CA2320750C - System and method of aspirating and dispensing reagent - Google Patents

System and method of aspirating and dispensing reagent Download PDF

Info

Publication number
CA2320750C
CA2320750C CA002320750A CA2320750A CA2320750C CA 2320750 C CA2320750 C CA 2320750C CA 002320750 A CA002320750 A CA 002320750A CA 2320750 A CA2320750 A CA 2320750A CA 2320750 C CA2320750 C CA 2320750C
Authority
CA
Canada
Prior art keywords
probe
reagent
vial
hole
vial insert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002320750A
Other languages
English (en)
French (fr)
Other versions
CA2320750A1 (en
Inventor
William Richards
Anthony Ford
Vince Rizzo
Darin Mcdaniel
Kurt Reinhardt
Wayne Showalter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ventana Medical Systems Inc
Original Assignee
Ventana Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Medical Systems Inc filed Critical Ventana Medical Systems Inc
Publication of CA2320750A1 publication Critical patent/CA2320750A1/en
Application granted granted Critical
Publication of CA2320750C publication Critical patent/CA2320750C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002Reagent dispensers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31Apparatus therefor
    • G01N1/312Apparatus therefor for samples mounted on planar substrates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36Embedding or analogous mounting of samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31Apparatus therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Microscoopes, Condenser (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Laminated Bodies (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
CA002320750A 1998-02-27 1999-02-26 System and method of aspirating and dispensing reagent Expired - Lifetime CA2320750C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7619898P 1998-02-27 1998-02-27
US60/076,198 1998-02-27
PCT/US1999/004379 WO1999043434A1 (en) 1998-02-27 1999-02-26 System and method of aspirating and dispensing reagent

Publications (2)

Publication Number Publication Date
CA2320750A1 CA2320750A1 (en) 1999-09-02
CA2320750C true CA2320750C (en) 2004-08-24

Family

ID=22130540

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002320750A Expired - Lifetime CA2320750C (en) 1998-02-27 1999-02-26 System and method of aspirating and dispensing reagent
CA002321836A Expired - Lifetime CA2321836C (en) 1998-02-27 1999-02-26 Automated molecular pathology apparatus having independent slide heaters

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002321836A Expired - Lifetime CA2321836C (en) 1998-02-27 1999-02-26 Automated molecular pathology apparatus having independent slide heaters

Country Status (10)

Country Link
US (1) US6296809B1 (enExample)
EP (3) EP1056541B1 (enExample)
JP (5) JP3847559B2 (enExample)
CN (1) CN100403008C (enExample)
AT (1) ATE489613T1 (enExample)
AU (3) AU763354B2 (enExample)
CA (2) CA2320750C (enExample)
DE (1) DE69942975D1 (enExample)
ES (1) ES2354598T3 (enExample)
WO (2) WO1999043434A1 (enExample)

