CA2450087C - Benzisoselenazolonyl derivatives having antineoplastic, anti-inflammatory and antithrombotic activities as well as their use - Google Patents
Benzisoselenazolonyl derivatives having antineoplastic, anti-inflammatory and antithrombotic activities as well as their use Download PDFInfo
- Publication number
- CA2450087C CA2450087C CA2450087A CA2450087A CA2450087C CA 2450087 C CA2450087 C CA 2450087C CA 2450087 A CA2450087 A CA 2450087A CA 2450087 A CA2450087 A CA 2450087A CA 2450087 C CA2450087 C CA 2450087C
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- Prior art keywords
- inflammatory
- derivatives
- pharmaceutically acceptable
- antineoplastic
- solution
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- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 231100000338 sulforhodamine B assay Toxicity 0.000 description 1
- 238000003210 sulforhodamine B staining Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
- C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D293/12—Selenazoles; Hydrogenated selenazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011186666A CN1166651C (zh) | 2001-06-08 | 2001-06-08 | 具有抗炎和抗肿瘤作用r-双或糖苯丙异硒唑取代化合物 |
| CN01118666.6 | 2001-08-06 | ||
| PCT/CN2002/000412 WO2003095436A1 (en) | 2001-06-08 | 2002-06-10 | Benzoisoselenazole derivatives with anti-inflammation, antivirus and anti-thrombosis activity and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2450087A1 CA2450087A1 (en) | 2003-11-20 |
| CA2450087C true CA2450087C (en) | 2012-08-07 |
Family
ID=4663351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2450087A Expired - Fee Related CA2450087C (en) | 2001-06-08 | 2002-06-10 | Benzisoselenazolonyl derivatives having antineoplastic, anti-inflammatory and antithrombotic activities as well as their use |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7495019B2 (enExample) |
| EP (1) | EP1422225B1 (enExample) |
| JP (1) | JP4500672B2 (enExample) |
| CN (1) | CN1166651C (enExample) |
| AT (1) | ATE540030T1 (enExample) |
| AU (1) | AU2002346271A1 (enExample) |
| CA (1) | CA2450087C (enExample) |
| ES (1) | ES2378983T3 (enExample) |
| RU (1) | RU2324688C2 (enExample) |
| WO (1) | WO2003095436A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820829B2 (en) * | 2001-06-08 | 2010-10-26 | Peking University | Bisbenzisoselenazolonyl derivatives having antineoplastic, anti-inflammatory and antithrombotic activities as well as their use |
| CN100554255C (zh) * | 2004-05-31 | 2009-10-28 | 北京大学 | 苯并异硒唑酮衍生物及其制备方法与应用 |
| CN1990475B (zh) * | 2005-12-29 | 2011-09-07 | 曾慧慧 | 取代苯并异硒唑酮类化合物及其用途 |
| EP2061472A4 (en) * | 2006-05-22 | 2010-12-22 | Thioredoxin Systems Ab | BACTERIAL THIOREDOXINE REDUCTASE INHIBITORS AND METHODS OF USING THE SAME |
| CN101016319B (zh) * | 2007-02-13 | 2010-08-04 | 中国海洋大学 | 苯并异硒唑酮氨基糖衍生物及其制备方法和应用 |
| CN101781283B (zh) * | 2009-01-16 | 2014-04-23 | 凯熙医药（武汉）股份有限公司 | 硫氧还蛋白还原酶抑制剂化合物及其制备方法和其应用 |
| MD4014C2 (ro) * | 2009-04-23 | 2010-09-30 | Татьяна ГУЦУЛ | Complecşi polioxometalaţi cu activitate antitumorală |
| CN101921303A (zh) * | 2009-06-09 | 2010-12-22 | 曾慧慧 | 苯并异硒唑酮二氟胞苷类化合物及其制备方法和其用途 |
| CN102453050B (zh) * | 2010-11-03 | 2015-01-07 | 成都云克药业有限责任公司 | 一种二膦酸化合物及其制备方法 |
| AU2013202104B2 (en) * | 2012-01-13 | 2015-11-26 | Celgene Corporation | Biomarkers for the treatment of hepatocellular carcinoma |
| CN103483291B (zh) * | 2012-06-14 | 2015-08-12 | 沈阳药科大学 | 4,5-二芳基-1,3-硒唑类化合物及其制备方法和用途 |
| CN104177312B (zh) * | 2013-05-27 | 2018-02-13 | 黄英武 | 一种含硒化合物及其医药用途 |
| CN105277699B (zh) * | 2014-07-21 | 2017-05-03 | 武汉尚宜康健科技有限公司 | 测试试剂在制备评价临床肿瘤患者临床治疗监测的药品中的应用 |
| US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
| CN110856717A (zh) * | 2018-08-06 | 2020-03-03 | 上海元熙医药科技有限公司 | 一种肿瘤免疫调节剂及其用途 |
| US11952356B2 (en) | 2019-06-24 | 2024-04-09 | Shanghai Yuanxi Medicine Corp. | Crystalline form of 1,4-bis[1,2-benzisoselenazol-3(2H)-one]-butane, method for preparing same and use thereof |
| KR20230002109A (ko) * | 2021-06-29 | 2023-01-05 | (주)라이프신약 | 셀레늄 화합물을 유효성분으로 포함하는 노화세포 제거용 조성물 |
| WO2023277584A1 (ko) * | 2021-06-29 | 2023-01-05 | (주)라이프신약 | 셀레늄 화합물을 유효성분으로 포함하는 노화세포 제거용 조성물 |
| CN116891443B (zh) * | 2023-09-08 | 2023-12-01 | 潍坊医学院 | 一种异吲哚-1-酮衍生物及其制备方法、应用 |
| WO2025169231A1 (en) * | 2024-02-09 | 2025-08-14 | Indian Institute Of Science | Organoselenium compounds, preparation and implementations thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3027075A1 (de) * | 1980-07-17 | 1982-02-18 | A. Nattermann & Cie GmbH, 5000 Köln | Benzisoselenazolone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US4531001A (en) * | 1982-03-23 | 1985-07-23 | Brigham Young University | 2-β-D-ribofuranosylselenazole-4-carboxamide compounds |
| DE3226284A1 (de) * | 1982-07-14 | 1984-01-19 | A. Nattermann & Cie GmbH, 5000 Köln | Neue benzisoselenazolone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3407511A1 (de) * | 1984-03-01 | 1985-09-05 | A. Nattermann & Cie GmbH, 5000 Köln | Benzisoselenazolthione, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3663139D1 (en) * | 1985-04-12 | 1989-06-08 | Nattermann A & Cie | Diseleno-bis-benzamides of primary and secondary amines, processes for their production and pharmaceutical preparations containing them |
| DE3670635D1 (de) * | 1985-04-27 | 1990-05-31 | Nattermann A & Cie | Neue benzisoselenazolonyl-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. |
| DE3638124C2 (de) * | 1986-11-08 | 1996-09-05 | Nattermann A & Cie | Neue pharmazeutische Verwendung von Ebselen |
| US4778814A (en) * | 1987-03-18 | 1988-10-18 | Ciba-Geigy Corporation | Method of treating ocular allergy by topical application of a 2-substituted-1,2-benzisoselenazol-3(2H)-one |
| DE3827093A1 (de) * | 1988-08-10 | 1990-02-15 | Nattermann A & Cie | Verfahren zur herstellung von hochreinem ebselen |
| DE4024885C2 (de) * | 1990-08-06 | 2002-07-18 | Nattermann A & Cie | Verwendung von 2-Phenyl-1,2-benzisoselenazol-3(2H)-on |
| US5385726A (en) * | 1990-08-06 | 1995-01-31 | Rhone-Poulenc Rorer Gmbh | Use of 2-phenyl-1,2-benzisoselenazol-3-(2H)-one |
| DE4445966A1 (de) * | 1994-12-22 | 1996-06-27 | Agfa Gevaert Ag | Fotografisches Silberhalogenidmaterial |
| CN1110489C (zh) * | 1998-11-11 | 2003-06-04 | 中国医学科学院药物研究所 | 苯并异硒唑酮磺酰胺衍生物及其制法和其在制备药物中的应用 |
| US20040047852A1 (en) * | 2001-03-02 | 2004-03-11 | Kennedy Thomas Preston | Method of treating cancer |
-
2001
- 2001-06-08 CN CNB011186666A patent/CN1166651C/zh not_active Expired - Fee Related
-
2002
- 2002-06-10 AT AT02742662T patent/ATE540030T1/de active
- 2002-06-10 ES ES02742662T patent/ES2378983T3/es not_active Expired - Lifetime
- 2002-06-10 JP JP2004503452A patent/JP4500672B2/ja not_active Expired - Lifetime
- 2002-06-10 RU RU2003134946/04A patent/RU2324688C2/ru active IP Right Revival
- 2002-06-10 AU AU2002346271A patent/AU2002346271A1/en not_active Abandoned
- 2002-06-10 US US10/479,883 patent/US7495019B2/en not_active Expired - Lifetime
- 2002-06-10 EP EP02742662A patent/EP1422225B1/en not_active Expired - Lifetime
- 2002-06-10 WO PCT/CN2002/000412 patent/WO2003095436A1/zh not_active Ceased
- 2002-06-10 CA CA2450087A patent/CA2450087C/en not_active Expired - Fee Related
-
2009
- 2009-01-07 US US12/349,829 patent/US8609702B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1422225A1 (en) | 2004-05-26 |
| WO2003095436A1 (en) | 2003-11-20 |
| CN1390837A (zh) | 2003-01-15 |
| US8609702B2 (en) | 2013-12-17 |
| EP1422225A4 (en) | 2004-10-20 |
| ES2378983T3 (es) | 2012-04-19 |
| AU2002346271A1 (en) | 2003-11-11 |
| US20050014801A1 (en) | 2005-01-20 |
| US7495019B2 (en) | 2009-02-24 |
| RU2324688C2 (ru) | 2008-05-20 |
| ATE540030T1 (de) | 2012-01-15 |
| CA2450087A1 (en) | 2003-11-20 |
| EP1422225B1 (en) | 2012-01-04 |
| RU2003134946A (ru) | 2005-06-10 |
| JP4500672B2 (ja) | 2010-07-14 |
| JP2005519991A (ja) | 2005-07-07 |
| US20090117204A1 (en) | 2009-05-07 |
| CN1166651C (zh) | 2004-09-15 |
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| EEER | Examination request | ||
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