CA2709947C - Novel milk thistle extract, method for preparation, and use - Google Patents

Novel milk thistle extract, method for preparation, and use Download PDF

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Publication number
CA2709947C
CA2709947C CA2709947A CA2709947A CA2709947C CA 2709947 C CA2709947 C CA 2709947C CA 2709947 A CA2709947 A CA 2709947A CA 2709947 A CA2709947 A CA 2709947A CA 2709947 C CA2709947 C CA 2709947C
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CA
Canada
Prior art keywords
milk thistle
fruit extract
thistle fruit
release rate
preparing
Prior art date
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Active
Application number
CA2709947A
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English (en)
French (fr)
Other versions
CA2709947A1 (en
Inventor
Astrid Nagell
Jaime Xiol Aguirre
Santiago Rull Prous
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euromed SA
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Euromed SA
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Filing date
Publication date
Application filed by Euromed SA filed Critical Euromed SA
Priority to CA2922846A priority Critical patent/CA2922846A1/en
Publication of CA2709947A1 publication Critical patent/CA2709947A1/en
Application granted granted Critical
Publication of CA2709947C publication Critical patent/CA2709947C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2709947A 2007-12-23 2008-12-23 Novel milk thistle extract, method for preparation, and use Active CA2709947C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2922846A CA2922846A1 (en) 2007-12-23 2008-12-23 Novel milk thistle extract, method for preparation, and use

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102007063115 2007-12-23
DE102007063115.6 2007-12-23
DE102008039271A DE102008039271A1 (de) 2007-12-23 2008-08-23 Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung
DE102008039271.5 2008-08-23
PCT/DE2008/002117 WO2009080006A2 (de) 2007-12-23 2008-12-23 Neuer mariendistelextrakt, verfahren zur herstellung und verwendung

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2922846A Division CA2922846A1 (en) 2007-12-23 2008-12-23 Novel milk thistle extract, method for preparation, and use

Publications (2)

Publication Number Publication Date
CA2709947A1 CA2709947A1 (en) 2009-07-02
CA2709947C true CA2709947C (en) 2016-05-17

Family

ID=40690102

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2709947A Active CA2709947C (en) 2007-12-23 2008-12-23 Novel milk thistle extract, method for preparation, and use
CA2922846A Abandoned CA2922846A1 (en) 2007-12-23 2008-12-23 Novel milk thistle extract, method for preparation, and use

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2922846A Abandoned CA2922846A1 (en) 2007-12-23 2008-12-23 Novel milk thistle extract, method for preparation, and use

Country Status (20)

Country Link
US (1) US20110027396A1 (enExample)
EP (2) EP2567703A3 (enExample)
JP (2) JP5442632B2 (enExample)
KR (2) KR101607445B1 (enExample)
CN (2) CN101925360A (enExample)
AU (1) AU2008340922B2 (enExample)
BR (1) BRPI0822069B8 (enExample)
CA (2) CA2709947C (enExample)
CY (1) CY1115081T1 (enExample)
DE (1) DE102008039271A1 (enExample)
DK (1) DK2222320T3 (enExample)
ES (1) ES2438003T3 (enExample)
HK (1) HK1203352A1 (enExample)
HR (1) HRP20131165T1 (enExample)
MX (1) MX2010006982A (enExample)
PL (1) PL2222320T3 (enExample)
PT (1) PT2222320E (enExample)
RU (1) RU2489161C2 (enExample)
SI (1) SI2222320T1 (enExample)
WO (1) WO2009080006A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5841048B2 (ja) * 2009-05-14 2016-01-06 エウロメッド・エセ・ア ウイルス性肝炎の治療のための非晶質シリビニン
CN102225085B (zh) * 2011-06-20 2012-09-05 黑龙江大学 一种从水飞蓟秸秆中提取水飞蓟总黄酮的方法
KR101316806B1 (ko) * 2011-08-02 2013-10-10 (주)이뮤노텍 글루타치온과 실리마린을 유효성분으로 함유하는 항산화 및 간보호용 조성물
KR101655396B1 (ko) * 2013-08-06 2016-09-08 에스케이바이오랜드 주식회사 수용성 밀크씨슬 추출물 및 이의 제조방법
JP2015113332A (ja) * 2013-12-16 2015-06-22 花王株式会社 生薬粉体
CN104744447B (zh) * 2013-12-31 2017-12-26 天士力制药集团股份有限公司 水飞蓟宾迷迭香酸酯及其制备方法和用途
CN104651037A (zh) * 2014-01-17 2015-05-27 吴长军 一种亚临界流体萃取水飞蓟籽仁中油脂和蛋白的方法
CN105622594B (zh) * 2016-03-17 2019-05-17 江苏中兴药业有限公司 一种高纯度水飞蓟素的制备方法
ES2706008B8 (es) * 2017-09-22 2021-07-12 Euromed S A Procedimiento para la preparacion de una composicion a partir del cardo mariano y composicion obtenida
KR102242002B1 (ko) 2019-02-21 2021-04-19 주식회사 노바케이메드 동충하초균사체로 고상발효된 홍삼 추출물을 유효성분으로 함유하는 지방간 질환 예방 또는 치료용 조성물
CN111518090B (zh) * 2020-05-12 2021-08-10 沈阳药科大学 黄烷黄酮衍生物及其制备方法和用途
KR102669644B1 (ko) * 2023-06-27 2024-05-27 한국자연한방 주식회사 실리마린 생체이용률이 증대된 밀크씨슬 추출물을 포함하는 지방간 개선, 예방 또는 치료용 조성물

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1767666C3 (de) 1968-06-01 1986-07-31 Dr. Madaus & Co, 5000 Koeln Pharmazeutische Zubereitung gegen Lebererkrankungen
DE1923982C3 (de) 1969-05-10 1978-07-13 Hoechst Ag, 6000 Frankfurt Flammfestmachen von Polyurethanschaumstoffen
DE2020407A1 (de) 1970-04-27 1971-11-11 Bernhard Dr Janiak Technisches Verfahren zur Isolierung von Silimarin
FR2181188A5 (en) * 1972-04-20 1973-11-30 Dott Inverni Della Beffa Polyhydroxyphenylchromones - by solvent extn of non-defatted fruit of Silybum marianum
US4061765A (en) * 1973-01-19 1977-12-06 Dr. Madaus & Co. Polyhydroxyphenylchromanone salts and therapeutic composition
DD112261A1 (enExample) * 1974-06-18 1975-04-05
DE2914330A1 (de) 1979-04-09 1980-10-30 Madaus & Co Dr Verfahren zur gewinnung von silymarin aus pflanzen
CH646695A5 (en) * 1980-10-06 1984-12-14 Madaus & Co Dr Method of obtaining silymarin from plants
DE3225688A1 (de) * 1982-07-09 1984-01-12 Suschnik Matthias Dr Verfahren zur gewinnung von silymarin aus silybum marianum
IT1241673B (it) 1989-10-09 1994-01-27 Istituto Biochimico Italiano Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.
DE19501266A1 (de) 1995-01-18 1996-07-25 Madaus Ag Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
KR0161349B1 (ko) 1995-01-20 1998-11-16 무라따 야스따까 압전 자기 조성물
RU2102999C1 (ru) * 1996-07-10 1998-01-27 Куркин Владимир Александрович Способ получения экстракта расторопши пятнистой
DE19744459A1 (de) * 1997-10-08 1999-04-15 Schwabe Willmar Gmbh & Co Flavonolignan-Zubereitungen, insbesondere Silymarin-Zubereitungen
IN192343B (enExample) * 2000-05-26 2004-04-10 Ranbaxy Lab Ltd
CZ292832B6 (cs) * 2001-08-30 2003-12-17 Ivax Pharmaceuticals S.R.O. Způsob přípravy silymarinu se zvýšenou rozpustností
JP2003135023A (ja) * 2001-10-30 2003-05-13 Os Kogyo Kk 健康食品
US7238373B2 (en) * 2003-04-04 2007-07-03 Nutritox Llc Nutritional supplement

Also Published As

Publication number Publication date
BRPI0822069B8 (pt) 2021-05-25
WO2009080006A2 (de) 2009-07-02
EP2567703A2 (de) 2013-03-13
JP2014074051A (ja) 2014-04-24
KR20150038663A (ko) 2015-04-08
RU2489161C2 (ru) 2013-08-10
PL2222320T3 (pl) 2014-02-28
KR101541938B1 (ko) 2015-08-04
CA2709947A1 (en) 2009-07-02
US20110027396A1 (en) 2011-02-03
EP2222320A2 (de) 2010-09-01
BRPI0822069A2 (pt) 2015-06-23
CN104189043A (zh) 2014-12-10
HK1203352A1 (en) 2015-10-30
RU2010130855A (ru) 2012-01-27
AU2008340922B2 (en) 2012-07-19
DE102008039271A1 (de) 2009-06-25
JP5442632B2 (ja) 2014-03-12
CA2922846A1 (en) 2009-07-02
EP2222320B1 (de) 2013-09-18
CN101925360A (zh) 2010-12-22
KR101607445B1 (ko) 2016-03-29
MX2010006982A (es) 2010-12-06
DK2222320T3 (da) 2013-12-16
ES2438003T3 (es) 2014-01-15
SI2222320T1 (sl) 2014-01-31
HRP20131165T1 (hr) 2014-01-03
EP2567703A3 (de) 2013-03-20
WO2009080006A3 (de) 2009-10-08
KR20100126272A (ko) 2010-12-01
PT2222320E (pt) 2013-12-23
JP2011507812A (ja) 2011-03-10
AU2008340922A1 (en) 2009-07-02
CY1115081T1 (el) 2016-12-14
BRPI0822069B1 (pt) 2019-10-08

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