PL2914593T3 - Stabilizacja solwatów tiotropiowych - Google Patents

Stabilizacja solwatów tiotropiowych

Info

Publication number
PL2914593T3
PL2914593T3 PL12786801T PL12786801T PL2914593T3 PL 2914593 T3 PL2914593 T3 PL 2914593T3 PL 12786801 T PL12786801 T PL 12786801T PL 12786801 T PL12786801 T PL 12786801T PL 2914593 T3 PL2914593 T3 PL 2914593T3
Authority
PL
Poland
Prior art keywords
tiotropium
solvates
stabilization
tiotropium solvates
Prior art date
Application number
PL12786801T
Other languages
English (en)
Inventor
Igor Cerna
Josef Hajicek
Ondrej Dammer
Mokhtar Kebbati
Pascal Billot
Patrik Hosek
Original Assignee
Zentiva, K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, K.S. filed Critical Zentiva, K.S.
Publication of PL2914593T3 publication Critical patent/PL2914593T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • C07D451/10Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Cleaning And De-Greasing Of Metallic Materials By Chemical Methods (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Steroid Compounds (AREA)
PL12786801T 2012-11-05 2012-11-05 Stabilizacja solwatów tiotropiowych PL2914593T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CZ2012/000112 WO2014067499A1 (en) 2012-11-05 2012-11-05 Stabilization of tiotropium solvates

Publications (1)

Publication Number Publication Date
PL2914593T3 true PL2914593T3 (pl) 2017-07-31

Family

ID=47178436

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12786801T PL2914593T3 (pl) 2012-11-05 2012-11-05 Stabilizacja solwatów tiotropiowych

Country Status (23)

Country Link
EP (1) EP2914593B1 (pl)
JP (1) JP6158939B2 (pl)
KR (1) KR20150079671A (pl)
CN (1) CN104797579A (pl)
BR (1) BR112015009654A2 (pl)
CY (1) CY1118828T1 (pl)
DK (1) DK2914593T3 (pl)
EA (1) EA025960B1 (pl)
ES (1) ES2620758T3 (pl)
HK (1) HK1207625A1 (pl)
HR (1) HRP20170523T1 (pl)
HU (1) HUE032455T2 (pl)
IL (1) IL238503A0 (pl)
LT (1) LT2914593T (pl)
ME (1) ME02679B (pl)
MX (1) MX2015005319A (pl)
PL (1) PL2914593T3 (pl)
PT (1) PT2914593T (pl)
RS (1) RS55919B1 (pl)
SI (1) SI2914593T1 (pl)
UA (1) UA115888C2 (pl)
WO (1) WO2014067499A1 (pl)
ZA (1) ZA201503043B (pl)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
NZ525733A (en) 2000-10-12 2005-01-28 Boehringer Ingelheim Pharma Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
IL159238A0 (en) 2001-06-22 2004-06-01 Boehringer Ingelheim Pharma Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
CN100509809C (zh) 2003-11-03 2009-07-08 贝林格尔·英格海姆国际有限公司 具有抗胆碱能作用的新颖无水晶体
RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
DK1881980T3 (da) * 2005-05-02 2012-10-01 Boehringer Ingelheim Int Nye krystalline former af tiotropiumbromid
SI1869035T2 (sl) * 2005-12-19 2015-12-31 Sicor, Inc. Nove kristalne oblike tiotropij bromida in postopek njihove priprave
EP2123650B1 (en) 2005-12-19 2012-04-04 Sicor, Inc. Novel form of tiotropium bromide and process for preparation thereof
WO2010101538A2 (en) * 2009-03-06 2010-09-10 Bilgic Mahmut New crystal forms
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use

Also Published As

Publication number Publication date
EP2914593A1 (en) 2015-09-09
MX2015005319A (es) 2015-07-14
WO2014067499A1 (en) 2014-05-08
LT2914593T (lt) 2017-04-10
BR112015009654A2 (pt) 2017-07-04
EA201590872A1 (ru) 2015-10-30
CN104797579A (zh) 2015-07-22
EA025960B1 (ru) 2017-02-28
JP2016502518A (ja) 2016-01-28
SI2914593T1 (sl) 2017-05-31
HK1207625A1 (en) 2016-02-05
ES2620758T3 (es) 2017-06-29
DK2914593T3 (en) 2017-04-18
HUE032455T2 (en) 2017-09-28
HRP20170523T1 (hr) 2017-06-02
CY1118828T1 (el) 2018-01-10
UA115888C2 (uk) 2018-01-10
ME02679B (me) 2017-06-20
EP2914593B1 (en) 2017-01-11
RS55919B1 (sr) 2017-09-29
PT2914593T (pt) 2017-04-03
KR20150079671A (ko) 2015-07-08
JP6158939B2 (ja) 2017-07-05
ZA201503043B (en) 2016-01-27
IL238503A0 (en) 2015-06-30

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