CA1268180A - Derivatives of 4-phenyl-1,4-dihydropyridine-3, 5-dicarboxylic acid - Google Patents
Derivatives of 4-phenyl-1,4-dihydropyridine-3, 5-dicarboxylic acidInfo
- Publication number
- CA1268180A CA1268180A CA000489261A CA489261A CA1268180A CA 1268180 A CA1268180 A CA 1268180A CA 000489261 A CA000489261 A CA 000489261A CA 489261 A CA489261 A CA 489261A CA 1268180 A CA1268180 A CA 1268180A
- Authority
- CA
- Canada
- Prior art keywords
- general formula
- compounds
- dimethyl
- group
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B2205/00—Fibre drawing or extruding details
- C03B2205/44—Monotoring or regulating the preform feed rate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22383/84A IT1175620B (it) | 1984-08-22 | 1984-08-22 | Derivati piridinici |
| IT22383A/84 | 1984-08-22 | ||
| IT21460/85A IT1187678B (it) | 1985-07-05 | 1985-07-05 | Procedimento di preparazione di derivati eterociclici |
| IT21460A/85 | 1985-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1268180A true CA1268180A (en) | 1990-04-24 |
Family
ID=26327905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000489261A Expired - Lifetime CA1268180A (en) | 1984-08-22 | 1985-08-22 | Derivatives of 4-phenyl-1,4-dihydropyridine-3, 5-dicarboxylic acid |
Country Status (33)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
| AT394043B (de) * | 1985-08-21 | 1992-01-27 | Glaxo Spa | Verfahren zur herstellung von neuen dihydropyridinderivaten |
| DE3675747D1 (de) * | 1985-08-21 | 1991-01-03 | Glaxo Spa | 1,4-dihydropyridinverbindungen und ihre herstellung und pharmazeutische formulierung. |
| IT1204460B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
| IT1204461B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
| IT1204462B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
| IT1233370B (it) * | 1988-11-21 | 1992-03-27 | Glaxo Spa | Procedimento di preparazione di derivati diidropipiridinici utili nel trattamento di disturbi cardiovascolari |
| EP0395369B1 (en) | 1989-04-27 | 1997-07-02 | Canon Inc. | Optical recording medium and process for production thereof |
| US5177202A (en) * | 1990-10-09 | 1993-01-05 | Merck & Co., Inc. | 2-phenanthrenyl-carbapenems |
| US5196529A (en) * | 1990-10-09 | 1993-03-23 | Merck & Co., Inc. | 2-phenanthrenyl carbapenem intermediates |
| US5132422A (en) * | 1990-10-09 | 1992-07-21 | Merck & Co., Inc. | 2-naphthyl-carbapenem intermediates |
| US5132421A (en) * | 1990-10-09 | 1992-07-21 | Merck & Co., Inc. | 2-naphthyl-carbapenem intermediates |
| US5144028A (en) * | 1990-10-09 | 1992-09-01 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem intermediates |
| US5356889A (en) * | 1990-08-01 | 1994-10-18 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem intermediates |
| US5208329A (en) * | 1990-10-09 | 1993-05-04 | Merck & Co., Inc. | 2-biphenyl carbapenem intermediates |
| IT1244728B (it) * | 1991-02-13 | 1994-08-08 | Glaxo Spa | Impiego medicamentoso di derivati diidropiridinici |
| TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
| WO2000027397A1 (en) * | 1998-11-06 | 2000-05-18 | Glaxo Group Limited | Antihypertensive medicaments containing lacidipine and telmisartan |
| ES2362998T3 (es) | 2002-08-19 | 2011-07-18 | Pfizer Inc. | Terapia de combinación para enfermedades hiperproliferativas. |
| GEP20084406B (en) * | 2003-05-30 | 2008-06-25 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
| US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
| US20060147520A1 (en) * | 2004-07-26 | 2006-07-06 | Curtis Ruegg | Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation |
| EP1868577A4 (en) | 2005-04-15 | 2009-12-09 | Reddys Lab Inc Dr | Lacidipine PARTICLE |
| US20070043088A1 (en) * | 2005-08-16 | 2007-02-22 | Eswaraiah Sajja | Process for preparing lacidipine |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| EP2111863B1 (en) | 2005-10-26 | 2012-03-28 | Asahi Kasei Pharma Corporation | Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension |
| AU2006313430B2 (en) * | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| AR059838A1 (es) * | 2006-03-14 | 2008-04-30 | Ranbaxy Lab Ltd | Formulaciones para dosis estabilizantes de estatina |
| CN101494980A (zh) * | 2006-07-14 | 2009-07-29 | 兰贝克赛实验室有限公司 | HMG-CoA还原酶抑制剂的多晶型形式及其应用 |
| US20080089947A1 (en) * | 2006-08-18 | 2008-04-17 | Knox Clayton D | Calcium Influx Inhibitors in the Treatment of Ischemia |
| US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
| PL2705839T3 (pl) | 2012-09-10 | 2018-07-31 | Rivopharm Sa | Farmaceutyczna kompozycja zawierająca lacydypinę i proces przygotowania |
| AU2014255381A1 (en) | 2013-04-17 | 2015-10-08 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| MX2021008533A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3455945A (en) * | 1967-06-07 | 1969-07-15 | Smithkline Corp | 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines |
| DE2228363A1 (de) * | 1972-06-10 | 1974-01-03 | Bayer Ag | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
| US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
| DE3018259A1 (de) * | 1980-05-13 | 1981-11-19 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
| DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
| NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
-
1985
- 1985-07-29 NZ NZ212895A patent/NZ212895A/xx unknown
- 1985-08-20 ZW ZW131/85A patent/ZW13185A1/xx unknown
- 1985-08-20 DK DK378085A patent/DK165949C/da not_active IP Right Cessation
- 1985-08-20 US US06/767,593 patent/US4801599A/en not_active Expired - Lifetime
- 1985-08-20 SE SE8503888A patent/SE459920B/sv not_active IP Right Cessation
- 1985-08-20 NL NL8502296A patent/NL193065C/nl not_active IP Right Cessation
- 1985-08-20 GR GR852016A patent/GR852016B/el unknown
- 1985-08-21 MX MX206376A patent/MX159974A/es unknown
- 1985-08-21 CY CY1494A patent/CY1494A/xx unknown
- 1985-08-21 CH CH3593/85A patent/CH666684A5/de not_active IP Right Cessation
- 1985-08-21 ES ES546324A patent/ES8703839A1/es not_active Expired
- 1985-08-21 IE IE205485A patent/IE58486B1/en not_active IP Right Cessation
- 1985-08-21 NO NO853293A patent/NO167142C/no not_active IP Right Cessation
- 1985-08-21 LU LU88267C patent/LU88267I2/xx unknown
- 1985-08-21 JP JP60181934A patent/JPS6193162A/ja active Granted
- 1985-08-21 LU LU86047A patent/LU86047A1/fr active Protection Beyond IP Right Term
- 1985-08-21 FI FI853206A patent/FI81568C/fi not_active IP Right Cessation
- 1985-08-21 GB GB08520924A patent/GB2164336B/en not_active Expired
- 1985-08-22 AT AT0245485A patent/AT394042B/de not_active IP Right Cessation
- 1985-08-22 PT PT81000A patent/PT81000B/pt unknown
- 1985-08-22 PH PH32680A patent/PH22014A/en unknown
- 1985-08-22 CA CA000489261A patent/CA1268180A/en not_active Expired - Lifetime
- 1985-08-22 HU HU853202A patent/HU196754B/hu unknown
- 1985-08-22 DE DE3529997A patent/DE3529997C2/de not_active Expired - Lifetime
- 1985-08-22 FR FR8512631A patent/FR2569402B1/fr not_active Expired
- 1985-08-22 BE BE0/215493A patent/BE903103A/fr not_active IP Right Cessation
- 1985-08-22 KR KR1019850006044A patent/KR920004482B1/ko not_active IP Right Cessation
- 1985-08-22 AU AU46576/85A patent/AU578724B2/en not_active Expired
-
1986
- 1986-02-14 ES ES552049A patent/ES8802497A1/es not_active Expired
- 1986-02-14 ES ES552048A patent/ES8707931A1/es not_active Expired
- 1986-02-14 ES ES552050A patent/ES8707930A1/es not_active Expired
- 1986-02-14 ES ES552051A patent/ES8707932A1/es not_active Expired
-
1988
- 1988-07-27 JP JP63185661A patent/JPH0686430B2/ja not_active Expired - Lifetime
-
1989
- 1989-01-23 US US07/300,022 patent/US5011848A/en not_active Expired - Lifetime
- 1989-07-06 SG SG40889A patent/SG40889G/en unknown
-
1990
- 1990-07-12 HK HK529/90A patent/HK52990A/xx not_active IP Right Cessation
-
1991
- 1991-12-16 SA SA91120277A patent/SA91120277B1/ar unknown
- 1991-12-23 CS CS914030A patent/CS403091A3/cs unknown
- 1991-12-23 SK SK4030-91A patent/SK278327B6/sk unknown
-
1993
- 1993-08-20 BG BG98061A patent/BG60409B2/bg unknown
-
1998
- 1998-11-27 NL NL980037C patent/NL980037I2/nl unknown
-
1999
- 1999-04-23 NO NO1999007C patent/NO1999007I1/no unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |