CA2395654A1 - Acides nucleiques, proteines et anticorps - Google Patents
Acides nucleiques, proteines et anticorps Download PDFInfo
- Publication number
- CA2395654A1 CA2395654A1 CA002395654A CA2395654A CA2395654A1 CA 2395654 A1 CA2395654 A1 CA 2395654A1 CA 002395654 A CA002395654 A CA 002395654A CA 2395654 A CA2395654 A CA 2395654A CA 2395654 A1 CA2395654 A1 CA 2395654A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- polypeptide
- polynucleotide
- sequence
- cdna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 122
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 121
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 92
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 92
- 108091005461 Nucleic proteins Proteins 0.000 title description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 530
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 515
- 229920001184 polypeptide Polymers 0.000 claims abstract description 514
- 108091033319 polynucleotide Proteins 0.000 claims abstract description 372
- 102000040430 polynucleotide Human genes 0.000 claims abstract description 372
- 239000002157 polynucleotide Substances 0.000 claims abstract description 372
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 172
- 238000000034 method Methods 0.000 claims abstract description 98
- 239000013598 vector Substances 0.000 claims abstract description 40
- 238000004519 manufacturing process Methods 0.000 claims abstract description 11
- 239000002299 complementary DNA Substances 0.000 claims description 145
- 239000012634 fragment Substances 0.000 claims description 140
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 121
- 125000003729 nucleotide group Chemical group 0.000 claims description 109
- 239000002773 nucleotide Substances 0.000 claims description 106
- 150000001413 amino acids Chemical class 0.000 claims description 52
- 230000014509 gene expression Effects 0.000 claims description 32
- 230000000694 effects Effects 0.000 claims description 31
- 238000012217 deletion Methods 0.000 claims description 29
- 230000037430 deletion Effects 0.000 claims description 29
- 230000004071 biological effect Effects 0.000 claims description 23
- 230000027455 binding Effects 0.000 claims description 18
- 239000000047 product Substances 0.000 claims description 10
- 230000035772 mutation Effects 0.000 claims description 5
- 238000004166 bioassay Methods 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 230000001575 pathological effect Effects 0.000 claims 8
- 239000006228 supernatant Substances 0.000 claims 2
- 241000282414 Homo sapiens Species 0.000 abstract description 379
- 239000000203 mixture Substances 0.000 abstract description 14
- 238000010188 recombinant method Methods 0.000 abstract description 5
- 238000010189 synthetic method Methods 0.000 abstract description 5
- 238000002560 therapeutic procedure Methods 0.000 abstract description 5
- 239000000556 agonist Substances 0.000 abstract description 4
- 238000012216 screening Methods 0.000 abstract description 4
- 238000002405 diagnostic procedure Methods 0.000 abstract description 3
- 230000002708 enhancing effect Effects 0.000 abstract description 3
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 246
- 206010028980 Neoplasm Diseases 0.000 description 140
- 235000018102 proteins Nutrition 0.000 description 112
- 230000000295 complement effect Effects 0.000 description 77
- 235000001014 amino acid Nutrition 0.000 description 74
- 201000011510 cancer Diseases 0.000 description 68
- 210000004556 brain Anatomy 0.000 description 66
- 210000001072 colon Anatomy 0.000 description 62
- 229940024606 amino acid Drugs 0.000 description 57
- 108091028043 Nucleic acid sequence Proteins 0.000 description 51
- 210000001744 T-lymphocyte Anatomy 0.000 description 47
- 206010061535 Ovarian neoplasm Diseases 0.000 description 44
- 210000001519 tissue Anatomy 0.000 description 42
- 206010033128 Ovarian cancer Diseases 0.000 description 41
- 230000001605 fetal effect Effects 0.000 description 40
- 210000001672 ovary Anatomy 0.000 description 38
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 36
- 238000009396 hybridization Methods 0.000 description 36
- 210000002307 prostate Anatomy 0.000 description 35
- 229920001223 polyethylene glycol Polymers 0.000 description 34
- 239000002202 Polyethylene glycol Substances 0.000 description 32
- 210000004185 liver Anatomy 0.000 description 32
- 108020004414 DNA Proteins 0.000 description 30
- -1 allelic variants Proteins 0.000 description 30
- 230000000890 antigenic effect Effects 0.000 description 28
- 210000004072 lung Anatomy 0.000 description 28
- 238000006467 substitution reaction Methods 0.000 description 28
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 27
- 210000000481 breast Anatomy 0.000 description 27
- 201000010099 disease Diseases 0.000 description 26
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
- 108020001507 fusion proteins Proteins 0.000 description 23
- 102000037865 fusion proteins Human genes 0.000 description 23
- 210000002216 heart Anatomy 0.000 description 23
- 208000009956 adenocarcinoma Diseases 0.000 description 22
- 125000000539 amino acid group Chemical group 0.000 description 22
- 210000003719 b-lymphocyte Anatomy 0.000 description 22
- 230000005714 functional activity Effects 0.000 description 22
- 210000000601 blood cell Anatomy 0.000 description 21
- 201000009030 Carcinoma Diseases 0.000 description 20
- 108700026244 Open Reading Frames Proteins 0.000 description 20
- 230000004048 modification Effects 0.000 description 20
- 238000012986 modification Methods 0.000 description 20
- 239000000523 sample Substances 0.000 description 19
- 210000003734 kidney Anatomy 0.000 description 18
- 208000029742 colonic neoplasm Diseases 0.000 description 17
- 230000002163 immunogen Effects 0.000 description 16
- 238000006243 chemical reaction Methods 0.000 description 15
- 210000000987 immune system Anatomy 0.000 description 15
- 210000000952 spleen Anatomy 0.000 description 15
- 108091026890 Coding region Proteins 0.000 description 14
- 239000002253 acid Substances 0.000 description 14
- 210000004899 c-terminal region Anatomy 0.000 description 14
- 230000002611 ovarian Effects 0.000 description 14
- 210000002741 palatine tonsil Anatomy 0.000 description 14
- 238000000746 purification Methods 0.000 description 14
- 210000001550 testis Anatomy 0.000 description 14
- 238000003556 assay Methods 0.000 description 13
- 230000015572 biosynthetic process Effects 0.000 description 13
- 230000002759 chromosomal effect Effects 0.000 description 13
- 206010006187 Breast cancer Diseases 0.000 description 12
- 208000026310 Breast neoplasm Diseases 0.000 description 12
- 210000000988 bone and bone Anatomy 0.000 description 12
- 210000002826 placenta Anatomy 0.000 description 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 12
- 239000000427 antigen Substances 0.000 description 11
- 108091007433 antigens Proteins 0.000 description 11
- 102000036639 antigens Human genes 0.000 description 11
- 210000004907 gland Anatomy 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 206010009944 Colon cancer Diseases 0.000 description 10
- 241000699666 Mus <mouse, genus> Species 0.000 description 10
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 10
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- 230000003511 endothelial effect Effects 0.000 description 10
- 230000028993 immune response Effects 0.000 description 10
- 210000001161 mammalian embryo Anatomy 0.000 description 10
- 238000003752 polymerase chain reaction Methods 0.000 description 10
- 210000003462 vein Anatomy 0.000 description 10
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 9
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 9
- 238000004590 computer program Methods 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 238000005755 formation reaction Methods 0.000 description 9
- 210000003205 muscle Anatomy 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 241000588724 Escherichia coli Species 0.000 description 8
- 240000008042 Zea mays Species 0.000 description 8
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 8
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 235000005822 corn Nutrition 0.000 description 8
- 230000002950 deficient Effects 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 210000002540 macrophage Anatomy 0.000 description 8
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 8
- 210000001577 neostriatum Anatomy 0.000 description 8
- 210000000496 pancreas Anatomy 0.000 description 8
- 210000003491 skin Anatomy 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 210000002536 stromal cell Anatomy 0.000 description 8
- 238000013519 translation Methods 0.000 description 8
- 102000008100 Human Serum Albumin Human genes 0.000 description 7
- 108091006905 Human Serum Albumin Proteins 0.000 description 7
- 238000007792 addition Methods 0.000 description 7
- 210000001185 bone marrow Anatomy 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 210000002458 fetal heart Anatomy 0.000 description 7
- 230000002068 genetic effect Effects 0.000 description 7
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 7
- 210000000867 larynx Anatomy 0.000 description 7
- 108020004999 messenger RNA Proteins 0.000 description 7
- 230000001394 metastastic effect Effects 0.000 description 7
- 206010061289 metastatic neoplasm Diseases 0.000 description 7
- 210000000440 neutrophil Anatomy 0.000 description 7
- 230000001817 pituitary effect Effects 0.000 description 7
- 239000013612 plasmid Substances 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 210000002460 smooth muscle Anatomy 0.000 description 7
- 210000001541 thymus gland Anatomy 0.000 description 7
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 6
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 6
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 6
- 206010039491 Sarcoma Diseases 0.000 description 6
- 210000004727 amygdala Anatomy 0.000 description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 210000000349 chromosome Anatomy 0.000 description 6
- 125000004122 cyclic group Chemical group 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 210000002950 fibroblast Anatomy 0.000 description 6
- 230000004927 fusion Effects 0.000 description 6
- 239000003446 ligand Substances 0.000 description 6
- 210000002751 lymph Anatomy 0.000 description 6
- 230000000284 resting effect Effects 0.000 description 6
- 230000000717 retained effect Effects 0.000 description 6
- 238000003786 synthesis reaction Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 102000009027 Albumins Human genes 0.000 description 5
- 108010088751 Albumins Proteins 0.000 description 5
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 description 5
- 108010002352 Interleukin-1 Proteins 0.000 description 5
- 241000235058 Komagataella pastoris Species 0.000 description 5
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
- 108091034117 Oligonucleotide Proteins 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 150000007513 acids Chemical class 0.000 description 5
- 230000004913 activation Effects 0.000 description 5
- 210000001789 adipocyte Anatomy 0.000 description 5
- 230000004075 alteration Effects 0.000 description 5
- 229960000723 ampicillin Drugs 0.000 description 5
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 5
- 230000000692 anti-sense effect Effects 0.000 description 5
- 230000000903 blocking effect Effects 0.000 description 5
- 210000002449 bone cell Anatomy 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000001684 chronic effect Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 230000004069 differentiation Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 229940088598 enzyme Drugs 0.000 description 5
- 210000000981 epithelium Anatomy 0.000 description 5
- 239000013604 expression vector Substances 0.000 description 5
- 230000002519 immonomodulatory effect Effects 0.000 description 5
- 238000003018 immunoassay Methods 0.000 description 5
- 230000003308 immunostimulating effect Effects 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 210000004698 lymphocyte Anatomy 0.000 description 5
- 230000001404 mediated effect Effects 0.000 description 5
- 201000001441 melanoma Diseases 0.000 description 5
- 210000001616 monocyte Anatomy 0.000 description 5
- 230000002969 morbid Effects 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 230000006320 pegylation Effects 0.000 description 5
- 230000001323 posttranslational effect Effects 0.000 description 5
- 238000012163 sequencing technique Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 108020004705 Codon Proteins 0.000 description 4
- 108020004635 Complementary DNA Proteins 0.000 description 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 4
- 101001063991 Homo sapiens Leptin Proteins 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 4
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 4
- 239000004472 Lysine Substances 0.000 description 4
- 125000000729 N-terminal amino-acid group Chemical group 0.000 description 4
