ATE130196T1 - Menschliches mangansuperoxiddismutase und behandlungsverfahren. - Google Patents

Menschliches mangansuperoxiddismutase und behandlungsverfahren.

Info

Publication number
ATE130196T1
ATE130196T1 AT88104880T AT88104880T ATE130196T1 AT E130196 T1 ATE130196 T1 AT E130196T1 AT 88104880 T AT88104880 T AT 88104880T AT 88104880 T AT88104880 T AT 88104880T AT E130196 T1 ATE130196 T1 AT E130196T1
Authority
AT
Austria
Prior art keywords
superoxide dismutase
manganese superoxide
human manganese
treatment methods
terminus
Prior art date
Application number
AT88104880T
Other languages
English (en)
Inventor
Jacob R Hartman
Yaffa Beck
Abraham Nimrod
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Application granted granted Critical
Publication of ATE130196T1 publication Critical patent/ATE130196T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT88104880T 1987-03-27 1988-03-25 Menschliches mangansuperoxiddismutase und behandlungsverfahren. ATE130196T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3273487A 1987-09-27 1987-09-27
US16111788A 1988-02-26 1988-02-26

Publications (1)

Publication Number Publication Date
ATE130196T1 true ATE130196T1 (de) 1995-12-15

Family

ID=26708809

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88104880T ATE130196T1 (de) 1987-03-27 1988-03-25 Menschliches mangansuperoxiddismutase und behandlungsverfahren.

Country Status (8)

Country Link
EP (2) EP0284105B1 (de)
JP (2) JP3013896B2 (de)
AT (1) ATE130196T1 (de)
CA (1) CA1339299C (de)
DE (1) DE3854678T2 (de)
GR (1) GR3018728T3 (de)
HK (1) HK210196A (de)
IL (1) IL85876A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326003B1 (en) 1986-10-14 2001-12-04 Chiron Corporation Manganese superoxide dismutase cloning and expression in microorganisms
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
ATE132902T1 (de) * 1987-03-14 1996-01-15 Boehringer Ingelheim Int Humane mangan-superoxiddismutase (hmn-sod)
JPH0780784B2 (ja) * 1987-10-23 1995-08-30 宇部興産株式会社 微小循環障害に基づく心筋虚血傷害治療薬
JPH01233228A (ja) * 1988-03-11 1989-09-19 Toyo Jozo Co Ltd 悪性腫瘍細胞転移防止剤
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
DE4038563A1 (de) * 1990-12-04 1992-06-11 Gruenenthal Gmbh Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
EP0587055B1 (de) * 1992-09-09 2001-12-05 Bio-Technology General Corporation Verwendung von Mangan-Superoxiddismutase (Mn-SOD) zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen in niedriger Dosierung
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
AU5717094A (en) * 1992-12-28 1994-07-19 Sii Technoresearch, Inc. Human variant manganese superoxide dismutase
AU6491394A (en) * 1993-03-24 1994-10-11 Boehringer Ingelheim Pharmaceuticals, Inc. Method for inhibiting pulmonary oxygen toxicity using manganese superoxide dismutase
US6887856B1 (en) * 1993-10-15 2005-05-03 University Of Pittsburgh Protection from ionizing irradiation or chemotherapeutic drug damage by in vivo gene therapy
US5985633A (en) * 1997-09-10 1999-11-16 University Of Florida Human manganese superoxide dismutase proteins
AU2001255226A1 (en) * 2000-03-31 2001-10-15 University Of Southern California Manganese superoxide dismutase gene polymorphism for predicting cancer susceptibility
CN101955918B (zh) * 2009-07-17 2014-05-21 华东理工大学 一种生产重组高活性锰超氧化物歧化酶的方法
CA2929380A1 (en) 2013-11-04 2015-05-07 Aldo Mancini Manganese superoxide dismutase variants and uses thereof
ITRM20130608A1 (it) * 2013-11-04 2015-05-05 Aldo Mancini Manganese superossido dismutasi ricombinante e usi di essa
US10632089B2 (en) 2015-04-18 2020-04-28 Jo Cosmetics Co., Ltd. Tyrosinase activity inhibitor and external preparation for skin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5816685A (ja) * 1981-07-22 1983-01-31 Takeda Chem Ind Ltd 固定化酵素，その製造法および製剤
JPS5886098A (ja) * 1981-11-17 1983-05-23 Mamoru Sugiura マンガン−ス−パ−オキシドデイスムタ−ゼ測定用試薬
DE3485284D1 (de) * 1983-10-03 1992-01-02 Chiron Corp Klonieren von superoxid-dismutase und expression in mikroorganismen.
ATE63757T1 (de) * 1985-03-28 1991-06-15 Chiron Corp Expression durch verwendung von fusionsgenen fuer proteinproduktion.
DK402785D0 (da) * 1985-09-03 1985-09-03 Syn Tek Ab Fremgangsmaade til fremstilling af et enzym
EP0213628A3 (de) * 1985-09-03 1988-09-21 Yeda Research And Development Company, Ltd. Expression von Superoxiddismutase in eukaryotischen Zellen
IE59498B1 (en) * 1985-11-22 1994-03-09 Bio Technology General Corp Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form
ATE132902T1 (de) * 1987-03-14 1996-01-15 Boehringer Ingelheim Int Humane mangan-superoxiddismutase (hmn-sod)

Also Published As

Publication number Publication date
GR3018728T3 (en) 1996-04-30
CA1339299C (en) 1997-08-19
IL85876A (en) 2001-11-25
JPS6427470A (en) 1989-01-30
JPH08317789A (ja) 1996-12-03
HK210196A (en) 1996-12-06
EP0284105A3 (en) 1989-01-25
JP3013896B2 (ja) 2000-02-28
DE3854678D1 (de) 1995-12-21
EP0284105B1 (de) 1995-11-15
IL85876A0 (en) 1988-09-30
DE3854678T2 (de) 1996-06-13
EP0284105A2 (de) 1988-09-28
EP0691401A1 (de) 1996-01-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee