CA2712685A1 - Novel heterocyclic compounds - Google Patents
Novel heterocyclic compounds Download PDFInfo
- Publication number
- CA2712685A1 CA2712685A1 CA2712685A CA2712685A CA2712685A1 CA 2712685 A1 CA2712685 A1 CA 2712685A1 CA 2712685 A CA2712685 A CA 2712685A CA 2712685 A CA2712685 A CA 2712685A CA 2712685 A1 CA2712685 A1 CA 2712685A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- independently selected
- pharmaceutically acceptable
- cycloalkyl
- solvates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 290
- 150000003839 salts Chemical class 0.000 claims abstract description 75
- 238000000034 method Methods 0.000 claims abstract description 46
- 239000012453 solvate Substances 0.000 claims abstract description 43
- 229940002612 prodrug Drugs 0.000 claims abstract description 41
- 239000000651 prodrug Substances 0.000 claims abstract description 41
- 239000002207 metabolite Substances 0.000 claims abstract description 39
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 7
- 125000001424 substituent group Chemical group 0.000 claims description 81
- 238000002360 preparation method Methods 0.000 claims description 79
- -1 NHSO2R9 Inorganic materials 0.000 claims description 71
- 125000000623 heterocyclic group Chemical group 0.000 claims description 57
- 229910052739 hydrogen Inorganic materials 0.000 claims description 55
- 125000001072 heteroaryl group Chemical group 0.000 claims description 53
- 239000001257 hydrogen Substances 0.000 claims description 52
- 229910052757 nitrogen Inorganic materials 0.000 claims description 52
- 125000003118 aryl group Chemical group 0.000 claims description 48
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims description 43
- 125000003342 alkenyl group Chemical group 0.000 claims description 43
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 42
- 125000000304 alkynyl group Chemical group 0.000 claims description 40
- 229910052736 halogen Inorganic materials 0.000 claims description 39
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 38
- 150000002431 hydrogen Chemical class 0.000 claims description 37
- 239000000203 mixture Substances 0.000 claims description 37
- 125000000262 haloalkenyl group Chemical group 0.000 claims description 36
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 34
- 150000002367 halogens Chemical class 0.000 claims description 32
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- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 21
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- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
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- Biomedical Technology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
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- Urology & Nephrology (AREA)
- Dermatology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Transplantation (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202DE2008 | 2008-01-24 | ||
| IN202/DEL/2008 | 2008-01-24 | ||
| IN688/DEL/2008 | 2008-03-18 | ||
| IN688DE2008 | 2008-03-18 | ||
| PCT/IN2009/000061 WO2009093269A1 (en) | 2008-01-24 | 2009-01-23 | Novel heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2712685A1 true CA2712685A1 (en) | 2009-07-30 |
Family
ID=40474786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2712685A Abandoned CA2712685A1 (en) | 2008-01-24 | 2009-01-23 | Novel heterocyclic compounds |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8455479B2 (enExample) |
| EP (1) | EP2250157B1 (enExample) |
| JP (1) | JP5640208B2 (enExample) |
| KR (1) | KR20100113122A (enExample) |
| CN (1) | CN101925586B (enExample) |
| AP (1) | AP2010005364A0 (enExample) |
| AR (1) | AR070520A1 (enExample) |
| AU (1) | AU2009207297B2 (enExample) |
| BR (1) | BRPI0906705A2 (enExample) |
| CA (1) | CA2712685A1 (enExample) |
| CL (1) | CL2009000135A1 (enExample) |
| EA (1) | EA018612B1 (enExample) |
| PE (1) | PE20091353A1 (enExample) |
| WO (1) | WO2009093269A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8492376B2 (en) * | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| IN2010DE02164A (enExample) | 2010-09-13 | 2015-07-24 | Panacea Biotec Ltd | |
| CN102617566B (zh) * | 2011-01-30 | 2015-03-04 | 山东轩竹医药科技有限公司 | 吡啶并咪唑烷衍生物 |
| CN104230935A (zh) * | 2011-04-26 | 2014-12-24 | 辽宁利锋科技开发有限公司 | 含有脂环结构化合物的抗肿瘤作用与应用 |
| CN102241678B (zh) * | 2011-04-26 | 2014-10-29 | 辽宁利锋科技开发有限公司 | 含有脂环结构化合物的抗肿瘤作用与应用 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN105142621A (zh) | 2012-10-24 | 2015-12-09 | 国家健康科学研究所 | 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂 |
| KR20160028241A (ko) | 2014-09-03 | 2016-03-11 | 김형도 | 목욕탕용 순환배관 슬러지 제거방법 |
| EP3273981B1 (en) | 2015-03-24 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of diabetes |
| CA3014644A1 (en) | 2016-02-15 | 2017-08-24 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines and related analogs as bet bromodomain inhibitors |
| CN106883152A (zh) * | 2017-04-07 | 2017-06-23 | 上海应用技术大学 | 一种β‑氨基酮的制备方法 |
| CN108084187A (zh) * | 2017-12-15 | 2018-05-29 | 宜昌人福药业有限责任公司 | 苯并二氮杂*类氢化物 |
| JP7825618B2 (ja) | 2020-11-06 | 2026-03-06 | サイトキネティックス， インコーポレイテッド | 二環式１，４－ジアゼパノン及びその治療的使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| WO2004007468A1 (en) * | 2002-07-15 | 2004-01-22 | Merck & Co., Inc. | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes |
| WO2004032836A2 (en) * | 2002-10-07 | 2004-04-22 | Merck & Co., Inc. | Antidiabetic beta-amino heterocylcic dipeptidyl peptidase inhibitors |
| HRP20050343A2 (en) * | 2002-10-18 | 2007-03-31 | Merck & Co. Inc. | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| EP1583534A4 (en) * | 2002-12-20 | 2007-08-29 | Merck & Co Inc | 3-AMINO-4-PHENYLBUTANIC ACID DERIVATIVES AS DIPEPTIDYL-PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES |
| WO2004103276A2 (en) * | 2003-05-14 | 2004-12-02 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| CN1882551A (zh) * | 2003-07-31 | 2006-12-20 | 麦克公司 | 用作用于治疗或预防糖尿病的二肽基肽酶－iv酶抑制剂的六氢二氮杂吖庚因酮 |
| US20090156465A1 (en) * | 2005-12-30 | 2009-06-18 | Sattigeri Jitendra A | Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors |
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2009
- 2009-01-23 JP JP2010543630A patent/JP5640208B2/ja not_active Expired - Fee Related
- 2009-01-23 CA CA2712685A patent/CA2712685A1/en not_active Abandoned
- 2009-01-23 EA EA201070864A patent/EA018612B1/ru not_active IP Right Cessation
- 2009-01-23 EP EP09703708.9A patent/EP2250157B1/en not_active Not-in-force
- 2009-01-23 US US12/863,016 patent/US8455479B2/en not_active Expired - Fee Related
- 2009-01-23 PE PE2009000101A patent/PE20091353A1/es not_active Application Discontinuation
- 2009-01-23 CL CL2009000135A patent/CL2009000135A1/es unknown
- 2009-01-23 CN CN200980103148.5A patent/CN101925586B/zh not_active Expired - Fee Related
- 2009-01-23 AU AU2009207297A patent/AU2009207297B2/en not_active Ceased
- 2009-01-23 AP AP2010005364A patent/AP2010005364A0/en unknown
- 2009-01-23 BR BRPI0906705-1A patent/BRPI0906705A2/pt not_active IP Right Cessation
- 2009-01-23 WO PCT/IN2009/000061 patent/WO2009093269A1/en not_active Ceased
- 2009-01-23 KR KR1020107018056A patent/KR20100113122A/ko not_active Withdrawn
- 2009-01-26 AR ARP090100236A patent/AR070520A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20091353A1 (es) | 2009-09-05 |
| EA018612B1 (ru) | 2013-09-30 |
| US20100311732A1 (en) | 2010-12-09 |
| CN101925586A (zh) | 2010-12-22 |
| JP5640208B2 (ja) | 2014-12-17 |
| KR20100113122A (ko) | 2010-10-20 |
| EP2250157A1 (en) | 2010-11-17 |
| AR070520A1 (es) | 2010-04-14 |
| EA201070864A1 (ru) | 2011-02-28 |
| WO2009093269A1 (en) | 2009-07-30 |
| AU2009207297A1 (en) | 2009-07-30 |
| CN101925586B (zh) | 2014-05-07 |
| AP2010005364A0 (en) | 2010-08-31 |
| JP2011510068A (ja) | 2011-03-31 |
| CL2009000135A1 (es) | 2009-10-09 |
| WO2009093269A9 (en) | 2009-10-15 |
| US8455479B2 (en) | 2013-06-04 |
| EP2250157B1 (en) | 2014-11-05 |
| AU2009207297B2 (en) | 2011-11-10 |
| BRPI0906705A2 (pt) | 2015-06-30 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20150123 |