- 108091006006 PEGylated Proteins Proteins 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 4
- 101710086015 RNA ligase Proteins 0.000 description 4
- 230000021736 acetylation Effects 0.000 description 4
- 238000006640 acetylation reaction Methods 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 230000002788 anti-peptide Effects 0.000 description 4
- 210000001367 artery Anatomy 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000008827 biological function Effects 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 239000002738 chelating agent Substances 0.000 description 4
- 238000007385 chemical modification Methods 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 238000010367 cloning Methods 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 4
- 235000018417 cysteine Nutrition 0.000 description 4
- 230000002357 endometrial effect Effects 0.000 description 4
- 210000003238 esophagus Anatomy 0.000 description 4
- 230000003325 follicular Effects 0.000 description 4
- 238000002873 global sequence alignment Methods 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 102000049953 human LEP Human genes 0.000 description 4
- 210000005260 human cell Anatomy 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 210000002865 immune cell Anatomy 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 230000005847 immunogenicity Effects 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 230000001976 improved effect Effects 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 235000018977 lysine Nutrition 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 230000026731 phosphorylation Effects 0.000 description 4
- 238000006366 phosphorylation reaction Methods 0.000 description 4
- 230000004853 protein function Effects 0.000 description 4
- 210000000664 rectum Anatomy 0.000 description 4
- 210000001525 retina Anatomy 0.000 description 4
- 238000002864 sequence alignment Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 210000001685 thyroid gland Anatomy 0.000 description 4
- 238000010798 ubiquitination Methods 0.000 description 4
- 230000034512 ubiquitination Effects 0.000 description 4
- 210000004291 uterus Anatomy 0.000 description 4
- FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 description 3
- 229920000936 Agarose Polymers 0.000 description 3
- 108010025188 Alcohol oxidase Proteins 0.000 description 3
- 241000972773 Aulopiformes Species 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 3
- 206010012289 Dementia Diseases 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 240000001304 Hippeastrum striatum Species 0.000 description 3
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 3
- 241000408529 Libra Species 0.000 description 3
- 206010025323 Lymphomas Diseases 0.000 description 3
- 101100348047 Mus musculus Ncam2 gene Proteins 0.000 description 3
- 208000001715 Osteoblastoma Diseases 0.000 description 3
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 3
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 description 3
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 description 3
- 102100040247 Tumor necrosis factor Human genes 0.000 description 3
- 230000001919 adrenal effect Effects 0.000 description 3
- 238000001042 affinity chromatography Methods 0.000 description 3
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 210000000709 aorta Anatomy 0.000 description 3
- 235000003704 aspartic acid Nutrition 0.000 description 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 210000001638 cerebellum Anatomy 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
- 238000001212 derivatisation Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000000539 dimer Substances 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- 210000003527 eukaryotic cell Anatomy 0.000 description 3
- 210000004700 fetal blood Anatomy 0.000 description 3
- 230000022244 formylation Effects 0.000 description 3
- 238000006170 formylation reaction Methods 0.000 description 3
- 210000001652 frontal lobe Anatomy 0.000 description 3
- 206010017758 gastric cancer Diseases 0.000 description 3
- 235000013922 glutamic acid Nutrition 0.000 description 3
- 239000004220 glutamic acid Substances 0.000 description 3
- 230000013595 glycosylation Effects 0.000 description 3
- 238000006206 glycosylation reaction Methods 0.000 description 3
- 210000004013 groin Anatomy 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 210000001320 hippocampus Anatomy 0.000 description 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
- 235000014304 histidine Nutrition 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 229960001438 immunostimulant agent Drugs 0.000 description 3
- 239000003022 immunostimulating agent Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 230000003211 malignant effect Effects 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229930182817 methionine Natural products 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 238000002887 multiple sequence alignment Methods 0.000 description 3
- 210000000066 myeloid cell Anatomy 0.000 description 3
- 210000003254 palate Anatomy 0.000 description 3
- 239000013600 plasmid vector Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 230000006798 recombination Effects 0.000 description 3
- 238000005215 recombination Methods 0.000 description 3
- 230000001177 retroviral effect Effects 0.000 description 3
- 238000010839 reverse transcription Methods 0.000 description 3
- 235000019515 salmon Nutrition 0.000 description 3
- 230000003248 secreting effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 201000011549 stomach cancer Diseases 0.000 description 3
- 210000001258 synovial membrane Anatomy 0.000 description 3
- 238000001890 transfection Methods 0.000 description 3
- 239000013638 trimer Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- JVGVDSSUAVXRDY-UHFFFAOYSA-N 3-(4-hydroxyphenyl)lactic acid Chemical compound OC(=O)C(O)CC1=CC=C(O)C=C1 JVGVDSSUAVXRDY-UHFFFAOYSA-N 0.000 description 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 2
- 230000005730 ADP ribosylation Effects 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 101100230428 Caenorhabditis elegans hil-5 gene Proteins 0.000 description 2
- 241000282461 Canis lupus Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
- 101710154606 Hemagglutinin Proteins 0.000 description 2
- 206010019695 Hepatic neoplasm Diseases 0.000 description 2
- 206010019799 Hepatitis viral Diseases 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 108010093488 His-His-His-His-His-His Proteins 0.000 description 2
- 102000003839 Human Proteins Human genes 0.000 description 2
- 108090000144 Human Proteins Proteins 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- 102000006992 Interferon-alpha Human genes 0.000 description 2
- 108010047761 Interferon-alpha Proteins 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 102000000588 Interleukin-2 Human genes 0.000 description 2
- 102000004388 Interleukin-4 Human genes 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 102000004856 Lectins Human genes 0.000 description 2
- 206010026749 Mania Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 208000008955 Mucolipidoses Diseases 0.000 description 2
- 206010072927 Mucolipidosis type I Diseases 0.000 description 2
- 229930193140 Neomycin Natural products 0.000 description 2
- DTAFLBZLAZYRDX-UHFFFAOYSA-N OOOOOO Chemical compound OOOOOO DTAFLBZLAZYRDX-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 2
- 241001471187 Patu Species 0.000 description 2
- 241000235648 Pichia Species 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 101710176177 Protein A56 Proteins 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 description 2
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- 102400001051 Restin Human genes 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 2
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 2
- 241000011102 Thera Species 0.000 description 2
- 108020004566 Transfer RNA Proteins 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
- 230000010933 acylation Effects 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000007818 agglutination assay Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 238000012870 ammonium sulfate precipitation Methods 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000002491 angiogenic effect Effects 0.000 description 2
- 238000005571 anion exchange chromatography Methods 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 230000001640 apoptogenic effect Effects 0.000 description 2
- 230000010516 arginylation Effects 0.000 description 2
- 210000003651 basophil Anatomy 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- HRURXKIZWNSHQB-UHFFFAOYSA-N bis(trifluoromethylsulfonyl)azanide;cobalt(2+) Chemical compound [Co+2].FC(F)(F)S(=O)(=O)[N-]S(=O)(=O)C(F)(F)F.FC(F)(F)S(=O)(=O)[N-]S(=O)(=O)C(F)(F)F HRURXKIZWNSHQB-UHFFFAOYSA-N 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 238000006664 bond formation reaction Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 125000000837 carbohydrate group Chemical group 0.000 description 2
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 2
- 208000002458 carcinoid tumor Diseases 0.000 description 2
- 238000005277 cation exchange chromatography Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 210000003477 cochlea Anatomy 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 2
- XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 description 2
- 108010038764 cytoplasmic linker protein 170 Proteins 0.000 description 2
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000017858 demethylation Effects 0.000 description 2
- 238000010520 demethylation reaction Methods 0.000 description 2
- 210000004443 dendritic cell Anatomy 0.000 description 2
- 229960002086 dextran Drugs 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 201000003908 endometrial adenocarcinoma Diseases 0.000 description 2
- 208000029382 endometrium adenocarcinoma Diseases 0.000 description 2
- 210000003979 eosinophil Anatomy 0.000 description 2
- 230000001037 epileptic effect Effects 0.000 description 2
- 238000012869 ethanol precipitation Methods 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 230000006251 gamma-carboxylation Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 125000003827 glycol group Chemical group 0.000 description 2
- 201000008977 glycoproteinosis Diseases 0.000 description 2
- 150000003278 haem Chemical group 0.000 description 2
- 239000000833 heterodimer Substances 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 2
- 239000000710 homodimer Substances 0.000 description 2
- 238000002744 homologous recombination Methods 0.000 description 2
- 230000006801 homologous recombination Effects 0.000 description 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 2
- 238000012872 hydroxylapatite chromatography Methods 0.000 description 2
- 230000033444 hydroxylation Effects 0.000 description 2
- 238000005805 hydroxylation reaction Methods 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 239000002955 immunomodulating agent Substances 0.000 description 2
- 229940121354 immunomodulator Drugs 0.000 description 2
- 230000001506 immunosuppresive effect Effects 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000005007 innate immune system Anatomy 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000026045 iodination Effects 0.000 description 2
- 238000006192 iodination reaction Methods 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
- 210000003246 kidney medulla Anatomy 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- 201000005296 lung carcinoma Diseases 0.000 description 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 230000007498 myristoylation Effects 0.000 description 2
- 229960004927 neomycin Drugs 0.000 description 2
- 231100000417 nephrotoxicity Toxicity 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- 229940080469 phosphocellulose Drugs 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000013823 prenylation Effects 0.000 description 2
- 210000005267 prostate cell Anatomy 0.000 description 2
- 230000002797 proteolythic effect Effects 0.000 description 2
- 229940043131 pyroglutamate Drugs 0.000 description 2
- 230000006340 racemization Effects 0.000 description 2
- 238000002708 random mutagenesis Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000007363 ring formation reaction Methods 0.000 description 2
- 210000003079 salivary gland Anatomy 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 208000011985 sialidosis Diseases 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000019635 sulfation Effects 0.000 description 2
- 238000005670 sulfation reaction Methods 0.000 description 2
- 201000004595 synovitis Diseases 0.000 description 2
- 210000000538 tail Anatomy 0.000 description 2
- 208000001608 teratocarcinoma Diseases 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 201000001862 viral hepatitis Diseases 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- 210000005253 yeast cell Anatomy 0.000 description 2
- BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical compound OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 description 1
