es) 2008-10-07 2015-04-08 Actelion Pharmaceuticals Ltd. Compuestos antibióticos de oxazolidinona tricíclicos
JP2012505201A (ja) * 2008-10-10 2012-03-01 アクテリオン ファーマシューティカルズ リミテッド ２−ベンゾチオフェニル−及び２−ナフチル−オキサゾリジノン、並びにそれらのアザアイソスター（ａｚａｉｓｏｓｔｅｒｅ）類似体
FR2945533B1 (fr) * 2009-05-12 2011-05-27 Sanofi Aventis Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
EP2388260A1 (de) * 2010-05-21 2011-11-23 Archimica GmbH Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors
JPWO2012108376A1 (ja) 2011-02-07 2014-07-03 第一三共株式会社 アミノ基含有ピロリジノン誘導体
JP2014525396A (ja) 2011-08-11 2014-09-29 アクテリオン ファーマシューティカルズ リミテッド キナゾリン−２，４−ジオン誘導体
CA2854264A1 (en) * 2011-11-08 2013-05-16 Actelion Pharmaceuticals Ltd 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives
DE102012006884A1 (de) * 2012-04-04 2013-10-10 Merck Patent Gmbh Cyclische Amide als MetAP-2 Inhibitoren
LT2861566T (lt) 2012-06-13 2017-02-10 F. Hoffmann-La Roche Ag Nauji diazaspirocikloalkanai ir azaspirocikloalkanai
KR20150033652A (ko) 2012-06-20 2015-04-01 노파르티스 아게 보체 경로 조절제 및 그의 용도
WO2014024056A1 (en) 2012-08-06 2014-02-13 Daiichi Sankyo Company, Limited Pyrrolidine derivatives with antibacterial properties
CA2878442A1 (en) 2012-09-25 2014-04-03 F. Hoffmann-La Roche Ag Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
CN103012389A (zh) * 2013-01-24 2013-04-03 中国药科大学 一种利伐沙班中间体的制备方法
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
EA201691044A1 (ru) 2013-11-26 2016-09-30 Ф. Хоффманн-Ля Рош Аг Новый октагидро-циклобута[1,2-c;3,4-c']дипиррол-2-ил
KR20160128428A (ko) 2014-03-26 2016-11-07 에프. 호프만-라 로슈 아게 오토탁신(atx) 및 리소포스파티드산(lpa) 생성 억제제로서의 축합형 [1,4]다이아제핀 화합물
ES2753549T3 (es) 2014-03-26 2020-04-13 Hoffmann La Roche Compuestos bicíclicos como inhibidores de la producción de autotaxina (ATX) y ácido lisofosfatídico (LPA)
AR102256A1 (es) * 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
MA41168A (fr) * 2014-12-17 2017-10-24 Acraf Nouveaux composés antibactériens
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
PE20180479A1 (es) 2015-09-04 2018-03-07 Hoffmann La Roche Nuevos derivados de fenoximetilo
JP6877413B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物
BR112017026682A2 (pt) 2015-09-24 2018-08-14 Hoffmann La Roche novos compostos bicíclicos como inibidores de dupla ação de atx/ca
MA42919A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
EP3353180B1 (en) 2015-09-24 2022-03-16 F. Hoffmann-La Roche AG Bicyclic compounds as atx inhibitors
JP6840148B2 (ja) 2015-12-10 2021-03-10 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 造影剤
CN108368067B (zh) 2015-12-10 2022-04-29 伯拉考成像股份公司 二聚造影剂
KR20180094939A (ko) 2015-12-17 2018-08-24 메르크 파텐트 게엠베하 폴리시클릭 tlr7/8 안타고니스트 및 면역 질환의 치료에서 이들의 용도
EP3413976A1 (en) 2016-02-08 2018-12-19 Redx Pharma PLC Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds
GB201602235D0 (en) * 2016-02-08 2016-03-23 Redx Pharma Plc Antibacterial compounds
CA3012569A1 (en) * 2016-02-08 2017-08-17 Redx Pharma Plc Antibacterial compounds
WO2017178301A1 (en) 2016-04-13 2017-10-19 Bracco Imaging Spa Contrast agents
JP7125385B2 (ja) 2016-08-08 2022-08-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｌｒ７／８アンタゴニストおよびそれらの使用
CN109963838B (zh) 2016-12-12 2023-04-11 伯拉考成像股份公司 二聚造影剂
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
MA49879A (fr) 2017-03-16 2020-06-24 Hoffmann La Roche Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
