CA2395872A1 - Acides nucleiques, proteines et anticorps - Google Patents
Acides nucleiques, proteines et anticorps Download PDFInfo
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- CA2395872A1 CA2395872A1 CA002395872A CA2395872A CA2395872A1 CA 2395872 A1 CA2395872 A1 CA 2395872A1 CA 002395872 A CA002395872 A CA 002395872A CA 2395872 A CA2395872 A CA 2395872A CA 2395872 A1 CA2395872 A1 CA 2395872A1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention concerne de nouvelles protéines et plus spécifiquement des molécules d'acide nucléique isolées qui codent de nouveaux polypeptides, ainsi que de nouveaux polypeptides et des anticorps qui se lient à ces polypeptides. Elle concerne également des vecteurs, des cellules hôtes et des méthodes synthétiques et de recombinaison destinées à produire des polynucléotides et/ou des polypeptides humains, et des anticorps. Elle concerne encore des méthodes diagnostiques et thérapeutiques utiles pour diagnostiquer, traiter, prévenir et/ou pronostiquer des troubles liés à ces nouveaux polypeptides. Elle concerne enfin des méthodes de criblage permettant d'identifier des agonistes et des antagonistes de polynucléotides et de polypeptides selon la présente invention, ainsi que des méthodes et/ou compositions destinées à inhiber ou à favoriser la production et la fonction des polypeptides selon la présente invention.
Applications Claiming Priority (235)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17906500P | 2000-01-31 | 2000-01-31 | |
| US60/179,065 | 2000-01-31 | ||
| US18062800P | 2000-02-04 | 2000-02-04 | |
| US60/180,628 | 2000-02-04 | ||
| US18466400P | 2000-02-24 | 2000-02-24 | |
| US60/184,664 | 2000-02-24 | ||
| US18635000P | 2000-03-02 | 2000-03-02 | |
| US60/186,350 | 2000-03-02 | ||
| US18987400P | 2000-03-16 | 2000-03-16 | |
| US60/189,874 | 2000-03-16 | ||
| US19007600P | 2000-03-17 | 2000-03-17 | |
| US60/190,076 | 2000-03-17 | ||
| US19812300P | 2000-04-18 | 2000-04-18 | |
| US60/198,123 | 2000-04-18 | ||
| US20551500P | 2000-05-19 | 2000-05-19 | |
| US60/205,515 | 2000-05-19 | ||
| US20946700P | 2000-06-07 | 2000-06-07 | |
| US60/209,467 | 2000-06-07 | ||
| US21488600P | 2000-06-28 | 2000-06-28 | |
| US60/214,886 | 2000-06-28 | ||
| US21513500P | 2000-06-30 | 2000-06-30 | |
| US60/215,135 | 2000-06-30 | ||
| US21664700P | 2000-07-07 | 2000-07-07 | |
| US21688000P | 2000-07-07 | 2000-07-07 | |
| US60/216,880 | 2000-07-07 | ||
| US60/216,647 | 2000-07-07 | ||
| US21749600P | 2000-07-11 | 2000-07-11 | |
| US21748700P | 2000-07-11 | 2000-07-11 | |
| US60/217,496 | 2000-07-11 | ||
| US60/217,487 | 2000-07-11 | ||
| US21829000P | 2000-07-14 | 2000-07-14 | |
| US60/218,290 | 2000-07-14 | ||
| US22096400P | 2000-07-26 | 2000-07-26 | |
| US22096300P | 2000-07-26 | 2000-07-26 | |
| US60/220,964 | 2000-07-26 | ||
| US60/220,963 | 2000-07-26 | ||
| US22521400P | 2000-08-14 | 2000-08-14 | |
| US22521300P | 2000-08-14 | 2000-08-14 | |
| US22575800P | 2000-08-14 | 2000-08-14 | |
| US22526800P | 2000-08-14 | 2000-08-14 | |
| US22526600P | 2000-08-14 | 2000-08-14 | |
| US22544700P | 2000-08-14 | 2000-08-14 | |
| US22575700P | 2000-08-14 | 2000-08-14 | |
| US22575900P | 2000-08-14 | 2000-08-14 | |
| US22451900P | 2000-08-14 | 2000-08-14 | |
| US22451800P | 2000-08-14 | 2000-08-14 | |
| US22526700P | 2000-08-14 | 2000-08-14 | |
| US22527000P | 2000-08-14 | 2000-08-14 | |
| US60/225,757 | 2000-08-14 | ||
| US60/225,447 | 2000-08-14 | ||
| US60/225,267 | 2000-08-14 | ||
| US60/225,266 | 2000-08-14 | ||
| US60/225,214 | 2000-08-14 | ||
| US60/224,519 | 2000-08-14 | ||
| US60/224,518 | 2000-08-14 | ||
| US60/225,758 | 2000-08-14 | ||
| US60/225,270 | 2000-08-14 | ||
| US60/225,213 | 2000-08-14 | ||
| US60/225,759 | 2000-08-14 | ||
| US60/225,268 | 2000-08-14 | ||
| US22627900P | 2000-08-18 | 2000-08-18 | |
| US60/226,279 | 2000-08-18 | ||
| US22686800P | 2000-08-22 | 2000-08-22 | |
| US22718200P | 2000-08-22 | 2000-08-22 | |
| US22668100P | 2000-08-22 | 2000-08-22 | |
| US60/227,182 | 2000-08-22 | ||
| US60/226,868 | 2000-08-22 | ||
| US60/226,681 | 2000-08-22 | ||
| US22700900P | 2000-08-23 | 2000-08-23 | |
| US60/227,009 | 2000-08-23 | ||
| US22892400P | 2000-08-30 | 2000-08-30 | |
| US60/228,924 | 2000-08-30 | ||
| US22928700P | 2000-09-01 | 2000-09-01 | |
| US22934300P | 2000-09-01 | 2000-09-01 | |
| US22934400P | 2000-09-01 | 2000-09-01 | |
| US22934500P | 2000-09-01 | 2000-09-01 | |
| US60/229,343 | 2000-09-01 | ||
| US60/229,344 | 2000-09-01 | ||
| US60/229,345 | 2000-09-01 | ||
| US60/229,287 | 2000-09-01 | ||
| US22950900P | 2000-09-05 | 2000-09-05 | |
| US22951300P | 2000-09-05 | 2000-09-05 | |
| US60/229,513 | 2000-09-05 | ||
| US60/229,509 | 2000-09-05 | ||
| US23043800P | 2000-09-06 | 2000-09-06 | |
| US23043700P | 2000-09-06 | 2000-09-06 | |
| US60/230,438 | 2000-09-06 | ||
| US60/230,437 | 2000-09-06 | ||
| US23124200P | 2000-09-08 | 2000-09-08 | |
| US23208000P | 2000-09-08 | 2000-09-08 | |
| US23124400P | 2000-09-08 | 2000-09-08 | |
| US23208100P | 2000-09-08 | 2000-09-08 | |
| US23124300P | 2000-09-08 | 2000-09-08 | |
| US23141300P | 2000-09-08 | 2000-09-08 | |
| US23141400P | 2000-09-08 | 2000-09-08 | |
| US60/231,244 | 2000-09-08 | ||
| US60/231,242 | 2000-09-08 | ||
| US60/232,081 | 2000-09-08 | ||
| US60/231,243 | 2000-09-08 | ||
| US60/232,080 | 2000-09-08 | ||
| US60/231,413 | 2000-09-08 | ||
| US60/231,414 | 2000-09-08 | ||
| US23196800P | 2000-09-12 | 2000-09-12 | |
| US60/231,968 | 2000-09-12 | ||
| US23306300P | 2000-09-14 | 2000-09-14 | |
| US23240000P | 2000-09-14 | 2000-09-14 | |
| US23306400P | 2000-09-14 | 2000-09-14 | |
| US23306500P | 2000-09-14 | 2000-09-14 | |
| US23240100P | 2000-09-14 | 2000-09-14 | |
| US23239800P | 2000-09-14 | 2000-09-14 | |
| US23239700P | 2000-09-14 | 2000-09-14 | |
| US23239900P | 2000-09-14 | 2000-09-14 | |
| US60/233,064 | 2000-09-14 | ||
| US60/233,063 | 2000-09-14 | ||
| US60/232,399 | 2000-09-14 | ||
| US60/232,397 | 2000-09-14 | ||
| US60/232,401 | 2000-09-14 | ||
| US60/232,400 | 2000-09-14 | ||
| US60/233,065 | 2000-09-14 | ||
| US60/232,398 | 2000-09-14 | ||
| US23427400P | 2000-09-21 | 2000-09-21 | |
| US23422300P | 2000-09-21 | 2000-09-21 | |
| US60/234,274 | 2000-09-21 | ||
| US60/234,223 | 2000-09-21 | ||
| US23499700P | 2000-09-25 | 2000-09-25 | |
| US23499800P | 2000-09-25 | 2000-09-25 | |
| US60/234,997 | 2000-09-25 | ||
| US60/234,998 | 2000-09-25 | ||
| US23548400P | 2000-09-26 | 2000-09-26 | |
| US60/235,484 | 2000-09-26 | ||
| US23583400P | 2000-09-27 | 2000-09-27 | |
| US23583600P | 2000-09-27 | 2000-09-27 | |
| US60/235,834 | 2000-09-27 | ||
| US60/235,836 | 2000-09-27 | ||
| US23636900P | 2000-09-29 | 2000-09-29 | |
| US23636700P | 2000-09-29 | 2000-09-29 | |
| US23636800P | 2000-09-29 | 2000-09-29 | |
| US23632700P | 2000-09-29 | 2000-09-29 | |
| US23637000P | 2000-09-29 | 2000-09-29 | |
| US60/236,327 | 2000-09-29 | ||
| US60/236,367 | 2000-09-29 | ||
| US60/236,368 | 2000-09-29 | ||
| US60/236,370 | 2000-09-29 | ||
| US60/236,369 | 2000-09-29 | ||
| US23703800P | 2000-10-02 | 2000-10-02 | |
| US23704000P | 2000-10-02 | 2000-10-02 | |
| US23703700P | 2000-10-02 | 2000-10-02 | |
| US23703900P | 2000-10-02 | 2000-10-02 | |
| US23680200P | 2000-10-02 | 2000-10-02 | |
| US60/236,802 | 2000-10-02 | ||
| US60/237,039 | 2000-10-02 | ||
| US60/237,037 | 2000-10-02 | ||
| US60/237,038 | 2000-10-02 | ||
| US60/237,040 | 2000-10-02 | ||
| US23993500P | 2000-10-13 | 2000-10-13 | |
| US23993700P | 2000-10-13 | 2000-10-13 | |
| US60/239,935 | 2000-10-13 | ||
| US60/239,937 | 2000-10-13 | ||
| US24182600P | 2000-10-20 | 2000-10-20 | |
| US24122100P | 2000-10-20 | 2000-10-20 | |
| US24178500P | 2000-10-20 | 2000-10-20 | |
| US24178700P | 2000-10-20 | 2000-10-20 | |
| US24180900P | 2000-10-20 | 2000-10-20 | |
| US24096000P | 2000-10-20 | 2000-10-20 | |
| US24178600P | 2000-10-20 | 2000-10-20 | |
| US24180800P | 2000-10-20 | 2000-10-20 | |
| US60/241,221 | 2000-10-20 | ||
| US60/241,786 | 2000-10-20 | ||
| US60/241,809 | 2000-10-20 | ||
| US60/241,787 | 2000-10-20 | ||
| US60/241,785 | 2000-10-20 | ||
| US60/240,960 | 2000-10-20 | ||
| US60/241,808 | 2000-10-20 | ||
| US60/241,826 | 2000-10-20 | ||
| US24461700P | 2000-11-01 | 2000-11-01 | |
| US60/244,617 | 2000-11-01 | ||
| US24647700P | 2000-11-08 | 2000-11-08 | |
| US24661100P | 2000-11-08 | 2000-11-08 | |
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| US24647600P | 2000-11-08 | 2000-11-08 | |
| US24652700P | 2000-11-08 | 2000-11-08 | |
| US24652500P | 2000-11-08 | 2000-11-08 | |
| US24652800P | 2000-11-08 | 2000-11-08 | |
| US24647500P | 2000-11-08 | 2000-11-08 | |
| US24652600P | 2000-11-08 | 2000-11-08 | |
| US60/246,527 | 2000-11-08 | ||
| US60/246,476 | 2000-11-08 | ||
| US60/246,523 | 2000-11-08 | ||
| US60/246,526 | 2000-11-08 | ||
| US60/246,475 | 2000-11-08 | ||
| US60/246,613 | 2000-11-08 | ||
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| US60/246,524 | 2000-11-08 | ||
| US60/246,477 | 2000-11-08 | ||
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| US60/246,532 | 2000-11-08 | ||
| US60/246,610 | 2000-11-08 | ||
| US60/246,478 | 2000-11-08 | ||
| US60/246,609 | 2000-11-08 | ||
| US60/249,300 | 2000-11-17 | ||
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| US60/249,208 | 2000-11-17 | ||
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| US60/250,160 | 2000-12-01 | ||
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Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2395872A1 true CA2395872A1 (fr) | 2001-08-02 |
Family
ID=27587117
Family Applications (37)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002395295A Withdrawn CA2395295A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392422A Abandoned CA2392422A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392438A Abandoned CA2392438A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002393002A Withdrawn CA2393002A1 (fr) | 2000-01-31 | 2001-01-17 | Acides ncleiques, proteines et anticorps |
| CA002395666A Withdrawn CA2395666A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395398A Withdrawn CA2395398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines, et anticorps |
| CA002397407A Withdrawn CA2397407A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002393618A Abandoned CA2393618A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392751A Abandoned CA2392751A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002393912A Withdrawn CA2393912A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002398877A Withdrawn CA2398877A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395827A Withdrawn CA2395827A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395671A Withdrawn CA2395671A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395849A Pending CA2395849A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392428A Abandoned CA2392428A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395787A Withdrawn CA2395787A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392757A Abandoned CA2392757A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002394841A Withdrawn CA2394841A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395816A Withdrawn CA2395816A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392450A Abandoned CA2392450A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395178A Withdrawn CA2395178A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395699A Pending CA2395699A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395872A Withdrawn CA2395872A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395654A Withdrawn CA2395654A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392398A Abandoned CA2392398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002397839A Withdrawn CA2397839A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395734A Withdrawn CA2395734A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002394039A Abandoned CA2394039A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002393652A Withdrawn CA2393652A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395724A Pending CA2395724A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395885A Withdrawn CA2395885A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002398411A Withdrawn CA2398411A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395729A Pending CA2395729A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395693A Pending CA2395693A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395858A Withdrawn CA2395858A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395738A Withdrawn CA2395738A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395403A Withdrawn CA2395403A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
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| CA002395295A Withdrawn CA2395295A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392422A Abandoned CA2392422A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392438A Abandoned CA2392438A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002393002A Withdrawn CA2393002A1 (fr) | 2000-01-31 | 2001-01-17 | Acides ncleiques, proteines et anticorps |
| CA002395666A Withdrawn CA2395666A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395398A Withdrawn CA2395398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines, et anticorps |