- MRTPISKDZDHEQI-YFKPBYRVSA-N (2s)-2-(tert-butylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NC(C)(C)C MRTPISKDZDHEQI-YFKPBYRVSA-N 0.000 description 1
- NPDBDJFLKKQMCM-SCSAIBSYSA-N (2s)-2-amino-3,3-dimethylbutanoic acid Chemical compound CC(C)(C)[C@H](N)C(O)=O NPDBDJFLKKQMCM-SCSAIBSYSA-N 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- VOYADQIFGGIKAT-UHFFFAOYSA-N 1,3-dibutyl-4-hydroxy-2,6-dioxopyrimidine-5-carboximidamide Chemical compound CCCCn1c(O)c(C(N)=N)c(=O)n(CCCC)c1=O VOYADQIFGGIKAT-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- CXCHEKCRJQRVNG-UHFFFAOYSA-N 2,2,2-trifluoroethanesulfonyl chloride Chemical compound FC(F)(F)CS(Cl)(=O)=O CXCHEKCRJQRVNG-UHFFFAOYSA-N 0.000 description 1
- OGNSCSPNOLGXSM-UHFFFAOYSA-N 2,4-diaminobutyric acid Chemical compound NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- QRYXYRQPMWQIDM-UHFFFAOYSA-N 3-benzoyl-3-(2,5-dioxopyrrol-1-yl)-1-hydroxypyrrolidine-2,5-dione Chemical compound O=C1N(O)C(=O)CC1(C(=O)C=1C=CC=CC=1)N1C(=O)C=CC1=O QRYXYRQPMWQIDM-UHFFFAOYSA-N 0.000 description 1
- ZLOIGESWDJYCTF-XVFCMESISA-N 4-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=S)C=C1 ZLOIGESWDJYCTF-XVFCMESISA-N 0.000 description 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N 5-oxoproline Chemical compound OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 102000012440 Acetylcholinesterase Human genes 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- 108010000239 Aequorin Proteins 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 102100030343 Antigen peptide transporter 2 Human genes 0.000 description 1
- 206010003594 Ataxia telangiectasia Diseases 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 208000003950 B-cell lymphoma Diseases 0.000 description 1
- 102100026044 Biotinidase Human genes 0.000 description 1
- 108010039206 Biotinidase Proteins 0.000 description 1
- 206010061728 Bone lesion Diseases 0.000 description 1
- 201000010717 Bruton-type agammaglobulinemia Diseases 0.000 description 1
- 101150013553 CD40 gene Proteins 0.000 description 1
- 101100328886 Caenorhabditis elegans col-2 gene Proteins 0.000 description 1
- 101100114362 Caenorhabditis elegans col-7 gene Proteins 0.000 description 1
- 101100086716 Caenorhabditis elegans ran-3 gene Proteins 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 208000005243 Chondrosarcoma Diseases 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000000989 Complement System Proteins Human genes 0.000 description 1
- 108010069112 Complement System Proteins Proteins 0.000 description 1
- 206010053138 Congenital aplastic anaemia Diseases 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
- XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 101000651200 Dictyostelium discoideum Sphingosine kinase B Proteins 0.000 description 1
- 102100024746 Dihydrofolate reductase Human genes 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
- 208000006402 Ductal Carcinoma Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 101150030061 Eloc gene Proteins 0.000 description 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- QTANTQQOYSUMLC-UHFFFAOYSA-O Ethidium cation Chemical compound C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 QTANTQQOYSUMLC-UHFFFAOYSA-O 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- 201000004939 Fanconi anemia Diseases 0.000 description 1
- 108091006020 Fc-tagged proteins Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 description 1
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 108010051815 Glutamyl endopeptidase Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 1
- 208000018565 Hemochromatosis Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 230000010556 Heparin Binding Activity Effects 0.000 description 1
- 101000801195 Homo sapiens TLE family member 5 Proteins 0.000 description 1
- 101000845188 Homo sapiens Tetratricopeptide repeat protein 4 Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 101150090950 Hsc70-1 gene Proteins 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 description 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
- XIGSAGMEBXLVJJ-YFKPBYRVSA-N L-homocitrulline Chemical compound NC(=O)NCCCC[C@H]([NH3+])C([O-])=O XIGSAGMEBXLVJJ-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 description 1
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 description 1
- 206010023825 Laryngeal cancer Diseases 0.000 description 1
- 241001523179 Lasia <small-headed fly> Species 0.000 description 1
- 241000283986 Lepus Species 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000001826 Marfan syndrome Diseases 0.000 description 1
- 102100030550 Menin Human genes 0.000 description 1
- 101710169972 Menin Proteins 0.000 description 1
- 101100063504 Mus musculus Dlx2 gene Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 101500006448 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) Endonuclease PI-MboI Proteins 0.000 description 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- KUGRPPRAQNPSQD-UHFFFAOYSA-N OOOOO Chemical compound OOOOO KUGRPPRAQNPSQD-UHFFFAOYSA-N 0.000 description 1
- YAVWDJDEOLOYQO-UHFFFAOYSA-N OOOOOOOOOO Chemical compound OOOOOOOOOO YAVWDJDEOLOYQO-UHFFFAOYSA-N 0.000 description 1
- 201000010133 Oligodendroglioma Diseases 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 102000008108 Osteoprotegerin Human genes 0.000 description 1
- 108010035042 Osteoprotegerin Proteins 0.000 description 1
- 201000010810 Otospondylomegaepiphyseal dysplasia Diseases 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 108010004729 Phycoerythrin Proteins 0.000 description 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 101100084022 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) lapA gene Proteins 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 102000009609 Pyrophosphatases Human genes 0.000 description 1
- 108010009413 Pyrophosphatases Proteins 0.000 description 1
- 108091034057 RNA (poly(A)) Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 208000005587 Refsum Disease Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 206010038910 Retinitis Diseases 0.000 description 1
- 241000612182 Rexea solandri Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- 101100150366 Schizosaccharomyces pombe (strain 972 / ATCC 24843) sks2 gene Proteins 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 108050007496 Shikimate kinase 2 Proteins 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 241000256248 Spodoptera Species 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 101800000849 Tachykinin-associated peptide 2 Proteins 0.000 description 1
- 108010006785 Taq Polymerase Proteins 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 102100031279 Tetratricopeptide repeat protein 4 Human genes 0.000 description 1
- 108010022394 Threonine synthase Proteins 0.000 description 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
- YJQCOFNZVFGCAF-UHFFFAOYSA-N Tunicamycin II Natural products O1C(CC(O)C2C(C(O)C(O2)N2C(NC(=O)C=C2)=O)O)C(O)C(O)C(NC(=O)C=CCCCCCCCCC(C)C)C1OC1OC(CO)C(O)C(O)C1NC(C)=O YJQCOFNZVFGCAF-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000006110 Wiskott-Aldrich syndrome Diseases 0.000 description 1
- 208000016349 X-linked agammaglobulinemia Diseases 0.000 description 1
- 206010048218 Xeroderma Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 206010001323 adrenal adenoma Diseases 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 208000030597 adult Refsum disease Diseases 0.000 description 1
- 239000007801 affinity label Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 238000012867 alanine scanning Methods 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 150000001408 amides Chemical group 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 230000000781 anti-lymphocytic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
- 210000004082 barrier epithelial cell Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000008568 cell cell communication Effects 0.000 description 1
- 210000003588 centroblast Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000003200 chromosome mapping Methods 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 229960002173 citrulline Drugs 0.000 description 1
- 235000013477 citrulline Nutrition 0.000 description 1
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 description 1
- 201000010897 colon adenocarcinoma Diseases 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 208000030381 cutaneous melanoma Diseases 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 208000012106 cystic neoplasm Diseases 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 108010057085 cytokine receptors Proteins 0.000 description 1
- 102000003675 cytokine receptors Human genes 0.000 description 1
- SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 1
- SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229960000633 dextran sulfate Drugs 0.000 description 1
- 102000004419 dihydrofolate reductase Human genes 0.000 description 1
- 108020001096 dihydrofolate reductase Proteins 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 210000001951 dura mater Anatomy 0.000 description 1
- 206010013932 dyslexia Diseases 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 201000011523 endocrine gland cancer Diseases 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000004890 epithelial barrier function Effects 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 208000001031 fetal erythroblastosis Diseases 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000037433 frameshift Effects 0.000 description 1
- 210000005153 frontal cortex Anatomy 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 229910052733 gallium Inorganic materials 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 238000012817 gel-diffusion technique Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 210000001280 germinal center Anatomy 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 210000002837 heart atrium Anatomy 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 238000012188 high-throughput screening assay Methods 0.000 description 1
- 102000056245 human TLE5 Human genes 0.000 description 1
- 210000003917 human chromosome Anatomy 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 206010021198 ichthyosis Diseases 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 238000000760 immunoelectrophoresis Methods 0.000 description 1
- 239000003547 immunosorbent Substances 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000003017 in situ immunoassay Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 230000031146 intracellular signal transduction Effects 0.000 description 1
- 208000020082 intraepithelial neoplasia Diseases 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 201000002529 islet cell tumor Diseases 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 210000000231 kidney cortex Anatomy 0.000 description 1
- 206010023841 laryngeal neoplasm Diseases 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000007056 liver toxicity Effects 0.000 description 1
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
- 201000005249 lung adenocarcinoma Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 210000001806 memory b lymphocyte Anatomy 0.000 description 1
- 210000000716 merkel cell Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000031864 metaphase Effects 0.000 description 1
- SXTAYKAGBXMACB-UHFFFAOYSA-N methionine S-imide-S-oxide Natural products CS(=N)(=O)CCC(N)C(O)=O SXTAYKAGBXMACB-UHFFFAOYSA-N 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 208000016055 micropapillary serous carcinoma Diseases 0.000 description 1
- 230000000897 modulatory effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- ZTLGJPIZUOVDMT-UHFFFAOYSA-N n,n-dichlorotriazin-4-amine Chemical compound ClN(Cl)C1=CC=NN=N1 ZTLGJPIZUOVDMT-UHFFFAOYSA-N 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 230000007896 negative regulation of T cell activation Effects 0.000 description 1
- 230000013184 negative regulation of T cell differentiation Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000003349 osteoarthritic effect Effects 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 108010071584 oxidized low density lipoprotein Proteins 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000009996 pancreatic endocrine effect Effects 0.000 description 1
- 208000022102 pancreatic neuroendocrine neoplasm Diseases 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 201000005163 papillary serous adenocarcinoma Diseases 0.000 description 1
- 208000024641 papillary serous cystadenocarcinoma Diseases 0.000 description 1
- 230000000849 parathyroid Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
- 101150009573 phoA gene Proteins 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 108010039177 polyphenylalanine Proteins 0.000 description 1