DK3655401T3 (da) 2017-07-18 2023-10-30 Merck Patent Gmbh Tlr7/8-antagonister og anvendelser deraf
ES2952989T3 (es) * 2017-11-29 2023-11-07 Bugworks Res Inc Compuestos heterocíclicos antibacterianos y su síntesis
CN109265389B (zh) * 2018-08-31 2020-08-18 南京富润凯德生物医药有限公司 2-(氨基甲基)-1-氧杂-7-氮杂螺[3.5]壬烷衍生物、中间体及其制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3723797A1 (de) * 1987-07-18 1989-01-26 Merck Patent Gmbh Oxazolidinone
KR950014567B1 (ko) 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체
DE19707628A1 (de) * 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
CN1166636C (zh) 1999-01-07 2004-09-15 惠氏 用于治疗抑郁症的芳基哌嗪基-环己基吲哚衍生物
US6962917B2 (en) 2000-07-26 2005-11-08 Smithkline Beecham P.L.C. Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
DE10247233A1 (de) * 2002-10-10 2004-06-17 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Topoisomerase IV inhibieren
DE60324179D1 (de) * 2002-12-04 2008-11-27 Glaxo Group Ltd Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
FR2872164B1 (fr) * 2004-06-29 2006-11-17 Aventis Pharma Sa Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
CA2572442A1 (fr) * 2004-07-30 2006-03-09 Palumed S.A. Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
CA2580621A1 (en) 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
WO2006081289A2 (en) * 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
EP1954697B1 (en) 2005-10-21 2010-02-24 Glaxo Group Limited Peri condensed tricyclic compounds useful as antibacterial agents
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
ES2344523T3 (es) 2005-12-22 2010-08-30 Glaxo Group Limited Compuestos heterociclicos, su preparacion y su uso como agentes antibacterianos.
ES2345166T3 (es) 2006-03-23 2010-09-16 Actelion Pharmaceuticals Ltd. Derivados antibioticos del tipo de ciclohexil- o piperidinilcarboxamida.
EP2007377A4 (en) 2006-04-06 2011-08-17 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
CL2008001002A1 (es) 2008-10-17
MX351589B (es) 2017-10-20
JP5427770B2 (ja) 2014-02-26
AU2008238904A1 (en) 2008-10-23
CA2679071C (en) 2016-06-07
ES2557172T3 (es) 2016-01-22
PL2905283T3 (pl) 2017-06-30
TW200848031A (en) 2008-12-16
PL2915813T3 (pl) 2017-07-31
KR101495269B1 (ko) 2015-02-26
EP2915813A1 (en) 2015-09-09
CN102746296A (zh) 2012-10-24
MX2009010642A (es) 2009-10-22
EP2144910B1 (en) 2015-10-28
WO2008126034A3 (en) 2008-12-31
EP2915813B1 (en) 2017-02-01
EP2905283A1 (en) 2015-08-12
KR20090130086A (ko) 2009-12-17
RU2470022C2 (ru) 2012-12-20
MX351590B (es) 2017-10-20
WO2008126034A2 (en) 2008-10-23
CN102746296B (zh) 2015-10-28
CA2876878C (en) 2017-07-11
JP2010523646A (ja) 2010-07-15
CN101679415B (zh) 2013-07-31
TWI411434B (zh) 2013-10-11
US8217029B2 (en) 2012-07-10
CA2876879C (en) 2017-11-28
BRPI0809977A8 (pt) 2017-12-26
ES2622961T3 (es) 2017-07-10
PL2144910T3 (pl) 2016-04-29
CA2876878A1 (en) 2008-10-23
EP2905283B1 (en) 2016-12-14
CN101679415A (zh) 2010-03-24
CN102746297B (zh) 2015-08-26
CN102746297A (zh) 2012-10-24
US20110039823A1 (en) 2011-02-17
ES2618492T3 (es) 2017-06-21
EP2144910A2 (en) 2010-01-20
CA2876879A1 (en) 2008-10-23
CA2679071A1 (en) 2008-10-23
AR066013A1 (es) 2009-07-15
RU2009141311A (ru) 2011-05-20
AU2008238904B2 (en) 2013-11-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B25C Requirement related to requested transfer of rights

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements