CA1341362C - Human manganese superoxide dismutase cdna, its expression in bacteria and method of recovering enzymatically active human manganese superoxide dismutase - Google Patents

Human manganese superoxide dismutase cdna, its expression in bacteria and method of recovering enzymatically active human manganese superoxide dismutase Download PDF

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Publication number
CA1341362C
CA1341362C CA000523536A CA523536A CA1341362C CA 1341362 C CA1341362 C CA 1341362C CA 000523536 A CA000523536 A CA 000523536A CA 523536 A CA523536 A CA 523536A CA 1341362 C CA1341362 C CA 1341362C
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CA
Canada
Prior art keywords
superoxide dismutase
human manganese
manganese superoxide
human
plasmid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000523536A
Other languages
English (en)
French (fr)
Inventor
Jacob R. Hartman
Yaffa Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Savient Pharmaceuticals Inc
Original Assignee
Savient Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc
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Publication of CA1341362C publication Critical patent/CA1341362C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA000523536A 1985-11-22 1986-11-21 Human manganese superoxide dismutase cdna, its expression in bacteria and method of recovering enzymatically active human manganese superoxide dismutase Expired - Lifetime CA1341362C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80109085A 1985-11-22 1985-11-22
US90705186A 1986-09-12 1986-09-12
US907,051 1986-09-12
US801,090 1997-02-14

Publications (1)

Publication Number Publication Date
CA1341362C true CA1341362C (en) 2002-05-28

Family

ID=27122291

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000523536A Expired - Lifetime CA1341362C (en) 1985-11-22 1986-11-21 Human manganese superoxide dismutase cdna, its expression in bacteria and method of recovering enzymatically active human manganese superoxide dismutase

Country Status (21)

Country Link
JP (2) JP2609449B2 (de)
AT (1) AT400443B (de)
AU (1) AU607897B2 (de)
BE (1) BE905796A (de)
CA (1) CA1341362C (de)
CH (1) CH676990A5 (de)
DE (1) DE3639725C2 (de)
DK (1) DK534686A (de)
ES (1) ES2003518A6 (de)
FI (1) FI90353C (de)
FR (1) FR2590591B1 (de)
GB (1) GB2183658B (de)
GR (1) GR862713B (de)
HK (1) HK75195A (de)
IE (1) IE59498B1 (de)
IL (2) IL106449A (de)
IT (1) IT1205418B (de)
LU (1) LU86676A1 (de)
NL (1) NL8602960A (de)
PT (1) PT83792B (de)
SE (1) SE8604884L (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610520B1 (en) 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
JPS62215532A (ja) * 1986-03-18 1987-09-22 Ube Ind Ltd 抗炎症剤
JPH0643341B2 (ja) * 1986-03-27 1994-06-08 宇部興産株式会社 臓器機能改善剤
JPH0643340B2 (ja) * 1986-09-03 1994-06-08 宇部興産株式会社 虚血性心疾患治療薬
JPS6377822A (ja) * 1986-09-18 1988-04-08 Ube Ind Ltd 臓器機能改善剤
US6326003B1 (en) 1986-10-14 2001-12-04 Chiron Corporation Manganese superoxide dismutase cloning and expression in microorganisms
DE3854872D1 (de) * 1987-03-14 1996-02-22 Boehringer Ingelheim Int Humane Mangan-Superoxiddismutase (hMn-SOD)
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
ATE130196T1 (de) * 1987-03-27 1995-12-15 Bio Technology General Corp Menschliches mangansuperoxiddismutase und behandlungsverfahren.
JPH01233228A (ja) * 1988-03-11 1989-09-19 Toyo Jozo Co Ltd 悪性腫瘍細胞転移防止剤
US5772996A (en) * 1990-08-03 1998-06-30 Public Health Laboratory Service Board Pharmaceutical compositions containing superoxide dismutase from Bacillus Stearothermophilus and Bacillus Caldotenax
DE4038563A1 (de) * 1990-12-04 1992-06-11 Gruenenthal Gmbh Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
ATE209928T1 (de) * 1992-09-09 2001-12-15 Bio Technology General Corp Verwendung von mangan-superoxiddismutase (mn-sod) zur herstellung von arzneimitteln zur behandlung von erkrankungen in niedriger dosierung
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56102787A (en) * 1980-01-18 1981-08-17 Mamoru Sugiura Preparation of human placenta superoxide dismutase
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
EP0138111B1 (de) * 1983-10-03 1991-11-21 Chiron Corporation Klonieren von Superoxid-Dismutase und Expression in Mikroorganismen

Also Published As

Publication number Publication date
IL106449A0 (en) 1993-11-15
JP2609449B2 (ja) 1997-05-14
ATA308986A (de) 1995-05-15
PT83792B (pt) 1989-01-17
IE59498B1 (en) 1994-03-09
IT1205418B (it) 1989-03-15
FI864756A0 (fi) 1986-11-21
SE8604884L (sv) 1987-05-23
IL80702A0 (en) 1987-02-27
BE905796A (fr) 1987-03-16
HK75195A (en) 1995-05-26
JPH08289792A (ja) 1996-11-05
SE8604884D0 (sv) 1986-11-14
GR862713B (en) 1987-03-24
FI90353B (fi) 1993-10-15
FR2590591A1 (fr) 1987-05-29
LU86676A1 (fr) 1987-05-04
DK534686D0 (da) 1986-11-07
FI90353C (fi) 1994-01-25
JP2967557B2 (ja) 1999-10-25
GB8627294D0 (en) 1986-12-17
AT400443B (de) 1995-12-27
IL106449A (en) 1997-02-18
FR2590591B1 (fr) 1989-12-01
IT8667865A0 (it) 1986-11-21
GB2183658B (en) 1990-04-25
AU6497586A (en) 1987-05-28
ES2003518A6 (es) 1988-11-01
NL8602960A (nl) 1987-06-16
FI864756A (fi) 1987-05-23
AU607897B2 (en) 1991-03-21
DE3639725A1 (de) 1987-07-23
PT83792A (en) 1986-12-01
DK534686A (da) 1987-05-23
GB2183658A (en) 1987-06-10
IE862851L (en) 1987-05-22
CH676990A5 (de) 1991-03-28
JPS62289187A (ja) 1987-12-16
DE3639725C2 (de) 1998-02-19

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Effective date: 20190528