CA1272713C - - Google Patents

Info

Publication number
CA1272713C
CA1272713C CA 464215 CA464215A CA1272713C CA 1272713 C CA1272713 C CA 1272713C CA 464215 CA464215 CA 464215 CA 464215 A CA464215 A CA 464215A CA 1272713 C CA1272713 C CA 1272713C
Authority
CA
Canada
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 464215
Other versions
CA1238910A (fr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58186601A external-priority patent/JPS6078987A/ja
Priority claimed from JP59018563A external-priority patent/JPS60163884A/ja
Priority claimed from JP59100890A external-priority patent/JPH0780892B2/ja
Application filed filed Critical
Priority to CA000531176A priority Critical patent/CA1272713A/fr
Publication of CA1238910A publication Critical patent/CA1238910A/fr
Application granted granted Critical
Publication of CA1272713C publication Critical patent/CA1272713C/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Steroid Compounds (AREA)
CA000464215A 1983-10-04 1984-09-27 Acides carboxyalcenoiques Expired CA1238910A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000531176A CA1272713A (fr) 1983-10-04 1987-03-04 Carboxyalkenamidocephalosporines

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58186601A JPS6078987A (ja) 1983-10-04 1983-10-04 アクリルアミドセフアロスポリン類
JP59018563A JPS60163884A (ja) 1984-02-03 1984-02-03 カルボキシアルケンアミドセフアロスポリン
JP59100890A JPH0780892B2 (ja) 1984-05-18 1984-05-18 カルボキシアルケンアミドセフアロスポリン

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000531176A Division CA1272713A (fr) 1983-10-04 1987-03-04 Carboxyalkenamidocephalosporines

Publications (2)

Publication Number Publication Date
CA1238910A CA1238910A (fr) 1988-07-05
CA1272713C true CA1272713C (fr) 1990-08-14

Family

ID=27282263

Family Applications (2)

Application Number Title Priority Date Filing Date
CA000464215A Expired CA1238910A (fr) 1983-10-04 1984-09-27 Acides carboxyalcenoiques
CA000531176A Expired - Lifetime CA1272713A (fr) 1983-10-04 1987-03-04 Carboxyalkenamidocephalosporines

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA000531176A Expired - Lifetime CA1272713A (fr) 1983-10-04 1987-03-04 Carboxyalkenamidocephalosporines

Country Status (22)

Country Link
US (3) US4634697A (fr)
EP (1) EP0136721B1 (fr)
KR (2) KR880002376B1 (fr)
AR (1) AR242392A1 (fr)
AT (1) ATE99311T1 (fr)
AU (2) AU575854B2 (fr)
CA (2) CA1238910A (fr)
DE (2) DE3486259T2 (fr)
DK (1) DK171043B1 (fr)
ES (3) ES8604602A1 (fr)
FI (1) FI82057C (fr)
GB (3) GB2154580B (fr)
GR (1) GR80544B (fr)
HU (1) HU193298B (fr)
IE (1) IE57744B1 (fr)
IL (3) IL84653A (fr)
MX (1) MX174328B (fr)
NL (1) NL940013I2 (fr)
NO (2) NO173238C (fr)
NZ (2) NZ209634A (fr)
PH (2) PH20223A (fr)
PT (1) PT79287A (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
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AU575854B2 (en) * 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
JP2501785B2 (ja) * 1984-07-09 1996-05-29 明治製菓株式会社 新規セフアロスポリン系化合物
JPS6124580A (ja) * 1984-07-12 1986-02-03 Shionogi & Co Ltd アミノチアゾリルグルタル酸誘導体の製造方法
JPS6153272A (ja) * 1984-08-24 1986-03-17 Shionogi & Co Ltd グルタル酸誘導体の製法
AU580855B2 (en) * 1985-03-29 1989-02-02 Shionogi & Co., Ltd. Alkeneamidocephalosporin esters
CA1274832A (fr) 1985-04-30 1990-10-02 Richard Elmer Holmes Pyrazolidines bicycliques substituees en 7
US4731362A (en) * 1985-08-05 1988-03-15 Shionogi & Co., Ltd. Alkylcarbamoyloxymethylcephem compounds
DE3745094B4 (de) * 1986-07-02 2004-12-30 Shionogi & Co., Ltd. Ein kristallines Hydrat der 7ß-[(Z)-2-(2-Aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4-carbonsäure enthaltende Hartgelatinekapsel-Zusammensetzung
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
US5017380A (en) * 1986-07-02 1991-05-21 Shionogi & Co., Ltd. Gelatin hard capsule containing crystalline hydrate of oral cephalosporin
AT396652B (de) * 1986-07-02 1993-11-25 Shionogi & Co Verfahren zur herstellung von hartgelatinekapsel-zusammensetzungen
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
US5242913A (en) * 1987-03-11 1993-09-07 Pfizer Inc. Substituted 3-cephem compounds as antibacterial agents
US5079242A (en) * 1987-03-11 1992-01-07 Pfizer Inc. Substituted 3-cephem compounds as antibacterial agents
US4820832A (en) * 1988-03-23 1989-04-11 Eli Lilly And Company Process for preparing 3-unsubstituted cephalosporins and 1-carba(dethia)cephalosporins
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
US5245027A (en) * 1989-11-21 1993-09-14 Bristol-Myers Squibb Company 3-fluorosulfonyloxyceph-3-em compounds
US5612048A (en) * 1994-11-22 1997-03-18 Amvac Chemical Corporation Stabilized moisture-sensitive pesticide composition and method of making
US5571910A (en) * 1994-12-09 1996-11-05 Schering Corporation Process for the preparation of intermediates useful in the synthesis of cephalosporins
JPH101482A (ja) * 1996-06-13 1998-01-06 Otsuka Chem Co Ltd ３−ノルセフェム化合物の製造法
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
US8225458B1 (en) 2001-07-13 2012-07-24 Hoffberg Steven M Intelligent door restraint
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US20050152852A1 (en) * 2002-05-27 2005-07-14 Morinaga & Co., Ltd. Use of antibacterial component extracted from cacao mass for inhibiting the growth of periodontal bacteria
CA2533178C (fr) * 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Produit antibiotique, son utilisation et sa formulation
AU2004258953B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
WO2005009364A2 (fr) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Produit antibiotique, utilisation et formulation associees
WO2005016311A1 (fr) * 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Pastille robuste
JP2007502294A (ja) * 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
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US20110104109A1 (en) * 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
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US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
WO2008136815A2 (fr) 2006-12-22 2008-11-13 Schering Corporation Dérivés indoliques annelés à cycle à 5 ou 6 éléments et leurs méthodes d'utilisation
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US8697694B2 (en) 2008-08-20 2014-04-15 Merck Sharp & Dohme Corp. Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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CA2763140A1 (fr) 2009-05-29 2010-12-02 Schering Corporation Composes antiviraux de trois fractions d'aryle liees pour traiter des maladies telles que l'hepatite c
EP2503881B1 (fr) 2009-11-25 2015-05-13 Merck Sharp & Dohme Corp. Composés tricycliques fusionnés et leurs dérivés utiles pour le traitement de maladies virales
CA2785488A1 (fr) 2009-12-22 2011-07-21 Merck Sharp & Dohme Corp. Composes tricycliques fusionnes et leurs methodes d'utilisation pour le traitement de maladies virales
WO2011103441A1 (fr) 2010-02-18 2011-08-25 Schering Corporation Dérivés de pyridine et pyrimidine substitués et leur utilisation dans le traitement d'infections virales
AU2011224698A1 (en) 2010-03-09 2012-11-01 Merck Sharp & Dohme Corp. Fused Tricyclic Silyl Compounds and methods of use thereof for the treatment of viral diseases
CN101824004B (zh) * 2010-04-30 2012-02-22 黄山市歙县宏辉化工有限公司 一种头孢布烯侧链的合成工艺
WO2011139253A2 (fr) 2010-05-04 2011-11-10 Mahmut Bilgic Compositions pharmaceutiques comprenant du ceftibutène
AU2011286276A1 (en) 2010-07-26 2013-01-24 Merck Sharp & Dohme Corp. Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
EP2621279B1 (fr) 2010-09-29 2018-04-04 Merck Sharp & Dohme Corp. Dérivés tétracycliques condensés et procédés d'utilisation de ceux-ci dans le traitement de maladies virales
US9061041B2 (en) 2011-04-13 2015-06-23 Merck Sharp & Dohme Corp. 2′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
US9156872B2 (en) 2011-04-13 2015-10-13 Merck Sharp & Dohme Corp. 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
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Also Published As