| CA002397407A Withdrawn CA2397407A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002393618A Abandoned CA2393618A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392751A Abandoned CA2392751A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002393912A Withdrawn CA2393912A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002398877A Withdrawn CA2398877A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395827A Withdrawn CA2395827A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395671A Withdrawn CA2395671A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395849A Pending CA2395849A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392428A Abandoned CA2392428A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395787A Withdrawn CA2395787A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392757A Abandoned CA2392757A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002394841A Withdrawn CA2394841A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395816A Withdrawn CA2395816A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392450A Abandoned CA2392450A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395178A Withdrawn CA2395178A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395699A Pending CA2395699A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
Family Applications After (14)
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| CA002395654A Withdrawn CA2395654A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002392398A Abandoned CA2392398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002397839A Withdrawn CA2397839A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395734A Withdrawn CA2395734A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002394039A Abandoned CA2394039A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002393652A Withdrawn CA2393652A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395724A Pending CA2395724A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395885A Withdrawn CA2395885A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002398411A Withdrawn CA2398411A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395729A Pending CA2395729A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395693A Pending CA2395693A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395858A Withdrawn CA2395858A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395738A Withdrawn CA2395738A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
| CA002395403A Withdrawn CA2395403A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
Country Status (3)
| Country | Link |
|---|---|
| AU (16) | AU2001241408A1 (fr) |
| CA (37) | CA2395295A1 (fr) |
| WO (48) | WO2001055321A2 (fr) |
Families Citing this family (271)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001070982A2 (fr) * | 2000-03-23 | 2001-09-27 | Immusol Incorporated | Regulateurs de brca-1 et procedes d'utilisation |
| US20020137890A1 (en) | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6960570B2 (en) | 1998-03-18 | 2005-11-01 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6706262B1 (en) | 1998-03-18 | 2004-03-16 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
| US7258860B2 (en) | 1998-03-18 | 2007-08-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US7579160B2 (en) | 1998-03-18 | 2009-08-25 | Corixa Corporation | Methods for the detection of cervical cancer |
| DE69936382T3 (de) | 1998-05-15 | 2011-07-07 | Genentech, Inc., Calif. | Therapeutische verwendungen von il-17 homologe polypeptide |
| US7771719B1 (en) | 2000-01-11 | 2010-08-10 | Genentech, Inc. | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E |
| US6929938B2 (en) | 2001-08-15 | 2005-08-16 | Millennium Pharmaceuticals, Inc. | 25501, a human transferase family member and uses therefor |
| US7141417B1 (en) | 1999-02-25 | 2006-11-28 | Thomas Jefferson University | Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene |
| EP1163252A4 (fr) * | 1999-02-25 | 2004-04-07 | Univ Jefferson | Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs |
| EP1157038A4 (fr) * | 1999-02-26 | 2005-01-19 | Smithkline Beecham Corp | Clonage du recepteur 7tm (axor 17) du type p2y |
| EP1169440A4 (fr) * | 1999-03-23 | 2004-01-14 | Human Genome Sciences Inc | 48 proteines humaines secretees |
| WO2000058480A1 (fr) | 1999-03-29 | 2000-10-05 | Kansai Technology Licensing Organization Co., Ltd. | Nouvelle cytidine desaminase |
| EP1621620A3 (fr) * | 1999-09-01 | 2006-05-10 | Genetech, Inc. | Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci |
| US7083944B1 (en) * | 1999-10-27 | 2006-08-01 | Millennium Pharmaceuticals, Inc. | Molecules of the card-related protein family and uses thereof |
| US6893818B1 (en) | 1999-10-28 | 2005-05-17 | Agensys, Inc. | Gene upregulated in cancers of the prostate |
| US7005499B1 (en) * | 1999-11-18 | 2006-02-28 | Genentech, Inc. | Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same |
| EP1878795A3 (fr) * | 1999-11-30 | 2008-01-23 | Genentech, Inc. | Compositions et procédés pour le traitement de maladies liées au système immunitaire |
| CA2492070A1 (fr) * | 1999-12-01 | 2001-06-07 | Kevin P. Baker | Polypeptides pro4329 marqueurs de tumeurs du poumon et acides nucleiques codant lesdits polypeptides |
| CN1300781A (zh) * | 1999-12-22 | 2001-06-27 | 上海博德基因开发有限公司 | 一种新的多肽-人shc蛋白43和编码这种多肽的多核苷酸 |
| US20040043397A1 (en) | 2000-01-11 | 2004-03-04 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US7510855B2 (en) | 2000-01-26 | 2009-03-31 | Agensys, Inc. | 84P2A9: a prostate and testis specific protein highly expressed in prostate cancer |
| US6953682B2 (en) | 2000-02-10 | 2005-10-11 | Millennium Pharmaceuticals, Inc. | Nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and atpase-like molecules and uses therefor |
| US7078205B2 (en) | 2000-02-17 | 2006-07-18 | Millennium Pharmaceuticals, Inc. | Nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, atpase molecules, acyltransferase molecules, pyridoxal-phosphate dependent enzyme molecules and uses therefor |
| US20020082212A1 (en) * | 2000-07-20 | 2002-06-27 | Millennium Pharmaceuticals, Inc. | 7716, a novel human ATPase and uses therefor |
| US20020031815A1 (en) * | 2000-06-26 | 2002-03-14 | Millennium Pharmaceuticals, Inc. | 46619, a novel human beta-ketoacyl synthase and uses thereof |
| US7718397B2 (en) | 2000-03-21 | 2010-05-18 | Genentech, Inc. | Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof |
| US20020025931A1 (en) | 2000-03-24 | 2002-02-28 | Rachel Meyers | 3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor |
| US20030198953A1 (en) * | 2000-03-30 | 2003-10-23 | Spytek Kimberly A. | Novel proteins and nucleic acids encoding same |
| US7632929B2 (en) | 2000-04-20 | 2009-12-15 | The Board Of Trustees Of The University Of Arkansas | Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof |
| CA2407044A1 (fr) | 2000-04-25 | 2001-11-01 | Lexicon Genetics Incorporated | Nouvelles proteines kinases humaines et polynucleotides les codant |
| WO2001081586A2 (fr) * | 2000-04-26 | 2001-11-01 | Millennium Pharmaceuticals, Inc. | 21657, deshydrogenase humaine a chaine courte et ses utilisations |
| US6808876B1 (en) * | 2000-05-02 | 2004-10-26 | Immusol, Inc. | Cellular regulators of infectious agents and methods of use |
| CA2408828A1 (fr) * | 2000-05-12 | 2001-11-15 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Nouvelle serine-threonine kinase-4 |
| EP1158001B1 (fr) * | 2000-05-26 | 2007-11-14 | F. Hoffmann-La Roche Ag | Un acide nucléique produit excessivement dans des cellules tumorales humaines, une protéine codée par ledit acide nucléique et un procédé de diagnose de tumeurs |
| AU7634301A (en) * | 2000-05-26 | 2001-12-03 | Bayer Aktiengesellschaft | Regulation of human p78-like serine/threonine kinase |
| DE10027170A1 (de) * | 2000-05-31 | 2001-12-13 | Schering Ag | Humanes PEM als Target für die Fertilitätskontrolle |
| US7098311B2 (en) * | 2000-06-02 | 2006-08-29 | Brigham And Women's Hospital | Fusion of jAZF1 and jjAZ1 genes in endometrial stromal tumors |
| AU6531101A (en) * | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20030096969A1 (en) | 2000-06-02 | 2003-05-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2001094385A2 (fr) * | 2000-06-05 | 2001-12-13 | Bayer Aktiengesellschaft | Regulation du recepteur couple a la proteine humaine g de type hm74 |
| JP2004512023A (ja) * | 2000-06-09 | 2004-04-22 | コリクサ コーポレイション | 結腸癌の治療および診断のための組成物および方法 |
| US6323016B1 (en) | 2000-06-09 | 2001-11-27 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| AU2001268435A1 (en) * | 2000-06-15 | 2001-12-24 | Millennium Pharmaceuticals, Inc. | 23680, a novel human aminotransferase and uses therefor |
| WO2001096546A2 (fr) * | 2000-06-16 | 2001-12-20 | Incyte Genomics, Inc. | Proteine-phosphatases |
| CA2648048A1 (fr) * | 2000-06-23 | 2002-01-03 | Genentech, Inc. | Compositions et procedes de diagnostic et de traitement de troubles dont l'angiogenese |
| US7094587B2 (en) | 2000-06-27 | 2006-08-22 | Millennium Pharmaceuticals, Inc. | 16002 Molecules and uses therefor |
| EP1309684A2 (fr) * | 2000-06-27 | 2003-05-14 | Curagen Corporation | Polynucleotides et polypeptides codes par ceux-ci |
| WO2002000939A2 (fr) | 2000-06-28 | 2002-01-03 | Diadexus, Inc. | Procede de diagnostic, de surveillance, de determination du stade, d'imagerie et de traitement du cancer du colon |
| AU2001273148A1 (en) * | 2000-06-30 | 2002-01-14 | Millennium Pharmaceuticals, Inc. | 57658, a human uridine kinase and uses thereof |
| WO2002004510A2 (fr) * | 2000-07-07 | 2002-01-17 | Incyte Genomics, Inc. | Proteines liant le nucleotide guanine |
| JP2004513618A (ja) * | 2000-07-07 | 2004-05-13 | インサイト・ゲノミックス・インコーポレイテッド | 輸送体及びイオンチャネル |
| WO2002006326A2 (fr) * | 2000-07-14 | 2002-01-24 | Millennium Pharmaceuticals, Inc. | 62088, un nouveau membre humain de la famille nucleoside phosphatase, et utilisations de ce dernier |
| AU2001281967A1 (en) * | 2000-07-18 | 2002-01-30 | Bayer Aktiengesellschaft | Regulation of human desc1-like serine protease |
| WO2002006318A2 (fr) | 2000-07-18 | 2002-01-24 | Board Of Regents, The University Of Texas System | Procedes et compositions permettant de stabiliser des microtubules et des filaments intermediaires dans des cellules de muscle strie |
| CA2416456A1 (fr) * | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides |
| AU8762901A (en) * | 2000-07-25 | 2002-02-05 | Merck Patent Gmbh | Novel protein containing ring finger domaine r1p4 |
| AU2001277202A1 (en) * | 2000-07-26 | 2002-02-05 | Applied Genomics, Inc. | Bstp-ras/rerg protein and related reagents and methods of use thereof |
| WO2002008281A2 (fr) * | 2000-07-26 | 2002-01-31 | Stanford University | Proteine bstp-cad et reactifs associes et methodes d'utilisation |
| EP1657254A3 (fr) * | 2000-08-01 | 2006-06-07 | Genentech, Inc. | Polypeptide, acides nucléiques le codant, et leur utilisation pour le diagnostic du cancer |
| US7335732B2 (en) | 2000-08-01 | 2008-02-26 | Genentech, Inc. | PRO9799 polypeptides |
| WO2002010217A2 (fr) | 2000-08-02 | 2002-02-07 | The Johns Hopkins University | Profils d'expression de cellules endotheliales |
| EP1315431A1 (fr) * | 2000-08-02 | 2003-06-04 | Millennium Pharmaceuticals, Inc. | Membre de la famille du facteur de liberation du gtp humain (15368) et ses utilisations |
| US6924364B2 (en) | 2000-08-04 | 2005-08-02 | Zymogenetics, Inc. | Human secreted protein, Zzp1 |
| AU2001281252A1 (en) | 2000-08-10 | 2002-02-18 | Board Of Regents, The University Of Texas System | The tumor suppressor car-1 |
| AU9174501A (en) * | 2000-08-11 | 2002-02-25 | Merck Patent Gmbh | Novel mitogen activated kinase |
| EP1326985A1 (fr) * | 2000-08-18 | 2003-07-16 | MERCK PATENT GmbH | Identification d'un gene d'acetyltransferase n-terminale humaine |
| AU2001285109A1 (en) * | 2000-08-21 | 2002-03-04 | Incyte Genomics, Inc. | Microtubule-associated proteins and tubulins |
| US6706513B2 (en) | 2000-08-21 | 2004-03-16 | Bristol-Myers Squibb Company | Adenosine deaminase homolog |
| WO2002016579A2 (fr) * | 2000-08-24 | 2002-02-28 | Eli Lilly And Company | Acides nucleiques, vecteurs, cellules hotes, polypeptides et utilisations de ces derniers |
| CA2420902A1 (fr) * | 2000-08-28 | 2002-03-07 | Craig A. Rosen | 18 proteines humaines secretees |
| AU2001284176A1 (en) * | 2000-08-28 | 2002-03-13 | Astrazeneca Ab | Molecules involved in the regulation of insulin in resistance syndrome (irs) |
| EP2022797A3 (fr) | 2000-08-28 | 2011-11-09 | Agensys, Inc. | Acide nucléique et protéine correspondante intitulée 85P1B3 utile dans le traitement et la détection du cancer |
| US20030224396A1 (en) * | 2000-08-30 | 2003-12-04 | Yonghong Xiao | Regulation of human aminotransferase-like enzyme |
| US20020091238A1 (en) * | 2000-08-30 | 2002-07-11 | Curtis Rory A.J. | 54370, a novel human sulfate transporter and uses therefor |
| US20020146800A1 (en) * | 2000-08-30 | 2002-10-10 | Curtis Rory A.J. | 48921, a novel human GTP releasing factor and uses therefor |
| AU2002210464A1 (en) * | 2000-08-30 | 2002-03-13 | Bayer Aktiengesellschaft | Regulation of human aminotransferase-like enzyme |
| AU2001288600A1 (en) * | 2000-08-31 | 2002-03-13 | Millennium Pharmaceuticals, Inc. | 62112, a novel human dehydrogenase and uses thereof |
| WO2002020762A2 (fr) | 2000-09-05 | 2002-03-14 | Amgen Inc. | Molecules analogues au recepteur du tnf et ses utilisations |
| CA2421265A1 (fr) * | 2000-09-05 | 2002-03-14 | Incyte Genomics, Inc. | Molecules utilisees a des fins diagnostiques et therapeutiques |
| AU2001288999A1 (en) * | 2000-09-08 | 2002-03-22 | Millennium Pharmaceuticals, Inc. | 38646, a guanine nucleotide exchange factor and uses therefor |
| US6391606B1 (en) * | 2000-09-14 | 2002-05-21 | Pe Corporation | Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof |
| US6372468B1 (en) * | 2000-09-14 | 2002-04-16 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| EP1349930A2 (fr) * | 2000-10-05 | 2003-10-08 | Curagen Corporation | Polypeptides humains, acides nucleiques codant ces deuniers et leurs methodes d'utilisation |
| EP1402010A2 (fr) * | 2000-10-11 | 2004-03-31 | Millennium Pharmaceuticals, Inc. | Nouvel element de la famille des phosphatases humaines a double specificite, appele 8843, et utilisation de ce dernier |
| AU2002220613A1 (en) * | 2000-10-11 | 2002-04-22 | Bayer Aktiengesellschaft | Regulation of human cyclophilin-type peptidyl-prolyl cis-trans isomerase |
| WO2002031143A2 (fr) * | 2000-10-12 | 2002-04-18 | The Texas A & M University System | Sequences d'acides nucleiques codant des proteines cmg, proteines cmg et leurs procedes d'utilisation |
| EP1474528A4 (fr) * | 2000-10-13 | 2006-06-14 | Protein Design Labs Inc | Procedes de diagnostic du cancer de la prostate, compositions et procedes de criblage de modulateurs du cancer de la prostate |
| US6531297B2 (en) * | 2000-10-20 | 2003-03-11 | Applera Corporation | Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof |
| JP2004518437A (ja) | 2000-10-25 | 2004-06-24 | ディアデクサス インコーポレーテッド | 肺特異的遺伝子およびタンパク質に関する組成物および方法 |
| AU2002220668A1 (en) * | 2000-10-31 | 2002-05-15 | Bayer Aktiengesellschaft | Regulation of human glutathione-s-transferase |
| AU2002229011A1 (en) * | 2000-11-09 | 2002-05-21 | Glaxo Group Limited | Deaminase catalyzing the removal of the cyclopropyl moiety from abacavir-mp |
| WO2002040672A2 (fr) | 2000-11-20 | 2002-05-23 | Diadexus, Inc. | Compositions et methodes relatives a des genes et des proteines specifiques aux seins |
| WO2002081667A2 (fr) * | 2000-12-05 | 2002-10-17 | Incyte Genomics, Inc. | Ligases |
| CA2430379A1 (fr) | 2000-12-07 | 2002-06-13 | Chiron Corporation | Retrovirus endogenes regules positivement dans le cancer de la prostate |
| AU2002226033A1 (en) | 2000-12-07 | 2002-06-18 | Zymogenetics Inc. | Adipocyte complement related protein zacrp3x2 |
| CA2439800A1 (fr) * | 2000-12-14 | 2002-06-20 | Pe Corporation (Ny) | Proteines kinases humaines isolees, molecules d'acide nucleique codant des proteines kinases humaines et utilisations associees |
| US20020142376A1 (en) * | 2000-12-20 | 2002-10-03 | Gennady Merkulov | Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof |
| US6858407B2 (en) | 2000-12-22 | 2005-02-22 | Bristol-Myers Squibb Company | Human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1 |
| US7892730B2 (en) | 2000-12-22 | 2011-02-22 | Sagres Discovery, Inc. | Compositions and methods for cancer |
| US6423521B1 (en) * | 2000-12-28 | 2002-07-23 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| WO2002053591A1 (fr) * | 2000-12-30 | 2002-07-11 | Lion Bioscience Ag | Cofacteur de recepteur nucleaire mammalien cf12 et ses procedes d'utilisation |
| AU2002236717A1 (en) * | 2001-01-08 | 2002-07-16 | Lexicon Genetics Incorporated | Human protease and polynucleotides encoding the same |
| AU2002243750A1 (en) * | 2001-01-30 | 2002-08-12 | Regeneron Pharmaceuticals, Inc. | Novel nucleic acid and polypeptide molecules |
| WO2002098917A2 (fr) * | 2001-02-12 | 2002-12-12 | Curagen Corporation | Proteines, polynucleotides codant pour lesdites proteines et methodes d'utilisation desdites proteines |
| EP1637601A3 (fr) * | 2001-02-21 | 2006-03-29 | Curagen Corporation | Protéines , polynucléotides codant pour ces protéines et procédés d'utilisation |
| US7271240B2 (en) | 2001-03-14 | 2007-09-18 | Agensys, Inc. | 125P5C8: a tissue specific protein highly expressed in various cancers |
| EP1434783A4 (fr) * | 2001-03-16 | 2006-06-07 | Lilly Co Eli | Proteines de mammiferes lp et reactifs associes |
| US6913904B2 (en) * | 2001-03-27 | 2005-07-05 | Applera Corporation | Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof |
| AU2002258626B2 (en) | 2001-04-10 | 2007-01-18 | Agensys, Inc. | Nucleid acid and corresponding protein entitled 158P3D2 useful in treatment and detection of cancer |
| CA2443123A1 (fr) | 2001-04-10 | 2002-10-24 | Agensys, Inc. | Acides nucleiques et proteines correspondantes utiles pour la detection et le traitement de divers cancers |
| ATE512216T1 (de) | 2001-04-10 | 2011-06-15 | Agensys Inc | Nukleinsäure und dieser entsprechendes, 184p1e2 genanntes, für die behandlung und den nachweis von krebs geeignetes protein |
| JP2004532030A (ja) * | 2001-04-24 | 2004-10-21 | イシス・イノベイション・リミテッド | 疾病用酵素とｓｎｐマーカー |
| WO2002088175A1 (fr) * | 2001-04-24 | 2002-11-07 | Otsuka Pharmaceutical Co., Ltd. | Peptide de liaison a des anticorps de la maladie de crohn et methode d'examen de ladite maladie |
| KR100882762B1 (ko) * | 2001-05-07 | 2009-02-09 | 시오노기세이야쿠가부시키가이샤 | 혈관신생 마커로서 사용되는 폴리펩티드 및 이의 ｄｎａ |
| WO2002090543A2 (fr) * | 2001-05-09 | 2002-11-14 | Bayer Aktiengesellschaft | Régulation de la protéine semblable à celle de type 2c de la phosphatase de l'acide phosphatidique humain |
| US7157558B2 (en) | 2001-06-01 | 2007-01-02 | Genentech, Inc. | Polypeptide encoded by a polynucleotide overexpresses in tumors |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| WO2003000901A2 (fr) * | 2001-06-26 | 2003-01-03 | Decode Genetics Ehf. | Acides nucleiques codant des proteines kinases |
| GB2399087A (en) * | 2001-08-02 | 2004-09-08 | Aeomica Inc | Human zinc finger containing gene MDZ7 |
| JP2005504546A (ja) * | 2001-08-17 | 2005-02-17 | インサイト・ゲノミックス・インコーポレイテッド | 細胞内シグナル伝達分子 |
| US7270960B2 (en) * | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
| WO2003023063A1 (fr) * | 2001-09-07 | 2003-03-20 | Sankyo Company, Limited | Methode d'estimation du risque d'apparition de diabetes |
| WO2003040369A2 (fr) * | 2001-09-17 | 2003-05-15 | Molecular Engines Laboratories | Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments |
| WO2003025175A2 (fr) * | 2001-09-17 | 2003-03-27 | Molecular Engines Laboratories | Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments |
| EP1463806B1 (fr) | 2001-09-28 | 2011-01-05 | Brigham Young University | Nouveaux variants de la cyclooxygenase et methodes d'utilisation |
| WO2003038087A1 (fr) | 2001-10-04 | 2003-05-08 | Kansai Technology Licensing Organization Co., Ltd. | Promoteur du gene dr5 et promoteur du gene siah-1 |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| WO2003031607A1 (fr) * | 2001-10-10 | 2003-04-17 | Bayer Healthcare Ag | Regulation de deshydrogenase/reductase des chaines courtes humaine |
| ATE364690T1 (de) | 2001-11-09 | 2007-07-15 | Proteologics Inc | Posh nukleinsäure, polypeptide und darauf bezogene verfahren |
| US7491690B2 (en) | 2001-11-14 | 2009-02-17 | Northwestern University | Self-assembly and mineralization of peptide-amphiphile nanofibers |
| JPWO2003044197A1 (ja) * | 2001-11-21 | 2005-03-24 | 独立行政法人科学技術振興機構 | ハンチントン病遺伝子転写因子 |
| US7151162B2 (en) | 2001-12-06 | 2006-12-19 | The University Of Children's Hospital Of Both Cantons Of Basel | Nuclear protein |
| AU2002339697A1 (en) * | 2001-12-19 | 2003-06-30 | Genset S.A. | Gmg-5 polynucleotides and polypeptides and uses thereof |
| JP2003245084A (ja) | 2001-12-20 | 2003-09-02 | Morinaga Milk Ind Co Ltd | 脳梁又は精子の形成不全の診断及び治療に有用な新規遺伝子、並びにその用途 |
| DE10163467A1 (de) * | 2001-12-21 | 2003-11-27 | Axaron Bioscience Ag | Protein 24B2 und zugrundliegende DNA-Sequenz |
| US6759222B2 (en) | 2002-01-02 | 2004-07-06 | Millennium Pharmaceuticals, Inc. | 14815, a human kinase family member and uses therefor |
| AU2003202543A1 (en) * | 2002-01-07 | 2003-07-24 | Bayer Aktiengesellschaft | Human phosphatidic acid phosphatase type 2-like protein |
| WO2003060109A2 (fr) * | 2002-01-15 | 2003-07-24 | Bayer Healthcare Ag | Regulation d'une subtilase humaine |
| WO2003059948A1 (fr) * | 2002-01-15 | 2003-07-24 | Medigene Ag | Gene-2 associe a la myocardiopathie dilatee (dcmag-2) : inducteur cytoplasmique du remodelage sarcomerique de cardiomyocytes |
| JPWO2003062429A1 (ja) * | 2002-01-23 | 2005-05-26 | 山之内製薬株式会社 | 新規セリンプロテアーゼ |
| US7371719B2 (en) | 2002-02-15 | 2008-05-13 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
| EP1338609A1 (fr) * | 2002-02-21 | 2003-08-27 | MEMOREC Stoffel GmbH-Medizinisch-Molekulare Entwicklung, Köln | Un outre récepteur KDR et son utilisation |
| EP1497311A2 (fr) * | 2002-03-05 | 2005-01-19 | Applera Corporation | Proteines transporteuses humaines isolees, molecules d'acide nucleique codant celles-ci, et utilisations associees |
| AU2003208472A1 (en) * | 2002-03-06 | 2003-09-16 | Oxford Glycosciences (Uk) Ltd | Novel b-cell malignancy-associated protein |
| DK2258872T3 (da) | 2002-03-13 | 2013-11-18 | Genomic Health Inc | Genekspressionsprofilering i biopsier af tumorvæv |
| JP3949111B2 (ja) * | 2002-03-19 | 2007-07-25 | 田辺製薬株式会社 | 新規ｇタンパク質共役型受容体およびその遺伝子 |
| US7527935B2 (en) | 2002-03-19 | 2009-05-05 | Mitsubishi Tanabe Pharma Corporation | G-protein coupled receptor having eicosanoid as ligand and gene thereof |
| GB0206684D0 (en) * | 2002-03-21 | 2002-05-01 | Babraham Inst | Novel proteins |
| US7193069B2 (en) * | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| US7329502B2 (en) | 2002-04-25 | 2008-02-12 | The United States Of America As Represented By The Department Of Health And Human Services | ZAP-70 expression as a marker for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) |
| JP2004041003A (ja) * | 2002-05-17 | 2004-02-12 | Takeda Chem Ind Ltd | 新規タンパク質、そのｄｎａおよびその用途 |
| AU2003238178A1 (en) | 2002-05-29 | 2003-12-12 | Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung | Pancreas-specific proteins |
| WO2003101401A2 (fr) | 2002-06-03 | 2003-12-11 | Chiron Corporation | Utilisation de nrg4, ou d'inhibiteurs de nrg4, dans le traitement du cancer du colon et du pancreas |
| EP1513934B1 (fr) | 2002-06-06 | 2011-03-02 | Oncotherapy Science, Inc. | Genes et polypeptides en rapport avec les cancers du colon chez l'homme |
| AU2003276679A1 (en) | 2002-06-13 | 2003-12-31 | Chiron Corporation | Vectors for expression of hml-2 polypeptides |
| CA2493263A1 (fr) * | 2002-07-22 | 2004-01-29 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau gene associe a l'arthrite rhumatoide |
| JP4186004B2 (ja) | 2002-08-14 | 2008-11-26 | 独立行政法人産業技術総合研究所 | 新規ｎ−アセチルガラクトサミン転移酵素およびそれをコードする核酸 |
| WO2004016733A2 (fr) | 2002-08-16 | 2004-02-26 | Agensys, Inc. | Acides nucleiques et proteines correspondantes connues sous 251p5g2 que l'on utilise dans le traitement et la detection de cancers |
| WO2004018518A1 (fr) * | 2002-08-23 | 2004-03-04 | Japan Science And Technology Agency | Peptides antigeniques de tumeur cancereuse solide humains, polynucleotides codant pour ceux-ci et utilisation de ceux-ci |
| EP1540014A2 (fr) * | 2002-08-27 | 2005-06-15 | Epigenomics AG | Procede et acides nucleiques servant a l'analyse de troubles lies a la proliferation des cellules mammaires |
| US7452969B2 (en) | 2002-08-30 | 2008-11-18 | Licentia Ltd | Neurotrophic factor protein and uses thereof |
| CA2500472A1 (fr) | 2002-09-30 | 2004-04-15 | Oncotherapy Science, Inc. | Genes et polypeptides associes aux cancers du pancreas chez l'homme |
| WO2004035823A2 (fr) * | 2002-10-17 | 2004-04-29 | Evotec Neurosciences Gmbh | Utilisation diagnostique et therapeutique des gene et proteine ensadin-0625 destinee a des maladies neurodegeneratives |
| AU2002952216A0 (en) * | 2002-10-23 | 2002-11-07 | The Walter And Eliza Hall Institute Of Medical Research | Novel therapeutic molecules |
| US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| EP1570080A4 (fr) | 2002-11-15 | 2006-03-01 | Genomic Health Inc | Etablissement de profils d'expressions genetique du cancer a recepteur de facteur de croissance epidermique positif |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| AU2002953341A0 (en) * | 2002-12-13 | 2003-01-09 | The Walter And Eliza Hall Institute Of Medical Research | A novel phosphoprotein |
| AU2003287764B2 (en) * | 2002-12-13 | 2010-01-21 | The Walter And Eliza Hall Institute Of Medical Research | A novel phosphoprotein |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| WO2004070025A2 (fr) * | 2003-02-05 | 2004-08-19 | Juan Saus | Nouvelles isoformes de la proteine liant l'antigene de goodpasture et troubles induits par une proteine incorrectement repliee |
| EP1445614A1 (fr) * | 2003-02-06 | 2004-08-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Méthodes d'évaluation in vitro de l'état de progression d'un virus HIV chez un individu |
| US7074891B2 (en) | 2003-02-07 | 2006-07-11 | Posco | Leukocyte stimulating peptides |
| EP1597391B1 (fr) | 2003-02-20 | 2008-10-29 | Genomic Health, Inc. | Utilisation d'arn intronique pour mesurer l'expression genique |
| US20060142222A1 (en) * | 2003-03-04 | 2006-06-29 | Makoto Ogino | Novel gene relating to fibrotic conditions |
| EP1606409B1 (fr) * | 2003-03-19 | 2010-09-01 | Biogen Idec MA Inc. | Proteine de liaison de recepteur de nogo |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| EP3170906B1 (fr) | 2003-06-24 | 2018-08-22 | Genomic Health, Inc. | Prédiction de probabilité de récurrence de cancer |
| WO2005008213A2 (fr) | 2003-07-10 | 2005-01-27 | Genomic Health, Inc. | Algorithme de profile d'expression et test du pronostic du cancer |
| EP1652923B1 (fr) | 2003-08-08 | 2011-10-12 | Perseus Proteomics Inc. | Gene surexprime dans le cancer |
| WO2005018554A2 (fr) * | 2003-08-12 | 2005-03-03 | Washington University In St. Louis | Proteine de surface cellulaire isolee inductible par la chaleur et therapie d'immunociblage de tumeurs basee sur l'hyperthermie |
| US20070178458A1 (en) * | 2003-09-05 | 2007-08-02 | O'brien Philippa | Methods of diagnosis and prognosis of ovarian cancer II |
| TW200517503A (en) * | 2003-09-10 | 2005-06-01 | Japan Science & Tech Agency | Group of genes differentially expressed in peripheral blood cells and diagnostic method and assay method using the same |
| WO2005032584A2 (fr) * | 2003-10-02 | 2005-04-14 | Glaxosmithkline Biologicals S.A. | Composes |
| MXPA06003686A (es) | 2003-10-03 | 2007-03-01 | Brigham & Womens Hospital | Ligandos tim-3 y sus metodos. |
| WO2005040791A2 (fr) * | 2003-10-21 | 2005-05-06 | Bayer Healthcare Ag | Diagnostics et therapeutiques pour maladies liees au recepteur de peptides similaire a la somatostatine et a l'angiogenine (salpr) |
| WO2005051994A2 (fr) * | 2003-11-21 | 2005-06-09 | Zymogenetics, Inc. | Facteur de necrose tumorale ztnf11 |
| ATE541580T1 (de) | 2003-12-05 | 2012-02-15 | Univ Northwestern | Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor |
| WO2005064019A2 (fr) | 2003-12-23 | 2005-07-14 | Genomic Health, Inc. | Amplification universelle d'arn fragmente |
| US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
