CA2395738A1 - Acides nucleiques, proteines et anticorps - Google Patents
Acides nucleiques, proteines et anticorps Download PDFInfo
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- CA2395738A1 CA2395738A1 CA002395738A CA2395738A CA2395738A1 CA 2395738 A1 CA2395738 A1 CA 2395738A1 CA 002395738 A CA002395738 A CA 002395738A CA 2395738 A CA2395738 A CA 2395738A CA 2395738 A1 CA2395738 A1 CA 2395738A1
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention concerne de nouvelles protéines. Plus spécialement, elle s'applique à des molécules d'acide nucléique isolées qui codent pour de nouveaux polypeptides. L'invention concerne des polypeptides et des anticorps. Elle concerne également des vecteurs, des cellules hôtes et des méthodes synthétiques et recombinantes permettant de produire des polynucléotides et/ou des polypeptides humains, ainsi que des anticorps. Par ailleurs, l'invention concerne des méthodes diagnostiques et thérapeutiques utiles pour le diagnostic, le traitement, la prévention e/ou le pronostic de troubles en rapport avec des nouveaux polypeptides. Sont également décrites des méthodes de criblage permettant d'identifier des agonistes et des antagonistes des polynucléotides et polypeptides de l'invention, ainsi que des méthodes et/ou des compositions propres à inhiber ou accentuer la production et la fonction des polypeptides selon l'invention.
Applications Claiming Priority (235)
Application Number | Priority Date | Filing Date | Title |
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US17906500P | 2000-01-31 | 2000-01-31 | |
US60/179,065 | 2000-01-31 | ||
US18062800P | 2000-02-04 | 2000-02-04 | |
US60/180,628 | 2000-02-04 | ||
US18466400P | 2000-02-24 | 2000-02-24 | |
US60/184,664 | 2000-02-24 | ||
US18635000P | 2000-03-02 | 2000-03-02 | |
US60/186,350 | 2000-03-02 | ||
US18987400P | 2000-03-16 | 2000-03-16 | |
US60/189,874 | 2000-03-16 | ||
US19007600P | 2000-03-17 | 2000-03-17 | |
US60/190,076 | 2000-03-17 | ||
US19812300P | 2000-04-18 | 2000-04-18 | |
US60/198,123 | 2000-04-18 | ||
US20551500P | 2000-05-19 | 2000-05-19 | |
US60/205,515 | 2000-05-19 | ||
US20946700P | 2000-06-07 | 2000-06-07 | |
US60/209,467 | 2000-06-07 | ||
US21488600P | 2000-06-28 | 2000-06-28 | |
US60/214,886 | 2000-06-28 | ||
US21513500P | 2000-06-30 | 2000-06-30 | |
US60/215,135 | 2000-06-30 | ||
US21688000P | 2000-07-07 | 2000-07-07 | |
US21664700P | 2000-07-07 | 2000-07-07 | |
US60/216,880 | 2000-07-07 | ||
US60/216,647 | 2000-07-07 | ||
US21748700P | 2000-07-11 | 2000-07-11 | |
US21749600P | 2000-07-11 | 2000-07-11 | |
US60/217,496 | 2000-07-11 | ||
US60/217,487 | 2000-07-11 | ||
US21829000P | 2000-07-14 | 2000-07-14 | |
US60/218,290 | 2000-07-14 | ||
US22096300P | 2000-07-26 | 2000-07-26 | |
US22096400P | 2000-07-26 | 2000-07-26 | |
US60/220,963 | 2000-07-26 | ||
US60/220,964 | 2000-07-26 | ||
US22526600P | 2000-08-14 | 2000-08-14 | |
US22575900P | 2000-08-14 | 2000-08-14 | |
US22527000P | 2000-08-14 | 2000-08-14 | |
US22521300P | 2000-08-14 | 2000-08-14 | |
US22575800P | 2000-08-14 | 2000-08-14 | |
US22526800P | 2000-08-14 | 2000-08-14 | |
US22521400P | 2000-08-14 | 2000-08-14 | |
US22544700P | 2000-08-14 | 2000-08-14 | |
US22526700P | 2000-08-14 | 2000-08-14 | |
US22451800P | 2000-08-14 | 2000-08-14 | |
US22451900P | 2000-08-14 | 2000-08-14 | |
US22575700P | 2000-08-14 | 2000-08-14 | |
US60/225,759 | 2000-08-14 | ||
US60/225,268 | 2000-08-14 | ||
US60/225,447 | 2000-08-14 | ||
US60/225,266 | 2000-08-14 | ||
US60/224,519 | 2000-08-14 | ||
US60/225,213 | 2000-08-14 | ||
US60/224,518 | 2000-08-14 | ||
US60/225,270 | 2000-08-14 | ||
US60/225,758 | 2000-08-14 | ||
US60/225,757 | 2000-08-14 | ||
US60/225,267 | 2000-08-14 | ||
US60/225,214 | 2000-08-14 | ||
US22627900P | 2000-08-18 | 2000-08-18 | |
US60/226,279 | 2000-08-18 | ||
US22668100P | 2000-08-22 | 2000-08-22 | |
US22718200P | 2000-08-22 | 2000-08-22 | |
US22686800P | 2000-08-22 | 2000-08-22 | |
US60/226,681 | 2000-08-22 | ||
US60/226,868 | 2000-08-22 | ||
US60/227,182 | 2000-08-22 | ||
US22700900P | 2000-08-23 | 2000-08-23 | |
US60/227,009 | 2000-08-23 | ||
US22892400P | 2000-08-30 | 2000-08-30 | |
US60/228,924 | 2000-08-30 | ||
US22934500P | 2000-09-01 | 2000-09-01 | |
US22928700P | 2000-09-01 | 2000-09-01 | |
US22934300P | 2000-09-01 | 2000-09-01 | |
US22934400P | 2000-09-01 | 2000-09-01 | |
US60/229,287 | 2000-09-01 | ||
US60/229,345 | 2000-09-01 | ||
US60/229,343 | 2000-09-01 | ||
US60/229,344 | 2000-09-01 | ||
US22950900P | 2000-09-05 | 2000-09-05 | |
US22951300P | 2000-09-05 | 2000-09-05 | |
US60/229,509 | 2000-09-05 | ||
US60/229,513 | 2000-09-05 | ||
US23043700P | 2000-09-06 | 2000-09-06 | |
US23043800P | 2000-09-06 | 2000-09-06 | |
US60/230,437 | 2000-09-06 | ||
US60/230,438 | 2000-09-06 | ||
US23124400P | 2000-09-08 | 2000-09-08 | |
US23124200P | 2000-09-08 | 2000-09-08 | |
US23208100P | 2000-09-08 | 2000-09-08 | |
US23208000P | 2000-09-08 | 2000-09-08 | |
US23141300P | 2000-09-08 | 2000-09-08 | |
US23124300P | 2000-09-08 | 2000-09-08 | |
US23141400P | 2000-09-08 | 2000-09-08 | |
US60/231,244 | 2000-09-08 | ||
US60/231,414 | 2000-09-08 | ||
US60/232,080 | 2000-09-08 | ||
US60/231,242 | 2000-09-08 | ||
US60/232,081 | 2000-09-08 | ||
US60/231,243 | 2000-09-08 | ||
US60/231,413 | 2000-09-08 | ||
US23196800P | 2000-09-12 | 2000-09-12 | |
US60/231,968 | 2000-09-12 | ||
US23239900P | 2000-09-14 | 2000-09-14 | |
US23306400P | 2000-09-14 | 2000-09-14 | |
US23239700P | 2000-09-14 | 2000-09-14 | |
US23240000P | 2000-09-14 | 2000-09-14 | |
US23240100P | 2000-09-14 | 2000-09-14 | |
US23239800P | 2000-09-14 | 2000-09-14 | |
US23306300P | 2000-09-14 | 2000-09-14 | |
US23306500P | 2000-09-14 | 2000-09-14 | |
US60/232,400 | 2000-09-14 | ||
US60/233,063 | 2000-09-14 | ||
US60/233,065 | 2000-09-14 | ||
US60/232,399 | 2000-09-14 | ||
US60/232,398 | 2000-09-14 | ||
US60/232,397 | 2000-09-14 | ||
US60/232,401 | 2000-09-14 | ||
US60/233,064 | 2000-09-14 | ||
US23427400P | 2000-09-21 | 2000-09-21 | |
US23422300P | 2000-09-21 | 2000-09-21 | |
US60/234,274 | 2000-09-21 | ||
US60/234,223 | 2000-09-21 | ||
US23499700P | 2000-09-25 | 2000-09-25 | |
US23499800P | 2000-09-25 | 2000-09-25 | |
US60/234,998 | 2000-09-25 | ||
US60/234,997 | 2000-09-25 | ||
US23548400P | 2000-09-26 | 2000-09-26 | |
US60/235,484 | 2000-09-26 | ||
US23583600P | 2000-09-27 | 2000-09-27 | |
US23583400P | 2000-09-27 | 2000-09-27 | |
US60/235,836 | 2000-09-27 | ||
US60/235,834 | 2000-09-27 | ||
US23636900P | 2000-09-29 | 2000-09-29 | |
US23632700P | 2000-09-29 | 2000-09-29 | |
US23636800P | 2000-09-29 | 2000-09-29 | |
US23636700P | 2000-09-29 | 2000-09-29 | |
US23637000P | 2000-09-29 | 2000-09-29 | |
US60/236,367 | 2000-09-29 | ||
US60/236,369 | 2000-09-29 | ||
US60/236,370 | 2000-09-29 | ||
US60/236,368 | 2000-09-29 | ||
US60/236,327 | 2000-09-29 | ||
US23680200P | 2000-10-02 | 2000-10-02 | |
US23703700P | 2000-10-02 | 2000-10-02 | |
US23704000P | 2000-10-02 | 2000-10-02 | |
US23703900P | 2000-10-02 | 2000-10-02 | |
US23703800P | 2000-10-02 | 2000-10-02 | |
US60/237,039 | 2000-10-02 | ||
US60/236,802 | 2000-10-02 | ||
US60/237,038 | 2000-10-02 | ||
US60/237,040 | 2000-10-02 | ||
US60/237,037 | 2000-10-02 | ||
US23993700P | 2000-10-13 | 2000-10-13 | |
US23993500P | 2000-10-13 | 2000-10-13 | |
US60/239,937 | 2000-10-13 | ||
US60/239,935 | 2000-10-13 | ||
US24096000P | 2000-10-20 | 2000-10-20 | |
US24178700P | 2000-10-20 | 2000-10-20 | |
US24122100P | 2000-10-20 | 2000-10-20 | |
US24180900P | 2000-10-20 | 2000-10-20 | |
US24182600P | 2000-10-20 | 2000-10-20 | |
US24178600P | 2000-10-20 | 2000-10-20 | |
US24178500P | 2000-10-20 | 2000-10-20 | |
US24180800P | 2000-10-20 | 2000-10-20 | |
US60/241,809 | 2000-10-20 | ||
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US60/241,826 | 2000-10-20 | ||
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US60/241,221 | 2000-10-20 | ||
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US60/246,609 | 2000-11-08 | ||
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US60/246,528 | 2000-11-08 | ||
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US60/246,613 | 2000-11-08 | ||
US60/246,477 | 2000-11-08 | ||
US60/249,207 | 2000-11-17 | ||
US60/249,300 | 2000-11-17 | ||
US60/249,214 | 2000-11-17 | ||
US60/249,216 | 2000-11-17 | ||
US60/249,209 | 2000-11-17 | ||
US60/249,297 | 2000-11-17 | ||
US60/249,264 | 2000-11-17 | ||
US60/249,208 | 2000-11-17 | ||
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US60/249,213 | 2000-11-17 | ||
US60/249,211 | 2000-11-17 | ||
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US60/254,097 | 2000-12-11 | ||
US60/259,678 | 2001-01-05 |
Publications (1)
Publication Number | Publication Date |
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CA2395738A1 true CA2395738A1 (fr) | 2002-08-02 |
Family
ID=27587117
Family Applications (37)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002395827A Withdrawn CA2395827A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392450A Abandoned CA2392450A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395295A Withdrawn CA2395295A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393652A Withdrawn CA2393652A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395693A Pending CA2395693A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395849A Pending CA2395849A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395671A Withdrawn CA2395671A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392428A Abandoned CA2392428A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392422A Abandoned CA2392422A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393002A Withdrawn CA2393002A1 (fr) | 2000-01-31 | 2001-01-17 | Acides ncleiques, proteines et anticorps |
CA002395724A Pending CA2395724A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392398A Abandoned CA2392398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002397839A Withdrawn CA2397839A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395787A Withdrawn CA2395787A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002394039A Abandoned CA2394039A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395654A Withdrawn CA2395654A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395178A Withdrawn CA2395178A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395734A Withdrawn CA2395734A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392438A Abandoned CA2392438A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395816A Withdrawn CA2395816A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395858A Withdrawn CA2395858A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002398411A Withdrawn CA2398411A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395885A Withdrawn CA2395885A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002398877A Withdrawn CA2398877A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393912A Withdrawn CA2393912A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395729A Pending CA2395729A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395403A Withdrawn CA2395403A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002397407A Withdrawn CA2397407A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395699A Pending CA2395699A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002394841A Withdrawn CA2394841A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395738A Withdrawn CA2395738A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395872A Withdrawn CA2395872A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395666A Withdrawn CA2395666A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393618A Abandoned CA2393618A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395398A Withdrawn CA2395398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines, et anticorps |
CA002392751A Abandoned CA2392751A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392757A Abandoned CA2392757A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
Family Applications Before (30)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002395827A Withdrawn CA2395827A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392450A Abandoned CA2392450A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395295A Withdrawn CA2395295A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393652A Withdrawn CA2393652A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395693A Pending CA2395693A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395849A Pending CA2395849A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395671A Withdrawn CA2395671A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392428A Abandoned CA2392428A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392422A Abandoned CA2392422A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393002A Withdrawn CA2393002A1 (fr) | 2000-01-31 | 2001-01-17 | Acides ncleiques, proteines et anticorps |
CA002395724A Pending CA2395724A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392398A Abandoned CA2392398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002397839A Withdrawn CA2397839A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395787A Withdrawn CA2395787A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002394039A Abandoned CA2394039A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395654A Withdrawn CA2395654A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395178A Withdrawn CA2395178A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395734A Withdrawn CA2395734A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392438A Abandoned CA2392438A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395816A Withdrawn CA2395816A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395858A Withdrawn CA2395858A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002398411A Withdrawn CA2398411A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395885A Withdrawn CA2395885A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002398877A Withdrawn CA2398877A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393912A Withdrawn CA2393912A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395729A Pending CA2395729A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395403A Withdrawn CA2395403A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002397407A Withdrawn CA2397407A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395699A Pending CA2395699A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002394841A Withdrawn CA2394841A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002395872A Withdrawn CA2395872A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395666A Withdrawn CA2395666A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002393618A Abandoned CA2393618A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002395398A Withdrawn CA2395398A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines, et anticorps |
CA002392751A Abandoned CA2392751A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
CA002392757A Abandoned CA2392757A1 (fr) | 2000-01-31 | 2001-01-17 | Acides nucleiques, proteines et anticorps |
Country Status (3)
Country | Link |
---|---|
AU (16) | AU2001241415A1 (fr) |
CA (37) | CA2395827A1 (fr) |
WO (48) | WO2001055320A2 (fr) |
Families Citing this family (273)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001070982A2 (fr) * | 2000-03-23 | 2001-09-27 | Immusol Incorporated | Regulateurs de brca-1 et procedes d'utilisation |
US20020137890A1 (en) | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US7258860B2 (en) | 1998-03-18 | 2007-08-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US6960570B2 (en) | 1998-03-18 | 2005-11-01 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US7579160B2 (en) | 1998-03-18 | 2009-08-25 | Corixa Corporation | Methods for the detection of cervical cancer |
US6706262B1 (en) | 1998-03-18 | 2004-03-16 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
US7771719B1 (en) | 2000-01-11 | 2010-08-10 | Genentech, Inc. | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E |
NZ508878A (en) | 1998-05-15 | 2003-08-29 | Genentech Inc | IL-17B and IL-17Cactive variants of IL-17 which stimulates epithelial, endothelial and fibroblastic cells |
US6929938B2 (en) | 2001-08-15 | 2005-08-16 | Millennium Pharmaceuticals, Inc. | 25501, a human transferase family member and uses therefor |
US7141417B1 (en) | 1999-02-25 | 2006-11-28 | Thomas Jefferson University | Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene |
EP1163252A4 (fr) * | 1999-02-25 | 2004-04-07 | Univ Jefferson | Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs |
WO2000050458A1 (fr) * | 1999-02-26 | 2000-08-31 | Smithkline Beecham Corporation | Clonage du recepteur 7tm (axor 17) du type p2y |
WO2000056881A1 (fr) * | 1999-03-23 | 2000-09-28 | Human Genome Sciences, Inc. | 48 proteines humaines secretees |
WO2000058480A1 (fr) * | 1999-03-29 | 2000-10-05 | Kansai Technology Licensing Organization Co., Ltd. | Nouvelle cytidine desaminase |
EP1621620A3 (fr) * | 1999-09-01 | 2006-05-10 | Genetech, Inc. | Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci |
WO2001030971A2 (fr) * | 1999-10-27 | 2001-05-03 | Millennium Pharmaceuticals, Inc. | Nouvelles molecules de la famille des proteines se rapportant aux card et leurs utilisations |
US6893818B1 (en) | 1999-10-28 | 2005-05-17 | Agensys, Inc. | Gene upregulated in cancers of the prostate |
US7005499B1 (en) * | 1999-11-18 | 2006-02-28 | Genentech, Inc. | Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same |
EP1878794A3 (fr) * | 1999-11-30 | 2008-01-23 | Genentech, Inc. | Compositions et procédés pour le traitement de maladies liées au système immunitaire |
EP1686134A3 (fr) * | 1999-12-01 | 2006-08-09 | Genentech, Inc. | Polypeptides transmembranaires et secrétés et les acides nucléiques codant ceux-ci |
CN1300781A (zh) * | 1999-12-22 | 2001-06-27 | 上海博德基因开发有限公司 | 一种新的多肽-人shc蛋白43和编码这种多肽的多核苷酸 |
US20040043397A1 (en) | 2000-01-11 | 2004-03-04 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
AU3797301A (en) | 2000-01-26 | 2001-08-07 | Urogenesys Inc | 84p2a9: a prostate and testis specific protein highly expressed in prostate cancer |
US6953682B2 (en) | 2000-02-10 | 2005-10-11 | Millennium Pharmaceuticals, Inc. | Nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and atpase-like molecules and uses therefor |
US20020082212A1 (en) * | 2000-07-20 | 2002-06-27 | Millennium Pharmaceuticals, Inc. | 7716, a novel human ATPase and uses therefor |
US7078205B2 (en) | 2000-02-17 | 2006-07-18 | Millennium Pharmaceuticals, Inc. | Nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, atpase molecules, acyltransferase molecules, pyridoxal-phosphate dependent enzyme molecules and uses therefor |
US20020031815A1 (en) * | 2000-06-26 | 2002-03-14 | Millennium Pharmaceuticals, Inc. | 46619, a novel human beta-ketoacyl synthase and uses thereof |
US20020090705A1 (en) * | 2000-07-14 | 2002-07-11 | Rachel Meyers | 62088, a novel human nucleoside phosphatase family member and uses thereof |
US7718397B2 (en) | 2000-03-21 | 2010-05-18 | Genentech, Inc. | Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof |
EP1272640A2 (fr) | 2000-03-24 | 2003-01-08 | Millennium Pharmaceuticals, Inc. | 3714, 16742, 23546, et 13887 nouvelles molecules de proteine kinase et leurs utilisations |
US20030198953A1 (en) * | 2000-03-30 | 2003-10-23 | Spytek Kimberly A. | Novel proteins and nucleic acids encoding same |
US7632929B2 (en) | 2000-04-20 | 2009-12-15 | The Board Of Trustees Of The University Of Arkansas | Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof |
AU2001257195B2 (en) * | 2000-04-25 | 2006-10-05 | Lexicon Pharmaceuticals, Inc. | Novel human kinase proteins and polynucleotides encoding the same |
AU2001257407A1 (en) * | 2000-04-26 | 2001-11-07 | Millennium Pharmaceuticals, Inc. | 21657, a human short-chain dehydrogenase and uses thereof |
US6808876B1 (en) * | 2000-05-02 | 2004-10-26 | Immusol, Inc. | Cellular regulators of infectious agents and methods of use |
WO2001085921A2 (fr) * | 2000-05-12 | 2001-11-15 | Merck Patent Gmbh | Nouvelle serine-threonine kinase-4 |
EP1158001B1 (fr) * | 2000-05-26 | 2007-11-14 | F. Hoffmann-La Roche Ag | Un acide nucléique produit excessivement dans des cellules tumorales humaines, une protéine codée par ledit acide nucléique et un procédé de diagnose de tumeurs |
US20040175815A1 (en) * | 2000-05-26 | 2004-09-09 | Yonghong Xiao | Regulation of human p78-like serube/threonine kinase |
DE10027170A1 (de) * | 2000-05-31 | 2001-12-13 | Schering Ag | Humanes PEM als Target für die Fertilitätskontrolle |