Families Citing this family (249)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040191128A1 (en) * 1992-05-11 2004-09-30 Cytologix Corporation Slide stainer with heating
US6180061B1 (en) 1992-05-11 2001-01-30 Cytologix Corporation Moving platform slide stainer with heating elements
US6735531B2 (en) 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
JP3750772B2 (ja) * 1998-01-27 2006-03-01 富士写真フイルム株式会社 生化学分析装置
GB9803684D0 (en) * 1998-02-24 1998-04-15 Genevac Ltd Method and apparatus for controlling temperature during evaporation of samples
US7396508B1 (en) 2000-07-12 2008-07-08 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6183693B1 (en) * 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US7188001B2 (en) * 1998-03-23 2007-03-06 Cepheid System and method for temperature control
US6495106B1 (en) * 1998-03-24 2002-12-17 Biogenex Laboratories Automated staining apparatus
US6620620B1 (en) * 1998-04-27 2003-09-16 Era Systems, Inc. Micro liquid evaporator
US7550298B2 (en) * 1998-09-03 2009-06-23 Ventana Medical Systems, Inc. Automated immunohistochemical and in situ hybridization assay formulations
US6855552B2 (en) * 1998-09-03 2005-02-15 Ventana Medical Systems Automated immunohistochemical and in situ hybridization assay formulations
US6649128B1 (en) * 1998-09-23 2003-11-18 Randox Laboratories Ltd Assay device processing instrument
US6544798B1 (en) * 1999-02-26 2003-04-08 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
AU6079500A (en) 1999-07-08 2001-01-30 Lee Angros Antigen recovery and/or staining apparatus and method
US8298485B2 (en) 1999-07-08 2012-10-30 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US7951612B2 (en) * 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US7897106B2 (en) 1999-07-08 2011-03-01 Lee Angros Situ heat induced antigen recovery and staining apparatus and method
JP2003510571A (ja) * 1999-09-24 2003-03-18 ジョナサン コヘン 組織試料中の分子標的の臨床的有用性を評価するための高処理量システム
US6403931B1 (en) 1999-10-07 2002-06-11 Ventana Medical Systems, Inc. Slide heater calibrator and temperature converter apparatus and method
DE10006084B4 (de) * 2000-02-11 2009-01-02 Leica Biosystems Nussloch Gmbh Färbeautomat mit einer Heizstation
US6824738B1 (en) * 2000-04-14 2004-11-30 Discovery Partners International, Inc. System and method for treatment of samples on solid supports
DE10041227B4 (de) * 2000-08-22 2011-12-29 Leica Biosystems Nussloch Gmbh Vorrichtung zur Behandlung von Objekten
US6656685B2 (en) * 2001-01-29 2003-12-02 Ventana Medical Systems, Inc. Hybridization buffers using low molecular weight dextran sulfate and methods for their use
GB0117706D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Automated semi-solid matrix assay and liquid handler apparatus for the same
US7691598B2 (en) * 2001-03-30 2010-04-06 Nanoprobes, Inc. Method for detecting a target molecule by metal deposition
US7888060B2 (en) * 2001-03-30 2011-02-15 Nanoprobes, Inc. Method for detecting a target using enzyme directed deposition of elemental metal
US6662136B2 (en) * 2001-04-10 2003-12-09 International Business Machines Corporation Digital temperature sensor (DTS) system to monitor temperature in a memory subsystem
EP1385999B1 (en) * 2001-04-30 2012-12-12 Ventana Medical Systems, Inc. Reagents and methods for automated in situ or microarray hybridization
US7425306B1 (en) 2001-09-11 2008-09-16 Ventana Medical Systems, Inc. Slide heater
US7270785B1 (en) * 2001-11-02 2007-09-18 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having fixed slide platforms
US6936474B2 (en) * 2001-11-05 2005-08-30 Industrial Technology Research Institute Method and apparatus for manufacturing biochip
AU2002361618A1 (en) * 2001-11-13 2003-05-26 Chromavision Medical Systems, Inc. A system for tracking biological samples
US6998270B2 (en) * 2001-11-26 2006-02-14 Lab Vision Corporation Automated tissue staining system and reagent container
US20040033163A1 (en) * 2001-11-26 2004-02-19 Lab Vision Corporation Automated tissue staining system and reagent container
US6889468B2 (en) * 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US11249095B2 (en) 2002-04-15 2022-02-15 Ventana Medical Systems, Inc. Automated high volume slide processing system
ES2424988T3 (es) * 2002-04-15 2013-10-10 Ventana Medical Systems, Inc. Sistema automatizado de coloración de placas portaobjetos con elevada velocidad de producción
US7468161B2 (en) 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
EP2420814B1 (en) * 2002-04-26 2015-08-26 Ventana Medical Systems, Inc. Automatic slide processing apparatus
US6833536B2 (en) * 2002-05-22 2004-12-21 Applera Corporation Non-contact radiant heating and temperature sensing device for a chemical reaction chamber
WO2003099222A2 (en) * 2002-05-23 2003-12-04 Invitrogen Corporation Pseudo-tissues and uses thereof
AU2003249291A1 (en) * 2002-07-16 2004-02-02 Ventana Medical Systems, Inc. Tray for automated histochemical processing
KR20040023999A (ko) * 2002-09-12 2004-03-20 엘지전자 주식회사 의류건조기의 모터축 구조
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7850912B2 (en) * 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7584019B2 (en) * 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US7875245B2 (en) 2003-05-14 2011-01-25 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US20060073074A1 (en) * 2004-10-06 2006-04-06 Lars Winther Enhanced sample processing system and methods of biological slide processing
JP4637847B2 (ja) * 2003-05-19 2011-02-23 ベンタナ・メデイカル・システムズ・インコーポレーテツド 電気泳動によるそのインサイチューでの組織染色
CA2529016A1 (en) 2003-06-12 2004-12-23 Accupath Diagnostic Laboratories, Inc. Method and system for the analysis of high density cells samples
US7642064B2 (en) 2003-06-24 2010-01-05 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
US7767152B2 (en) 2003-08-11 2010-08-03 Sakura Finetek U.S.A., Inc. Reagent container and slide reaction retaining tray, and method of operation
US9518899B2 (en) 2003-08-11 2016-12-13 Sakura Finetek U.S.A., Inc. Automated reagent dispensing system and method of operation
US7501283B2 (en) 2003-08-11 2009-03-10 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
US7744817B2 (en) 2003-08-11 2010-06-29 Sakura Finetek U.S.A., Inc. Manifold assembly
US7273591B2 (en) * 2003-08-12 2007-09-25 Idexx Laboratories, Inc. Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same
EP1671117A4 (en) * 2003-09-09 2008-02-20 Biogenex Lab SAMPLE PROCESSING SYSTEM
US7588733B2 (en) 2003-12-04 2009-09-15 Idexx Laboratories, Inc. Retaining clip for reagent test slides
US8012693B2 (en) * 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US8026106B1 (en) 2003-12-18 2011-09-27 Ventana Medical Systems, Inc. Removal of mercuric chloride crystals from fixed tissues
CA2551305C (en) 2003-12-23 2013-08-13 Ventana Medical Systems, Inc. Method and apparatus for efficient thin film fluid processing of flat surfaces
AU2005218498A1 (en) * 2004-03-02 2005-09-15 Dako Denmark A/S Reagent delivery system, dispensing device and container for a biological staining apparatus
RU2007101705A (ru) 2004-06-18 2008-07-27 Биолипокс Аб (Se) Индолы, полезные для лечения воспаления
AU2005259981B2 (en) * 2004-06-29 2012-01-12 Dako Denmark A/S Method of pre-treatment and staining of and support device for a biological sample
WO2006012498A1 (en) * 2004-07-23 2006-02-02 Ventana Medical Systems, Inc. Method and apparatus for applying fluids to a biological sample
US7867443B2 (en) 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US7514041B2 (en) * 2004-07-28 2009-04-07 N-Solv Corporation Method and apparatus for testing heavy oil production processes
ZA200705827B (en) 2005-01-19 2008-10-29 Biolipox Ab Indoles useful in the treatment of inflammation
GB0501590D0 (en) * 2005-01-25 2005-03-02 Ceres Power Ltd Processing of enhanced performance LSCF fuel cell cathode microstructure and a fuel cell cathode
WO2006116037A2 (en) * 2005-04-21 2006-11-02 Celerus Diagnostics, Inc. Enhanced fluidic method and apparatus for automated rapid immunohistochemistry
DE102005020426B4 (de) * 2005-04-29 2017-05-04 Leica Biosystems Nussloch Gmbh Eindeckautomat
US8377377B2 (en) 2005-05-24 2013-02-19 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
JP5335420B2 (ja) * 2005-05-24 2013-11-06 リー エイチ. アングロス, insitu熱誘導抗原回復・着色装置および方法
CN100406874C (zh) * 2005-06-20 2008-07-30 北京源德生物医学工程有限公司 半自动微孔板单光子计数仪的门组件
CN101365830B (zh) * 2005-06-28 2013-06-12 俄克拉荷马州大学评议会 生长和收获碳纳米管的方法
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
GB0521851D0 (en) * 2005-10-26 2005-12-07 Genial Genetic Solutions Ltd Biological apparatus
US9551635B2 (en) * 2006-03-09 2017-01-24 Biogenex Laboratories Inc. Sample processing system
US8459509B2 (en) 2006-05-25 2013-06-11 Sakura Finetek U.S.A., Inc. Fluid dispensing apparatus
CA2549614C (en) * 2006-06-07 2014-11-25 N-Solv Corporation Methods and apparatuses for sagd hydrocarbon production
CA2552482C (en) * 2006-07-19 2015-02-24 N-Solv Corporation Methods and apparatuses for enhanced in situ hydrocarbon production
EP2069800B1 (en) * 2006-09-22 2012-03-28 Fujifilm Corporation Clinical analysis apparatus
EP3029461B1 (en) 2006-11-01 2017-12-20 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
WO2008140742A1 (en) 2007-05-08 2008-11-20 Idexx Laboratories, Inc. Chemical analyzer
JP2010528285A (ja) 2007-05-23 2010-08-19 ベンタナ・メデイカル・システムズ・インコーポレーテツド 免疫組織化学およびinsituハイブリダーゼーションのためのポリマー担体
EP2362228B1 (en) * 2007-07-10 2013-09-18 Ventana Medical Systems, Inc. Apparatus and method for biological sample processing
US8440425B2 (en) * 2007-12-18 2013-05-14 Abbott Laboratories Method of preparing a biological specimen slide
WO2009106081A1 (en) 2008-02-29 2009-09-03 Dako Denmark A/S Systems and methods for tracking and providing workflow information
US9802022B2 (en) * 2008-03-06 2017-10-31 Resmed Limited Humidification of respiratory gases
DK2300799T3 (en) 2008-06-05 2015-12-14 Ventana Med Syst Inc Process for the histo chemical processing and use of a composition for histo chemical processing
CA2734783C (en) 2008-08-22 2016-04-19 Ventana Medical Systems, Inc. Method for chromogenic detection of two or more target molecules in a single sample
US8501115B2 (en) * 2008-10-24 2013-08-06 Statspin, Inc. Modular system for performing laboratory protocols and associated methods
EP2356423B1 (en) 2008-11-12 2024-08-07 Ventana Medical Systems, Inc. Methods and apparatuses for heating slides carrying specimens
WO2010138908A1 (en) 2009-05-29 2010-12-02 Ventana Medical Systems, Inc. Igfir gene copy number as a prognostic marker in a non-small cell lung cancer
WO2010138912A1 (en) 2009-05-29 2010-12-02 Ventana Medical Systems, Inc. Methods of scoring gene copy number in a biological sample using in situ hybridization
DE102010010975B4 (de) 2009-09-14 2012-05-31 Dcs Innovative Diagnostik-Systeme Dr. Christian Sartori Gmbh & Co. Kg Objektträgerhalter
EP2499500B1 (en) * 2009-11-13 2020-12-30 Ventana Medical Systems, Inc. Thin film processing apparatuses for adjustable volume accommodation
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