| ES2537633T3 (es) | 2004-03-02 | 2015-06-10 | The Johns Hopkins University | Mutaciones del gen de PIK3CA en cánceres humanos |
| TW200539890A (en) | 2004-03-12 | 2005-12-16 | Brigham & Womens Hospital | Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function |
| WO2005090569A1 (fr) * | 2004-03-24 | 2005-09-29 | The Council Of The Queensland Institute Of Medical Research | Cancer et acides nucleiques et proteines de testicule vsm1 et vsm2, et leurs utilisations |
| EP2289911A3 (fr) * | 2004-03-30 | 2011-03-30 | NsGene A/S | Utilisation thérapeutique du facteur de croissance nsg33 |
| CA2563074C (fr) | 2004-04-09 | 2014-05-20 | Genomic Health, Inc. | Marqueurs d'expression genique permettant de predire la reponse a la chimiotherapie |
| DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| WO2005118832A2 (fr) * | 2004-06-01 | 2005-12-15 | Bayer Healthcare Ag | Agents diagnostiques et therapeutiques pour des maladies associees a une proteine de type kinase regulee par serum/glucocorticoide (sgkl) |
| JP4960865B2 (ja) | 2004-06-24 | 2012-06-27 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 脱髄に関連する状態の処置 |
| US7587279B2 (en) | 2004-07-06 | 2009-09-08 | Genomic Health | Method for quantitative PCR data analysis system (QDAS) |
| US7985831B2 (en) * | 2004-08-05 | 2011-07-26 | Toagosei Co., Ltd. | Crohn's disease antibody epitope peptide and reagent for testing Crohn's disease |
| PL1836629T3 (pl) | 2004-11-05 | 2020-06-15 | Genomic Health, Inc. | Przewidywanie odpowiedzi na chemioterapię z zastosowaniem markerów ekspresji genu |
| ATE550440T1 (de) | 2004-11-05 | 2012-04-15 | Genomic Health Inc | Molekulare indikatoren für brustkrebsprognose und vorhersage des ansprechens auf eine behandlung |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| KR101027427B1 (ko) | 2004-11-12 | 2011-04-11 | 젠코어 인코포레이티드 | ＦcRn에 대하여 증가된 결합력을 갖는 Ｆc 변이체 |
| CA2598251A1 (fr) | 2005-03-04 | 2006-09-14 | Northwestern University | Epitopes angiogeniques de liaison a l'heparine, amphiphiles peptidiques, compositions auto-assemblees et procedes d'utilisation associes |
| CA2608315C (fr) * | 2005-05-13 | 2014-08-05 | Centre National De La Recherche Scientifique | Utilisation de nouveau codage genique pour nouvel element de la famille mcm2-8 dans les compositions pharmaceutiques |
| KR101245462B1 (ko) | 2005-07-08 | 2013-03-20 | 바이오겐 아이덱 엠에이 인코포레이티드 | Ｓｐ35 항체 및 그의 용도 |
| EP1907589A4 (fr) * | 2005-07-26 | 2010-11-24 | Siemens Healthcare Diagnostics | Polymorphismes de nucleotides uniques a susceptibilite par rapport a une maladie cardio-vasculaire |
| US8207128B2 (en) * | 2005-09-28 | 2012-06-26 | Supadelixir Inc. | Polypeptide inhibiting transmigration of leukocytes or growth and/or metastasis of cancer cells, and fusion protein thereof |
| EP1790664A1 (fr) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Anticorps monoclonaux contre claudin-18 pour le traitement du cancer |
| JP5236488B2 (ja) | 2005-12-14 | 2013-07-17 | ハーモ ファーマ エルテーデー． | 新規な神経栄養因子タンパク質およびその用途 |
| WO2008003656A2 (fr) * | 2006-07-03 | 2008-01-10 | Exonhit Therapeutics Sa | Produits de la transcription spécifiques de la prostate et leur utilisation pour des thérapeutiques et des diagnostics du cancer de la prostate |
| US20080108070A1 (en) * | 2006-09-08 | 2008-05-08 | Corixa Corporation | Methods, compositions, and kits for the detection and monitoring of colon cancer |
| US8076295B2 (en) | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
| US8999634B2 (en) * | 2007-04-27 | 2015-04-07 | Quest Diagnostics Investments Incorporated | Nucleic acid detection combining amplification with fragmentation |
| GB0805159D0 (en) | 2008-03-19 | 2008-04-23 | Sancho Madrid David | Immune modulation via C-type lectin |
| EP2565204B1 (fr) | 2007-07-27 | 2015-10-07 | immatics biotechnologies GmbH | Nouveaux épitopes immunogènes pour l'immunothérapie |
| US7863021B2 (en) * | 2007-09-05 | 2011-01-04 | Celera Corporation | Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof |
| WO2009034661A1 (fr) * | 2007-09-12 | 2009-03-19 | Toppan Printing Co., Ltd. | Procédé de diagnostic et induction d'une résistance à un virus |
| EP2216340B1 (fr) | 2007-10-17 | 2012-12-12 | Universidad De Córdoba | Isoformes du récepteur de la somatostatine humaine de type 5 produites par traitement alternatif et paires d'oligonucléotides permettant de les détecter par pcr |
| SI2235059T1 (sl) | 2007-12-26 | 2015-06-30 | Xencor, Inc. | Fc variante s spremenjeno vezjo na fcrn |
| GB0803352D0 (en) * | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
| EP3112379A1 (fr) * | 2008-03-21 | 2017-01-04 | Universiteit Hasselt | Biomarqueurs pour la polyarthrite rhumatoïde |
| EP2315779A2 (fr) | 2008-07-09 | 2011-05-04 | Biogen Idec MA Inc. | Compositions comprenant des anticorps anti-lingo ou leurs fragments |
| CN102164611B (zh) | 2008-07-24 | 2015-01-07 | Ns基因公司 | 生长因子metrnl的治疗用途 |
| SI2172211T1 (sl) | 2008-10-01 | 2015-03-31 | Immatics Biotechnologies Gmbh | Sestavek s tumorjem povezanih peptidov in zadevnih cepiv proti raku za zdravljenje glioblastoma (GBM) in drugih vrst raka |
| AU2009313808B2 (en) | 2008-11-14 | 2013-05-16 | Gen-Probe Incorporated | Compositions, kits and methods for detection of campylobacter nucleic acid |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| CA2745849A1 (fr) * | 2008-12-09 | 2010-06-17 | Alethia Biotherapeutics Inc. | Nouveau variant retroviral endogene humain d'erv3 et utilisations de celui-ci pour diagnostiquer le cancer des ovaires |
| JP2012523463A (ja) | 2009-04-13 | 2012-10-04 | ノースウエスタン ユニバーシティ | 軟骨再生のための新規なペプチドベースの足場およびその使用方法 |
| WO2011028952A1 (fr) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions et procédés pour une co-liaison bivalente et monovalente simultanée d'antigènes |
| ES2802623T3 (es) * | 2010-01-27 | 2021-01-20 | Massachusetts Inst Technology | Agentes polipeptídicos técnicamente diseñados para la neutralización dirigida de amplio espectro de la gripe |
| TW202344270A (zh) | 2010-09-29 | 2023-11-16 | 美商艾澤西公司 | 與191p4d12蛋白結合之抗體藥物共軛物(adc) |
| KR101886029B1 (ko) | 2010-10-01 | 2018-08-07 | 호바 세라퓨틱스 에이피에스 | 무해자극통증, 통각과민증, 자발통증 및 헛통증의 치료를 위한 메테오린의 용도 |
| DK2651430T3 (en) * | 2010-12-14 | 2018-08-27 | Hananja Ehf | Biological activity of placental protein 13 |
| EP2753347B1 (fr) | 2011-09-05 | 2016-08-03 | NsGene A/S | Traitement de l'allodynie, de l'hyperalgie, de la douleur spontanée et de la douleur illusionnelle |
| WO2013068445A1 (fr) * | 2011-11-09 | 2013-05-16 | Sanofi | Diacylglycérol lipase et applications associées |
| CN104334573A (zh) | 2012-04-30 | 2015-02-04 | 比奥孔有限公司 | 靶向/免疫调节性融合蛋白及其制造方法 |
| WO2013167153A1 (fr) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Anticorps utiles dans le diagnostic du cancer |
| CN104470541A (zh) | 2012-05-14 | 2015-03-25 | 比奥根艾迪克Ma公司 | 用于治疗涉及运动神经元的疾患的lingo-2拮抗剂 |
| WO2013174404A1 (fr) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer |
| RU2678127C2 (ru) | 2012-11-13 | 2019-01-23 | Бионтех Аг | Агенты для лечения экспрессирующих клаудин раковых заболеваний |
