CA2443214C - Vaccine composition comprising human papilloma virus 16 l1 virus-like particle (hpv 16 l1 vlp), human papilloma virus 18 l1 virus-like particle (hpv 18 l1 vlp) and 3-de-o-acylatedmonphosphoryl lipid a (3d-mpl) and alum - Google Patents
Vaccine composition comprising human papilloma virus 16 l1 virus-like particle (hpv 16 l1 vlp), human papilloma virus 18 l1 virus-like particle (hpv 18 l1 vlp) and 3-de-o-acylatedmonphosphoryl lipid a (3d-mpl) and alum Download PDFInfo
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- CA2443214C CA2443214C CA 2443214 CA2443214A CA2443214C CA 2443214 C CA2443214 C CA 2443214C CA 2443214 CA2443214 CA 2443214 CA 2443214 A CA2443214 A CA 2443214A CA 2443214 C CA2443214 C CA 2443214C
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- virus
- hpv
- vlp
- antigen
- mpl
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| US20060029617A1 (en) * | 1997-10-03 | 2006-02-09 | Charreyre Catherine E | Porcine circovirus and Helicobacter combination vaccines and methods of use |
| FR2772047B1 (fr) | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
| ES2272069T3 (es) | 1998-05-22 | 2007-04-16 | Ottawa Health Research Institute | Metodos y productos para inducir inmunidad en mucosas. |
| PL201482B1 (pl) * | 1998-10-16 | 2009-04-30 | Smithkline Beecham Biolog | Sposoby wytwarzania kompozycji szczepionki oraz kompozycja szczepionki |
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| DE60126737T2 (de) | 2001-03-23 | 2007-11-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Modifizierte HPV E6- und E7-Gene und -Proteine als Impfstoff |
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| GB0206360D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| JP4614765B2 (ja) † | 2002-05-17 | 2011-01-19 | ユニバーシティ・オブ・ケープ・タウン | L2ペプチドを含むキメラ・ヒト・パピローマウイルス16l1タンパク質、それから調製したウイルス様粒子および該粒子の調製方法 |
| CN1650012A (zh) | 2002-07-24 | 2005-08-03 | 英特塞尔股份公司 | 来自致病病毒的备选阅读框所编码的抗原 |
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| EA008777B1 (ru) | 2002-10-29 | 2007-08-31 | Коли Фармасьютикал Груп, Лтд. | Способы и продукты, относящиеся к лечению и предупреждению инфекции вируса гепатита c |
| US7956043B2 (en) | 2002-12-11 | 2011-06-07 | Coley Pharmaceutical Group, Inc. | 5′ CpG nucleic acids and methods of use |
| US7858098B2 (en) * | 2002-12-20 | 2010-12-28 | Glaxosmithkline Biologicals, S.A. | Vaccine |
| CA2510457C (en) * | 2002-12-20 | 2011-12-06 | Glaxosmithkline Biologicals S.A. | Hpv-16 and -18 l1 vlp vaccine |
| CN100418577C (zh) * | 2002-12-20 | 2008-09-17 | 葛兰素史密丝克莱恩生物有限公司 | Hpv-16和hpv-18l1vlp疫苗 |
| JP4676426B2 (ja) | 2003-03-24 | 2011-04-27 | インターツェル・アクチェンゲゼルシャフト | 改良型ワクチン |
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| US7758866B2 (en) * | 2004-06-16 | 2010-07-20 | Glaxosmithkline Biologicals, S.A. | Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52 |
| PL1758609T3 (pl) * | 2004-06-16 | 2013-02-28 | Glaxosmithkline Biologicals Sa | Szczepionka przeciw HPV16 i HPV18 oraz co najmniej jednemu HPV innego typu wybranemu spośród HPV 31, 45 lub 52 |
| US7833707B2 (en) | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
| KR20070110513A (ko) * | 2005-02-16 | 2007-11-19 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 알루미늄 포스페이트 및 3d-mpl을 포함하는 보조약조성물 |
| JP4182074B2 (ja) | 2005-03-03 | 2008-11-19 | ファナック株式会社 | ハンド及びハンドリングロボット |
| KR20160064249A (ko) * | 2005-03-23 | 2016-06-07 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | Cd4 t-세포 및/또는 개선된 b-메모리 세포 반응을 유도하는 인플루엔자 바이러스 및 수중유 에멀젼 애주번트의 용도 |
| KR20080005585A (ko) * | 2005-04-26 | 2008-01-14 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| EA013325B1 (ru) * | 2005-04-26 | 2010-04-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