US9498791B2 (en) 2009-11-13 2016-11-22 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
ES2549170T3 (es) 2010-02-05 2015-10-23 Nichirei Biosciences Inc. Solución de pretratamiento para la tinción inmunohistoquímica y solución condensada de la misma
EP2539466A4 (en) 2010-02-26 2013-08-07 Ventana Med Syst Inc CYTOGEN ANALYSIS OF CHROMOSOMES IN METAPHASE
CA2787487C (en) 2010-02-26 2018-07-24 Ventana Medical Systems, Inc. Polytag probes
US10126216B2 (en) 2011-02-17 2018-11-13 Ventana Medical Systems, Inc. Method for tissue sample fixation
US10539487B2 (en) 2010-03-04 2020-01-21 Ventana Medical Systems, Inc. Systems and methods for monitoring tissue sample processing
WO2011109769A1 (en) 2010-03-04 2011-09-09 Ventana Medical Systems, Inc. Processing system for processing specimens using acoustic energy
EP2564203B1 (en) 2010-04-27 2017-06-07 Ventana Medical Systems, Inc. Antibody-nanoparticle conjugates and methods for making and using such conjugates
US10697990B2 (en) 2010-04-29 2020-06-30 Leica Biosystems Richmond, Inc. Analytical system for performing laboratory protocols and associated methods
WO2011149943A1 (en) 2010-05-24 2011-12-01 Ventana Midical Systems, Inc. Method for differentiation of non-small cellung carcinoma
CN104345165B (zh) * 2010-07-23 2016-09-14 贝克曼考尔特公司 包含分析单元的系统和方法
JP5393610B2 (ja) * 2010-07-28 2014-01-22 株式会社日立ハイテクノロジーズ 核酸分析装置
CA2851101C (en) 2010-10-06 2017-02-14 Biocare Medical, Llc Methods and systems for efficient processing of biological samples
JP5815046B2 (ja) 2010-12-30 2015-11-17 ヴェンタナ メディカル システムズ, インク. ピリミジンアナログを用いた色素原の沈着増強
JP2014505248A (ja) 2011-01-10 2014-02-27 ヴェンタナ メディカル システムズ, インク. ヘマトキシリン染色法
US8752732B2 (en) 2011-02-01 2014-06-17 Sakura Finetek U.S.A., Inc. Fluid dispensing system
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples
EP2686662B1 (en) 2011-02-28 2022-01-19 Agilent Technologies, Inc. Two phase immiscible system for the pretreatment of embedded biological samples
CN103534359B (zh) 2011-03-14 2016-07-06 文塔纳医疗系统公司 分析染色体易位的方法及其系统
KR20140022399A (ko) 2011-05-18 2014-02-24 쓰리엠 이노베이티브 프로퍼티즈 컴파니 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법
EP2709760B1 (en) 2011-05-18 2019-06-05 DiaSorin S.p.A. Systems and methods for valving on a sample processing device
AU2012255151B2 (en) 2011-05-18 2015-09-03 Diasorin Italia S.P.A. Systems and methods for detecting the presence of a selected volume of material in a sample processing device
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
US8580568B2 (en) 2011-09-21 2013-11-12 Sakura Finetek U.S.A., Inc. Traceability for automated staining system
US8932543B2 (en) 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
WO2013079606A1 (en) 2011-12-01 2013-06-06 Ventana Medical Systems, Inc. Automated dual stain of mirna and protein targets
EP2798355B1 (en) 2011-12-30 2018-09-12 Ventana Medical Systems, Inc. Automated analysis of circulating tumor cells
EP2807490B1 (en) 2012-01-26 2017-09-13 Leica Biosystems Richmond, Inc. Method for hematoxylin and eosin staining
US20130196880A1 (en) 2012-01-27 2013-08-01 Ventana Medical Systems, Inc. Patterned devices and methods for detecting analytes
EP2810213B1 (en) 2012-02-01 2020-01-22 Ventana Medical Systems, Inc. System for detecting genes in tissue samples
WO2013134583A1 (en) 2012-03-09 2013-09-12 Statspin, Inc. Device and method for controlling the temperature in a moving fluid in a laboratory sample processing system
AU2013234664B2 (en) 2012-03-19 2017-01-19 Ventana Medical Systems, Inc. Gram staining method with improved decolorization of the crystal violet-iodine complex from Gram negative bacteria
JP6197030B2 (ja) * 2012-04-27 2017-09-13 セフェィド 異種の処理モジュールを有する装置
ES2969390T3 (es) 2012-10-08 2024-05-17 Ventana Med Syst Inc Procedimientos y kits para clarificar muestras pigmentadas
CN104769410B (zh) 2012-11-06 2018-07-27 拜奥-多特公司 用于核型分析的细胞样本的受控印刷
WO2014079802A2 (en) 2012-11-20 2014-05-30 Ventana Medical Systems, Inc. Laser ablation inductively-coupled plasma mass spectral tissue diagnostics
EP2925450B1 (en) 2012-12-03 2017-09-13 Leica Biosystems Melbourne Pty Ltd Thermal module for a sample processing assembly
US9989448B2 (en) 2012-12-26 2018-06-05 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
CN104870972A (zh) * 2012-12-26 2015-08-26 文塔纳医疗系统公司 自动化标本处理系统和使用该系统的方法
CA2890956A1 (en) * 2012-12-26 2014-07-03 Ventana Medical Systems, Inc. Specimen processing systems and method for uniformly heating slides
US11274998B2 (en) 2012-12-26 2022-03-15 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
CN103149070B (zh) * 2013-03-11 2014-10-08 黄石市第一医院 一种自动染片机
USD728120S1 (en) 2013-03-15 2015-04-28 Ventana Medical Systems, Inc. Arcuate member for moving liquids along a microscope slide
US10429279B2 (en) 2013-07-28 2019-10-01 Xmd, Llc Devices and cartridges for extracting bio-sample regions and molecules of interest
ES2927378T3 (es) 2013-12-13 2022-11-04 Ventana Med Syst Inc Aparato de procesamiento de portaobjetos automatizado
JP6302066B2 (ja) 2013-12-13 2018-03-28 ベンタナ メディカル システムズ, インコーポレイテッド 顕微鏡スライドを熱処理する自動化された処理システムおよび方法
EP3080580B1 (en) 2013-12-13 2021-05-05 Ventana Medical Systems, Inc. Staining reagents and other liquids for histological processing of biological specimens and associated technology
AU2014363718B2 (en) 2013-12-13 2017-02-23 Ventana Medical Systems, Inc. Thermal management in the context of automated histological processing of biological specimens and associated technology
US9797916B2 (en) 2014-01-10 2017-10-24 Idexx Laboratories, Inc. Chemical analyzer
WO2015124703A1 (en) 2014-02-24 2015-08-27 Ventana Medical Systems, Inc. Quinone methide analog signal amplification
CA2940118C (en) 2014-02-24 2023-05-23 Ventana Medical Systems, Inc. Automated rna detection using labeled 2'-o-methyl rna oligonucleotide probes and signal amplification systems
JP6626097B2 (ja) 2014-06-06 2019-12-25 ヴェンタナ メディカル システムズ, インク. 乳がんにおける腫瘍内her2不均質性の意義及びそのための使用
EP3160648B1 (en) * 2014-06-30 2024-04-03 Ventana Medical Systems, Inc. Specimen processing systems, pipette assemblies and methods for preparing reagents
CA2957783C (en) 2014-10-02 2023-02-28 Ventana Medical Systems, Inc. Polymers and conjugates comprising the same
EP3241180B1 (en) 2014-12-30 2021-06-30 Ventana Medical Systems, Inc. Systems and methods for co-expression analysis in immunoscore computation
WO2016120195A1 (en) 2015-01-27 2016-08-04 Ventana Medical Systems, Inc. Methods for tissue sample fixation using an extended soak in aldehyde-based fixative solutions
EP3251087B1 (en) 2015-01-29 2018-11-28 Ventana Medical Systems, Inc. Dot detection, color classification of dots and counting of color classified dots
WO2016120442A1 (en) 2015-01-30 2016-08-04 Ventana Medical Systems, Inc. Foreground segmentation and nucleus ranking for scoring dual ish images
WO2016120441A2 (en) 2015-01-30 2016-08-04 Ventana Medical Systems, Inc. Quality metrics for automatic evaluation of dual ish images
WO2016146616A1 (en) 2015-03-16 2016-09-22 Ventana Medical Systems, Inc. Control slides for immunohistochemistry generated from three-dimensional cell line cultures
WO2016166073A1 (en) * 2015-04-13 2016-10-20 Ventana Medical Systems, Inc. Thermochemical-based antibody inactivation methods and systems
AU2016261279B2 (en) 2015-05-10 2020-12-10 Ventana Medical Systems, Inc. Compositions and methods for simultaneous inactivation of alkaline phosphatase and peroxidase enzymes during automated multiplex tissue staining assays
WO2016189065A1 (en) 2015-05-26 2016-12-01 Ventana Medical Systems, Inc. Method and system for assessing stain quality for in-situ hybridization and immunohistochemistry
WO2017040349A1 (en) 2015-08-28 2017-03-09 Ventana Medical Systems, Inc. Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
CN105400693B (zh) * 2015-12-15 2017-06-06 上海海洋大学 平板等温核酸扩增芯片
CN105400692B (zh) * 2015-12-15 2017-06-27 上海海洋大学 等温核酸扩增装置及等温核酸扩增实验方法
JP6876062B2 (ja) 2016-01-26 2021-05-26 ヴェンタナ メディカル システムズ, インク. 自動ダイセクション、次世代シークエンシング、及び自動スライド染色装置を用いる、腫瘍のための予測診断ワークフロー
CA3016555A1 (en) 2016-03-08 2017-09-14 Ventana Medical Systems, Inc. Multiplexed immunohistochemistry using recombinant antibodies with epitope tags
US11460383B2 (en) 2016-06-16 2022-10-04 Nanocytomics, LLC Automated staining system
WO2018002016A1 (en) 2016-06-28 2018-01-04 Ventana Medical Systems, Inc. Application of click chemistry for signal amplification in ihc and ish assays
EP4220163A3 (en) 2016-06-28 2024-03-27 Ventana Medical Systems, Inc. New colors for chromogenic ihc and ish staining with multi-dye quinone methide and tyramide conjugates
WO2018044280A1 (en) * 2016-08-30 2018-03-08 Qdaisat Sadeem Z S Automated slide dropping system
JP2019533149A (ja) 2016-09-23 2019-11-14 ヴェンタナ メディカル システムズ, インク. 腫瘍試料中の細胞外マトリックスバイオマーカーをスコアリングするための方法及びシステム
CN106370830A (zh) * 2016-11-14 2017-02-01 漯河医学高等专科学校 一种具有单独滑片加热器的分子病理学装置
EP3555634B1 (en) 2016-12-16 2023-09-06 Ventana Medical Systems, Inc. Dispenser nozzle residue mitigation
CN110291378B (zh) 2016-12-19 2022-03-25 文塔纳医疗系统公司 用于处理诊断系统中的流出物的被动式重力驱动系统
WO2018118786A1 (en) 2016-12-19 2018-06-28 Ventana Medical Systems, Inc. Methods and systems for quantitative immunohistochemistry
CN110121364A (zh) 2016-12-19 2019-08-13 文塔纳医疗系统公司 肽核酸缀合物
CN110073222A (zh) 2016-12-21 2019-07-30 文塔纳医疗系统公司 用于试剂递送的方法、系统和固体组合物
EP4567728A1 (en) 2016-12-22 2025-06-11 Ventana Medical Systems, Inc. Computer scoring based on primary stain and immunohistochemistry images
CN110050070B (zh) 2016-12-22 2023-12-22 文塔纳医疗系统公司 用于组织样品的全自动化核酸提取方法
WO2018134722A1 (en) * 2017-01-19 2018-07-26 Agilent Technologies, Inc. Multi-temperature optical spectrometer modules, systems and methods of using the same
CN110383035B (zh) * 2017-03-16 2024-04-02 美国西门子医学诊断股份有限公司 用于诊断分析仪中的培育系统的热控制的系统和方法
CN110494891B (zh) 2017-04-14 2023-11-28 文塔纳医疗系统公司 用于拼接的基于分块的局部配准以及全局放置
EP3622266B1 (en) 2017-05-10 2022-08-17 Ventana Medical Systems, Inc. Stabilized two-part hematoxylin solution utilizing ph adjustment, method for staining and kit
JP7100670B2 (ja) 2017-05-26 2022-07-13 ベンタナ メディカル システムズ, インコーポレイテッド 非接触のスライド上流体混合
EP4488657A1 (en) 2017-06-28 2025-01-08 Ventana Medical Systems, Inc. System level calibration
EP3659110A1 (en) 2017-07-24 2020-06-03 Ventana Medical Systems, Inc. Methods and systems for evaluation of immune cell infiltrate in tumor samples
WO2019025533A1 (en) 2017-08-04 2019-02-07 Ventana Medical Systems, Inc. AUTOMATIC ASSAY ASSESSMENT AND NORMALIZATION FOR IMAGE PROCESSING
CN111602172B (zh) 2017-08-04 2023-09-26 文塔纳医疗系统公司 利用散射校正进行颜色解混
CN111356912B (zh) 2017-11-21 2023-09-05 文塔纳医疗系统公司 使用调制气体射流的非接触式混合
EP3721406B1 (en) 2017-12-05 2024-01-24 Ventana Medical Systems, Inc. Method of computing tumor spatial and inter-marker heterogeneity
JP7197584B2 (ja) 2017-12-06 2022-12-27 ベンタナ メディカル システムズ, インコーポレイテッド デジタル病理学分析結果の格納および読み出し方法
WO2019110583A1 (en) 2017-12-07 2019-06-13 Ventana Medical Systems, Inc. Deep-learning systems and methods for joint cell and region classification in biological images
WO2019120635A1 (en) 2017-12-18 2019-06-27 Ventana Medical Systems, Inc. Peptide nucleic acid conjugates
WO2019122062A1 (en) 2017-12-24 2019-06-27 Ventana Medical Systems, Inc. Phenol-free acid-fast staining composition and use thereof
WO2019121564A2 (en) 2017-12-24 2019-06-27 Ventana Medical Systems, Inc. Computational pathology approach for retrospective analysis of tissue-based companion diagnostic driven clinical trial studies
EP3729047A2 (en) 2017-12-24 2020-10-28 Ventana Medical Systems, Inc. Eosin staining techniques
EP3738067A1 (en) 2018-01-11 2020-11-18 Ventana Medical Systems, Inc. Anti-fogging barcode reader
WO2019149817A1 (en) 2018-01-31 2019-08-08 Ventana Medical Systems, Inc. Methods and systems for evaluation of immune cell infiltrate in stage iii colorectal cancer
EP3776337B1 (en) 2018-04-13 2024-09-11 Ventana Medical Systems, Inc. Systems for cell shape estimation
WO2019219651A1 (en) 2018-05-15 2019-11-21 Ventana Medical Systems, Inc. Quantitation of signal in stain aggregates
EP3797296B1 (en) 2018-05-21 2024-09-04 Genentech, Inc. Her2 heterogeneity as a biomarker in cancer
EP3824288A1 (en) 2018-07-17 2021-05-26 Ventana Medical Systems, Inc. Materials and methods for detecting fusion proteins
CN112534439A (zh) 2018-07-27 2021-03-19 文塔纳医疗系统公司 用于自动化原位杂交分析的系统
CN112839710B (zh) 2018-08-09 2024-09-17 霍夫曼-拉罗奇有限公司 帕金森氏病的确定
CN112673258B (zh) 2018-09-13 2025-07-25 文塔纳医疗系统公司 用于检测ntrk融合蛋白的组织化学和细胞化学方法
EP3853214A1 (en) 2018-09-20 2021-07-28 Ventana Medical Systems, Inc. Coumarin-based crosslinking reagents
WO2020072348A1 (en) 2018-10-01 2020-04-09 Ventana Medical Systems, Inc. Methods and systems for predicting response to pd-1 axis directed therapeutics
JP7228031B2 (ja) 2018-10-15 2023-02-22 ベンタナ メディカル システムズ, インコーポレイテッド 細胞の分類のためのシステムおよび方法
WO2020081340A1 (en) 2018-10-15 2020-04-23 Ventana Medical Systems, Inc. Image enhancement to enable improved nuclei detection and segmentation
CN113348356A (zh) 2018-11-20 2021-09-03 文塔纳医疗系统公司 用于针对形态学特征和生物标志物表达而制备和分析细胞样品的方法和系统
EP3921648A1 (en) 2019-02-05 2021-12-15 Ventana Medical Systems, Inc. Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer
WO2020229578A1 (en) 2019-05-14 2020-11-19 Ventana Medical Systems, Inc. System including a biological sample treatment chamber
CN114341989A (zh) 2019-08-28 2022-04-12 文塔纳医疗系统公司 使用振动光谱法评估样本固定持续时间和质量的系统和方法
WO2021037869A1 (en) 2019-08-28 2021-03-04 Ventana Medical Systems, Inc. Assessing antigen retrieval and target retrieval progression quantitation with vibrational spectroscopy
EP4110823A1 (en) 2020-02-26 2023-01-04 A2 Biotherapeutics, Inc. Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof
US20250130143A1 (en) * 2020-03-11 2025-04-24 Jin V. WU Devices and components for automated tissue processing and staining and uses thereof
CN114207403B (zh) * 2020-03-11 2022-11-22 贵州美鑫达医疗科技有限公司 用于自动组织处理和染色的装置和组件及其使用
CN115244404B (zh) * 2020-03-17 2025-12-09 株式会社日立高新技术 自动分析装置
WO2021224293A1 (en) 2020-05-07 2021-11-11 Ventana Medical Systems, Inc. Histochemical systems and methods for evaluating egfr and egfr ligand expression in tumor samples
EP4147024A2 (en) 2020-05-08 2023-03-15 Ventana Medical Systems, Inc. Semi-synthesis and use of racemic hematoxylin
US20230221316A1 (en) 2020-05-20 2023-07-13 Roche Diagnostics Operations, Inc. Use of automated platforms for preparation of biomarker and romanowsky-type stained sample printed on a slide
ES3009236T3 (en) * 2020-05-27 2025-03-26 Agilent Technologies Inc Apparatus and method for processing biological samples
CN113804902B (zh) * 2020-06-16 2025-09-09 深圳迈瑞生物医疗电子股份有限公司 样本分析仪故障自诊断的方法及样本分析仪
WO2022011265A2 (en) 2020-07-10 2022-01-13 Idexx Laboratories Inc. Point-of-care medical diagnostic analyzer and devices, systems, and methods for medical diagnostic analysis of samples
CN116710131A (zh) 2020-09-22 2023-09-05 文塔纳医疗系统公司 使用表皮调节素和双调蛋白来预测对表皮生长因子受体定向疗法的反应
CN112799444A (zh) * 2020-12-27 2021-05-14 北京工业大学 一种基于51单片机的血液寄生虫检测温控加热仪
JP2024504944A (ja) 2021-01-15 2024-02-02 ヴェンタナ メディカル システムズ, インク. 保存安定なケージドハプテン
EP4281779A1 (en) 2021-01-25 2023-11-29 Ventana Medical Systems, Inc. Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties
WO2022223137A1 (en) 2021-04-18 2022-10-27 Ventana Medical Systems, Inc. Morphological marker staining
KR102736858B1 (ko) * 2021-12-16 2024-12-04 (주)레보스케치 회전형 다채널 형광스캐너
WO2023147252A1 (en) 2022-01-25 2023-08-03 Ventana Medical Systems, Inc. Materials and methods for bleaching melanin-pigmented tissues
EP4500183A1 (en) 2022-03-31 2025-02-05 Ventana Medical Systems, Inc. Methods and systems for predicting response to pd-1 axis directed therapeutics in colorectal tumors with deficient mismatch repair
DE102022111890B3 (de) * 2022-05-12 2023-03-16 Dermagnostix GmbH Verfahren zur Deparaffinierung von Formalin-fixiertem Paraffin-eingebettetem Gewebe
JP2025519560A (ja) 2022-06-09 2025-06-26 ベンタナ メディカル システムズ, インコーポレイテッド シッフ試薬のオンスライド合成
WO2024135135A1 (ja) 2022-12-23 2024-06-27 株式会社日立ハイテク スライドガラス冷却・加熱装置およびスライドガラスの冷却・加熱方法
EP4639170A1 (en) 2022-12-23 2025-10-29 Ventana Medical Systems, Inc. Materials and methods for evaluation of antigen presentation machinery components and uses thereof
WO2025014787A1 (en) 2023-07-07 2025-01-16 Ventana Medical Systems, Inc. Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells
WO2025038339A1 (en) 2023-08-16 2025-02-20 Ventana Medical Systems, Inc. Deep learning model to determine a fixation status of a morphologically stained biological specimen
WO2025166108A1 (en) 2024-02-01 2025-08-07 Ventana Medical Systems, Inc. Methods of generating digitally stained images from unstained biological samples
CN119223966B (zh) * 2024-12-02 2025-02-25 星纯(常州)生物科技有限公司 一种无醇磁珠法病毒提取残留检测装置