- 210000002729 polyribosome Anatomy 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 238000013197 protein A assay Methods 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000005932 reductive alkylation reaction Methods 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 238000002416 scanning tunnelling spectroscopy Methods 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 208000002491 severe combined immunodeficiency Diseases 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 201000003708 skin melanoma Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000000273 spinal nerve root Anatomy 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 208000011317 telomere syndrome Diseases 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- ZHSGGJXRNHWHRS-VIDYELAYSA-N tunicamycin Chemical compound O([C@H]1[C@@H]([C@H]([C@@H](O)[C@@H](CC(O)[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C(NC(=O)C=C2)=O)O)O1)O)NC(=O)/C=C/CC(C)C)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O ZHSGGJXRNHWHRS-VIDYELAYSA-N 0.000 description 1
- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 230000001755 vocal effect Effects 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention concerne de nouvelles protéines. Plus spécifiquement, l'invention concerne des molécules d'acide nucléique isolées, codant pour de nouveaux polypeptides. Cette invention concerne également : de nouveaux polypeptides et anticorps qui se lient à ces polypeptides ; des vecteurs, des cellules hôtes, et des procédés de recombinaison et de synthèse permettant de produire des polynucléotides et/ou polypeptides humains, et des anticorps ; des procédés diagnostiques et thérapeutiques utiles pour le diagnostic, le traitement, la prévention et/ou la prévision de troubles liés à ces nouveaux polypeptides ; des procédés de criblage permettant d'identifier des agonistes et des antagonistes de polynucléotides et polypeptides de l'invention ; des procédés et/ou des compositions permettant d'inhiber ou d'augmenter la production et la fonctionnalité de polypeptides de la présente invention.
Applications Claiming Priority (235)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17906500P | 2000-01-31 | 2000-01-31 | |
US60/179,065 | 2000-01-31 | ||
US18062800P | 2000-02-04 | 2000-02-04 | |
US60/180,628 | 2000-02-04 | ||
US18466400P | 2000-02-24 | 2000-02-24 | |
US60/184,664 | 2000-02-24 | ||
US18635000P | 2000-03-02 | 2000-03-02 | |
US60/186,350 | 2000-03-02 | ||
US18987400P | 2000-03-16 | 2000-03-16 | |
US60/189,874 | 2000-03-16 | ||
US19007600P | 2000-03-17 | 2000-03-17 | |
US60/190,076 | 2000-03-17 | ||
US19812300P | 2000-04-18 | 2000-04-18 | |
US60/198,123 | 2000-04-18 | ||
US20551500P | 2000-05-19 | 2000-05-19 | |
US60/205,515 | 2000-05-19 | ||
US20946700P | 2000-06-07 | 2000-06-07 | |
US60/209,467 | 2000-06-07 | ||
US21488600P | 2000-06-28 | 2000-06-28 | |
US60/214,886 | 2000-06-28 | ||
US21513500P | 2000-06-30 | 2000-06-30 | |
US60/215,135 | 2000-06-30 | ||
US21688000P | 2000-07-07 | 2000-07-07 | |
US21664700P | 2000-07-07 | 2000-07-07 | |
US60/216,880 | 2000-07-07 | ||
US60/216,647 | 2000-07-07 | ||
US21749600P | 2000-07-11 | 2000-07-11 | |
US21748700P | 2000-07-11 | 2000-07-11 | |
US60/217,487 | 2000-07-11 | ||
US60/217,496 | 2000-07-11 | ||
US21829000P | 2000-07-14 | 2000-07-14 | |
US60/218,290 | 2000-07-14 | ||
US22096400P | 2000-07-26 | 2000-07-26 | |
US22096300P | 2000-07-26 | 2000-07-26 | |
US60/220,963 | 2000-07-26 | ||
US60/220,964 | 2000-07-26 | ||
US22575700P | 2000-08-14 | 2000-08-14 | |
US22451800P | 2000-08-14 | 2000-08-14 | |
US22575800P | 2000-08-14 | 2000-08-14 | |
US22451900P | 2000-08-14 | 2000-08-14 | |
US22526700P | 2000-08-14 | 2000-08-14 | |
US22527000P | 2000-08-14 | 2000-08-14 | |
US22521400P | 2000-08-14 | 2000-08-14 | |
US22575900P | 2000-08-14 | 2000-08-14 | |
US22544700P | 2000-08-14 | 2000-08-14 | |
US22521300P | 2000-08-14 | 2000-08-14 | |
US22526600P | 2000-08-14 | 2000-08-14 | |
US22526800P | 2000-08-14 | 2000-08-14 | |
US60/225,267 | 2000-08-14 | ||
US60/225,213 | 2000-08-14 | ||
US60/225,268 | 2000-08-14 | ||
US60/224,518 | 2000-08-14 | ||
US60/225,266 | 2000-08-14 | ||
US60/225,447 | 2000-08-14 | ||
US60/224,519 | 2000-08-14 | ||
US60/225,270 | 2000-08-14 | ||
US60/225,759 | 2000-08-14 | ||
US60/225,214 | 2000-08-14 | ||
US60/225,758 | 2000-08-14 | ||
US60/225,757 | 2000-08-14 | ||
US22627900P | 2000-08-18 | 2000-08-18 | |
US60/226,279 | 2000-08-18 | ||
US22686800P | 2000-08-22 | 2000-08-22 | |
US22718200P | 2000-08-22 | 2000-08-22 | |
US22668100P | 2000-08-22 | 2000-08-22 | |
US60/226,681 | 2000-08-22 | ||
US60/227,182 | 2000-08-22 | ||
US60/226,868 | 2000-08-22 | ||
US22700900P | 2000-08-23 | 2000-08-23 | |
US60/227,009 | 2000-08-23 | ||
US22892400P | 2000-08-30 | 2000-08-30 | |
US60/228,924 | 2000-08-30 | ||
US22934300P | 2000-09-01 | 2000-09-01 | |
US22928700P | 2000-09-01 | 2000-09-01 | |
US22934500P | 2000-09-01 | 2000-09-01 | |
US22934400P | 2000-09-01 | 2000-09-01 | |
US60/229,287 | 2000-09-01 | ||
US60/229,343 | 2000-09-01 | ||
US60/229,345 | 2000-09-01 | ||
US60/229,344 | 2000-09-01 | ||
US22951300P | 2000-09-05 | 2000-09-05 | |
US22950900P | 2000-09-05 | 2000-09-05 | |
US60/229,513 | 2000-09-05 | ||
US60/229,509 | 2000-09-05 | ||
US23043700P | 2000-09-06 | 2000-09-06 | |
US23043800P | 2000-09-06 | 2000-09-06 | |
US60/230,437 | 2000-09-06 | ||
US60/230,438 | 2000-09-06 | ||
US23124400P | 2000-09-08 | 2000-09-08 | |
US23124300P | 2000-09-08 | 2000-09-08 | |
US23141300P | 2000-09-08 | 2000-09-08 | |
US23124200P | 2000-09-08 | 2000-09-08 | |
US23208100P | 2000-09-08 | 2000-09-08 | |
US23208000P | 2000-09-08 | 2000-09-08 | |
US23141400P | 2000-09-08 | 2000-09-08 | |
US60/231,244 | 2000-09-08 | ||
US60/231,413 | 2000-09-08 | ||
US60/232,080 | 2000-09-08 | ||
US60/231,414 | 2000-09-08 | ||
US60/231,242 | 2000-09-08 | ||
US60/231,243 | 2000-09-08 | ||
US60/232,081 | 2000-09-08 | ||
US23196800P | 2000-09-12 | 2000-09-12 | |
US60/231,968 | 2000-09-12 | ||
US23239700P | 2000-09-14 | 2000-09-14 | |
US23240000P | 2000-09-14 | 2000-09-14 | |
US23240100P | 2000-09-14 | 2000-09-14 | |
US23239800P | 2000-09-14 | 2000-09-14 | |
US23306500P | 2000-09-14 | 2000-09-14 | |
US23306400P | 2000-09-14 | 2000-09-14 | |
US23306300P | 2000-09-14 | 2000-09-14 | |
US23239900P | 2000-09-14 | 2000-09-14 | |
US60/232,400 | 2000-09-14 | ||
US60/233,064 | 2000-09-14 | ||
US60/232,397 | 2000-09-14 | ||
US60/232,401 | 2000-09-14 | ||
US60/232,399 | 2000-09-14 | ||
US60/232,398 | 2000-09-14 | ||
US60/233,065 | 2000-09-14 | ||
US60/233,063 | 2000-09-14 | ||
US23427400P | 2000-09-21 | 2000-09-21 | |
US23422300P | 2000-09-21 | 2000-09-21 | |
US60/234,223 | 2000-09-21 | ||
US60/234,274 | 2000-09-21 | ||
US23499700P | 2000-09-25 | 2000-09-25 | |
US23499800P | 2000-09-25 | 2000-09-25 | |
US60/234,998 | 2000-09-25 | ||
US60/234,997 | 2000-09-25 | ||
US23548400P | 2000-09-26 | 2000-09-26 | |
US60/235,484 | 2000-09-26 | ||
US23583600P | 2000-09-27 | 2000-09-27 | |
US23583400P | 2000-09-27 | 2000-09-27 | |
US60/235,836 | 2000-09-27 | ||
US60/235,834 | 2000-09-27 | ||
US23636700P | 2000-09-29 | 2000-09-29 | |
US23636800P | 2000-09-29 | 2000-09-29 | |
US23637000P | 2000-09-29 | 2000-09-29 | |
US23632700P | 2000-09-29 | 2000-09-29 | |
US23636900P | 2000-09-29 | 2000-09-29 | |
US60/236,367 | 2000-09-29 | ||
US60/236,327 | 2000-09-29 | ||
US60/236,368 | 2000-09-29 | ||
US60/236,370 | 2000-09-29 | ||
US60/236,369 | 2000-09-29 | ||
US23703800P | 2000-10-02 | 2000-10-02 | |
US23680200P | 2000-10-02 | 2000-10-02 | |
US23703700P | 2000-10-02 | 2000-10-02 | |
US23704000P | 2000-10-02 | 2000-10-02 | |
US23703900P | 2000-10-02 | 2000-10-02 | |
US60/237,038 | 2000-10-02 | ||
US60/237,040 | 2000-10-02 | ||
US60/237,037 | 2000-10-02 | ||
US60/237,039 | 2000-10-02 | ||
US60/236,802 | 2000-10-02 | ||
US23993500P | 2000-10-13 | 2000-10-13 | |
US23993700P | 2000-10-13 | 2000-10-13 | |
US60/239,937 | 2000-10-13 | ||
US60/239,935 | 2000-10-13 | ||
US24122100P | 2000-10-20 | 2000-10-20 | |
US24182600P | 2000-10-20 | 2000-10-20 | |
US24180900P | 2000-10-20 | 2000-10-20 | |
US24178500P | 2000-10-20 | 2000-10-20 | |
US24180800P | 2000-10-20 | 2000-10-20 | |
US24178700P | 2000-10-20 | 2000-10-20 | |
US24178600P | 2000-10-20 | 2000-10-20 | |
US24096000P | 2000-10-20 | 2000-10-20 | |
US60/241,809 | 2000-10-20 | ||
US60/241,786 | 2000-10-20 | ||
US60/241,808 | 2000-10-20 | ||
US60/241,826 | 2000-10-20 | ||
US60/241,785 | 2000-10-20 | ||
US60/241,221 | 2000-10-20 | ||
US60/240,960 | 2000-10-20 | ||
US60/241,787 | 2000-10-20 | ||
US24461700P | 2000-11-01 | 2000-11-01 | |
US60/244,617 | 2000-11-01 | ||
US24652600P | 2000-11-08 | 2000-11-08 | |
US24652500P | 2000-11-08 | 2000-11-08 | |
US24652700P | 2000-11-08 | 2000-11-08 | |
US24647600P | 2000-11-08 | 2000-11-08 | |
US24661100P | 2000-11-08 | 2000-11-08 | |
US24647500P | 2000-11-08 | 2000-11-08 | |
US24647400P | 2000-11-08 | 2000-11-08 | |
US24652800P | 2000-11-08 | 2000-11-08 | |
US24647700P | 2000-11-08 | 2000-11-08 | |
US24661000P | 2000-11-08 | 2000-11-08 | |
US24653200P | 2000-11-08 | 2000-11-08 | |
US60/246,525 | 2000-11-08 | ||
US60/246,475 | 2000-11-08 | ||
US60/246,526 | 2000-11-08 | ||
US60/246,609 | 2000-11-08 | ||
US60/246,474 | 2000-11-08 | ||
US60/246,611 | 2000-11-08 | ||
US60/246,527 | 2000-11-08 | ||
US60/246,613 | 2000-11-08 | ||
US60/246,478 | 2000-11-08 | ||
US60/246,477 | 2000-11-08 | ||
US60/246,476 | 2000-11-08 | ||
US60/246,532 | 2000-11-08 | ||
US60/246,528 | 2000-11-08 | ||
US60/246,610 | 2000-11-08 | ||
US60/246,524 | 2000-11-08 | ||
US60/246,523 | 2000-11-08 | ||
US60/249,211 | 2000-11-17 | ||
US60/249,244 | 2000-11-17 | ||
US60/249,212 | 2000-11-17 | ||
US60/249,214 | 2000-11-17 | ||
US60/249,265 | 2000-11-17 | ||
US60/249,213 | 2000-11-17 | ||
US60/249,217 | 2000-11-17 | ||
US60/249,264 | 2000-11-17 | ||
US60/249,216 | 2000-11-17 | ||
US60/249,208 | 2000-11-17 | ||
US60/249,245 | 2000-11-17 | ||
US60/249,207 | 2000-11-17 | ||
US60/249,300 | 2000-11-17 | ||
US60/249,299 | 2000-11-17 | ||
US60/249,218 | 2000-11-17 | ||
US60/249,215 | 2000-11-17 | ||
US60/249,297 | 2000-11-17 | ||
US60/249,209 | 2000-11-17 | ||
US60/249,210 | 2000-11-17 | ||
US60/250,160 | 2000-12-01 | ||
US60/250,391 | 2000-12-01 | ||
US60/251,988 | 2000-12-05 | ||
US60/251,030 | 2000-12-05 | ||
US60/256,719 | 2000-12-05 | ||
US60/251,479 | 2000-12-06 | ||
US60/251,869 | 2000-12-08 | ||
US60/251,856 | 2000-12-08 | ||
US60/251,990 | 2000-12-08 | ||
US60/251,989 | 2000-12-08 | ||
US60/251,868 | 2000-12-08 | ||
US60/254,097 | 2000-12-11 | ||
US60/259,678 | 2001-01-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2395654A1 true CA2395654A1 (fr) | 2001-08-02 |
Family
ID=27587117
Family Applications (37)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002395666A Withdrawn CA2395666A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395729A Pending CA2395729A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395699A Pending CA2395699A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002394039A Abandoned CA2394039A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395827A Withdrawn CA2395827A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395734A Withdrawn CA2395734A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002398877A Withdrawn CA2398877A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392438A Abandoned CA2392438A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395787A Withdrawn CA2395787A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002397407A Withdrawn CA2397407A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393912A Withdrawn CA2393912A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395403A Withdrawn CA2395403A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395654A Withdrawn CA2395654A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395885A Withdrawn CA2395885A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002398411A Withdrawn CA2398411A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395849A Pending CA2395849A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395872A Withdrawn CA2395872A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395693A Pending CA2395693A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392751A Abandoned CA2392751A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395858A Withdrawn CA2395858A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393652A Withdrawn CA2393652A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392398A Abandoned CA2392398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002397839A Withdrawn CA2397839A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395295A Withdrawn CA2395295A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395671A Withdrawn CA2395671A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395738A Withdrawn CA2395738A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393618A Abandoned CA2393618A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392428A Abandoned CA2392428A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395398A Withdrawn CA2395398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines, et anticorps |
CA002395178A Withdrawn CA2395178A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392422A Abandoned CA2392422A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392450A Abandoned CA2392450A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395724A Pending CA2395724A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393002A Withdrawn CA2393002A1 (fr) | 2000-01-31 | 2001-01-17 | Acides ncleiques, proteines et anticorps |
CA002394841A Withdrawn CA2394841A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392757A Abandoned CA2392757A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395816A Withdrawn CA2395816A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
Family Applications Before (12)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002395666A Withdrawn CA2395666A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395729A Pending CA2395729A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395699A Pending CA2395699A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002394039A Abandoned CA2394039A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395827A Withdrawn CA2395827A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395734A Withdrawn CA2395734A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002398877A Withdrawn CA2398877A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392438A Abandoned CA2392438A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395787A Withdrawn CA2395787A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002397407A Withdrawn CA2397407A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393912A Withdrawn CA2393912A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395403A Withdrawn CA2395403A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
Family Applications After (24)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002395885A Withdrawn CA2395885A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002398411A Withdrawn CA2398411A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395849A Pending CA2395849A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395872A Withdrawn CA2395872A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395693A Pending CA2395693A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392751A Abandoned CA2392751A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395858A Withdrawn CA2395858A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393652A Withdrawn CA2393652A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392398A Abandoned CA2392398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002397839A Withdrawn CA2397839A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395295A Withdrawn CA2395295A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395671A Withdrawn CA2395671A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395738A Withdrawn CA2395738A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393618A Abandoned CA2393618A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392428A Abandoned CA2392428A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395398A Withdrawn CA2395398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines, et anticorps |
CA002395178A Withdrawn CA2395178A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392422A Abandoned CA2392422A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392450A Abandoned CA2392450A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395724A Pending CA2395724A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393002A Withdrawn CA2393002A1 (fr) | 2000-01-31 | 2001-01-17 | Acides ncleiques, proteines et anticorps |
CA002394841A Withdrawn CA2394841A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392757A Abandoned CA2392757A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395816A Withdrawn CA2395816A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
Country Status (3)
Country | Link |
---|---|
AU (16) | AU2001241409A1 (fr) |
CA (37) | CA2395666A1 (fr) |
WO (48) | WO2001055355A1 (fr) |
Families Citing this family (271)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002008288A2 (fr) * | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Polypeptides secretes et transmembranaires et acides nucleiques codant ces polypeptides |
US20020137890A1 (en) | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US7579160B2 (en) | 1998-03-18 | 2009-08-25 | Corixa Corporation | Methods for the detection of cervical cancer |
US6960570B2 (en) | 1998-03-18 | 2005-11-01 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US7258860B2 (en) | 1998-03-18 | 2007-08-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6706262B1 (en) | 1998-03-18 | 2004-03-16 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
CA2328496C (fr) | 1998-05-15 | 2016-01-05 | Genentech, Inc. | Polypeptides homologues de il-17 et utilisations therapeutiques de ceux-ci |
US7771719B1 (en) | 2000-01-11 | 2010-08-10 | Genentech, Inc. | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E |
US6929938B2 (en) | 2001-08-15 | 2005-08-16 | Millennium Pharmaceuticals, Inc. | 25501, a human transferase family member and uses therefor |
WO2000050565A2 (fr) * | 1999-02-25 | 2000-08-31 | Thomas Jefferson University | Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs |
US7141417B1 (en) | 1999-02-25 | 2006-11-28 | Thomas Jefferson University | Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene |
EP1157038A4 (fr) * | 1999-02-26 | 2005-01-19 | Smithkline Beecham Corp | Clonage du recepteur 7tm (axor 17) du type p2y |
WO2000056881A1 (fr) * | 1999-03-23 | 2000-09-28 | Human Genome Sciences, Inc. | 48 proteines humaines secretees |
CA2365601A1 (fr) | 1999-03-29 | 2000-10-05 | Kansai Technology Licensing Organization Co., Ltd. | Nouvelle cytidine desaminase |
EP1637541B1 (fr) * | 1999-09-01 | 2010-03-03 | Genentech, Inc. | Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci |
US20020151047A1 (en) * | 2001-01-08 | 2002-10-17 | Yi Hu | Novel human protease and polynucleotides encoding the same |
AU1238201A (en) * | 1999-10-27 | 2001-05-08 | Millennium Pharmaceuticals, Inc. | Novel molecules and the card-related protein family and uses thereof |
US6893818B1 (en) | 1999-10-28 | 2005-05-17 | Agensys, Inc. | Gene upregulated in cancers of the prostate |
US7005499B1 (en) * | 1999-11-18 | 2006-02-28 | Genentech, Inc. | Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same |
EP1878795A3 (fr) * | 1999-11-30 | 2008-01-23 | Genentech, Inc. | Compositions et procédés pour le traitement de maladies liées au système immunitaire |
EP1250426A2 (fr) * | 1999-12-01 | 2002-10-23 | Genentech Inc. | Polypeptides transmembranaires et secretes et les acides nucleiques codant ceux-ci |
CN1300781A (zh) * | 1999-12-22 | 2001-06-27 | 上海博德基因开发有限公司 | 一种新的多肽-人shc蛋白43和编码这种多肽的多核苷酸 |
US20040043397A1 (en) | 2000-01-11 | 2004-03-04 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
AU2001237973B2 (en) | 2000-01-26 | 2006-09-07 | Agensys, Inc. | 84p2a9: a prostate and testis specific protein highly expressed in prostate cancer |
US6953682B2 (en) | 2000-02-10 | 2005-10-11 | Millennium Pharmaceuticals, Inc. | Nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and atpase-like molecules and uses therefor |
US7078205B2 (en) | 2000-02-17 | 2006-07-18 | Millennium Pharmaceuticals, Inc. | Nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, atpase molecules, acyltransferase molecules, pyridoxal-phosphate dependent enzyme molecules and uses therefor |
US20020082212A1 (en) * | 2000-07-20 | 2002-06-27 | Millennium Pharmaceuticals, Inc. | 7716, a novel human ATPase and uses therefor |
US20020090705A1 (en) * | 2000-07-14 | 2002-07-11 | Rachel Meyers | 62088, a novel human nucleoside phosphatase family member and uses thereof |
US20020055159A1 (en) * | 2000-06-15 | 2002-05-09 | Meyers Rachel A. | 23680,a novel human aminotransferase and uses therefor |
US7718397B2 (en) | 2000-03-21 | 2010-05-18 | Genentech, Inc. | Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof |
AU2001250980A1 (en) * | 2000-03-23 | 2001-10-03 | Carmela Beger | Brca-1 regulators and methods of use |
AU2001245974A1 (en) | 2000-03-24 | 2001-10-08 | Millennium Pharmaceuticals, Inc. | 3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor |
US20030198953A1 (en) * | 2000-03-30 | 2003-10-23 | Spytek Kimberly A. | Novel proteins and nucleic acids encoding same |
US7632929B2 (en) | 2000-04-20 | 2009-12-15 | The Board Of Trustees Of The University Of Arkansas | Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof |
JP2004511205A (ja) | 2000-04-25 | 2004-04-15 | レキシコン・ジェネティクス・インコーポレーテッド | 新規ヒトキナーゼプロテインおよびそれをコードするポリヌクレオチド |
AU2001257407A1 (en) * | 2000-04-26 | 2001-11-07 | Millennium Pharmaceuticals, Inc. | 21657, a human short-chain dehydrogenase and uses thereof |
US6808876B1 (en) * | 2000-05-02 | 2004-10-26 | Immusol, Inc. | Cellular regulators of infectious agents and methods of use |
WO2001085921A2 (fr) * | 2000-05-12 | 2001-11-15 | Merck Patent Gmbh | Nouvelle serine-threonine kinase-4 |
EP1158001B1 (fr) * | 2000-05-26 | 2007-11-14 | F. Hoffmann-La Roche Ag | Un acide nucléique produit excessivement dans des cellules tumorales humaines, une protéine codée par ledit acide nucléique et un procédé de diagnose de tumeurs |
AU7634301A (en) * | 2000-05-26 | 2001-12-03 | Bayer Aktiengesellschaft | Regulation of human p78-like serine/threonine kinase |
DE10027170A1 (de) * | 2000-05-31 | 2001-12-13 | Schering Ag | Humanes PEM als Target für die Fertilitätskontrolle |
US7098311B2 (en) * | 2000-06-02 | 2006-08-29 | Brigham And Women's Hospital | Fusion of jAZF1 and jjAZ1 genes in endometrial stromal tumors |
US20030096969A1 (en) | 2000-06-02 | 2003-05-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
AU6531101A (en) * | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
AU6604901A (en) * | 2000-06-05 | 2001-12-17 | Bayer Aktiengesellschaft | Regulation of human hm74-like g protein coupled receptor |
US6323016B1 (en) | 2000-06-09 | 2001-11-27 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
EP1287029A2 (fr) * | 2000-06-09 | 2003-03-05 | Corixa Corporation | Compositions et procedes pour la therapie et le diagnostic du cancer du colon |
WO2001096546A2 (fr) * | 2000-06-16 | 2001-12-20 | Incyte Genomics, Inc. | Proteine-phosphatases |
EP2075253A1 (fr) * | 2000-06-23 | 2009-07-01 | Genentech, Inc. | Méthodes et composés pour la diagnose et le traitement de troubles associés à l'angiogenèse |
WO2002000861A2 (fr) * | 2000-06-26 | 2002-01-03 | Millennium Pharmaceuticals, Inc. | 46619, une nouvelle synthase beta-cetoacyle et utilisations de cette derniere |
AU2001270215A1 (en) * | 2000-06-27 | 2002-01-08 | Curagen Corporation | Novel polynucleotides and polypeptides encoded thereby |
US7094587B2 (en) | 2000-06-27 | 2006-08-22 | Millennium Pharmaceuticals, Inc. | 16002 Molecules and uses therefor |
US6774223B2 (en) | 2000-06-28 | 2004-08-10 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating colon cancer |
WO2002002761A2 (fr) * | 2000-06-30 | 2002-01-10 | Millennium Pharmaceuticals, Inc. | 57658, nouvelle uridine kinase humaine et utilisations correspondantes |
AU2001271843A1 (en) * | 2000-07-07 | 2002-01-21 | Incyte Genomics, Inc. | Gtp-binding proteins |
AU2001273239A1 (en) * | 2000-07-07 | 2002-01-21 | Incyte Genomics, Inc. | Transporters and ion channels |
EP1303620A2 (fr) * | 2000-07-18 | 2003-04-23 | Bayer Aktiengesellschaft | Regulation de protease a serine humaine de type desc1 |
US6740751B2 (en) | 2000-07-18 | 2004-05-25 | Board Of Regents, The University Of Texas System | Methods and compositions for stabilizing microtubules and intermediate filaments in striated muscle cells |
AU8762901A (en) * | 2000-07-25 | 2002-02-05 | Merck Patent Gmbh | Novel protein containing ring finger domaine r1p4 |
AU2001277202A1 (en) * | 2000-07-26 | 2002-02-05 | Applied Genomics, Inc. | Bstp-ras/rerg protein and related reagents and methods of use thereof |
AU2001277200A1 (en) * | 2000-07-26 | 2002-02-05 | Applied Genomics, Inc. | Bstp-cad protein and related reagents and methods of use thereof |
EP1657254A3 (fr) * | 2000-08-01 | 2006-06-07 | Genentech, Inc. | Polypeptide, acides nucléiques le codant, et leur utilisation pour le diagnostic du cancer |
US7335732B2 (en) | 2000-08-01 | 2008-02-26 | Genentech, Inc. | PRO9799 polypeptides |
EP1315431A1 (fr) * | 2000-08-02 | 2003-06-04 | Millennium Pharmaceuticals, Inc. | Membre de la famille du facteur de liberation du gtp humain (15368) et ses utilisations |
WO2002010217A2 (fr) | 2000-08-02 | 2002-02-07 | The Johns Hopkins University | Profils d'expression de cellules endotheliales |
WO2002012330A2 (fr) * | 2000-08-04 | 2002-02-14 | Zymogenetics, Inc. | Zzp1, proteine humaine secretee |
US6943245B2 (en) | 2000-08-10 | 2005-09-13 | Board Of Regents, The University Of Texas System | Tumor suppressor CAR-1 |
JP2004506422A (ja) * | 2000-08-11 | 2004-03-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 新規マイトジェン活性化キナーゼ |
EP1326985A1 (fr) * | 2000-08-18 | 2003-07-16 | MERCK PATENT GmbH | Identification d'un gene d'acetyltransferase n-terminale humaine |
US6706513B2 (en) | 2000-08-21 | 2004-03-16 | Bristol-Myers Squibb Company | Adenosine deaminase homolog |
JP2004519217A (ja) * | 2000-08-21 | 2004-07-02 | インサイト・ゲノミックス・インコーポレイテッド | 微小管関連タンパク質およびチューブリン |
WO2002016579A2 (fr) * | 2000-08-24 | 2002-02-28 | Eli Lilly And Company | Acides nucleiques, vecteurs, cellules hotes, polypeptides et utilisations de ces derniers |
CA2705366A1 (fr) * | 2000-08-28 | 2002-03-07 | Agensys, Inc. | Acide nucleique et proteine correspondante denommes 85p1b3 utilises dans le traitement et la detection de cancers |
CA2420902A1 (fr) * | 2000-08-28 | 2002-03-07 | Craig A. Rosen | 18 proteines humaines secretees |
AU2001284176A1 (en) * | 2000-08-28 | 2002-03-13 | Astrazeneca Ab | Molecules involved in the regulation of insulin in resistance syndrome (irs) |
AU2002210464A1 (en) * | 2000-08-30 | 2002-03-13 | Bayer Aktiengesellschaft | Regulation of human aminotransferase-like enzyme |
WO2002018577A2 (fr) * | 2000-08-30 | 2002-03-07 | Millennium Pharmaceuticals, Inc. | Nouveau facteur de terminaison du gtp humain 48921 et ses utilisations |
WO2002018552A2 (fr) * | 2000-08-30 | 2002-03-07 | Bayer Aktiengesellschaft | Regulation d'enzyme humaine de type aminotransferase |
AU2001286714A1 (en) * | 2000-08-30 | 2002-03-13 | Millennium Pharmaceuticals, Inc. | 54370, a novel human sulfate transporter and uses therefor |
WO2002018582A2 (fr) * | 2000-08-31 | 2002-03-07 | Millennium Pharmaceuticals, Inc. | 62112, nouvelle deshydrogenase humaine et ses utilisations |
US7153669B2 (en) | 2000-09-05 | 2006-12-26 | Amgen Inc. | Nucleic acids encoding MK61 receptors |
CA2421265A1 (fr) * | 2000-09-05 | 2002-03-14 | Incyte Genomics, Inc. | Molecules utilisees a des fins diagnostiques et therapeutiques |
US20020142464A1 (en) * | 2000-09-08 | 2002-10-03 | Millennium Pharmaceuticals, Inc. | 38646, a novel guanine nucleotide exchange factor and uses therefor |
US6372468B1 (en) * | 2000-09-14 | 2002-04-16 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
US6391606B1 (en) * | 2000-09-14 | 2002-05-21 | Pe Corporation | Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof |
US20040048245A1 (en) * | 2000-10-05 | 2004-03-11 | Shimkets Richard A. | Novel human proteins, polynucleotides encoding them and methods of using the same |
WO2002031126A2 (fr) * | 2000-10-11 | 2002-04-18 | Bayer Aktiengesellschaft | Regulation d'une peptidyl-prolyl cis-trans isomerase de type cyclophiline humaine |
WO2002031132A2 (fr) * | 2000-10-11 | 2002-04-18 | Millennium Pharmaceuticals, Inc. | Nouvel element de la famille des phosphatases humaines a double specificite, appele 8843, et utilisation de ce dernier |
US20020064831A1 (en) * | 2000-10-12 | 2002-05-30 | The Texas A&M University System | Nucleic acid sequences encoding CMG proteins, CMG proteins, and methods for their use |
EP1474528A4 (fr) * | 2000-10-13 | 2006-06-14 | Protein Design Labs Inc | Procedes de diagnostic du cancer de la prostate, compositions et procedes de criblage de modulateurs du cancer de la prostate |
US6531297B2 (en) * | 2000-10-20 | 2003-03-11 | Applera Corporation | Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof |
WO2002062945A2 (fr) | 2000-10-25 | 2002-08-15 | Diadexus, Inc. | Compositions et techniques relatives a des genes et a des proteines specifiques du poumon |
WO2002036781A2 (fr) * | 2000-10-31 | 2002-05-10 | Bayer Aktiengesellschaft | Regulation de la glutathione-s-transferase humaine |
WO2002038743A2 (fr) * | 2000-11-09 | 2002-05-16 | Glaxo Group Limited | Enzyme |
EP1349934A2 (fr) | 2000-11-20 | 2003-10-08 | Diadexus, Inc. | Compositions et methodes relatives a des genes et des proteines specifiques aux seins |
AU2001297765A1 (en) * | 2000-12-05 | 2002-10-21 | Incyte Genomics, Inc. | Ligases |
US7776523B2 (en) | 2000-12-07 | 2010-08-17 | Novartis Vaccines And Diagnostics, Inc. | Endogenous retroviruses up-regulated in prostate cancer |
EP1339845A2 (fr) | 2000-12-07 | 2003-09-03 | ZymoGenetics, Inc. | Proteine associee au complement adipocyte zacrp3x2 |
WO2002048328A2 (fr) * | 2000-12-14 | 2002-06-20 | Pe Corporation (Ny) | Proteines kinases humaines isolees, molecules d'acide nucleique codant des proteines kinases humaines et utilisations associees |
US20020142376A1 (en) * | 2000-12-20 | 2002-10-03 | Gennady Merkulov | Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof |
IL155687A0 (en) | 2000-12-22 | 2003-11-23 | Bristol Myers Squibb Co | Polynucleotides encoding hlrrsi1 polypeptides |
US7892730B2 (en) | 2000-12-22 | 2011-02-22 | Sagres Discovery, Inc. | Compositions and methods for cancer |
US6423521B1 (en) | 2000-12-28 | 2002-07-23 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
WO2002053591A1 (fr) * | 2000-12-30 | 2002-07-11 | Lion Bioscience Ag | Cofacteur de recepteur nucleaire mammalien cf12 et ses procedes d'utilisation |
US20030219739A1 (en) * | 2001-01-30 | 2003-11-27 | Glass David J. | Novel nucleic acid and polypeptide molecules |
WO2002098917A2 (fr) * | 2001-02-12 | 2002-12-12 | Curagen Corporation | Proteines, polynucleotides codant pour lesdites proteines et methodes d'utilisation desdites proteines |
EP1637601A3 (fr) * | 2001-02-21 | 2006-03-29 | Curagen Corporation | Protéines , polynucléotides codant pour ces protéines et procédés d'utilisation |
US7271240B2 (en) | 2001-03-14 | 2007-09-18 | Agensys, Inc. | 125P5C8: a tissue specific protein highly expressed in various cancers |
AU2002250143A1 (en) * | 2001-03-16 | 2002-10-03 | Eli Lilly And Company | Lp mammalian proteins; related reagents |
US6913904B2 (en) * | 2001-03-27 | 2005-07-05 | Applera Corporation | Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof |
AU2002258626B2 (en) | 2001-04-10 | 2007-01-18 | Agensys, Inc. | Nucleid acid and corresponding protein entitled 158P3D2 useful in treatment and detection of cancer |
EP2280030A3 (fr) | 2001-04-10 | 2011-06-15 | Agensys, Inc. | Acides nucléiques et protéines correspondantes utiles dans la détection et le traitement des différents cancers |
EP1573022B1 (fr) | 2001-04-10 | 2011-06-08 | Agensys, Inc. | Acide nucleique et proteine correspondante intitulee 184p1e2, utilises dans le traitement et la detection de cancers |
WO2002086113A2 (fr) * | 2001-04-24 | 2002-10-31 | Isis Innovation Ltd | Enzyme et marqueur snp pour le depistage d'une maladie |
JPWO2002088175A1 (ja) * | 2001-04-24 | 2004-08-19 | 大塚製薬株式会社 | クローン病抗体結合性ペプチド及びクローン病の検査方法 |
KR100882762B1 (ko) | 2001-05-07 | 2009-02-09 | 시오노기세이야쿠가부시키가이샤 | 혈관신생 마커로서 사용되는 폴리펩티드 및 이의 dna |
AU2002314048A1 (en) * | 2001-05-09 | 2002-11-18 | Bayer Aktiengesellschaft | Regulation of human phosphatidic acid phosphatase type 2c-like protein |
US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
WO2003000901A2 (fr) * | 2001-06-26 | 2003-01-03 | Decode Genetics Ehf. | Acides nucleiques codant des proteines kinases |
US20030120040A1 (en) | 2001-06-29 | 2003-06-26 | Genentech, Inc. | Secreted and Transmembrane polypeptides and nucleic acids encoding the same |
GB2399086A (en) * | 2001-08-02 | 2004-09-08 | Aeomica Inc | Human zinc finger containing gene MDZ4 |
WO2003031568A2 (fr) * | 2001-08-17 | 2003-04-17 | Incyte Genomics, Inc. | Molecules de signalisation intracellulaire |
US7270960B2 (en) | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
WO2003023063A1 (fr) * | 2001-09-07 | 2003-03-20 | Sankyo Company, Limited | Methode d'estimation du risque d'apparition de diabetes |
WO2003025175A2 (fr) * | 2001-09-17 | 2003-03-27 | Molecular Engines Laboratories | Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments |
WO2003040369A2 (fr) * | 2001-09-17 | 2003-05-15 | Molecular Engines Laboratories | Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments |
CA2417455C (fr) | 2001-09-28 | 2008-01-29 | Brigham Young University | Variants nouveaux de la cyclooxygenase et methodes d'utilisation |
WO2003038087A1 (fr) | 2001-10-04 | 2003-05-08 | Kansai Technology Licensing Organization Co., Ltd. | Promoteur du gene dr5 et promoteur du gene siah-1 |
US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
WO2003031607A1 (fr) * | 2001-10-10 | 2003-04-17 | Bayer Healthcare Ag | Regulation de deshydrogenase/reductase des chaines courtes humaine |
DE60220621T2 (de) | 2001-11-09 | 2008-03-06 | Proteologics, Inc. | Posh Nukleinsäure, Polypeptide und darauf bezogene Verfahren |
AU2002365162A1 (en) | 2001-11-14 | 2003-07-09 | Northwestern University | Self-assembly and mineralization of peptide-amphiphile nanofibers |
CA2468145A1 (fr) * | 2001-11-21 | 2003-05-30 | Japan Science And Technology Agency | Facteurs de transcription de gene de la choree de huntington |
US7151162B2 (en) | 2001-12-06 | 2006-12-19 | The University Of Children's Hospital Of Both Cantons Of Basel | Nuclear protein |
AU2002339697A1 (en) * | 2001-12-19 | 2003-06-30 | Genset S.A. | Gmg-5 polynucleotides and polypeptides and uses thereof |
JP2003245084A (ja) * | 2001-12-20 | 2003-09-02 | Morinaga Milk Ind Co Ltd | 脳梁又は精子の形成不全の診断及び治療に有用な新規遺伝子、並びにその用途 |
DE10163467A1 (de) * | 2001-12-21 | 2003-11-27 | Axaron Bioscience Ag | Protein 24B2 und zugrundliegende DNA-Sequenz |
US6759222B2 (en) | 2002-01-02 | 2004-07-06 | Millennium Pharmaceuticals, Inc. | 14815, a human kinase family member and uses therefor |
WO2003057870A1 (fr) * | 2002-01-07 | 2003-07-17 | Bayer Healthcare Ag | Proteine humaine analogue a la phosphatase de l'acide phosphatidique de type 2 |
AU2003235631A1 (en) * | 2002-01-15 | 2003-07-30 | Bayer Aktiengesellschaft | Human subtilisin/kexin-like convertase |
AU2003205611A1 (en) * | 2002-01-15 | 2003-07-30 | Medigene Ag | Dilated cardiomyopathy associated gene-2 (dcmag-2): a cytoplasmatic inducer of sarcomeric remodeling in cardiomyocytes |
WO2003062429A1 (fr) * | 2002-01-23 | 2003-07-31 | Yamanouchi Pharmaceutical Co., Ltd. | Nouvelle serine protease |
US7371719B2 (en) | 2002-02-15 | 2008-05-13 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
EP1338609A1 (fr) * | 2002-02-21 | 2003-08-27 | MEMOREC Stoffel GmbH-Medizinisch-Molekulare Entwicklung, Köln | Un outre récepteur KDR et son utilisation |
CA2478271A1 (fr) * | 2002-03-05 | 2003-09-18 | Applera Corporation | Proteines transporteuses humaines isolees, molecules d'acide nucleique codant celles-ci, et utilisations associees |
GB2388113A (en) * | 2002-03-06 | 2003-11-05 | Oxford Glycosciences | B-cell malignancy-associated protein |
DK1918386T3 (da) | 2002-03-13 | 2012-01-02 | Genomic Health Inc | Genekspressionsprofiler i biopsier af tumorvæv |
AU2003220913A1 (en) * | 2002-03-19 | 2003-09-29 | Tanabe Seiyaku Co., Ltd. | Novel g protein-coupled recepotrs and genes thereof |
US7527935B2 (en) | 2002-03-19 | 2009-05-05 | Mitsubishi Tanabe Pharma Corporation | G-protein coupled receptor having eicosanoid as ligand and gene thereof |
GB0206684D0 (en) * | 2002-03-21 | 2002-05-01 | Babraham Inst | Novel proteins |
US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
US7329502B2 (en) | 2002-04-25 | 2008-02-12 | The United States Of America As Represented By The Department Of Health And Human Services | ZAP-70 expression as a marker for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) |
JP2004041003A (ja) * | 2002-05-17 | 2004-02-12 | Takeda Chem Ind Ltd | 新規タンパク質、そのdnaおよびその用途 |
EP2275118A3 (fr) | 2002-05-29 | 2011-10-19 | DeveloGen Aktiengesellschaft | Proteines specifiques du pancreas |
AU2003237367A1 (en) | 2002-06-03 | 2003-12-19 | Chiron Corporation | Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer |
DK1513934T3 (da) | 2002-06-06 | 2011-05-02 | Oncotherapy Science Inc | Gener og polypeptider relateret til humane coloncancersygdomme |
JP2005535308A (ja) | 2002-06-13 | 2005-11-24 | カイロン コーポレイション | Hml−2ポリペプチド発現用ベクター |
AU2003281626A1 (en) * | 2002-07-22 | 2004-02-09 | Masayoshi Harigai | Novel gene associated with rheumatoid arthritis |
JP4186004B2 (ja) | 2002-08-14 | 2008-11-26 | 独立行政法人産業技術総合研究所 | 新規n−アセチルガラクトサミン転移酵素およびそれをコードする核酸 |
AU2003243151A1 (en) * | 2002-08-16 | 2004-03-03 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer |
WO2004018518A1 (fr) * | 2002-08-23 | 2004-03-04 | Japan Science And Technology Agency | Peptides antigeniques de tumeur cancereuse solide humains, polynucleotides codant pour ceux-ci et utilisation de ceux-ci |
AU2003250989A1 (en) * | 2002-08-27 | 2004-03-19 | Epigenomics Ag | Method and nucleic acids for the analysis of breast cell proliferative disorders |
US7452969B2 (en) | 2002-08-30 | 2008-11-18 | Licentia Ltd | Neurotrophic factor protein and uses thereof |
CN1703524B (zh) * | 2002-09-30 | 2010-04-07 | 肿瘤疗法科学股份有限公司 | 与人胰腺癌相关的基因和多肽 |
EP1552310A2 (fr) * | 2002-10-17 | 2005-07-13 | EVOTEC Neurosciences GmbH | L'utilisation de la proteine et du gene de la nicotinamide mononucleotide adenylyltransferase 2 (nmnat-2) pour le diagnostique et la therapie des maladies neurodegeneratives |
AU2002952216A0 (en) * | 2002-10-23 | 2002-11-07 | The Walter And Eliza Hall Institute Of Medical Research | Novel therapeutic molecules |
US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
EP1570080A4 (fr) | 2002-11-15 | 2006-03-01 | Genomic Health Inc | Etablissement de profils d'expressions genetique du cancer a recepteur de facteur de croissance epidermique positif |
DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
AU2002953341A0 (en) * | 2002-12-13 | 2003-01-09 | The Walter And Eliza Hall Institute Of Medical Research | A novel phosphoprotein |
AU2003287764B2 (en) * | 2002-12-13 | 2010-01-21 | The Walter And Eliza Hall Institute Of Medical Research | A novel phosphoprotein |
US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
WO2004070025A2 (fr) * | 2003-02-05 | 2004-08-19 | Juan Saus | Nouvelles isoformes de la proteine liant l'antigene de goodpasture et troubles induits par une proteine incorrectement repliee |
EP1445614A1 (fr) * | 2003-02-06 | 2004-08-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Méthodes d'évaluation in vitro de l'état de progression d'un virus HIV chez un individu |
US7074891B2 (en) * | 2003-02-07 | 2006-07-11 | Posco | Leukocyte stimulating peptides |
AU2004213871B9 (en) | 2003-02-20 | 2009-09-03 | Genomic Health, Inc. | Use of intronic RNA to measure gene expression |
WO2004078784A1 (fr) * | 2003-03-04 | 2004-09-16 | Astellas Pharma Inc. | Nouveau gene associe a des conditions fibreuses |
PL378582A1 (pl) | 2003-03-19 | 2006-05-02 | Biogen Idec Ma Inc. | Białko wiążące receptor Nogo |
ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
EP3470535B1 (fr) | 2003-06-24 | 2020-04-01 | Genomic Health, Inc. | Prédiction de probabilité de récurrence de cancer |
US7526387B2 (en) | 2003-07-10 | 2009-04-28 | Genomic Health, Inc. | Expression profile algorithm and test for cancer prognosis |
ATE528397T1 (de) | 2003-08-08 | 2011-10-15 | Perseus Proteomics Inc | Bei krebs überexprimiertes gen |
US20050136434A1 (en) * | 2003-08-12 | 2005-06-23 | Mai Xu | Isolated heat-inducible cell surface protein and hyperthermia-based tumor immunotargeting therapy |
US20070178458A1 (en) * | 2003-09-05 | 2007-08-02 | O'brien Philippa | Methods of diagnosis and prognosis of ovarian cancer II |
TW200517503A (en) * | 2003-09-10 | 2005-06-01 | Japan Science & Tech Agency | Group of genes differentially expressed in peripheral blood cells and diagnostic method and assay method using the same |
EP1667712B1 (fr) * | 2003-10-02 | 2010-07-21 | GlaxoSmithKline Biologicals S.A. | Antigenes de b. pertussis et leur utilisation dans la vaccination |
CA2541006C (fr) | 2003-10-03 | 2015-02-17 | Brigham And Women's Hospital | Ligands de tim-3 et methodes associees |
WO2005040791A2 (fr) * | 2003-10-21 | 2005-05-06 | Bayer Healthcare Ag | Diagnostics et therapeutiques pour maladies liees au recepteur de peptides similaire a la somatostatine et a l'angiogenine (salpr) |
US20050255560A1 (en) * | 2003-11-21 | 2005-11-17 | Zeren Gao | Ztnf11, a tumor necrosis factor |
CA2549164A1 (fr) | 2003-12-05 | 2005-06-23 | Northwestern University | Amphiphiles peptidiques a assemblage automatique et procedes associes d'administration de facteur de croissance |
JP4718490B2 (ja) | 2003-12-23 | 2011-07-06 | ジェノミック ヘルス, インコーポレイテッド | フラグメント化rnaの全般的増幅 |
US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
PT3556866T (pt) | 2004-03-02 | 2021-04-30 | Univ Johns Hopkins | Mutações do gene de pik3ca em cancros humanos |
TW200539890A (en) | 2004-03-12 | 2005-12-16 | Brigham & Womens Hospital | Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function |
WO2005090569A1 (fr) * | 2004-03-24 | 2005-09-29 | The Council Of The Queensland Institute Of Medical Research | Cancer et acides nucleiques et proteines de testicule vsm1 et vsm2, et leurs utilisations |
WO2005095450A2 (fr) | 2004-03-30 | 2005-10-13 | Nsgene A/S | Utilisation therapeutique d'un facteur de croissance, nsg33 |
DK2163650T3 (en) | 2004-04-09 | 2015-11-02 | Genomic Health Inc | Genekspressionsmarkører for prediction of response to chemotherapy |
DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
WO2005118832A2 (fr) * | 2004-06-01 | 2005-12-15 | Bayer Healthcare Ag | Agents diagnostiques et therapeutiques pour des maladies associees a une proteine de type kinase regulee par serum/glucocorticoide (sgkl) |
AU2005258335B2 (en) | 2004-06-24 | 2011-03-17 | Biogen Ma Inc. | Treatment of conditions involving demyelination |
US7587279B2 (en) | 2004-07-06 | 2009-09-08 | Genomic Health | Method for quantitative PCR data analysis system (QDAS) |
US7985831B2 (en) * | 2004-08-05 | 2011-07-26 | Toagosei Co., Ltd. | Crohn's disease antibody epitope peptide and reagent for testing Crohn's disease |
HUE051605T2 (hu) | 2004-11-05 | 2021-03-01 | Nsabp Found Inc | Kemoterápiára adott válasz elõrejelzése génexpressziós markereket alkalmazva |
CA2585561C (fr) | 2004-11-05 | 2018-07-17 | Genomic Health, Inc. | Resultat de groupe esr1, pgr, bcl2 et scube2 comme indicateurs de pronostic de cancer du sein et de prediction de la reponse au traitement |
EP2845865A1 (fr) | 2004-11-12 | 2015-03-11 | Xencor Inc. | Variantes Fc avec liaison altérée en FcRn |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
CA2598251A1 (fr) | 2005-03-04 | 2006-09-14 | Northwestern University | Epitopes angiogeniques de liaison a l'heparine, amphiphiles peptidiques, compositions auto-assemblees et procedes d'utilisation associes |
WO2006120019A2 (fr) * | 2005-05-13 | 2006-11-16 | Centre National De La Recherche Scientifique | Utilisation de nouveau codage genique pour nouvel element de la famille mcm2-8 dans les compositions pharmaceutiques |
MX2008000253A (es) | 2005-07-08 | 2008-04-02 | Biogen Idec Inc | Anticuerpos de sp35 y usos de los mismos. |
WO2007014338A2 (fr) * | 2005-07-26 | 2007-02-01 | Siemens Medical Solutions Diagnostics | Polymorphismes de nucleotides uniques a susceptibilite par rapport a une maladie cardio-vasculaire |
WO2007037601A1 (fr) * | 2005-09-28 | 2007-04-05 | Knu-Industry Cooperation Foundation | Polypeptide inhibant la transmigration de leucocytes ou la croissance et/ou la métastase de cellules cancéreuses, et une protéine de fusion de celui-ci |
EP1790664A1 (fr) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Anticorps monoclonaux contre claudin-18 pour le traitement du cancer |
DE602005023550D1 (de) | 2005-12-14 | 2010-10-21 | Licentia Ltd | Verwendungen eines neurotrophischen Faktors |
EP2044216A2 (fr) * | 2006-07-03 | 2009-04-08 | Exonhit Therapeutics SA | Produits de la transcription spécifiques de la prostate et leur utilisation pour des thérapeutiques et des diagnostics du cancer de la prostate |
EP2066810A2 (fr) * | 2006-09-08 | 2009-06-10 | Corixa Corporation | Procédés, compositions, et kits de détection et de surveillance d'un cancer du colon |
US8076295B2 (en) | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
US8999634B2 (en) * | 2007-04-27 | 2015-04-07 | Quest Diagnostics Investments Incorporated | Nucleic acid detection combining amplification with fragmentation |
GB0805159D0 (en) | 2008-03-19 | 2008-04-23 | Sancho Madrid David | Immune modulation via C-type lectin |
ES2553270T3 (es) * | 2007-07-27 | 2015-12-07 | Immatics Biotechnologies Gmbh | Nuevo epítopo inmunogénico para inmunoterapia |
US7863021B2 (en) | 2007-09-05 | 2011-01-04 | Celera Corporation | Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof |
WO2009034661A1 (fr) * | 2007-09-12 | 2009-03-19 | Toppan Printing Co., Ltd. | Procédé de diagnostic et induction d'une résistance à un virus |
ES2401233T3 (es) | 2007-10-17 | 2013-04-18 | Universidad de Córdoba | Isoformas del receptor tipo 5 de somatostatina humana producidas por tratamiento alternativo y pares de oligonucleótidos para la detección de las mismas por PCR |
HUE024903T2 (en) | 2007-12-26 | 2016-02-29 | Xencor Inc | FC variants with modified binding to FCRN |
GB0803352D0 (en) * | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
ES2584438T3 (es) | 2008-03-21 | 2016-09-27 | Universiteit Hasselt | Biomarcadores para artritis reumatoide |
EP2315779A2 (fr) | 2008-07-09 | 2011-05-04 | Biogen Idec MA Inc. | Compositions comprenant des anticorps anti-lingo ou leurs fragments |
ATE531383T1 (de) | 2008-07-24 | 2011-11-15 | Nsgene As | Therapeutische verwendung eines wachstumsfaktors, metrnl |
ES2536465T3 (es) | 2008-10-01 | 2015-05-25 | Immatics Biotechnologies Gmbh | Composición de péptidos tumor-asociados y relacionados con la vacuna contra el cáncer para el tratamiento de glioblastoma (GBM) y otros cánceres |
CA2758687A1 (fr) | 2008-11-14 | 2010-05-20 | Gen-Probe Incorporated | Compositions, kits et procedes pour la detection d'acide nucleique de campylobacter |
WO2010062960A2 (fr) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | Méthodes de détermination d'une réceptivité à une thérapie par anti-tnfα lors d’une maladie intestinale inflammatoire |
WO2010066018A1 (fr) * | 2008-12-09 | 2010-06-17 | Alethia Biotherapeutics Inc. | Nouveau variant rétroviral endogène humain d’erv3 et utilisations de celui-ci pour diagnostiquer le cancer des ovaires |
WO2010120830A1 (fr) | 2009-04-13 | 2010-10-21 | Northwestern University | Nouvelles structures peptidiques pour la régénération des cartilages et procédés pour les utiliser |
WO2011028952A1 (fr) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions et procédés pour une co-liaison bivalente et monovalente simultanée d'antigènes |
ES2802623T3 (es) | 2010-01-27 | 2021-01-20 | Massachusetts Inst Technology | Agentes polipeptídicos técnicamente diseñados para la neutralización dirigida de amplio espectro de la gripe |
AU2011312417B2 (en) | 2010-09-29 | 2015-08-20 | Agensys, Inc. | Antibody drug conjugates (ADC) that bind to 191P4D12 proteins |
WO2012041328A1 (fr) | 2010-10-01 | 2012-04-05 | Nsgene A/S | Traitement de l'allodynie, de l'hyperalgésie, de la douleur spontanée et de la douleur illusionnelle |
DK2651430T3 (en) * | 2010-12-14 | 2018-08-27 | Hananja Ehf | Biological activity of placental protein 13 |
US9474786B2 (en) | 2011-09-05 | 2016-10-25 | Nsgene A/S | Treatment of allodynia |
WO2013068445A1 (fr) * | 2011-11-09 | 2013-05-16 | Sanofi | Diacylglycérol lipase et applications associées |
PT3489254T (pt) | 2012-04-30 | 2022-12-30 | Biocon Ltd | Proteínas de fusão direcionadas/imunomoduladoras e seus métodos de fabrico |
WO2013167153A1 (fr) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Anticorps utiles dans le diagnostic du cancer |
CN104470541A (zh) | 2012-05-14 | 2015-03-25 | 比奥根艾迪克Ma公司 | 用于治疗涉及运动神经元的疾患的lingo-2拮抗剂 |
WO2013174404A1 (fr) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer |
CN105073776B (zh) | 2012-11-13 | 2019-04-12 | 拜恩科技股份公司 | 用于治疗表达紧密连接蛋白的癌症疾病的制剂 |
WO2014127785A1 (fr) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer |
US9023353B2 (en) * | 2013-03-13 | 2015-05-05 | The Board Of Trustees Of The University Of Arkansas | Anti-(+)—methamphetamine monoclonal antibodies |
WO2014146672A1 (fr) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Thérapie comprenant des anticorps dirigés contre cldn 18.2 pour le traitement du cancer |
CA2908553A1 (fr) | 2013-03-27 | 2014-10-02 | Cedars-Sinai Medical Center | Attenuation ou regression de la fibrose et de l'inflammation par inhibition de la fonction tl1a et des voies de signalisation connexes |
JP7019233B2 (ja) | 2013-07-11 | 2022-02-15 | モデルナティエックス インコーポレイテッド | CRISPR関連タンパク質をコードする合成ポリヌクレオチドおよび合成sgRNAを含む組成物ならびに使用方法 |
WO2015010108A1 (fr) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature de la voie de signalisation de tl1a (tnfsf15) |
JP6915987B2 (ja) | 2013-09-25 | 2021-08-11 | シトムクス セラピューティクス,インコーポレイティド | マトリックスメタロプロテイナーゼ基質及び他の切断可能部分並びにそれらの使用方法 |
CA2925658C (fr) | 2013-10-01 | 2022-12-06 | Mie University | Antigene contenant une sequence d'interepitope favorisant la presentation d'antigene aux cellules t |
IL302642A (en) | 2014-01-31 | 2023-07-01 | Cytomx Therapeutics Inc | Polypeptide substrates that activate matriptase and U-plasminogen and other cleavable groups, preparations containing them and their uses |
JP2018504400A (ja) | 2015-01-08 | 2018-02-15 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Lingo‐1拮抗薬及び脱髄障害の治療のための使用 |
MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
EP3307070A4 (fr) * | 2015-06-12 | 2019-01-02 | Emory University | Compositions de croissance et de survie pour des cellules capables de produire des anticorps et procédés associés |
CN108138198B (zh) * | 2015-09-04 | 2022-10-28 | 合成基因组股份有限公司 | 为提高的产率而改造的微生物 |
KR20180127416A (ko) | 2016-03-17 | 2018-11-28 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
US20200330606A1 (en) * | 2016-03-29 | 2020-10-22 | Valkyrie Therapeutics Inc. | Modulation of structural maintenance of chromosome-1 expression |
US9611297B1 (en) | 2016-08-26 | 2017-04-04 | Thrasos Therapeutics Inc. | Compositions and methods for the treatment of cast nephropathy and related conditions |
US11125757B2 (en) | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
EP3508499A1 (fr) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Anticorps ciblant et d'autres modulateurs d'un gène d'immunoglobuline associé à une résistance contre des réponses immunitaires antitumorales et leurs utilisations |
AU2020261435A1 (en) * | 2019-04-26 | 2021-11-25 | Sangamo Therapeutics, Inc. | Engineering AAV |
JP2022538688A (ja) | 2019-07-05 | 2022-09-05 | イオックス セラピューティクス アーゲー | IGSF11(VSIG3)のIgC2に結合する抗体及びその使用 |
WO2021083958A1 (fr) * | 2019-10-29 | 2021-05-06 | Specialites Pet Food | Nouveaux peptides induisant la satiété |
EP4149952A1 (fr) * | 2020-05-12 | 2023-03-22 | Institut Curie | Épitopes néo-antigéniques associés à des mutations sf3b1 |
WO2022008027A1 (fr) | 2020-07-06 | 2022-01-13 | Iomx Therapeutics Ag | Anticorps de liaison à l'igv d'igsf11 (vsig3) et leurs utilisations |
CN117529492A (zh) * | 2021-01-21 | 2024-02-06 | 鹿特丹伊拉斯谟大学医疗中心 | 用于治疗的t细胞 |
US20220260597A1 (en) * | 2021-02-18 | 2022-08-18 | Beren Therapeutics P.B.C. | Methods for the treatment of familial heterozygous and homozygous hypercholesterolemia with cyclodextrins |
WO2023225602A1 (fr) * | 2022-05-20 | 2023-11-23 | Medikine, Inc. | Polypeptides de liaison au récepteur de l'interleukine-18 et leurs utilisations |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4446240A (en) * | 1981-01-30 | 1984-05-01 | Nerenberg Samuel T | Pancreas specific protein systems |
US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
US6080540A (en) * | 1990-04-20 | 2000-06-27 | Cold Spring Harbor Laboratory | Cloning of mammalian genes in microbial organisms and methods for pharmacological screening |
JP2845623B2 (ja) * | 1990-11-26 | 1999-01-13 | アメリカ合衆国 | 細胞のストレス転写因子 |
US5721352A (en) * | 1991-02-19 | 1998-02-24 | University Of Florida Research Foundation | Entomopoxvirus expression system |
US5840870A (en) * | 1995-12-29 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Polynucleotides PANC1A and PANC1B associated with pancreatic cancer |
WO1999014234A2 (fr) * | 1997-09-17 | 1999-03-25 | Genentech, Inc. | Stimulation ou inhibition de l'angiogenese et de la cardiovascularisation |
US5912160A (en) * | 1995-08-22 | 1999-06-15 | Thomas Jefferson University | Gab1, Grb2 binding protein, and compositions for making and methods of using the same |
JP3462313B2 (ja) * | 1995-08-24 | 2003-11-05 | キッコーマン株式会社 | 変異型ウリカーゼ、変異型ウリカーゼ遺伝子、新規な組み換え体dna及び変異型ウリカーゼの製造法 |
US5998165A (en) * | 1995-12-29 | 1999-12-07 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a protein associated with pancreatic cancer |
JP2000511410A (ja) * | 1996-04-29 | 2000-09-05 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | ナンセンス介在rna崩壊の哺乳動物の調節因子 |
US6500934B1 (en) * | 1996-07-24 | 2002-12-31 | Michael Rush Lerner | Bivalent agonists for G-protein coupled receptors |
US5976834A (en) * | 1997-01-09 | 1999-11-02 | Smithkline Beecham Corporation | cDNA clone HNFJD15 that encodes a novel human 7-transmembrane receptor |
US5925521A (en) * | 1997-03-31 | 1999-07-20 | Incyte Pharmaceuticals, Inc. | Human serine carboxypeptidase |
CA2232743A1 (fr) * | 1997-04-02 | 1998-10-02 | Smithkline Beecham Corporation | Tl5, homologue tnf |
WO1998045435A2 (fr) * | 1997-04-10 | 1998-10-15 | Genetics Institute, Inc. | MARQUEURS SECRETES DE SEQUENCE EXPRIMEE (sEST) |
IT1291110B1 (it) * | 1997-04-15 | 1998-12-29 | Istituto Europ Di Oncologia S | Interattori intracellulari e specificita' di legame del dominio eh |
US5948641A (en) * | 1997-05-29 | 1999-09-07 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a metal response element binding protein |
WO1998055620A1 (fr) * | 1997-06-06 | 1998-12-10 | Regeneron Pharmaceuticals, Inc. | Element ntn-2 de la famille des ligands du tnf |
US5932442A (en) * | 1997-09-23 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Human regulatory molecules |
US5972660A (en) * | 1997-10-22 | 1999-10-26 | Incyte Pharmaceuticals, Inc. | Human hydroxypyruvate reductase |
DE19818598A1 (de) * | 1998-04-19 | 1999-10-21 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Pankreasnormalgewebe |
CA2327317A1 (fr) * | 1998-04-29 | 1999-11-04 | Genesis Research And Development Corporation Limited | Polynucleotides isoles de cellules de la peau et leurs procedes d'utilisation |
US6262249B1 (en) * | 1998-06-23 | 2001-07-17 | Chiron Corporation | Pancreatic cancer genes |
CA2296792A1 (fr) * | 1999-02-26 | 2000-08-26 | Genset S.A. | Sequences marqueurs exprimees et proteines humaines codees |
-
2001
- 2001-01-17 WO PCT/US2001/001351 patent/WO2001055355A1/fr active Search and Examination
- 2001-01-17 AU AU2001241409A patent/AU2001241409A1/en not_active Abandoned
- 2001-01-17 WO PCT/US2001/001340 patent/WO2001055321A2/fr active Search and Examination
- 2001-01-17 CA CA002395666A patent/CA2395666A1/fr not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001309 patent/WO2001055308A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001333 patent/WO2001055448A1/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001348 patent/WO2001055368A1/fr active Search and Examination
- 2001-01-17 CA CA002395729A patent/CA2395729A1/fr active Pending
- 2001-01-17 WO PCT/US2001/001343 patent/WO2001055323A2/fr active Search and Examination
- 2001-01-17 CA CA002395699A patent/CA2395699A1/fr active Pending
- 2001-01-17 WO PCT/US2001/001355 patent/WO2001055207A1/fr not_active Application Discontinuation
- 2001-01-17 CA CA002394039A patent/CA2394039A1/fr not_active Abandoned
- 2001-01-17 WO PCT/US2001/001322 patent/WO2001055343A1/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001327 patent/WO2001055203A1/fr active Search and Examination
- 2001-01-17 AU AU2001250770A patent/AU2001250770A1/en not_active Abandoned
- 2001-01-17 CA CA002395827A patent/CA2395827A1/fr not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001312 patent/WO2001054733A1/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001314 patent/WO2001055310A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001326 patent/WO2001055315A2/fr active Search and Examination
- 2001-01-17 CA CA002395734A patent/CA2395734A1/fr not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001316 patent/WO2001054473A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001325 patent/WO2001055202A1/fr active Search and Examination
- 2001-01-17 CA CA002398877A patent/CA2398877A1/fr not_active Withdrawn
- 2001-01-17 AU AU2001241418A patent/AU2001241418A1/en not_active Abandoned
- 2001-01-17 WO PCT/US2001/001359 patent/WO2001055328A2/fr active Application Filing
- 2001-01-17 CA CA002392438A patent/CA2392438A1/fr not_active Abandoned
- 2001-01-17 AU AU2001241414A patent/AU2001241414A1/en not_active Abandoned
- 2001-01-17 CA CA002395787A patent/CA2395787A1/fr not_active Withdrawn
- 2001-01-17 AU AU2001241412A patent/AU2001241412A1/en not_active Abandoned
- 2001-01-17 WO PCT/US2001/001301 patent/WO2001055303A2/fr not_active Application Discontinuation
- 2001-01-17 CA CA002397407A patent/CA2397407A1/fr not_active Withdrawn
- 2001-01-17 AU AU2001241416A patent/AU2001241416A1/en not_active Abandoned
- 2001-01-17 CA CA002393912A patent/CA2393912A1/fr not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001302 patent/WO2001055304A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001240 patent/WO2001055302A2/fr not_active Application Discontinuation
- 2001-01-17 WO PCT/US2001/001353 patent/WO2001055206A1/fr not_active Application Discontinuation
- 2001-01-17 CA CA002395403A patent/CA2395403A1/fr not_active Withdrawn
- 2001-01-17 CA CA002395654A patent/CA2395654A1/fr not_active Withdrawn
- 2001-01-17 CA CA002395885A patent/CA2395885A1/fr not_active Withdrawn
- 2001-01-17 CA CA002398411A patent/CA2398411A1/fr not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001352 patent/WO2001055327A2/fr not_active Application Discontinuation
- 2001-01-17 WO PCT/US2001/001356 patent/WO2001055173A2/fr not_active Application Discontinuation
- 2001-01-17 CA CA002395849A patent/CA2395849A1/fr active Pending
- 2001-01-17 WO PCT/US2001/001349 patent/WO2001054474A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001338 patent/WO2001055367A1/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001335 patent/WO2001055319A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001344 patent/WO2001055324A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001315 patent/WO2001055311A2/fr active Search and Examination
- 2001-01-17 AU AU2001241415A patent/AU2001241415A1/en not_active Abandoned
- 2001-01-17 CA CA002395872A patent/CA2395872A1/fr not_active Withdrawn
- 2001-01-17 CA CA002395693A patent/CA2395693A1/fr active Pending
- 2001-01-17 WO PCT/US2001/001317 patent/WO2001055201A1/fr active Search and Examination
- 2001-01-17 CA CA002392751A patent/CA2392751A1/fr not_active Abandoned
- 2001-01-17 WO PCT/US2001/001306 patent/WO2001055307A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001336 patent/WO2001055204A1/fr active Search and Examination
- 2001-01-17 CA CA002395858A patent/CA2395858A1/fr not_active Withdrawn
- 2001-01-17 CA CA002393652A patent/CA2393652A1/fr not_active Withdrawn
- 2001-01-17 AU AU2001241408A patent/AU2001241408A1/en not_active Abandoned
- 2001-01-17 WO PCT/US2001/001313 patent/WO2001055200A1/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001332 patent/WO2001055318A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001357 patent/WO2001055208A1/fr not_active Application Discontinuation
- 2001-01-17 AU AU2001241417A patent/AU2001241417A1/en not_active Abandoned
- 2001-01-17 CA CA002392398A patent/CA2392398A1/fr not_active Abandoned
- 2001-01-17 CA CA002397839A patent/CA2397839A1/fr not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001342 patent/WO2001059064A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001311 patent/WO2001055309A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001358 patent/WO2001055163A1/fr not_active Application Discontinuation
- 2001-01-17 WO PCT/US2001/001330 patent/WO2001055447A1/fr active Search and Examination
- 2001-01-17 CA CA002395295A patent/CA2395295A1/fr not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001354 patent/WO2001057182A2/fr not_active Application Discontinuation
- 2001-01-17 WO PCT/US2001/001310 patent/WO2001055387A1/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001321 patent/WO2001055312A2/fr active Search and Examination
- 2001-01-17 CA CA002395671A patent/CA2395671A1/fr not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001308 patent/WO2001055364A2/fr active Search and Examination
- 2001-01-17 CA CA002395738A patent/CA2395738A1/fr not_active Withdrawn
- 2001-01-17 CA CA002393618A patent/CA2393618A1/fr not_active Abandoned
- 2001-01-17 CA CA002392428A patent/CA2392428A1/fr not_active Abandoned
- 2001-01-17 AU AU2001241405A patent/AU2001241405A1/en not_active Abandoned
- 2001-01-17 CA CA002395398A patent/CA2395398A1/fr not_active Withdrawn
- 2001-01-17 CA CA002395178A patent/CA2395178A1/fr not_active Withdrawn
- 2001-01-17 CA CA002392422A patent/CA2392422A1/fr not_active Abandoned
- 2001-01-17 CA CA002392450A patent/CA2392450A1/fr not_active Abandoned
- 2001-01-17 CA CA002395724A patent/CA2395724A1/fr active Pending
- 2001-01-17 WO PCT/US2001/001341 patent/WO2001055322A2/fr active Search and Examination
- 2001-01-17 AU AU2001241413A patent/AU2001241413A1/en not_active Abandoned
- 2001-01-17 CA CA002393002A patent/CA2393002A1/fr not_active Withdrawn
- 2001-01-17 CA CA002394841A patent/CA2394841A1/fr not_active Withdrawn
- 2001-01-17 WO PCT/US2001/001239 patent/WO2001055301A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001328 patent/WO2001055316A2/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001350 patent/WO2001055350A1/fr active Search and Examination
- 2001-01-17 WO PCT/US2001/001324 patent/WO2001055314A2/fr active Search and Examination
- 2001-01-17 AU AU2001241407A patent/AU2001241407A1/en not_active Abandoned
- 2001-01-17 WO PCT/US2001/001337 patent/WO2001055205A1/fr active Search and Examination
- 2001-01-17 AU AU2001241410A patent/AU2001241410A1/en not_active Abandoned
- 2001-01-17 WO PCT/US2001/001345 patent/WO2001055325A2/fr active Search and Examination
- 2001-01-17 CA CA002392757A patent/CA2392757A1/fr not_active Abandoned
- 2001-01-17 CA CA002395816A patent/CA2395816A1/fr not_active Withdrawn
- 2001-01-17 AU AU2001241406A patent/AU2001241406A1/en not_active Abandoned
- 2001-01-17 WO PCT/US2001/001339 patent/WO2001055320A2/fr not_active Application Discontinuation
- 2001-02-05 AU AU4313701A patent/AU4313701A/xx active Pending
- 2001-02-08 AU AU4141101A patent/AU4141101A/xx active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2395654A1 (fr) | Acides nucleiques, proteines et anticorps | |
WO2002095010A2 (fr) | Proteines secretees humaines | |
US20070055056A1 (en) | 251 human secreted proteins | |
CA2389722A1 (fr) | 15 proteines secretees humaines | |
WO2003004623A2 (fr) | Proteines humaines secretees | |
CA2390438A1 (fr) | Nouvelles proteines 19 secretees par l'homme | |
CA2395838A1 (fr) | Acides nucleiques, proteines et anticorps | |
CA2433469A1 (fr) | 83 proteines secretees humaines | |
US20030036646A1 (en) | Uncoupling protein polynucleotides, polypeptides, and antibodies | |
CA2398275A1 (fr) | Polynucleotides, polypeptides et anticorps humains | |
CA2385884A1 (fr) | 26 proteines secretees humaines | |
CA2389305A1 (fr) | 28 proteines secretees humaines | |
CA2433474A1 (fr) | 70 proteines humaines secretees | |
CA2390421A1 (fr) | 24 proteines humaines secretees | |
CA2395815A1 (fr) | Acides nucleiques, proteines et anticorps | |
CA2397502A1 (fr) | Polynucleotides de serine/threonine-phosphatases, polypeptides et anticorps | |
CA2446610A1 (fr) | 20 proteines humaines secretees | |
CA2384584A1 (fr) | 38 proteines secretees humaines | |
EP1255766A2 (fr) | Acides nucleiques, proteines et anticorps | |
CA2395857A1 (fr) | Acides nucleiques, proteines et anticorps | |
US20070015162A1 (en) | 99 human secreted proteins | |
US20070032414A1 (en) | Human secreted proteins | |
CA2393941A1 (fr) | Acides nucleiques, proteines et anticorps | |
CA2387754A1 (fr) | 10 proteines humaines secretees | |
CA2395794A1 (fr) | Acides nucleiques, proteines, et anticorps |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AZWI | Withdrawn application |