CA2554089C - Albumin fusion proteins - Google Patents

Albumin fusion proteins Download PDF

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Publication number
CA2554089C
CA2554089C CA2554089A CA2554089A CA2554089C CA 2554089 C CA2554089 C CA 2554089C CA 2554089 A CA2554089 A CA 2554089A CA 2554089 A CA2554089 A CA 2554089A CA 2554089 C CA2554089 C CA 2554089C
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Canada
Prior art keywords
hsa
albumin fusion
protein
fusion protein
albumin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2554089A
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English (en)
French (fr)
Other versions
CA2554089A1 (en
Inventor
Craig A. Rosen
William A. Haseltine
Paul A. Moore
Jason B. Bock
David Lafleur
Steven M. Ruben
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Human Genome Sciences Inc
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Human Genome Sciences Inc
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Publication of CA2554089A1 publication Critical patent/CA2554089A1/en
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Publication of CA2554089C publication Critical patent/CA2554089C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • C07K14/765Serum albumin, e.g. HSA
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
CA2554089A 2004-02-09 2005-02-09 Albumin fusion proteins Expired - Fee Related CA2554089C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US54227404P 2004-02-09 2004-02-09
US60/542,274 2004-02-09
US54990104P 2004-03-05 2004-03-05
US60/549,901 2004-03-05
US55690604P 2004-03-29 2004-03-29
US60/556,906 2004-03-29
US63660304P 2004-12-17 2004-12-17
US60/636,603 2004-12-17
PCT/US2005/004041 WO2005077042A2 (en) 2004-02-09 2005-02-09 Albumin fusion proteins

Publications (2)

Publication Number Publication Date
CA2554089A1 CA2554089A1 (en) 2005-08-25
CA2554089C true CA2554089C (en) 2013-10-22

Family

ID=34865403

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2554089A Expired - Fee Related CA2554089C (en) 2004-02-09 2005-02-09 Albumin fusion proteins

Country Status (20)

Country Link
US (3) US7569384B2 (cg-RX-API-DMAC7.html)
EP (1) EP1729795B1 (cg-RX-API-DMAC7.html)
JP (2) JP5010923B2 (cg-RX-API-DMAC7.html)
KR (1) KR101184391B1 (cg-RX-API-DMAC7.html)
CN (1) CN102816241B (cg-RX-API-DMAC7.html)
AU (2) AU2005211725B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0507026A (cg-RX-API-DMAC7.html)
CA (1) CA2554089C (cg-RX-API-DMAC7.html)
CY (1) CY1117401T1 (cg-RX-API-DMAC7.html)
DK (1) DK1729795T3 (cg-RX-API-DMAC7.html)
ES (1) ES2567634T3 (cg-RX-API-DMAC7.html)
HU (1) HUE027902T2 (cg-RX-API-DMAC7.html)
IL (1) IL176894A (cg-RX-API-DMAC7.html)
MA (1) MA28565B1 (cg-RX-API-DMAC7.html)
MX (1) MXPA06009072A (cg-RX-API-DMAC7.html)
NO (1) NO20064059L (cg-RX-API-DMAC7.html)
NZ (1) NZ548612A (cg-RX-API-DMAC7.html)
PL (1) PL1729795T3 (cg-RX-API-DMAC7.html)
SI (1) SI1729795T1 (cg-RX-API-DMAC7.html)
WO (1) WO2005077042A2 (cg-RX-API-DMAC7.html)

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