CA2066248A1 - Esters d'acides thiophenecarboxyliques et d'aminoalcools; composes quaternaires obtenus par cette voie; production et utilisation de ces substances - Google Patents

Esters d'acides thiophenecarboxyliques et d'aminoalcools; composes quaternaires obtenus par cette voie; production et utilisation de ces substances

Info

Publication number
CA2066248A1
CA2066248A1 CA2066248A CA2066248A CA2066248A1 CA 2066248 A1 CA2066248 A1 CA 2066248A1 CA 2066248 A CA2066248 A CA 2066248A CA 2066248 A CA2066248 A CA 2066248A CA 2066248 A1 CA2066248 A1 CA 2066248A1
Authority
CA
Canada
Prior art keywords
compounds
esters
manufacture
carboxylic acids
amino alcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2066248A
Other languages
English (en)
Other versions
CA2066248C (fr
Inventor
Rolf Banholzer
Rudolf Bauer
Richard Reichl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6389619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2066248(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2066248A1 publication Critical patent/CA2066248A1/fr
Application granted granted Critical
Publication of CA2066248C publication Critical patent/CA2066248C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Disintegrating Or Milling (AREA)
  • Glass Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Les nouveaux composés dont la formule est donnée à la figure 1 (A, R1, Ra et R sont définis dans la description) peuvent être préparés suivant des procédés connus et utilisés à titre d'ingrédients actifs dans des médicaments.
CA002066248A 1989-09-16 1990-09-08 Esters d'acides thiophenecarboxyliques et d'aminoalcools; composes quaternaires obtenus par cette voie; production et utilisation de ces substances Expired - Lifetime CA2066248C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3931041A DE3931041C2 (de) 1989-09-16 1989-09-16 Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DEP3931041.8 1989-09-16

Publications (2)

Publication Number Publication Date
CA2066248A1 true CA2066248A1 (fr) 1991-03-17
CA2066248C CA2066248C (fr) 1998-08-04

Family

ID=6389619

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002066248A Expired - Lifetime CA2066248C (fr) 1989-09-16 1990-09-08 Esters d'acides thiophenecarboxyliques et d'aminoalcools; composes quaternaires obtenus par cette voie; production et utilisation de ces substances

Country Status (33)

Country Link
US (1) USRE39820E1 (fr)
EP (1) EP0418716B1 (fr)
JP (1) JPH0730074B2 (fr)
KR (1) KR0168432B1 (fr)
AT (1) ATE103914T1 (fr)
AU (1) AU642913B2 (fr)
BG (1) BG61295B2 (fr)
CA (1) CA2066248C (fr)
CZ (1) CZ284589B6 (fr)
DD (1) DD297647A5 (fr)
DE (3) DE3931041C2 (fr)
DK (1) DK0418716T3 (fr)
ES (1) ES2052125T3 (fr)
FI (1) FI114395B (fr)
HR (1) HRP940723B1 (fr)
HU (2) HU208823B (fr)
IE (1) IE65528B1 (fr)
IL (1) IL95691A (fr)
LU (1) LU90949I2 (fr)
MX (1) MX9203150A (fr)
NL (1) NL300084I2 (fr)
NO (2) NO301478B1 (fr)
NZ (1) NZ235306A (fr)
PH (1) PH31617A (fr)
PL (1) PL168468B1 (fr)
PT (1) PT95312B (fr)
RU (1) RU2073677C1 (fr)
SI (1) SI9011744B (fr)
SK (1) SK279453B6 (fr)
UA (1) UA41272C2 (fr)
WO (1) WO1991004252A1 (fr)
YU (1) YU47800B (fr)
ZA (1) ZA907338B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890920B2 (en) 2001-10-26 2005-05-10 Pharmacia & Upjohn Company Quaternary ammonium compounds
AU2004285683B2 (en) * 2003-11-03 2011-04-21 Boehringer Ingelheim International Gmbh Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same

Families Citing this family (147)

* Cited by examiner, † Cited by third party
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DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
DE19921693A1 (de) 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
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US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
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WO2002036104A2 (fr) * 2000-10-31 2002-05-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Formulation d'une solution d'inhalation contenant un sel de tiotropium
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
EE05404B1 (et) 2000-12-28 2011-04-15 Almirall Prodesfarma Ag Kinuklidiini derivaat, selle saamine ja kasutamine ravimi valmistamiseks, mis on ette n„htud respiratoorsete, kuseelundite v?i mao-soolte haiguste ravimiseks, ning seda sisaldav ravimkompositsioon
US6506900B1 (en) 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
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HRP940723B1 (en) 1999-10-31
SI9011744B (sl) 1999-12-31
IE65528B1 (en) 1995-11-01
IL95691A (en) 1996-07-23
FI921087A0 (fi) 1992-03-13
KR910006272A (ko) 1991-04-29
YU174490A (sh) 1993-10-20
ES2052125T3 (es) 1994-07-01
HU210612A9 (en) 1995-05-29
DE3931041C2 (de) 2000-04-06
NL300084I2 (nl) 2002-08-01
ATE103914T1 (de) 1994-04-15
DD297647A5 (de) 1992-01-16
NO921002L (no) 1992-03-13
SI9011744A (en) 1997-10-31
DE3931041A1 (de) 1991-03-28
DK0418716T3 (da) 1994-05-02
NL300084I1 (nl) 2002-05-01
AU6431890A (en) 1991-04-18
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USRE39820E1 (en) 2007-09-04
SK452390A3 (en) 1998-11-04
YU47800B (sr) 1996-01-09
WO1991004252A1 (fr) 1991-04-04
MX9203150A (es) 1992-07-01
FI114395B (fi) 2004-10-15
HU208823B (en) 1994-01-28
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PT95312A (pt) 1991-05-22
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NO2002009I2 (no) 2004-10-11
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PL168468B1 (pl) 1996-02-29
IL95691A0 (en) 1991-06-30
IE903342A1 (en) 1991-04-10
ZA907338B (en) 1992-08-26
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CZ284589B6 (cs) 1999-01-13
DE10299026I2 (de) 2004-07-01
UA41272C2 (uk) 2001-09-17
AU642913B2 (en) 1993-11-04
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