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE373963B (enExample) 1973-06-14 1975-02-17 Janson Sven Olof
GB1445389A (en) * 1973-10-16 1976-08-11 Chemlab Mfg Ltd Sampling arrangements
US3853092A (en) 1973-10-25 1974-12-10 Corning Glass Works Apparatus for nutating and staining a microscope slide
US4043292A (en) * 1975-07-21 1977-08-23 Corning Glass Works Microscope slide staining apparatus having temperature control
US4092952A (en) 1977-08-19 1978-06-06 Wilkie Ronald N Automatic slide stainer
SE7801564L (sv) 1978-02-10 1979-08-11 Lkb Produkter Ab Anordning for infergning av biologiska preparat
DE2915248C3 (de) 1979-04-14 1982-01-14 Gise, Frhr. von, Hardo, Dr.med., 7400 Tübingen Einrichtung zum automatischen wahlweisen u. exakten Behandeln von Präparaten
AT364439B (de) * 1980-02-12 1981-10-27 List Hans Einrichtung zur anordnung an einer probeneingabeoeffnung eines analysengeraetes
US4647431A (en) 1980-05-31 1987-03-03 Fuji Photo Film Co., Ltd. Device for maintaining a constant temperature for chemical analysis
US4384193A (en) * 1981-06-09 1983-05-17 Immulok, Inc. Incubating device for specimen mounted on glass slides in immunoassays
US4430299A (en) 1981-06-18 1984-02-07 Coulter Electronics, Inc. Apparatus for monitoring chemical reactions
DK536881A (da) * 1981-12-04 1983-06-05 Radiometer As Proevebaeger
SE451164B (sv) * 1982-03-22 1987-09-07 Erik Ohlin Apparat och sett for serieutspedning av en provvetska
AT381794B (de) * 1984-02-02 1986-11-25 Avl Verbrennungskraft Messtech Analysengeraet zur messung fluessiger oder gasfoermiger proben
US4629862A (en) 1984-03-28 1986-12-16 Olympus Optical Company Ltd. Sample heater for use in microscopes
US4644807A (en) * 1985-02-21 1987-02-24 Dionex Corporation Fluid sample delivery apparatus
US4731335A (en) 1985-09-13 1988-03-15 Fisher Scientific Company Method for treating thin samples on a surface employing capillary flow
JPH0640054B2 (ja) * 1985-09-20 1994-05-25 株式会社千代田製作所 電子顕微鏡標本作成用包埋装置
US4695430A (en) 1985-10-31 1987-09-22 Bio/Data Corporation Analytical apparatus
US4858155A (en) 1985-12-24 1989-08-15 Beckman Instruments, Inc. Reaction temperature control system
US4933146A (en) 1986-07-11 1990-06-12 Beckman Instruments, Inc. Temperature control apparatus for automated clinical analyzer
EP0253519B1 (en) * 1986-07-11 1991-10-09 Beckman Instruments, Inc. Sample handling system
US4888998A (en) * 1986-07-11 1989-12-26 Beckman Instruments, Inc. Sample handling system
US5154889A (en) 1986-08-07 1992-10-13 Fuji Photo Film Co., Ltd. Chemical analysis apparatus
US4721680A (en) * 1986-08-11 1988-01-26 Multi-Technology, Inc. Methods of using micro pipette tips
FR2606885B1 (fr) * 1986-11-14 1989-08-04 Abx Sarl Dispositif de nettoyage d'une aiguille de prelevement d'un liquide
US4847208A (en) 1987-07-29 1989-07-11 Bogen Steven A Apparatus for immunohistochemical staining and method of rinsing a plurality of slides
GB8722902D0 (en) 1987-09-30 1987-11-04 Shandon Southern Prod Tissue &c processing
US4927765A (en) * 1988-02-29 1990-05-22 Pharmacia Eni Diagnostics, Inc. Automatic reagent dispenser
FI80147C (fi) * 1988-04-15 1990-04-10 Kone Oy Foerfarande foer foerverkligande av val av vaetska vid vaetskedosering i en analysator samt provtagningsanordning.
US5597733A (en) * 1988-07-25 1997-01-28 Precision Systems, Inc. Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer
JPH0718785B2 (ja) * 1988-09-19 1995-03-06 株式会社日立製作所 フローセル装置
US4865986A (en) 1988-10-06 1989-09-12 Coy Corporation Temperature control apparatus
US4962041A (en) * 1988-10-06 1990-10-09 Medical Automation Specialities, Inc. Method and apparatus for automatic processing and analyzing of blood serum
FR2641436A1 (enExample) 1988-12-30 1990-07-06 Labo Electronique Physique
US5429803A (en) * 1991-04-18 1995-07-04 Lamina, Inc. Liquid specimen container and attachable testing modules
US5264182A (en) * 1989-04-12 1993-11-23 Olympus Optical Co., Ltd. Sample and reagent delivery device with a probe and probe supporting member for preventing contamination
US5093557A (en) 1989-05-16 1992-03-03 Microscience, Inc. Substrate heater and heating element
CA2017111C (en) * 1989-06-01 1995-10-31 Andreas Greter Pipetting insert
FR2649018B1 (fr) * 1989-06-30 1991-09-13 Degremont Dispositif pour l'introduction d'un liquide dans un milieu constitue par un materiau granulaire, en vue de la fluidisation de ce materiau
GB8919145D0 (en) 1989-08-23 1989-10-04 Royal Postgrad Med School Apparatus for the in situ hybridisation of slide-mounted cell samples
US5089229A (en) 1989-11-22 1992-02-18 Vettest S.A. Chemical analyzer
US4989623A (en) * 1989-12-01 1991-02-05 Akzo N.V. Apparatus and method for cleaning reagent delivery probes
CA2035067C (en) * 1990-02-22 1995-06-27 William M. Blough, Jr. Fluid mixing device
AU7454691A (en) 1990-03-02 1991-09-18 Tekmar Company Analyzer transport device
US5595707A (en) 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
US5207987A (en) 1990-05-21 1993-05-04 Pb Diagnostic Systems Inc. Temperature controlled chamber for diagnostic analyzer
US5075079A (en) * 1990-05-21 1991-12-24 Technicon Instruments Corporation Slide analysis system
US5425918A (en) 1990-07-18 1995-06-20 Australian Biomedical Corporation Apparatus for automatic tissue staining for immunohistochemistry
JP2530738Y2 (ja) * 1990-11-13 1997-03-26 株式会社明電舎 ノズル洗浄ポート
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5280156A (en) 1990-12-25 1994-01-18 Ngk Insulators, Ltd. Wafer heating apparatus and with ceramic substrate and dielectric layer having electrostatic chucking means
US5273905A (en) * 1991-02-22 1993-12-28 Amoco Corporation Processing of slide mounted material
US5246665A (en) 1991-06-03 1993-09-21 Abbott Laboratories Heat and air flow control for assay carrier
CA2218875C (en) * 1991-07-23 2000-11-07 The Research Foundation Of State University Of New York Improvements in the in situ pcr
GB9123463D0 (en) 1991-11-05 1991-12-18 Hybaid Ltd Reaction temperature control device
FI915731A0 (fi) 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
FR2688313A1 (fr) * 1992-03-04 1993-09-10 Marteau D Autry Eric Filtration et identification automatique d'echantillons.
US5645114A (en) * 1992-05-11 1997-07-08 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5947167A (en) * 1992-05-11 1999-09-07 Cytologix Corporation Dispensing assembly with interchangeable cartridge pumps
US5316452A (en) 1992-05-11 1994-05-31 Gilbert Corporation Dispensing assembly with interchangeable cartridge pumps
US5314825A (en) * 1992-07-16 1994-05-24 Schiapparelli Biosystems, Inc. Chemical analyzer
US5601141A (en) 1992-10-13 1997-02-11 Intelligent Automation Systems, Inc. High throughput thermal cycler
US5408891A (en) * 1992-12-17 1995-04-25 Beckman Instruments, Inc. Fluid probe washing apparatus and method
US5364790A (en) * 1993-02-16 1994-11-15 The Perkin-Elmer Corporation In situ PCR amplification system
JP3323294B2 (ja) * 1993-09-14 2002-09-09 富士写真フイルム株式会社 点着チップおよびこの点着チップを用いた液体濃縮防止方法
US5439649A (en) * 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
JP3051626B2 (ja) 1993-12-09 2000-06-12 富士写真フイルム株式会社 インキュベータ
US5523056A (en) 1994-04-29 1996-06-04 Johnson & Johnson Clinical Diagnostics, Inc. Twin rotor incubator assembly
JP3387649B2 (ja) * 1994-09-16 2003-03-17 富士写真フイルム株式会社 点着チップ
EP0843169B1 (de) * 1995-02-25 2003-03-19 Roche Diagnostics GmbH Vorrichtung zur Bearbeitung von Proben auf Objekträgern
US5645144A (en) * 1995-08-22 1997-07-08 A-Dec, Inc. Control mechanism for sliding panel
ES2245462T3 (es) * 1996-04-26 2006-01-01 Dade Behring Inc. Procedimiento y aparato para retratar muestras en un analizador quimico automatico.
US6183693B1 (en) 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
US6096271A (en) * 1998-02-27 2000-08-01 Cytologix Corporation Random access slide stainer with liquid waste segregation
EP1579527B1 (en) * 2002-12-09 2012-04-25 Corridor Systems, Inc. Method and apparatus for launching a surface wave onto a single conductor transmission line
US20100128351A1 (en) * 2008-11-21 2010-05-27 3M Innovative Properties Company Curved sided cone structures for controlling gain and viewing angle in an optical film

