CA2315720A1 - Inhibition of p38 kinase activity using substituted heterocyclic ureas - Google Patents

Inhibition of p38 kinase activity using substituted heterocyclic ureas Download PDF

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Publication number
CA2315720A1
CA2315720A1 CA002315720A CA2315720A CA2315720A1 CA 2315720 A1 CA2315720 A1 CA 2315720A1 CA 002315720 A CA002315720 A CA 002315720A CA 2315720 A CA2315720 A CA 2315720A CA 2315720 A1 CA2315720 A1 CA 2315720A1
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Canada
Prior art keywords
butyl
urea
tert
substituted
pyridinyl
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Abandoned
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CA002315720A
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English (en)
French (fr)
Inventor
Jacques Dumas
Uday Khire
Timothy Bruno Lowinger
Holger Paulsen
Bernd Riedl
William J. Scott
Roger A. Smith
Jill E. Wood
Holia Hatoum-Mokdad
Jeffrey Johnson
Wendy Lee
Aniko Redman
Robert Sibley
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Bayer Healthcare LLC
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Individual
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Publication of CA2315720A1 publication Critical patent/CA2315720A1/en
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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