| WO2014127785A1 (fr) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer |
| US9023353B2 (en) | 2013-03-13 | 2015-05-05 | The Board Of Trustees Of The University Of Arkansas | Anti-(+)—methamphetamine monoclonal antibodies |
| WO2014146672A1 (fr) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Thérapie comprenant des anticorps dirigés contre cldn 18.2 pour le traitement du cancer |
| KR20210157418A (ko) | 2013-03-27 | 2021-12-28 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| EP3971287A1 (fr) | 2013-07-11 | 2022-03-23 | ModernaTX, Inc. | Compositions comprenant des polynucléotides synthétiques codant pour des protéines liées à crispr et des arnsg synthétiques et méthodes d'utilisation |
| EP4105236A1 (fr) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anticorps contre tl1a (tnfsf15) pour le traitement des maladies inflammatoires de l'intestin |
| EP3049111A2 (fr) | 2013-09-25 | 2016-08-03 | Cytomx Therapeutics Inc. | Substrats pour métalloprotéinases matricielles et autres fragments clivables et leurs procédés d'utilisation |
| JP6558699B2 (ja) | 2013-10-01 | 2019-08-14 | 国立大学法人三重大学 | 抗原提示を促進するエピトープ間配列を含むｔ細胞誘導ワクチン |
| CA2937370A1 (fr) | 2014-01-31 | 2015-08-06 | Cytomx Therapeutics, Inc. | Substrats pour matriptase et activateur u-plasminogene et autres fractions clivables, et leurs procedes d'utilisation |
| US10435467B2 (en) | 2015-01-08 | 2019-10-08 | Biogen Ma Inc. | LINGO-1 antagonists and uses for treatment of demyelinating disorders |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| US11124766B2 (en) * | 2015-06-12 | 2021-09-21 | Emory University | Growth and survival compositions for cells capable of producing antibodies and methods related thereto |
| PT3344776T (pt) | 2015-09-04 | 2021-08-03 | Synthetic Genomics Inc | Microorganismos recombinantes de algas com aumento de produtividade |
| EP3430172A4 (fr) | 2016-03-17 | 2019-08-21 | Cedars-Sinai Medical Center | Méthode de diagnostic d'une maladie inflammatoire chronique de l'intestin par l'intermédiaire de rnase t2 |
| WO2017172941A2 (fr) * | 2016-03-29 | 2017-10-05 | Berz David | Modulation de l'entretien structural de l'expression du chromosome-1 |
| US9611297B1 (en) | 2016-08-26 | 2017-04-04 | Thrasos Therapeutics Inc. | Compositions and methods for the treatment of cast nephropathy and related conditions |
| US11125757B2 (en) | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
| EP3508499A1 (fr) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Anticorps ciblant et d'autres modulateurs d'un gène d'immunoglobuline associé à une résistance contre des réponses immunitaires antitumorales et leurs utilisations |
| AU2020261435A1 (en) * | 2019-04-26 | 2021-11-25 | Sangamo Therapeutics, Inc. | Engineering AAV |
| US20220372138A1 (en) | 2019-07-05 | 2022-11-24 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
| WO2021083958A1 (fr) * | 2019-10-29 | 2021-05-06 | Specialites Pet Food | Nouveaux peptides induisant la satiété |
| WO2021228999A1 (fr) * | 2020-05-12 | 2021-11-18 | Institut Curie | Épitopes néo-antigéniques associés à des mutations sf3b1 |
| US20240010720A1 (en) | 2020-07-06 | 2024-01-11 | Iomx Therapeutics Ag | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
| CN117529492A (zh) * | 2021-01-21 | 2024-02-06 | 鹿特丹伊拉斯谟大学医疗中心 | 用于治疗的t细胞 |
| JP2024509376A (ja) * | 2021-02-18 | 2024-03-01 | ベレン セラピューティクス ピー．ビー．シー． | 家族性ヘテロ接合型及びホモ接合型高コレステロール血症のシクロデキストリンによる治療方法 |
| US20240158457A1 (en) * | 2022-05-20 | 2024-05-16 | Medikine, Inc. | Interleukin-18 receptor binding polypeptides and uses thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446240A (en) * | 1981-01-30 | 1984-05-01 | Nerenberg Samuel T | Pancreas specific protein systems |
| US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
| US6080540A (en) * | 1990-04-20 | 2000-06-27 | Cold Spring Harbor Laboratory | Cloning of mammalian genes in microbial organisms and methods for pharmacological screening |
| JP2845623B2 (ja) * | 1990-11-26 | 1999-01-13 | アメリカ合衆国 | 細胞のストレス転写因子 |
| US5721352A (en) * | 1991-02-19 | 1998-02-24 | University Of Florida Research Foundation | Entomopoxvirus expression system |
| US5840870A (en) * | 1995-12-29 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Polynucleotides PANC1A and PANC1B associated with pancreatic cancer |
| WO1997007827A1 (fr) * | 1995-08-22 | 1997-03-06 | Thomas Jefferson University | Gab1, QUI EST UNE PROTEINE SE LIANT A Grb2, ET COMPOSITIONS POUR PRODUIRE ET UTILISER CETTE PROTEINE |
| JP3462313B2 (ja) * | 1995-08-24 | 2003-11-05 | キッコーマン株式会社 | 変異型ウリカーゼ、変異型ウリカーゼ遺伝子、新規な組み換え体ｄｎａ及び変異型ウリカーゼの製造法 |
| US5998165A (en) * | 1995-12-29 | 1999-12-07 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a protein associated with pancreatic cancer |
| JP2000511410A (ja) * | 1996-04-29 | 2000-09-05 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | ナンセンス介在ｒｎａ崩壊の哺乳動物の調節因子 |
| US6500934B1 (en) * | 1996-07-24 | 2002-12-31 | Michael Rush Lerner | Bivalent agonists for G-protein coupled receptors |
| US5976834A (en) * | 1997-01-09 | 1999-11-02 | Smithkline Beecham Corporation | cDNA clone HNFJD15 that encodes a novel human 7-transmembrane receptor |
| US5925521A (en) * | 1997-03-31 | 1999-07-20 | Incyte Pharmaceuticals, Inc. | Human serine carboxypeptidase |
| CA2232743A1 (fr) * | 1997-04-02 | 1998-10-02 | Smithkline Beecham Corporation | Tl5, homologue tnf |
| JP2001519666A (ja) * | 1997-04-10 | 2001-10-23 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌発現配列タグ（ｓＥＳＴｓ） |
| IT1291110B1 (it) * | 1997-04-15 | 1998-12-29 | Istituto Europ Di Oncologia S | Interattori intracellulari e specificita' di legame del dominio eh |
| US5948641A (en) * | 1997-05-29 | 1999-09-07 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a metal response element binding protein |
| EP1012292A1 (fr) * | 1997-06-06 | 2000-06-28 | Regeneron Pharmaceuticals, Inc. | Element ntn-2 de la famille des ligands du tnf |
| AU9484398A (en) * | 1997-09-17 | 1999-04-05 | Genentech Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
| US5932442A (en) * | 1997-09-23 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Human regulatory molecules |
| US5972660A (en) * | 1997-10-22 | 1999-10-26 | Incyte Pharmaceuticals, Inc. | Human hydroxypyruvate reductase |
| DE19818598A1 (de) * | 1998-04-19 | 1999-10-21 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Pankreasnormalgewebe |
| NZ507728A (en) * | 1998-04-29 | 2002-06-28 | Genesis Res & Dev Corp Ltd | Information from a cDNA library created from keratinocytes, dermal papilla, neonatal foreskin fibroblast or embryonic skin cells is used to treating cancer, angiogenesis, skin inflammation, inflammatory diseases or stimulating keratinocyte growth |
| US6262249B1 (en) * | 1998-06-23 | 2001-07-17 | Chiron Corporation | Pancreatic cancer genes |
| CA2296792A1 (fr) * | 1999-02-26 | 2000-08-26 | Genset S.A. | Sequences marqueurs exprimees et proteines humaines codees |
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