EP0428615A4 - Method for stabilizing heterologous protein expression and vectors for use therein - Google Patents

Method for stabilizing heterologous protein expression and vectors for use therein

Info

Publication number
EP0428615A4
EP0428615A4 EP19890910335 EP89910335A EP0428615A4 EP 0428615 A4 EP0428615 A4 EP 0428615A4 EP 19890910335 EP19890910335 EP 19890910335 EP 89910335 A EP89910335 A EP 89910335A EP 0428615 A4 EP0428615 A4 EP 0428615A4
Authority
EP
European Patent Office
Prior art keywords
vectors
protein expression
heterologous protein
stabilizing
stabilizing heterologous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890910335
Other versions
EP0428615A1 (en
Inventor
Sandra Hilliker
R. Tyler White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scios LLC
Original Assignee
California Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Biotechnology Inc filed Critical California Biotechnology Inc
Publication of EP0428615A1 publication Critical patent/EP0428615A1/en
Publication of EP0428615A4 publication Critical patent/EP0428615A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12N9/1033—Chloramphenicol O-acetyltransferase (2.3.1.28)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
EP19890910335 1988-08-11 1989-08-09 Method for stabilizing heterologous protein expression and vectors for use therein Withdrawn EP0428615A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23122488A 1988-08-11 1988-08-11
US231224 1988-08-11

Publications (2)

Publication Number Publication Date
EP0428615A1 EP0428615A1 (en) 1991-05-29
EP0428615A4 true EP0428615A4 (en) 1991-11-13

Family

ID=22868276

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890910335 Withdrawn EP0428615A4 (en) 1988-08-11 1989-08-09 Method for stabilizing heterologous protein expression and vectors for use therein

Country Status (6)

Country Link
EP (1) EP0428615A4 (en)
JP (1) JPH04501204A (en)
AU (1) AU4216689A (en)
CA (1) CA1320162C (en)
IL (1) IL91272A0 (en)
WO (1) WO1990001540A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW327194B (en) * 1992-05-01 1998-02-21 American Cyanamid Co Novel amyloid precursor proteins and methods of using same
NL9201173A (en) * 1992-07-01 1994-02-01 Leuven K U Res & Dev Vector for positive selection of recombinants
DK144093D0 (en) * 1993-12-23 1993-12-23 Novo Nordisk As
US6031075A (en) * 1996-02-05 2000-02-29 Children's Hospital Medical Center Mature alveolar SP-B and a process for producing the same
DK1095141T3 (en) * 1998-07-10 2006-07-31 Scios Inc Process for producing a peptide having a pI value above 8 or below 5
AT410444B (en) * 2001-03-02 2003-04-25 Oesterr Forsch Seibersdorf METHOD FOR DETECTING NUCLEIC ACID MOLECULES
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
SI1729795T1 (en) 2004-02-09 2016-04-29 Human Genome Sciences, Inc. Albumin fusion proteins
WO2010068754A2 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
CN117343200B (en) * 2023-12-04 2024-01-30 北京质肽生物医药科技有限公司 Fusion protein containing amyloid core polypeptide, preparation method and application thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0131363A1 (en) * 1983-05-24 1985-01-16 Celltech Limited Polypeptide and protein products, and processes for their production and use
EP0207402A2 (en) * 1985-07-03 1987-01-07 Bayer Ag Process for producing proteins and polypeptides
GB2180539A (en) * 1985-07-24 1987-04-01 Glaxo Group Ltd Microbiological products
WO1987006588A1 (en) * 1986-04-30 1987-11-05 California Biotechnology Inc. Recombinant alveolar surfactant protein
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
WO1988003951A1 (en) * 1986-11-17 1988-06-02 California Biotechnology, Inc. Recombinant alzheimer's amyloid protein
WO1989004326A1 (en) * 1987-11-04 1989-05-18 California Biotechnology Inc. Alveolar surfactant proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78571A (en) * 1985-04-22 1991-06-30 Genentech Inc Human tissue plasminogen activator mutants resistant to enzymatic cleavage resulting in two-chain form

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0131363A1 (en) * 1983-05-24 1985-01-16 Celltech Limited Polypeptide and protein products, and processes for their production and use
EP0207402A2 (en) * 1985-07-03 1987-01-07 Bayer Ag Process for producing proteins and polypeptides
GB2180539A (en) * 1985-07-24 1987-04-01 Glaxo Group Ltd Microbiological products
WO1987006588A1 (en) * 1986-04-30 1987-11-05 California Biotechnology Inc. Recombinant alveolar surfactant protein
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
WO1988003951A1 (en) * 1986-11-17 1988-06-02 California Biotechnology, Inc. Recombinant alzheimer's amyloid protein
WO1989004326A1 (en) * 1987-11-04 1989-05-18 California Biotechnology Inc. Alveolar surfactant proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9001540A1 *

Also Published As

Publication number Publication date
AU4216689A (en) 1990-03-05
CA1320162C (en) 1993-07-13
WO1990001540A1 (en) 1990-02-22
EP0428615A1 (en) 1991-05-29
JPH04501204A (en) 1992-03-05
IL91272A0 (en) 1990-03-19

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