CA2381425A1 - Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties - Google Patents

Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties Download PDF

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Publication number
CA2381425A1
CA2381425A1 CA002381425A CA2381425A CA2381425A1 CA 2381425 A1 CA2381425 A1 CA 2381425A1 CA 002381425 A CA002381425 A CA 002381425A CA 2381425 A CA2381425 A CA 2381425A CA 2381425 A1 CA2381425 A1 CA 2381425A1
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CA
Canada
Prior art keywords
delivery
compound
conjugate
group
enhancing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002381425A
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English (en)
French (fr)
Inventor
Jonathan B. Rothbard
Paul A. Wender
P. Leo Mcgrane
Lalitha V. S. Sista
Thorsten A. Kirschberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CellGate Inc
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Individual
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Filing date
Publication date
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Publication of CA2381425A1 publication Critical patent/CA2381425A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
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    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
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    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biophysics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Nanotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
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  • Crystallography & Structural Chemistry (AREA)
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  • Rheumatology (AREA)
CA002381425A 1999-08-24 2000-08-24 Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties Abandoned CA2381425A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15051099P 1999-08-24 1999-08-24
US60/150,510 1999-08-24
PCT/US2000/023440 WO2001013957A2 (en) 1999-08-24 2000-08-24 Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties

Publications (1)

Publication Number Publication Date
CA2381425A1 true CA2381425A1 (en) 2001-03-01

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CA002381425A Abandoned CA2381425A1 (en) 1999-08-24 2000-08-24 Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties

Country Status (7)

Country Link
US (2) US6593292B1 (https=)
EP (2) EP1210121A2 (https=)
JP (1) JP2003507438A (https=)
AU (1) AU769315B2 (https=)
CA (1) CA2381425A1 (https=)
MX (1) MXPA02001857A (https=)
WO (1) WO2001013957A2 (https=)

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US7229961B2 (en) 1999-08-24 2007-06-12 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into ocular tissues
CA2381425A1 (en) * 1999-08-24 2001-03-01 Cellgate, Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
US6881825B1 (en) 1999-09-01 2005-04-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Identication of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and virues
US6541508B2 (en) 1999-09-13 2003-04-01 Nobex Corporation Taxane prodrugs
US6380405B1 (en) 1999-09-13 2002-04-30 Nobex Corporation Taxane prodrugs
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