CY1118828T1 - Σταθεροποιηση διαλυτωματων τιοτροπιου - Google Patents

Σταθεροποιηση διαλυτωματων τιοτροπιου

Info

Publication number
CY1118828T1
CY1118828T1 CY20171100433T CY171100433T CY1118828T1 CY 1118828 T1 CY1118828 T1 CY 1118828T1 CY 20171100433 T CY20171100433 T CY 20171100433T CY 171100433 T CY171100433 T CY 171100433T CY 1118828 T1 CY1118828 T1 CY 1118828T1
Authority
CY
Cyprus
Prior art keywords
solutions
tiotrop
stabilization
solvent
tiotropium bromide
Prior art date
Application number
CY20171100433T
Other languages
English (en)
Inventor
Igor Cerna
Josef Hajicek
Ondrej Dammer
Mokhtar Kebbati
Pascal Billot
Patrik Hosek
Original Assignee
Zentiva, K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, K.S. filed Critical Zentiva, K.S.
Publication of CY1118828T1 publication Critical patent/CY1118828T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Cleaning And De-Greasing Of Metallic Materials By Chemical Methods (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Steroid Compounds (AREA)

Abstract

Μια μέθοδος για τη σταθεροποίηση μικρονισμένων ή αλεσμένων διαλυτωμάτων βρωμιούχου τιοτροπίου, στην οποία τα διαλυτώματα εναποτίθενται σε μια κορεσμένη ατμόσφαιρα του κατάλληλου διαλύτη για μια χρονική περίοδο αρκετή για την ανάκαμψη της αρχικής ποσότητας του διαλύτη στο διαλύτωμα. Ένα σταθερό διαλύτωμα βρωμιούχου τιοτροπίου με 1,3-προπανοδιόλη.
CY20171100433T 2012-11-05 2017-04-11 Σταθεροποιηση διαλυτωματων τιοτροπιου CY1118828T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CZ2012/000112 WO2014067499A1 (en) 2012-11-05 2012-11-05 Stabilization of tiotropium solvates

Publications (1)

Publication Number Publication Date
CY1118828T1 true CY1118828T1 (el) 2018-01-10

Family

ID=47178436

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100433T CY1118828T1 (el) 2012-11-05 2017-04-11 Σταθεροποιηση διαλυτωματων τιοτροπιου

Country Status (23)

Country Link
EP (1) EP2914593B1 (el)
JP (1) JP6158939B2 (el)
KR (1) KR20150079671A (el)
CN (1) CN104797579A (el)
BR (1) BR112015009654A2 (el)
CY (1) CY1118828T1 (el)
DK (1) DK2914593T3 (el)
EA (1) EA025960B1 (el)
ES (1) ES2620758T3 (el)
HK (1) HK1207625A1 (el)
HR (1) HRP20170523T1 (el)
HU (1) HUE032455T2 (el)
IL (1) IL238503A0 (el)
LT (1) LT2914593T (el)
ME (1) ME02679B (el)
MX (1) MX2015005319A (el)
PL (1) PL2914593T3 (el)
PT (1) PT2914593T (el)
RS (1) RS55919B1 (el)
SI (1) SI2914593T1 (el)
UA (1) UA115888C2 (el)
WO (1) WO2014067499A1 (el)
ZA (1) ZA201503043B (el)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
NZ525733A (en) 2000-10-12 2005-01-28 Boehringer Ingelheim Pharma Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
IL159238A0 (en) 2001-06-22 2004-06-01 Boehringer Ingelheim Pharma Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
CN100509809C (zh) 2003-11-03 2009-07-08 贝林格尔·英格海姆国际有限公司 具有抗胆碱能作用的新颖无水晶体
RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
DK1881980T3 (da) * 2005-05-02 2012-10-01 Boehringer Ingelheim Int Nye krystalline former af tiotropiumbromid
SI1869035T2 (sl) * 2005-12-19 2015-12-31 Sicor, Inc. Nove kristalne oblike tiotropij bromida in postopek njihove priprave
EP2123650B1 (en) 2005-12-19 2012-04-04 Sicor, Inc. Novel form of tiotropium bromide and process for preparation thereof
WO2010101538A2 (en) * 2009-03-06 2010-09-10 Bilgic Mahmut New crystal forms
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use

Also Published As

Publication number Publication date
EP2914593A1 (en) 2015-09-09
MX2015005319A (es) 2015-07-14
WO2014067499A1 (en) 2014-05-08
LT2914593T (lt) 2017-04-10
BR112015009654A2 (pt) 2017-07-04
EA201590872A1 (ru) 2015-10-30
CN104797579A (zh) 2015-07-22
EA025960B1 (ru) 2017-02-28
JP2016502518A (ja) 2016-01-28
SI2914593T1 (sl) 2017-05-31
HK1207625A1 (en) 2016-02-05
ES2620758T3 (es) 2017-06-29
DK2914593T3 (en) 2017-04-18
HUE032455T2 (en) 2017-09-28
HRP20170523T1 (hr) 2017-06-02
UA115888C2 (uk) 2018-01-10
ME02679B (me) 2017-06-20
PL2914593T3 (pl) 2017-07-31
EP2914593B1 (en) 2017-01-11
RS55919B1 (sr) 2017-09-29
PT2914593T (pt) 2017-04-03
KR20150079671A (ko) 2015-07-08
JP6158939B2 (ja) 2017-07-05
ZA201503043B (en) 2016-01-27
IL238503A0 (en) 2015-06-30

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