MXPA00006233A - Inhibicion de la actividad de la cinasa p38 utilizando ureas heterociclicas sustituidas. - Google Patents
Inhibicion de la actividad de la cinasa p38 utilizando ureas heterociclicas sustituidas.Info
- Publication number
- MXPA00006233A MXPA00006233A MXPA00006233A MXPA00006233A MXPA00006233A MX PA00006233 A MXPA00006233 A MX PA00006233A MX PA00006233 A MXPA00006233 A MX PA00006233A MX PA00006233 A MXPA00006233 A MX PA00006233A MX PA00006233 A MXPA00006233 A MX PA00006233A
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- urea
- tert
- butyl
- substituted
- Prior art date
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- C07D333/36—Nitrogen atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99575097A | 1997-12-22 | 1997-12-22 | |
| PCT/US1998/026080 WO1999032111A1 (en) | 1997-12-22 | 1998-12-22 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA00006233A true MXPA00006233A (es) | 2002-09-18 |
Family
ID=25542167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA00006233A MXPA00006233A (es) | 1997-12-22 | 1998-12-22 | Inhibicion de la actividad de la cinasa p38 utilizando ureas heterociclicas sustituidas. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1041982B1 (enExample) |
| JP (1) | JP4403482B2 (enExample) |
| AT (1) | ATE529109T1 (enExample) |
| AU (1) | AU739642B2 (enExample) |
| CA (1) | CA2315720A1 (enExample) |
| DE (1) | DE1041982T1 (enExample) |
| ES (1) | ES2154253T3 (enExample) |
| IL (3) | IL136738A0 (enExample) |
| MX (1) | MXPA00006233A (enExample) |
| WO (1) | WO1999032111A1 (enExample) |
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| EA032030B1 (ru) | 2014-09-10 | 2019-03-29 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Соединения в качестве ингибиторов реаранжированной во время трансфекции (ret) киназы |
| US9638690B2 (en) | 2014-11-07 | 2017-05-02 | The University Of British Columbia | Compounds and compositions for use as alkylating agent sensors and methods of use thereof |
| CN107531631B (zh) | 2014-12-31 | 2021-09-03 | 安吉昂生物医药公司 | 用于治疗疾病的方法和药剂 |
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| CA2978226C (en) | 2015-03-04 | 2025-02-18 | Eisai R&D Management Co., Ltd. | COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR TO TREAT CANCER |
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| RU2019134940A (ru) | 2017-05-16 | 2021-06-16 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Лечение гепатоцеллюлярной карциномы |
| WO2019152711A1 (en) | 2018-01-31 | 2019-08-08 | Diciphera Pharmaceuticals Llc. | Combination therapy for the treatment of gastrointestinal stromal tumors |
| KR102708050B1 (ko) | 2018-01-31 | 2024-09-24 | 데시페라 파마슈티칼스, 엘엘씨. | 비만 세포증의 치료를 위한 병용 요법 |
| CA3093025A1 (en) | 2018-06-12 | 2019-12-19 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| CA3150433A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| CN115243681B (zh) | 2019-12-30 | 2024-08-16 | 德西费拉制药有限责任公司 | 1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物 |
| FI4084778T3 (fi) | 2019-12-30 | 2023-12-18 | Deciphera Pharmaceuticals Llc | Amorfisia kinaasi-inhibiittoriformulaatioita ja menetelmiä niiden käyttämiseksi |
| WO2021167840A1 (en) | 2020-02-18 | 2021-08-26 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
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| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
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| US3646059A (en) * | 1969-05-05 | 1972-02-29 | Du Pont | Plant growth regulatory ureidopyrazoles |
| CA2078790C (en) * | 1991-01-21 | 1998-10-06 | Susumu Kamata | 3-benzylidene-1-carbamoyl-2-pyrrolidone analogues |
| US5162360A (en) * | 1991-06-24 | 1992-11-10 | Warner-Lambert Company | 2-heteroatom containing urea and thiourea ACAT inhibitors |
| DE4227989A1 (de) | 1992-08-21 | 1994-06-09 | Schering Ag | Mittel zur transdermalen Applikation enthaltend 3-Keto-desogestrel |
| ATE186551T1 (de) * | 1993-09-17 | 1999-11-15 | Smithkline Beecham Corp | Medikamente bindendes protein |
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| BR9809451A (pt) * | 1997-05-22 | 2000-06-20 | Searle & Co | Pirazóis substituìdos com 3(5)-heteroarila como inibidores de quinase p38. |
| WO1998052941A1 (en) * | 1997-05-22 | 1998-11-26 | G.D. Searle And Co. | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS |
| JP4344960B2 (ja) * | 1997-05-23 | 2009-10-14 | バイエル、コーポレイション | アリール尿素によるp38キナーゼ活性の阻害 |
| US20020156104A1 (en) * | 1997-06-13 | 2002-10-24 | Jerry L. Adams | Novel pyrazole and pyrazoline substituted compounds |
| CA2308428A1 (en) * | 1997-11-03 | 1999-05-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
| JP4437270B2 (ja) * | 1997-12-22 | 2010-03-24 | バイエル コーポレイション | 置換複素環式尿素を用いたrafキナーゼの阻害 |
| ES2155045T3 (es) * | 1997-12-22 | 2007-02-01 | Bayer Pharmaceuticals Corp. | Inhibicion de la quinasa raf utilizando ureas heterociclicas sustituidas con arilo y heteroarilo. |
| DK1043995T3 (da) * | 1997-12-22 | 2007-03-05 | Bayer Pharmaceuticals Corp | Inhibering af p38 kinaseaktivitet ved anvendelse af aryl- og heteroaryl-substituerede, heterocykliske urinstoffer |
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- 1998-12-22 AU AU19971/99A patent/AU739642B2/en not_active Ceased
- 1998-12-22 IL IL13673898A patent/IL136738A0/xx active IP Right Grant
- 1998-12-22 AT AT98964709T patent/ATE529109T1/de not_active IP Right Cessation
- 1998-12-22 WO PCT/US1998/026080 patent/WO1999032111A1/en not_active Ceased
- 1998-12-22 EP EP98964709A patent/EP1041982B1/en not_active Expired - Lifetime
- 1998-12-22 DE DE1041982T patent/DE1041982T1/de active Pending
- 1998-12-22 CA CA002315720A patent/CA2315720A1/en not_active Abandoned
- 1998-12-22 JP JP2000525102A patent/JP4403482B2/ja not_active Expired - Fee Related
- 1998-12-22 ES ES98964709T patent/ES2154253T3/es not_active Expired - Lifetime
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2000
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2005
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| IL170201A (en) | 2006-12-31 |
| AU739642B2 (en) | 2001-10-18 |
| DE1041982T1 (de) | 2001-06-07 |
| WO1999032111A1 (en) | 1999-07-01 |
| ES2154253T3 (es) | 2012-01-27 |
| JP4403482B2 (ja) | 2010-01-27 |
| IL136738A0 (en) | 2001-06-14 |
| ATE529109T1 (de) | 2011-11-15 |
| EP1041982A4 (en) | 2006-06-14 |
| JP2001526223A (ja) | 2001-12-18 |
| EP1041982A1 (en) | 2000-10-11 |
| IL136738A (en) | 2007-06-17 |
| ES2154253T1 (es) | 2001-04-01 |
| CA2315720A1 (en) | 1999-07-01 |
| EP1041982B1 (en) | 2011-10-19 |
| AU1997199A (en) | 1999-07-12 |
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| GB | Transfer or rights |
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| FC | Refusal |