Publication number Publication date
ES8604602A1 (es) 1986-02-01
HU193298B (en) 1987-09-28
DE3486259T2 (de) 1994-07-21
GB8700123D0 (en) 1987-02-11
MX174328B (es) 1994-05-09
NO843956L (no) 1985-04-09
NZ209634A (en) 1988-07-28
PH21766A (en) 1988-02-18
ES547301A0 (es) 1986-03-16
US4912224A (en) 1990-03-27
NZ218741A (en) 1988-07-28
DK474584D0 (da) 1984-10-03
NO173238C (no) 1993-11-17
GB2198727A (en) 1988-06-22
IL84653A (en) 1990-08-31
AU3330084A (en) 1985-05-09
ES8700222A1 (es) 1986-11-16
HUT36129A (en) 1985-08-28
GB8726623D0 (en) 1987-12-16
KR880002376B1 (ko) 1988-11-03
PT79287A (en) 1984-11-01
AU601842B2 (en) 1990-09-20
NO853806L (no) 1985-04-09
ES8605278A1 (es) 1986-03-16
GB2190914A (en) 1987-12-02
CA1238910A (fr) 1988-07-05
DK171043B1 (da) 1996-04-29
GR80544B (en) 1985-02-05
NO173238B (no) 1993-08-09
GB2154580A (en) 1985-09-11
ES547300A0 (es) 1986-11-16
IL73159A (en) 1990-08-31
CA1272713A (fr) 1990-08-14
PH20223A (en) 1986-10-23
KR880002684B1 (ko) 1988-12-20
EP0136721A2 (fr) 1985-04-10
EP0136721B1 (fr) 1993-12-29
IL73159A0 (en) 1985-01-31
AU1619488A (en) 1988-08-11
GB2190914B (en) 1988-08-17
GB2154580B (en) 1988-08-17
DE136721T1 (de) 1985-08-29
AR242392A1 (es) 1993-03-31
ATE99311T1 (de) 1994-01-15
NL940013I2 (nl) 1999-06-01
IL84653A0 (en) 1988-04-29
ES536502A0 (es) 1986-02-01
IE57744B1 (en) 1993-03-24
DE3486259D1 (de) 1994-02-10
NO176567B (no) 1995-01-16
US4634697A (en) 1987-01-06
US4748170A (en) 1988-05-31
IE842524L (en) 1985-04-04
EP0136721A3 (en) 1986-01-22
NL940013I1 (nl) 1994-08-16
NO176567C (no) 1995-04-26
FI843871L (fi) 1985-04-05
GB2198727B (en) 1988-11-16
FI843871A0 (fi) 1984-10-02
DK474584A (da) 1985-04-05
FI82057C (fi) 1991-01-10
AU575854B2 (en) 1988-08-11
FI82057B (fi) 1990-09-28
GB8424923D0 (en) 1984-11-07
KR850002989A (ko) 1985-05-28

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