| US7790203B2 (en) * | 2005-12-13 | 2010-09-07 | Lowder Tom R | Composition and regimen for the treatment of herpes simplex virus, herpes zoster, and herpes genitalia epidermal herpetic lesions |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| ES2553254T3 (es) | 2005-12-29 | 2015-12-07 | Boehringer Ingelheim Vetmedica, Inc. | Uso de una composición inmunogénica de PCV2 para reducir los síntomas clínicos en cerdos |
| CN102698263B (zh) | 2005-12-29 | 2016-07-06 | 贝林格尔.英格海姆维特梅迪卡有限公司 | 多价pcv2免疫原性组合物和制备此类组合物的方法 |
| US20090246220A1 (en) * | 2006-08-28 | 2009-10-01 | Ertl Hildegund C J | Constructs for enhancing immune responses |
| WO2008153541A1 (en) | 2006-09-26 | 2008-12-18 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
| US7709010B2 (en) | 2007-03-09 | 2010-05-04 | Merck Sharp & Dohme Corp. | Papillomavirus vaccine compositions |
| MX2009014246A (es) | 2007-06-26 | 2010-03-31 | Japan Health Science Found | Antigeno de vacuna con la capacidad de inducir anticuerpo de neutralizacion y reaccion cruzada contra virus de papiloma humano del tipo de alto riesgo. |
| US7829274B2 (en) | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
| EP2298344B1 (en) | 2008-06-04 | 2016-08-17 | The Chemo-Sero-Therapeutic Research Institute | Use of inactivated japanese encephalitis virus particle as adjuvant |
| KR20110053340A (ko) * | 2008-07-31 | 2011-05-20 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | Hpv에 대한 백신 |
| ES2732815T3 (es) | 2009-05-22 | 2019-11-26 | Genocea Biosciences Inc | Vacunas frente al virus del herpes simple de tipo 2: composiciones y métodos para provocar una respuesta inmunitaria |
| EP3124491B1 (en) | 2009-06-05 | 2019-10-30 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants and vaccine compositions as well as pharmaceutical compositions containing them |
| JP5758385B2 (ja) * | 2009-06-19 | 2015-08-05 | アイジェン インコーポレーテッド | 子宮頸がんワクチン |
| US20120087937A1 (en) * | 2009-06-25 | 2012-04-12 | Brigitte Desiree Alberte Colau | Novel compositions |
| AR078253A1 (es) | 2009-09-02 | 2011-10-26 | Boehringer Ingelheim Vetmed | Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad |
| CA2800158C (en) * | 2010-05-28 | 2020-07-21 | Coley Pharmaceutical Group, Inc. | Vaccines comprising cholesterol and cpg as sole adjuvant-carrier molecules |
| UA112970C2 (uk) * | 2010-08-05 | 2016-11-25 | Мерк Шарп Енд Доме Корп. | Інактивований вірус вітряної віспи, спосіб його одержання і застосування |
| HUE028877T2 (en) * | 2010-08-27 | 2017-01-30 | Intervet Int Bv | Test of biological activity of vaccine formulation |
| CN102008721A (zh) * | 2010-11-16 | 2011-04-13 | 浙江大学 | 一种hpv多肽/dc混合疫苗及其制备 |
| EP2643014A4 (en) | 2010-11-24 | 2015-11-11 | Genocea Biosciences Inc | HERPES SIMPLEX TYPE 2 VIRUS VACCINES: COMPOSITIONS AND METHODS FOR STIMULATING AN IMMUNE RESPONSE |
| AU2012243039B2 (en) | 2011-04-08 | 2017-07-13 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| CN102210858B (zh) * | 2011-05-18 | 2013-05-08 | 北京科兴生物制品有限公司 | 一种肠道病毒71型与甲型肝炎联合疫苗 |
| AU2012272788B2 (en) * | 2011-06-24 | 2016-10-20 | Merck Sharp & Dohme Llc | HPV vaccine formulations comprising aluminum adjuvant and methods of producing same |
| JP6109165B2 (ja) * | 2011-07-01 | 2017-04-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ヘルペスウイルスワクチンおよび使用方法 |
| JP6199878B2 (ja) | 2011-11-23 | 2017-09-20 | ジェノセア バイオサイエンシーズ, インコーポレイテッド | 単純ヘルペスウイルス2型に対する核酸ワクチン:免疫応答を誘発する組成物及び方法 |
| EP3563834A1 (en) | 2012-02-07 | 2019-11-06 | Infectious Disease Research Institute | Improved adjuvant formulations comprising tlr4 agonists and methods of using the same |
| EA034351B1 (ru) | 2012-05-16 | 2020-01-30 | Иммьюн Дизайн Корп. | Трехкомпонентная вакцина против впг-2 и способы ее применения |
| US9624510B2 (en) | 2013-03-01 | 2017-04-18 | The Wistar Institute | Adenoviral vectors comprising partial deletions of E3 |
| CN105209047B (zh) | 2013-04-18 | 2020-08-18 | 免疫设计股份有限公司 | 用于癌症治疗的gla单一疗法 |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| IL310015B1 (en) | 2013-12-31 | 2025-10-01 | Access To Advanced Health Inst | Single vial formulation |
| CN109804075A (zh) | 2016-08-01 | 2019-05-24 | 威斯塔解剖学和生物学研究所 | 用于疫苗应用的复制缺陷型腺病毒载体的组合物和方法 |
| WO2018064232A1 (en) | 2016-09-28 | 2018-04-05 | Genocea Biosciences, Inc. | Methods and compositions for treating herpes |
| CN107987159B (zh) * | 2017-11-28 | 2021-06-22 | 上海药明生物医药有限公司 | 一种使用大剂量dna免疫技术免疫动物使血清中抗体滴度提高的方法 |
| GB201821207D0 (en) | 2018-12-24 | 2019-02-06 | Tcer Ab | Immunotherapy therapy |
| MX2021014363A (es) | 2019-05-25 | 2022-02-21 | Infectious Disease Res Inst | Composicion y metodo para secar por pulverizacion una emulsion de vacuna adyuvante. |
| CN110576034B (zh) * | 2019-10-09 | 2020-06-30 | 北京尚华生态环保科技股份公司 | 一种土壤原位修复方法 |
| CN110652980B (zh) * | 2019-10-09 | 2020-06-30 | 北京尚华生态环保科技股份公司 | 一种土壤原位修复剂 |
| EP4058581A1 (en) | 2019-11-15 | 2022-09-21 | Infectious Disease Research Institute | Rig-i agonist and adjuvant formulation for tumor treatment |
| CN114681602B (zh) * | 2020-12-25 | 2023-12-01 | 中国食品药品检定研究院 | 一种双价人乳头瘤病毒疫苗 |
| CN114796479A (zh) * | 2022-06-02 | 2022-07-29 | 金宇保灵生物药品有限公司 | 一种畜类动物疫苗用水包油包水佐剂及其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH085804B2 (ja) * | 1988-04-28 | 1996-01-24 | 財団法人化学及血清療法研究所 | A型及びb型肝炎混合アジュバントワクチン |
| GB9113809D0 (en) * | 1991-06-26 | 1991-08-14 | Cancer Res Campaign Tech | Papillomavirus l2 protein |
| ES2279020T3 (es) * | 1991-07-19 | 2007-08-16 | The University Of Queensland | Vacuna contra el papilomavirus humano. |
| US5437951A (en) * | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
| US5618536A (en) * | 1992-09-03 | 1997-04-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric papillomavirus-like particles |
| DK0689454T4 (da) | 1993-03-23 | 2005-05-30 | Smithkline Beecham Biolog | Vaccinepræparater indeholdende 3-O-deacyleret monophosphoryl-lipid A |
| GB9326253D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| GB9409962D0 (en) * | 1994-05-18 | 1994-07-06 | Smithkline Beecham Biolog | Novel compounds |
| CA2211995A1 (en) * | 1995-02-24 | 1996-08-29 | Cantab Pharmaceuticals Research Limited | Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation |
| US6172192B1 (en) * | 1996-01-26 | 2001-01-09 | Innogenetics N.V. | Toxoplasma gondii antigen Tg20 |
| EP0879060B1 (en) * | 1996-02-09 | 2008-03-26 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccines against varicella zoster virus gene 63 product |
| GB9711990D0 (en) * | 1997-06-11 | 1997-08-06 | Smithkline Beecham Biolog | Vaccine |
| GB9717953D0 (en) * | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
| CA2229955C (en) * | 1998-02-20 | 2003-12-09 | Medigene Gmbh | Papilloma virus capsomere vaccine formulations and methods of use |
| TR200002608T2 (tr) * | 1998-03-09 | 2000-11-21 | Smithkline Beecham Biologicals S.A | Kombine aşı kompozisyonları |
| US6500284B1 (en) | 1998-06-10 | 2002-12-31 | Suraltech, Inc. | Processes for continuously producing fine grained metal compositions and for semi-solid forming of shaped articles |
| GB9819898D0 (en) | 1998-09-11 | 1998-11-04 | Smithkline Beecham Plc | New vaccine and method of use |
| PL201482B1 (pl) | 1998-10-16 | 2009-04-30 | Smithkline Beecham Biolog | Sposoby wytwarzania kompozycji szczepionki oraz kompozycja szczepionki |
| EP1150712B1 (en) * | 1999-02-05 | 2008-11-05 | Merck & Co., Inc. | Human papilloma virus vaccine formulations |
| GB9921147D0 (en) * | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
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