Also Published As

Publication number Publication date
AU763354B2 (en) 2003-07-17
JP2002505089A (ja) 2002-02-19
CA2321836A1 (en) 1999-09-02
CN100403008C (zh) 2008-07-16
JP4505538B2 (ja) 2010-07-21
US6296809B1 (en) 2001-10-02
EP1073892B1 (en) 2010-11-24
DE69942975D1 (de) 2011-01-05
AU2879699A (en) 1999-09-15
AU2003255169A1 (en) 2003-11-13
EP1056541A1 (en) 2000-12-06
JP4505547B2 (ja) 2010-07-21
CA2321836C (en) 2004-09-28
EP1073892A4 (en) 2005-10-12
JP2002504694A (ja) 2002-02-12
JP2009216714A (ja) 2009-09-24
EP1073892A1 (en) 2001-02-07
ES2354598T3 (es) 2011-03-16
CA2320750A1 (en) 1999-09-02
EP1056541A4 (en) 2005-11-30
WO1999044030A9 (en) 1999-12-16
JP2006304806A (ja) 2006-11-09
EP2284543A3 (en) 2015-05-27
EP2284543A2 (en) 2011-02-16
JP3847559B2 (ja) 2006-11-22
EP1056541B1 (en) 2017-10-25
CN1297529A (zh) 2001-05-30
WO1999043434A1 (en) 1999-09-02
JP2010091579A (ja) 2010-04-22
WO1999044030A1 (en) 1999-09-02
AU2883499A (en) 1999-09-15
JP4091960B2 (ja) 2008-05-28
ATE489613T1 (de) 2010-12-15

Similar Documents

Publication Publication Date Title
CA2320750C (en) System and method of aspirating and dispensing reagent
US6537818B2 (en) System and method of aspirating and dispensing reagent
EP1004013B1 (en) Automated biological reaction system
US6192945B1 (en) Fluid dispenser
US6093574A (en) Method and apparatus for rinsing a microscope slide
US8147773B2 (en) Method and apparatus for modifying pressure within a fluid dispenser
US8574372B2 (en) Nozzle cleaning method, nozzle cleaning device, and automatic analyzer
US5948359A (en) Automated staining apparatus
US7470541B2 (en) Automated biological reaction apparatus
AU762808B2 (en) Automated staining apparatus
US7378058B2 (en) Method and apparatus for modifying pressure within a fluid dispenser
US20020110494A1 (en) Method and apparatus for modifying pressure within a fluid dispenser
EP2076323A2 (en) Method and device for cleaning a liquid aspiration and dispense probe
EP1284823A1 (en) Automated specimen processing apparatus with fluid detection
EP1335853B1 (en) Sample dispensing with liquid delivery without crossover

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20190226