CA2105251C - Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor - Google Patents

Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor Download PDF

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Publication number
CA2105251C
CA2105251C CA002105251A CA2105251A CA2105251C CA 2105251 C CA2105251 C CA 2105251C CA 002105251 A CA002105251 A CA 002105251A CA 2105251 A CA2105251 A CA 2105251A CA 2105251 C CA2105251 C CA 2105251C
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CA
Canada
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group
groups
formula
compound
defined above
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Expired - Fee Related
Application number
CA002105251A
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English (en)
French (fr)
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CA2105251A1 (en
Inventor
Mitsugi Shibano
Mutsuo Suzuki
Shunshi Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Agro Inc
Elanco Japan KK
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Sankyo Agro Co Ltd
Sankyo Lifetech Co Ltd
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Publication of CA2105251A1 publication Critical patent/CA2105251A1/en
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Publication of CA2105251C publication Critical patent/CA2105251C/en
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002105251A 1992-09-01 1993-08-31 Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor Expired - Fee Related CA2105251C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP4-233444 1992-09-01
JP23344492 1992-09-01
JP26366092 1992-10-01
JP4-263660 1992-10-01
JP4-322847 1992-12-02
JP32284792 1992-12-02

Publications (2)

Publication Number Publication Date
CA2105251A1 CA2105251A1 (en) 1994-03-02
CA2105251C true CA2105251C (en) 2004-12-07

Family

ID=27331997

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002105251A Expired - Fee Related CA2105251C (en) 1992-09-01 1993-08-31 Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor

Country Status (13)

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US (2) US5461168A (enExample)
EP (1) EP0594291B1 (enExample)
JP (1) JP2654337B2 (enExample)
KR (1) KR0161541B1 (enExample)
AT (1) ATE229960T1 (enExample)
AU (1) AU666750B2 (enExample)
CA (1) CA2105251C (enExample)
DE (1) DE69332577T2 (enExample)
DK (1) DK0594291T3 (enExample)
ES (1) ES2186672T3 (enExample)
NZ (1) NZ248559A (enExample)
PT (1) PT594291E (enExample)
TW (1) TW262474B (enExample)

Families Citing this family (165)

* Cited by examiner, † Cited by third party
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WO1999061447A1 (en) * 1998-05-25 1999-12-02 Sankyo Company, Limited Process for producing 13-ester derivatives of milbemycins
JP4499847B2 (ja) * 1998-05-25 2010-07-07 三井化学アグロ株式会社 ミルベマイシン類の１３−エステル誘導体の製造法
JP2002121195A (ja) * 2000-10-12 2002-04-23 Sankyo Co Ltd １３位置換ミルベマイシン誘導体の製造法
WO2005090313A1 (en) 2004-03-18 2005-09-29 Pfizer Limited N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides
US7919522B2 (en) 2007-05-03 2011-04-05 Merial Limited Compositions comprising C-13 alkoxyether macrolide compounds and phenylpyrazole compounds
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HK1010371A1 (en) 1999-06-17
AU666750B2 (en) 1996-02-22
ES2186672T3 (es) 2003-05-16
JPH06220068A (ja) 1994-08-09
CA2105251A1 (en) 1994-03-02
DK0594291T3 (da) 2003-01-27
KR0161541B1 (ko) 1998-12-01
US5461168A (en) 1995-10-24
KR940007038A (ko) 1994-04-26
TW262474B (enExample) 1995-11-11
EP0594291A1 (en) 1994-04-27
ATE229960T1 (de) 2003-01-15
AU4497993A (en) 1994-03-10
JP2654337B2 (ja) 1997-09-17
DE69332577D1 (de) 2003-01-30
PT594291E (pt) 2003-03-31
DE69332577T2 (de) 2003-11-20
EP0594291B1 (en) 2002-12-18
US5625078A (en) 1997-04-29

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