AU6531101A (en) * | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030096969A1 (en) | 2000-06-02 | 2003-05-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
WO2001093805A2 (fr) * | 2000-06-02 | 2001-12-13 | The Brigham & Women's Hospital, Inc. | Fusion de genes jazf1 et jjaz1 dans des tumeurs stromatolithiques endometriales |
AU6604901A (en) * | 2000-06-05 | 2001-12-17 | Bayer Aktiengesellschaft | Regulation of human hm74-like g protein coupled receptor |
WO2001096390A2 (fr) * | 2000-06-09 | 2001-12-20 | Corixa Corporation | Compositions et procedes pour la therapie et le diagnostic du cancer du colon |
US6323016B1 (en) | 2000-06-09 | 2001-11-27 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
AU2001268435A1 (en) * | 2000-06-15 | 2001-12-24 | Millennium Pharmaceuticals, Inc. | 23680, a novel human aminotransferase and uses therefor |
JP2004513620A (ja) * | 2000-06-16 | 2004-05-13 | インサイト・ゲノミックス・インコーポレイテッド | プロテインホスファターゼ |
EP2168980A1 (fr) * | 2000-06-23 | 2010-03-31 | Genentech, Inc. | Compositions et procédés pour le traitement et le diagnostic des troubles impliquant une angiogenèse |
US7094587B2 (en) | 2000-06-27 | 2006-08-22 | Millennium Pharmaceuticals, Inc. | 16002 Molecules and uses therefor |
EP1309684A2 (fr) * | 2000-06-27 | 2003-05-14 | Curagen Corporation | Polynucleotides et polypeptides codes par ceux-ci |
WO2002000939A2 (fr) | 2000-06-28 | 2002-01-03 | Diadexus, Inc. | Procede de diagnostic, de surveillance, de determination du stade, d'imagerie et de traitement du cancer du colon |
US6900303B2 (en) | 2000-06-30 | 2005-05-31 | Millennium Pharmaceuticals, Inc. | 57658, a novel human uridine kinase and uses thereof |
EP1313854A2 (fr) * | 2000-07-07 | 2003-05-28 | Incyte Genomics, Inc. | Transporteurs et canneaux d'ion |
AU2001271843A1 (en) * | 2000-07-07 | 2002-01-21 | Incyte Genomics, Inc. | Gtp-binding proteins |
WO2002006318A2 (fr) * | 2000-07-18 | 2002-01-24 | Board Of Regents, The University Of Texas System | Procedes et compositions permettant de stabiliser des microtubules et des filaments intermediaires dans des cellules de muscle strie |
WO2002006453A2 (fr) * | 2000-07-18 | 2002-01-24 | Bayer Aktiengesellschaft | Regulation de protease a serine humaine de type desc1 |
JP2004514420A (ja) * | 2000-07-20 | 2004-05-20 | ジェネンテック・インコーポレーテッド | 分泌及び膜貫通ポリペプチドとそれをコードする核酸 |
US20060252034A1 (en) * | 2000-07-25 | 2006-11-09 | Klaus Duecker | Novel protein containing ring finger domaine r1p4 |
WO2002008281A2 (fr) * | 2000-07-26 | 2002-01-31 | Stanford University | Proteine bstp-cad et reactifs associes et methodes d'utilisation |
WO2002008282A2 (fr) * | 2000-07-26 | 2002-01-31 | Stanford University | Proteine bstp-ras/rerg et reactifs apparentes, procedes d'utilisation de ces derniers |
EP1657254A3 (fr) * | 2000-08-01 | 2006-06-07 | Genentech, Inc. | Polypeptide, acides nucléiques le codant, et leur utilisation pour le diagnostic du cancer |
US7335732B2 (en) | 2000-08-01 | 2008-02-26 | Genentech, Inc. | PRO9799 polypeptides |
EP1315431A1 (fr) * | 2000-08-02 | 2003-06-04 | Millennium Pharmaceuticals, Inc. | Membre de la famille du facteur de liberation du gtp humain (15368) et ses utilisations |
WO2002010217A2 (fr) | 2000-08-02 | 2002-02-07 | The Johns Hopkins University | Profils d'expression de cellules endotheliales |
AU2001288231A1 (en) * | 2000-08-04 | 2002-02-18 | Zymogenetics Inc. | Human secreted protein, zzp1 |
AU2001281252A1 (en) | 2000-08-10 | 2002-02-18 | Board Of Regents, The University Of Texas System | The tumor suppressor car-1 |
US7091022B2 (en) * | 2000-08-11 | 2006-08-15 | Merck Patent Gmbh | Mitogen activated kinase |
EP1326985A1 (fr) * | 2000-08-18 | 2003-07-16 | MERCK PATENT GmbH | Identification d'un gene d'acetyltransferase n-terminale humaine |
US6962799B2 (en) * | 2000-08-21 | 2005-11-08 | Incyte Corporation | Microtubule-associated proteins and tubulins |
US6706513B2 (en) | 2000-08-21 | 2004-03-16 | Bristol-Myers Squibb Company | Adenosine deaminase homolog |
WO2002016579A2 (fr) * | 2000-08-24 | 2002-02-28 | Eli Lilly And Company | Acides nucleiques, vecteurs, cellules hotes, polypeptides et utilisations de ces derniers |
AU8846601A (en) | 2000-08-28 | 2002-03-13 | Agensys Inc | Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer |
EP1313761A4 (fr) * | 2000-08-28 | 2005-01-26 | Human Genome Sciences Inc | 18 proteines humaines secretees |
EP1334189A2 (fr) * | 2000-08-28 | 2003-08-13 | AstraZeneca AB | Molecules impliquees dans la regulation du syndrome de resistance a l'insuline |
AU2002210464A1 (en) * | 2000-08-30 | 2002-03-13 | Bayer Aktiengesellschaft | Regulation of human aminotransferase-like enzyme |
US20020146800A1 (en) * | 2000-08-30 | 2002-10-10 | Curtis Rory A.J. | 48921, a novel human GTP releasing factor and uses therefor |
WO2002018573A2 (fr) * | 2000-08-30 | 2002-03-07 | Millennium Pharmaceuticals, Inc. | Nouveau transporteur humain de sulfate: la proteine 54370, et utilisations associees |
AU2001285908A1 (en) * | 2000-08-30 | 2002-03-13 | Bayer Aktiengesellschaft | Regulation of human aminotransferase-like enzyme |
AU2001288600A1 (en) | 2000-08-31 | 2002-03-13 | Millennium Pharmaceuticals, Inc. | 62112, a novel human dehydrogenase and uses thereof |
ES2327102T3 (es) * | 2000-09-05 | 2009-10-26 | Amgen Inc. | Moleculas analogas al receptor de tnf y usos de las mismas. |
EP1364015A2 (fr) * | 2000-09-05 | 2003-11-26 | Incyte Genomics, Inc. | Molecules pour diagnostic et traitement |
AU2001288999A1 (en) * | 2000-09-08 | 2002-03-22 | Millennium Pharmaceuticals, Inc. | 38646, a guanine nucleotide exchange factor and uses therefor |
US6391606B1 (en) * | 2000-09-14 | 2002-05-21 | Pe Corporation | Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof |
US6372468B1 (en) | 2000-09-14 | 2002-04-16 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
JP2004531203A (ja) * | 2000-10-05 | 2004-10-14 | キュラジェン コーポレイション | ヒトタンパク質、これらをコードするポリヌクレオチド、ならびにこれらの利用方法 |
AU2002220613A1 (en) * | 2000-10-11 | 2002-04-22 | Bayer Aktiengesellschaft | Regulation of human cyclophilin-type peptidyl-prolyl cis-trans isomerase |
WO2002031132A2 (fr) * | 2000-10-11 | 2002-04-18 | Millennium Pharmaceuticals, Inc. | Nouvel element de la famille des phosphatases humaines a double specificite, appele 8843, et utilisation de ce dernier |
US20020064831A1 (en) * | 2000-10-12 | 2002-05-30 | The Texas A&M University System | Nucleic acid sequences encoding CMG proteins, CMG proteins, and methods for their use |
EP1474528A4 (fr) * | 2000-10-13 | 2006-06-14 | Protein Design Labs Inc | Procedes de diagnostic du cancer de la prostate, compositions et procedes de criblage de modulateurs du cancer de la prostate |
US6531297B2 (en) * | 2000-10-20 | 2003-03-11 | Applera Corporation | Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof |
AU2002249787A1 (en) | 2000-10-25 | 2002-08-19 | Diadexus, Inc. | Compositions and methods relating to lung specific genes and proteins |
