CA2105251C - Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor - Google Patents

Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor Download PDF

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Publication number
CA2105251C
CA2105251C CA002105251A CA2105251A CA2105251C CA 2105251 C CA2105251 C CA 2105251C CA 002105251 A CA002105251 A CA 002105251A CA 2105251 A CA2105251 A CA 2105251A CA 2105251 C CA2105251 C CA 2105251C
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CA
Canada
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group
groups
formula
compound
defined above
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002105251A
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English (en)
French (fr)
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CA2105251A1 (en
Inventor
Mitsugi Shibano
Mutsuo Suzuki
Shunshi Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Agro Inc
Elanco Japan KK
Original Assignee
Sankyo Agro Co Ltd
Sankyo Lifetech Co Ltd
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Publication of CA2105251A1 publication Critical patent/CA2105251A1/en
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Publication of CA2105251C publication Critical patent/CA2105251C/en
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002105251A 1992-09-01 1993-08-31 Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor Expired - Fee Related CA2105251C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP23344492 1992-09-01
JP26366092 1992-10-01
JP4-322847 1992-12-02
JP32284792 1992-12-02
JP4-233444 1992-12-02
JP4-263660 1992-12-02

Publications (2)

Publication Number Publication Date
CA2105251A1 CA2105251A1 (en) 1994-03-02
CA2105251C true CA2105251C (en) 2004-12-07

Family

ID=27331997

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002105251A Expired - Fee Related CA2105251C (en) 1992-09-01 1993-08-31 Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor

Country Status (13)

Country Link
US (2) US5461168A (enExample)
EP (1) EP0594291B1 (enExample)
JP (1) JP2654337B2 (enExample)
KR (1) KR0161541B1 (enExample)
AT (1) ATE229960T1 (enExample)
AU (1) AU666750B2 (enExample)
CA (1) CA2105251C (enExample)
DE (1) DE69332577T2 (enExample)
DK (1) DK0594291T3 (enExample)
ES (1) ES2186672T3 (enExample)
NZ (1) NZ248559A (enExample)
PT (1) PT594291E (enExample)
TW (1) TW262474B (enExample)

Families Citing this family (165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
US6136838A (en) * 1998-03-19 2000-10-24 Merck & Co., Inc. Sulfurpentafluorophenylpyrazoles for controlling ectoparasitic infestations
JP4499847B2 (ja) * 1998-05-25 2010-07-07 三井化学アグロ株式会社 ミルベマイシン類の１３−エステル誘導体の製造法
KR100612634B1 (ko) * 1998-05-25 2006-08-14 상꾜 아그로 가부시키가이샤 밀베마이신류의 13-에스테르 유도체의 제조법
JP2002121195A (ja) * 2000-10-12 2002-04-23 Sankyo Co Ltd １３位置換ミルベマイシン誘導体の製造法
EP1735284A1 (en) 2004-03-18 2006-12-27 Pfizer Limited N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides
US7919522B2 (en) 2007-05-03 2011-04-05 Merial Limited Compositions comprising C-13 alkoxyether macrolide compounds and phenylpyrazole compounds
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
ES2543747T3 (es) 2010-02-17 2015-08-21 Syngenta Participations Ag Derivados de isoxazolina como insecticidas
AP2012006432A0 (en) 2010-02-22 2012-08-31 Syngenta Participations Ag Dihydrofuran derivatives as insecticidal compounds
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US9339505B2 (en) 2011-05-31 2016-05-17 Syngenta Participations Ag Pesticidal mixtures including isoxazoline derivatives
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Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE184173C (enExample) *
US4423209A (en) * 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
JPS5933288A (ja) * 1982-08-19 1984-02-23 Sankyo Co Ltd ミルベマイシンｄの５−オキソ誘導体
JPS5933289A (ja) * 1982-08-20 1984-02-23 Sankyo Co Ltd ３，４−ジヒドロミルベマイシンｄ誘導体
US4530921A (en) * 1983-10-03 1985-07-23 Merck & Co., Inc. Avermectin epoxide derivatives and method of use
US4696922A (en) * 1984-11-26 1987-09-29 Ciba-Geigy Corporation 5-azolylacetoxymilbemycins as ecto- and endoparasites
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
FI860233L (fi) * 1985-01-22 1986-07-23 Ciba Geigy Ag 13 -alkyl-milbemycinderivat foer bekaempning av parasiter hos djur och vaexter.
JPH0678342B2 (ja) * 1986-01-07 1994-10-05 三共株式会社 新規マクロライド化合物
GB8606108D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
US4831016A (en) * 1986-10-31 1989-05-16 Merck & Co., Inc. Reduced avermectin derivatives
US4886829A (en) * 1987-03-06 1989-12-12 American Cyanamid Company 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
US4876272A (en) * 1987-03-06 1989-10-24 American Cyanamid Company Mono- and diepoxide derivatives of LL-F28249 compounds
US4851428A (en) * 1987-03-06 1989-07-25 American Cyanamid Company Mono- and diepoxide derivatives of Δ22-LL-F28249 compounds
US4886830A (en) * 1987-03-06 1989-12-12 American Cyanamid Company Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds
EP0285561A3 (de) * 1987-03-27 1989-10-25 Ciba-Geigy Ag Parasitizide und insektizide Milbemycin-Derivate
GB8709327D0 (en) * 1987-04-21 1987-05-28 Beecham Group Plc Compounds
AU613521B2 (en) * 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
US5126464A (en) * 1988-10-21 1992-06-30 The Research Foundation Of State University Of New York Polyazamacrocycles and their metal complexes and oxidations using same
US5030650A (en) * 1989-09-11 1991-07-09 American Cyanamid Company 13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
JPH085894B2 (ja) * 1990-03-01 1996-01-24 三共株式会社 ミルベマイシンエーテル誘導体
JP2656865B2 (ja) * 1991-10-04 1997-09-24 三共株式会社 １３−エーテル置換ミルベマイシン誘導体の製法
JP2591552B2 (ja) * 1991-10-04 1997-03-19 三共株式会社 １５−ヒドロキシミルベマイシン誘導体及びその製法

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CA2105251A1 (en) 1994-03-02
NZ248559A (en) 1995-05-26
AU666750B2 (en) 1996-02-22
KR0161541B1 (ko) 1998-12-01
KR940007038A (ko) 1994-04-26
TW262474B (enExample) 1995-11-11
US5625078A (en) 1997-04-29
ES2186672T3 (es) 2003-05-16
ATE229960T1 (de) 2003-01-15
HK1010371A1 (en) 1999-06-17
PT594291E (pt) 2003-03-31
DE69332577T2 (de) 2003-11-20
DE69332577D1 (de) 2003-01-30
AU4497993A (en) 1994-03-10
JP2654337B2 (ja) 1997-09-17
US5461168A (en) 1995-10-24
JPH06220068A (ja) 1994-08-09
DK0594291T3 (da) 2003-01-27

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