WO2002036781A2 (fr) * | 2000-10-31 | 2002-05-10 | Bayer Aktiengesellschaft | Regulation de la glutathione-s-transferase humaine |
AU2002229011A1 (en) * | 2000-11-09 | 2002-05-21 | Glaxo Group Limited | Deaminase catalyzing the removal of the cyclopropyl moiety from abacavir-mp |
WO2002040672A2 (fr) | 2000-11-20 | 2002-05-23 | Diadexus, Inc. | Compositions et methodes relatives a des genes et des proteines specifiques aux seins |
AU2001297765A1 (en) * | 2000-12-05 | 2002-10-21 | Incyte Genomics, Inc. | Ligases |
EP1415005B1 (fr) | 2000-12-07 | 2012-11-21 | Novartis Vaccines and Diagnostics, Inc. | Retrovirus endogenes regules positivement dans le cancer de la prostate |
US6692748B2 (en) | 2000-12-07 | 2004-02-17 | Zymogenetics, Inc. | Adipocyte complement related protein zacrp3x2 and nucleic acids encoding zacrp3x2 |
AU2002211305A1 (en) * | 2000-12-14 | 2002-06-24 | Pe Corporation (Ny) | Isolated human kinase proteins, their encoding nucleic acid molecules, and uses thereof |
US20020142376A1 (en) * | 2000-12-20 | 2002-10-03 | Gennady Merkulov | Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof |
US7892730B2 (en) * | 2000-12-22 | 2011-02-22 | Sagres Discovery, Inc. | Compositions and methods for cancer |
ATE329027T1 (de) | 2000-12-22 | 2006-06-15 | Brystol Myers Squibb Company | Menschliches leucinereiche wiederholungen enthaltendes protein, vorwiegend im dünndarm exprimiert, hlrrsi1 |
US6423521B1 (en) * | 2000-12-28 | 2002-07-23 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
WO2002053591A1 (fr) * | 2000-12-30 | 2002-07-11 | Lion Bioscience Ag | Cofacteur de recepteur nucleaire mammalien cf12 et ses procedes d'utilisation |
WO2002053754A2 (fr) * | 2001-01-08 | 2002-07-11 | Lexicon Genetics Incorporated | Nouvelle protease humaine et polynucleotides codant cette derniere |
AU2002243750A1 (en) * | 2001-01-30 | 2002-08-12 | Regeneron Pharmaceuticals, Inc. | Novel nucleic acid and polypeptide molecules |
EP1409536A2 (fr) * | 2001-02-12 | 2004-04-21 | Curagen Corporation | Proteines, polynucleotides codant pour lesdites proteines et methodes d'utilisation desdites proteines |
EP1637601A3 (fr) * | 2001-02-21 | 2006-03-29 | Curagen Corporation | Protéines , polynucléotides codant pour ces protéines et procédés d'utilisation |
US7271240B2 (en) | 2001-03-14 | 2007-09-18 | Agensys, Inc. | 125P5C8: a tissue specific protein highly expressed in various cancers |
WO2002074906A2 (fr) * | 2001-03-16 | 2002-09-26 | Eli Lilly And Company | Proteines de mammiferes lp et reactifs associes |
US6913904B2 (en) * | 2001-03-27 | 2005-07-05 | Applera Corporation | Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof |
EP1383922A4 (fr) | 2001-04-10 | 2005-03-30 | Agensys Inc | Acide nucleique et proteine correspondante intitule 158p3d2 utiles dans le traitement et la detection du cancer |
CA2443147A1 (fr) | 2001-04-10 | 2002-10-24 | Agensys, Inc. | Acide nucleique et proteine correspondante intitulee 184p1e2, utilises dans le traitement et la detection de cancers |
AU2002318112B2 (en) | 2001-04-10 | 2007-12-06 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
CN1505637A (zh) * | 2001-04-24 | 2004-06-16 | ��V��ҩ��ʽ���� | 克罗恩氏病抗体结合性肽以及克罗恩氏病检查方法 |
AU2002249453A1 (en) * | 2001-04-24 | 2002-11-05 | Isis Innovation Ltd | Enzyme and snp marker for disease |
KR100817467B1 (ko) | 2001-05-07 | 2008-03-31 | 시오노기세이야쿠가부시키가이샤 | 혈관신생 마커로서 사용되는 폴리펩티드 및 이의 dna |
AU2002314048A1 (en) * | 2001-05-09 | 2002-11-18 | Bayer Aktiengesellschaft | Regulation of human phosphatidic acid phosphatase type 2c-like protein |
US7235358B2 (en) | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
WO2003000901A2 (fr) * | 2001-06-26 | 2003-01-03 | Decode Genetics Ehf. | Acides nucleiques codant des proteines kinases |
US20030120040A1 (en) | 2001-06-29 | 2003-06-26 | Genentech, Inc. | Secreted and Transmembrane polypeptides and nucleic acids encoding the same |
GB2399086A (en) * | 2001-08-02 | 2004-09-08 | Aeomica Inc | Human zinc finger containing gene MDZ4 |
AU2002359242A1 (en) * | 2001-08-17 | 2003-04-22 | Incyte Genomics, Inc. | Intracellular signaling molecules |
US7270960B2 (en) * | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
WO2003023063A1 (fr) * | 2001-09-07 | 2003-03-20 | Sankyo Company, Limited | Methode d'estimation du risque d'apparition de diabetes |
WO2003025175A2 (fr) * | 2001-09-17 | 2003-03-27 | Molecular Engines Laboratories | Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments |
WO2003040369A2 (fr) * | 2001-09-17 | 2003-05-15 | Molecular Engines Laboratories | Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments |
ATE494363T1 (de) | 2001-09-28 | 2011-01-15 | Univ Brigham Young | Neue cyclooxygenase-varianten und verwendungsverfahren |
WO2003038087A1 (fr) | 2001-10-04 | 2003-05-08 | Kansai Technology Licensing Organization Co., Ltd. | Promoteur du gene dr5 et promoteur du gene siah-1 |
US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
WO2003031607A1 (fr) * | 2001-10-10 | 2003-04-17 | Bayer Healthcare Ag | Regulation de deshydrogenase/reductase des chaines courtes humaine |
ATE364690T1 (de) | 2001-11-09 | 2007-07-15 | Proteologics Inc | Posh nukleinsäure, polypeptide und darauf bezogene verfahren |
WO2003054146A2 (fr) | 2001-11-14 | 2003-07-03 | Northwestern University | Auto-assemblage et mineralisation de nanofibres de peptide amphiphile |
US20050053940A1 (en) * | 2001-11-21 | 2005-03-10 | Joh-E Ikeda | Huntington's disease gene transcriptional factors |
US7151162B2 (en) | 2001-12-06 | 2006-12-19 | The University Of Children's Hospital Of Both Cantons Of Basel | Nuclear protein |
WO2003051911A2 (fr) * | 2001-12-19 | 2003-06-26 | Genset S.A. | Polypeptides et polynucleotides gmg-5 et utilisations de ceux-ci |
JP2003245084A (ja) | 2001-12-20 | 2003-09-02 | Morinaga Milk Ind Co Ltd | 脳梁又は精子の形成不全の診断及び治療に有用な新規遺伝子、並びにその用途 |
DE10163467A1 (de) * | 2001-12-21 | 2003-11-27 | Axaron Bioscience Ag | Protein 24B2 und zugrundliegende DNA-Sequenz |
US6759222B2 (en) | 2002-01-02 | 2004-07-06 | Millennium Pharmaceuticals, Inc. | 14815, a human kinase family member and uses therefor |
AU2003202543A1 (en) * | 2002-01-07 | 2003-07-24 | Bayer Aktiengesellschaft | Human phosphatidic acid phosphatase type 2-like protein |
WO2003060109A2 (fr) * | 2002-01-15 | 2003-07-24 | Bayer Healthcare Ag | Regulation d'une subtilase humaine |
AU2003205611A1 (en) * | 2002-01-15 | 2003-07-30 | Medigene Ag | Dilated cardiomyopathy associated gene-2 (dcmag-2): a cytoplasmatic inducer of sarcomeric remodeling in cardiomyocytes |
WO2003062429A1 (fr) * | 2002-01-23 | 2003-07-31 | Yamanouchi Pharmaceutical Co., Ltd. | Nouvelle serine protease |
US7371719B2 (en) | 2002-02-15 | 2008-05-13 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
EP1338609A1 (fr) * | 2002-02-21 | 2003-08-27 | MEMOREC Stoffel GmbH-Medizinisch-Molekulare Entwicklung, Köln | Un outre récepteur KDR et son utilisation |
CA2478271A1 (fr) * | 2002-03-05 | 2003-09-18 | Applera Corporation | Proteines transporteuses humaines isolees, molecules d'acide nucleique codant celles-ci, et utilisations associees |
AU2003208472A1 (en) * | 2002-03-06 | 2003-09-16 | Oxford Glycosciences (Uk) Ltd | Novel b-cell malignancy-associated protein |
EP2241636A1 (fr) | 2002-03-13 | 2010-10-20 | Genomic Health, Inc. | Profilage de l'expression génétique dans des tissus de tumeurs prélevées par biopsie |
US7527935B2 (en) | 2002-03-19 | 2009-05-05 | Mitsubishi Tanabe Pharma Corporation | G-protein coupled receptor having eicosanoid as ligand and gene thereof |
JP3949111B2 (ja) * | 2002-03-19 | 2007-07-25 | 田辺製薬株式会社 | 新規gタンパク質共役型受容体およびその遺伝子 |
GB0206684D0 (en) * | 2002-03-21 | 2002-05-01 | Babraham Inst | Novel proteins |
US7193069B2 (en) * | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
CA2413475C (fr) | 2002-04-25 | 2010-07-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Expression de zap-70 en tant que marqueur de la leucemie chronique lymphoide/du lymphome a petits lymphocytes (lcl/lpl) |
JP2004041003A (ja) * | 2002-05-17 | 2004-02-12 | Takeda Chem Ind Ltd | 新規タンパク質、そのdnaおよびその用途 |
EP1507553A2 (fr) | 2002-05-29 | 2005-02-23 | DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung | Proteines specifiques du pancreas |
WO2003101401A2 (fr) | 2002-06-03 | 2003-12-11 | Chiron Corporation | Utilisation de nrg4, ou d'inhibiteurs de nrg4, dans le traitement du cancer du colon et du pancreas |
EP2275544A3 (fr) * | 2002-06-06 | 2011-03-30 | Oncotherapy Science, Inc. | Gènes et polypeptides en rapport avec les cancers du colon chez l'homme |
US8518694B2 (en) | 2002-06-13 | 2013-08-27 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acid vector comprising a promoter and a sequence encoding a polypeptide from the endogenous retrovirus PCAV |
US20060172296A1 (en) * | 2002-07-22 | 2006-08-03 | Masahiro Takeuchi | Novel gene associated with rheumatoid arthritis |
JP4186004B2 (ja) | 2002-08-14 | 2008-11-26 | 独立行政法人産業技術総合研究所 | 新規n−アセチルガラクトサミン転移酵素およびそれをコードする核酸 |
AU2003243151A1 (en) | 2002-08-16 | 2004-03-03 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer |
AU2003235316A1 (en) * | 2002-08-23 | 2004-03-11 | Japan Science And Technology Agency | Human solid cancer antigen peptides, polynucleotides encoding the same and utilization thereof |
EP1540014A2 (fr) * | 2002-08-27 | 2005-06-15 | Epigenomics AG | Procede et acides nucleiques servant a l'analyse de troubles lies a la proliferation des cellules mammaires |
US7452969B2 (en) | 2002-08-30 | 2008-11-18 | Licentia Ltd | Neurotrophic factor protein and uses thereof |
WO2007068784A1 (fr) | 2005-12-14 | 2007-06-21 | Licentia Ltd | Nouveau facteur neurotrophique et utilisations de celui-ci |
ES2320443T3 (es) * | 2002-09-30 | 2009-05-22 | Oncotherapy Science, Inc. | Genes y polipeptidos relacionados con canceres pancreaticos humanos. |
EP1552310A2 (fr) * | 2002-10-17 | 2005-07-13 | EVOTEC Neurosciences GmbH | L'utilisation de la proteine et du gene de la nicotinamide mononucleotide adenylyltransferase 2 (nmnat-2) pour le diagnostique et la therapie des maladies neurodegeneratives |
AU2002952216A0 (en) * | 2002-10-23 | 2002-11-07 | The Walter And Eliza Hall Institute Of Medical Research | Novel therapeutic molecules |
US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
WO2004046386A1 (fr) | 2002-11-15 | 2004-06-03 | Genomic Health, Inc. | Etablissement de profils d'expressions genetique du cancer a recepteur de facteur de croissance epidermique positif |
DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
AU2003287764B2 (en) * | 2002-12-13 | 2010-01-21 | The Walter And Eliza Hall Institute Of Medical Research | A novel phosphoprotein |
AU2002953341A0 (en) * | 2002-12-13 | 2003-01-09 | The Walter And Eliza Hall Institute Of Medical Research | A novel phosphoprotein |
US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
US7326768B2 (en) | 2003-02-05 | 2008-02-05 | Juan Saus | Goodpasture antigen-binding protein isoforms and protein misfolded-mediated disorders |
EP1445614A1 (fr) * | 2003-02-06 | 2004-08-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Méthodes d'évaluation in vitro de l'état de progression d'un virus HIV chez un individu |
US7074891B2 (en) | 2003-02-07 | 2006-07-11 | Posco | Leukocyte stimulating peptides |
AU2004213871B9 (en) | 2003-02-20 | 2009-09-03 | Genomic Health, Inc. | Use of intronic RNA to measure gene expression |
CA2517953A1 (fr) * | 2003-03-04 | 2004-09-16 | Astellas Pharma Inc. | Nouveau gene associe a des conditions fibreuses |
ATE479754T1 (de) * | 2003-03-19 | 2010-09-15 | Biogen Idec Inc | Nogo rezeptor bindendes protein |
ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
DK3170906T3 (en) | 2003-06-24 | 2018-11-05 | Genomic Health Inc | PREDICTION OF THE LIKELI REVENUE OF CANCER |
WO2005008213A2 (fr) | 2003-07-10 | 2005-01-27 | Genomic Health, Inc. | Algorithme de profile d'expression et test du pronostic du cancer |
WO2005014818A1 (fr) | 2003-08-08 | 2005-02-17 | Perseus Proteomics Inc. | Gene surexprime dans le cancer |
US20050136434A1 (en) * | 2003-08-12 | 2005-06-23 | Mai Xu | Isolated heat-inducible cell surface protein and hyperthermia-based tumor immunotargeting therapy |
US20070178458A1 (en) * | 2003-09-05 | 2007-08-02 | O'brien Philippa | Methods of diagnosis and prognosis of ovarian cancer II |
WO2005026314A2 (fr) * | 2003-09-10 | 2005-03-24 | Japan Science And Technology Agency | Groupe de genes exprimes de facon differentielle dans des cellules de sang peripherique ainsi que procede de diagnostic et procede d'analyse mettant en oeuvre ce groupe |
ES2346314T3 (es) * | 2003-10-02 | 2010-10-14 | Glaxosmithkline Biolog Sa | Antigenos de b. pertussis y uso de los mismos en vacunacion. |
WO2005033144A2 (fr) | 2003-10-03 | 2005-04-14 | Brigham And Women's Hospital | Ligands de tim-3 et methodes associees |
WO2005040791A2 (fr) * | 2003-10-21 | 2005-05-06 | Bayer Healthcare Ag | Diagnostics et therapeutiques pour maladies liees au recepteur de peptides similaire a la somatostatine et a l'angiogenine (salpr) |
WO2005051994A2 (fr) * | 2003-11-21 | 2005-06-09 | Zymogenetics, Inc. | Facteur de necrose tumorale ztnf11 |
ES2380340T3 (es) * | 2003-12-05 | 2012-05-10 | Northwestern University | Anfífilos peptídicos auto-ensamblantes y métodos relacionados para la administración de factores de crecimiento |
ES2360113T3 (es) | 2003-12-23 | 2011-06-01 | Genomic Health, Inc. | Amplificación universal de rna fragmentado. |
US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
DK1730303T3 (da) * | 2004-03-02 | 2013-11-04 | Univ Johns Hopkins | Mutationer i pik3ca-genet ved humane cancerformer |
TW200539890A (en) | 2004-03-12 | 2005-12-16 | Brigham & Womens Hospital | Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function |
WO2005090569A1 (fr) * | 2004-03-24 | 2005-09-29 | The Council Of The Queensland Institute Of Medical Research | Cancer et acides nucleiques et proteines de testicule vsm1 et vsm2, et leurs utilisations |
NZ550542A (en) * | 2004-03-30 | 2009-03-31 | Nsgene As | Therapeutic use of a growth factor, NsG33 |
ES2550614T3 (es) | 2004-04-09 | 2015-11-11 | Genomic Health, Inc. | Marcadores de expresión génica para predecir la respuesta a la quimioterapia |
DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
WO2005118832A2 (fr) * | 2004-06-01 | 2005-12-15 | Bayer Healthcare Ag | Agents diagnostiques et therapeutiques pour des maladies associees a une proteine de type kinase regulee par serum/glucocorticoide (sgkl) |
RS52593B (en) | 2004-06-24 | 2013-04-30 | Biogen Idec Ma Inc. | TREATMENT OF THE CONDITIONS CONCERNING DEMYELINIZATION |
US7587279B2 (en) | 2004-07-06 | 2009-09-08 | Genomic Health | Method for quantitative PCR data analysis system (QDAS) |
WO2006013661A1 (fr) * | 2004-08-05 | 2006-02-09 | Toagosei Co., Ltd. | Peptide déterminant antigénique anticorps de la maladie de crohn et reactif pour test de la maladie de crohn |
ATE550440T1 (de) | 2004-11-05 | 2012-04-15 | Genomic Health Inc | Molekulare indikatoren für brustkrebsprognose und vorhersage des ansprechens auf eine behandlung |
US7930104B2 (en) | 2004-11-05 | 2011-04-19 | Genomic Health, Inc. | Predicting response to chemotherapy using gene expression markers |
CN102746404B (zh) | 2004-11-12 | 2016-01-20 | 赞科股份有限公司 | 对FcRn的结合被改变的Fc变体 |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
JP2008531733A (ja) | 2005-03-04 | 2008-08-14 | ノースウエスタン ユニバーシティ | 血管新生性のヘパリン結合エピトープ、ペプチド両親媒性物質、自己集合組成物、および関連する使用法 |
EP1880005B1 (fr) * | 2005-05-13 | 2012-11-07 | Centre National de la Recherche Scientifique | Utilisation de nouveau codage genique pour nouvel element de la famille mcm2-8 dans les compositions pharmaceutiques |
EP2394661A1 (fr) | 2005-07-08 | 2011-12-14 | Biogen Idec MA Inc. | Anticorps Sp35 et utilisations associées |
WO2007014338A2 (fr) * | 2005-07-26 | 2007-02-01 | Siemens Medical Solutions Diagnostics | Polymorphismes de nucleotides uniques a susceptibilite par rapport a une maladie cardio-vasculaire |
US8207128B2 (en) * | 2005-09-28 | 2012-06-26 | Supadelixir Inc. | Polypeptide inhibiting transmigration of leukocytes or growth and/or metastasis of cancer cells, and fusion protein thereof |
EP1790664A1 (fr) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Anticorps monoclonaux contre claudin-18 pour le traitement du cancer |
KR20090111307A (ko) * | 2006-07-03 | 2009-10-26 | 엑손히트 써라퓨틱스 에스에이 | 전립선 특이적 전사물 및 전립선암의 치료 및 진단에 사용되는 이의 용도 |
CA2662915A1 (fr) * | 2006-09-08 | 2008-03-13 | Corixa Corporation | Procedes, compositions, et kits de detection et de surveillance d'un cancer du colon |
US8076295B2 (en) | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
US8999634B2 (en) * | 2007-04-27 | 2015-04-07 | Quest Diagnostics Investments Incorporated | Nucleic acid detection combining amplification with fragmentation |
GB0805159D0 (en) | 2008-03-19 | 2008-04-23 | Sancho Madrid David | Immune modulation via C-type lectin |
HUE026776T2 (en) | 2007-07-27 | 2016-08-29 | Immatics Biotechnologies Gmbh | New immunogenic epitope for immunotherapy |
US7863021B2 (en) | 2007-09-05 | 2011-01-04 | Celera Corporation | Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof |
WO2009034661A1 (fr) * | 2007-09-12 | 2009-03-19 | Toppan Printing Co., Ltd. | Procédé de diagnostic et induction d'une résistance à un virus |
ES2401233T3 (es) | 2007-10-17 | 2013-04-18 | Universidad de Córdoba | Isoformas del receptor tipo 5 de somatostatina humana producidas por tratamiento alternativo y pares de oligonucleótidos para la detección de las mismas por PCR |
PL2235059T3 (pl) | 2007-12-26 | 2015-08-31 | Xencor Inc | Warianty FC o zmodyfikowanym wiązaniu do FCRN |
GB0803352D0 (en) * | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
US9683031B2 (en) | 2008-03-21 | 2017-06-20 | Universiteit Hasselt | Biomarkers for rheumatoid arthritis |
CA2997870A1 (fr) | 2008-07-09 | 2010-01-14 | Biogen Ma Inc. | Compositions renfermant des anticorps au lingo ou des fragments associes |
US8334264B2 (en) | 2008-07-24 | 2012-12-18 | NsGenee A/S | Therapeutic use of a growth factor, METRNL |
EP2172211B1 (fr) | 2008-10-01 | 2014-12-03 | Immatics Biotechnologies GmbH | Composition de peptide associé aux tumeurs et vaccin anti-cancer associé pour le traitement de glioblastome (GBM) et autres cancers |
JP2012508586A (ja) | 2008-11-14 | 2012-04-12 | ジェン−プローブ・インコーポレーテッド | カンピロバクター属(Campylobacter)核酸を検出するための組成物、キットおよび方法 |
WO2010062960A2 (fr) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | Méthodes de détermination d'une réceptivité à une thérapie par anti-tnfα lors d’une maladie intestinale inflammatoire |
WO2010066018A1 (fr) * | 2008-12-09 | 2010-06-17 | Alethia Biotherapeutics Inc. | Nouveau variant rétroviral endogène humain d’erv3 et utilisations de celui-ci pour diagnostiquer le cancer des ovaires |
JP2012523463A (ja) | 2009-04-13 | 2012-10-04 | ノースウエスタン ユニバーシティ | 軟骨再生のための新規なペプチドベースの足場およびその使用方法 |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
CA2787940C (fr) | 2010-01-27 | 2020-01-07 | Massachusetts Institute Of Technology | Agents polypeptidiques techniques pour la neutralisation de la grippe a large spectre ciblee |
IL290591B2 (en) | 2010-09-29 | 2024-08-01 | Seagen Inc | Antibody drug preparations (ADC) that bind to 191P4D12 proteins |
WO2012041328A1 (fr) | 2010-10-01 | 2012-04-05 | Nsgene A/S | Traitement de l'allodynie, de l'hyperalgésie, de la douleur spontanée et de la douleur illusionnelle |
ES2677699T3 (es) * | 2010-12-14 | 2018-08-06 | Hananja Ehf | Actividad biológica de la proteína placentaria 13 |
CN107596346A (zh) | 2011-09-05 | 2018-01-19 | 霍巴治疗公司 | 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗 |
AR088699A1 (es) * | 2011-11-09 | 2014-06-25 | Sanofi Sa | Diacilglicerol lipasa y usos de la misma |
PT3489254T (pt) | 2012-04-30 | 2022-12-30 | Biocon Ltd | Proteínas de fusão direcionadas/imunomoduladoras e seus métodos de fabrico |
WO2013167153A1 (fr) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Anticorps utiles dans le diagnostic du cancer |
NZ702178A (en) | 2012-05-14 | 2017-01-27 | Biogen Ma Inc | Lingo-2 antagonists for treatment of conditions involving motor neurons |
WO2013174404A1 (fr) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer |
RU2678127C2 (ru) | 2012-11-13 | 2019-01-23 | Бионтех Аг | Агенты для лечения экспрессирующих клаудин раковых заболеваний |
WO2014127785A1 (fr) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer |
US9023353B2 (en) * | 2013-03-13 | 2015-05-05 | The Board Of Trustees Of The University Of Arkansas | Anti-(+)—methamphetamine monoclonal antibodies |
WO2014146672A1 (fr) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Thérapie comprenant des anticorps dirigés contre cldn 18.2 pour le traitement du cancer |
AU2014241162A1 (en) | 2013-03-27 | 2015-10-22 | Cedars-Sinai Medical Center | Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways |
PL3019619T3 (pl) | 2013-07-11 | 2022-01-10 | Modernatx, Inc. | Kompozycje zawierające syntetyczne polinkleotydy kodujące białka powiązane z crispr i syntetyczne sgrna oraz sposoby ich stosowania |
WO2015010108A1 (fr) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature de la voie de signalisation de tl1a (tnfsf15) |
US20150087810A1 (en) | 2013-09-25 | 2015-03-26 | Cytomx Therapeutics, Inc. | Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof |
WO2015050158A1 (fr) * | 2013-10-01 | 2015-04-09 | 国立大学法人三重大学 | Vaccin d'induction de lymphocytes t contenant une séquence interépitope favorisant une présentation d'antigène |
DK3628328T3 (da) | 2014-01-31 | 2022-12-05 | Cytomx Therapeutics Inc | Matriptase- og u-plasminogen-aktivatorsubstrater og andre spaltelige dele og fremgangsmåder til anvendelse deraf |
JP2018504400A (ja) | 2015-01-08 | 2018-02-15 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Lingo‐1拮抗薬及び脱髄障害の治療のための使用 |
MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
US11124766B2 (en) * | 2015-06-12 | 2021-09-21 | Emory University | Growth and survival compositions for cells capable of producing antibodies and methods related thereto |
US10351869B2 (en) | 2015-09-04 | 2019-07-16 | Synthetic Genomics, Inc. | Microorganisms engineered for increased productivity |
CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
RU2018137981A (ru) * | 2016-03-29 | 2020-04-29 | Валкири Терапьютикс Инк. | Модуляция экспрессии структурной поддержки хромосомы-1 (smc1) |
US9611297B1 (en) | 2016-08-26 | 2017-04-04 | Thrasos Therapeutics Inc. | Compositions and methods for the treatment of cast nephropathy and related conditions |
US11125757B2 (en) | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
EP3508499A1 (fr) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Anticorps ciblant et d'autres modulateurs d'un gène d'immunoglobuline associé à une résistance contre des réponses immunitaires antitumorales et leurs utilisations |
JP2022512124A (ja) | 2018-12-06 | 2022-02-02 | シートムエックス セラピューティクス,インコーポレイテッド | マトリックスメタロプロテアーゼ切断可能なおよびセリンまたはシステインプロテアーゼ切断可能な基質ならびにそれらの使用方法 |
KR20220012249A (ko) * | 2019-04-26 | 2022-02-03 | 상가모 테라퓨틱스, 인코포레이티드 | 조작 aav |
EP3994171A1 (fr) | 2019-07-05 | 2022-05-11 | iOmx Therapeutics AG | Anticorps de liant à l'igc2 de l'igsf11 (vsig3) et leurs utilisations |
WO2021083958A1 (fr) * | 2019-10-29 | 2021-05-06 | Specialites Pet Food | Nouveaux peptides induisant la satiété |
WO2021194186A1 (fr) * | 2020-03-27 | 2021-09-30 | 원큐어젠 주식회사 | Composition comprenant un peptide vgll1 pour le traitement du cancer |
WO2021228999A1 (fr) * | 2020-05-12 | 2021-11-18 | Institut Curie | Épitopes néo-antigéniques associés à des mutations sf3b1 |
WO2022008027A1 (fr) | 2020-07-06 | 2022-01-13 | Iomx Therapeutics Ag | Anticorps de liaison à l'igv d'igsf11 (vsig3) et leurs utilisations |
EP4281469A1 (fr) * | 2021-01-21 | 2023-11-29 | Erasmus University Rotterdam Medical Center | Lymphocytes t destinés à être utilisés en thérapie |
US20220260597A1 (en) * | 2021-02-18 | 2022-08-18 | Beren Therapeutics P.B.C. | Methods for the treatment of familial heterozygous and homozygous hypercholesterolemia with cyclodextrins |
WO2023225602A1 (fr) * | 2022-05-20 | 2023-11-23 | Medikine, Inc. | Polypeptides de liaison au récepteur de l'interleukine-18 et leurs utilisations |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4446240A (en) * | 1981-01-30 | 1984-05-01 | Nerenberg Samuel T | Pancreas specific protein systems |
US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
US6080540A (en) * | 1990-04-20 | 2000-06-27 | Cold Spring Harbor Laboratory | Cloning of mammalian genes in microbial organisms and methods for pharmacological screening |
WO1992009617A1 (fr) * | 1990-11-26 | 1992-06-11 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Facteurs de transcription d'agression de cellules |
US5721352A (en) * | 1991-02-19 | 1998-02-24 | University Of Florida Research Foundation | Entomopoxvirus expression system |
US5840870A (en) * | 1995-12-29 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Polynucleotides PANC1A and PANC1B associated with pancreatic cancer |
US5912160A (en) * | 1995-08-22 | 1999-06-15 | Thomas Jefferson University | Gab1, Grb2 binding protein, and compositions for making and methods of using the same |
JP3462313B2 (ja) * | 1995-08-24 | 2003-11-05 | キッコーマン株式会社 | 変異型ウリカーゼ、変異型ウリカーゼ遺伝子、新規な組み換え体dna及び変異型ウリカーゼの製造法 |
US5998165A (en) * | 1995-12-29 | 1999-12-07 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a protein associated with pancreatic cancer |
WO1997040855A1 (fr) * | 1996-04-29 | 1997-11-06 | The Johns Hopkins University School Of Medicine | Regulateur de la degradation de l'arn chez les mammiferes induite par des transcrits non-sens |
US6500934B1 (en) * | 1996-07-24 | 2002-12-31 | Michael Rush Lerner | Bivalent agonists for G-protein coupled receptors |
US5976834A (en) * | 1997-01-09 | 1999-11-02 | Smithkline Beecham Corporation | cDNA clone HNFJD15 that encodes a novel human 7-transmembrane receptor |
US5925521A (en) * | 1997-03-31 | 1999-07-20 | Incyte Pharmaceuticals, Inc. | Human serine carboxypeptidase |
CA2232743A1 (fr) * | 1997-04-02 | 1998-10-02 | Smithkline Beecham Corporation | Tl5, homologue tnf |
WO1998045435A2 (fr) * | 1997-04-10 | 1998-10-15 | Genetics Institute, Inc. | MARQUEURS SECRETES DE SEQUENCE EXPRIMEE (sEST) |
IT1291110B1 (it) * | 1997-04-15 | 1998-12-29 | Istituto Europ Di Oncologia S | Interattori intracellulari e specificita' di legame del dominio eh |
US5948641A (en) * | 1997-05-29 | 1999-09-07 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a metal response element binding protein |
AU743490B2 (en) * | 1997-06-06 | 2002-01-24 | Regeneron Pharmaceuticals, Inc. | NTN-2 member of TNF ligand family |
AU9484398A (en) * | 1997-09-17 | 1999-04-05 | Genentech Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
US5932442A (en) * | 1997-09-23 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Human regulatory molecules |
US5972660A (en) * | 1997-10-22 | 1999-10-26 | Incyte Pharmaceuticals, Inc. | Human hydroxypyruvate reductase |
DE19818598A1 (de) * | 1998-04-19 | 1999-10-21 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Pankreasnormalgewebe |
CN1158386C (zh) * | 1998-04-29 | 2004-07-21 | 吉尼西斯研究及发展有限公司 | 从皮肤细胞中分离的多核苷酸及其使用方法 |
US6262249B1 (en) * | 1998-06-23 | 2001-07-17 | Chiron Corporation | Pancreatic cancer genes |
CA2296792A1 (fr) * | 1999-02-26 | 2000-08-26 | Genset S.A. | Sequences marqueurs exprimees et proteines humaines codees |
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2001
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