CA1068261A - Chromogenic thrombin substrates - Google Patents
Chromogenic thrombin substratesInfo
- Publication number
- CA1068261A CA1068261A CA256,417A CA256417A CA1068261A CA 1068261 A CA1068261 A CA 1068261A CA 256417 A CA256417 A CA 256417A CA 1068261 A CA1068261 A CA 1068261A
- Authority
- CA
- Canada
- Prior art keywords
- group
- arg
- naphthyl
- formula
- tlc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7507975-6A SE407405B (sv) | 1975-07-11 | 1975-07-11 | Nya kromogena trombinsubstrat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1068261A true CA1068261A (en) | 1979-12-18 |
Family
ID=20325116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA256,417A Expired CA1068261A (en) | 1975-07-11 | 1976-07-06 | Chromogenic thrombin substrates |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5224590A (nl) |
| AT (1) | AT348686B (nl) |
| AU (1) | AU497547B2 (nl) |
| BE (1) | BE843970A (nl) |
| CA (1) | CA1068261A (nl) |
| CH (1) | CH622287A5 (nl) |
| CS (1) | CS196314B2 (nl) |
| DD (1) | DD128691A5 (nl) |
| DE (1) | DE2629195C3 (nl) |
| DK (1) | DK145799C (nl) |
| ES (1) | ES449739A1 (nl) |
| FI (1) | FI56525C (nl) |
| FR (1) | FR2317280A1 (nl) |
| GB (1) | GB1510926A (nl) |
| IL (1) | IL49829A (nl) |
| IT (1) | IT1062605B (nl) |
| NL (1) | NL188355C (nl) |
| NO (1) | NO142576C (nl) |
| PL (1) | PL103003B1 (nl) |
| SE (1) | SE407405B (nl) |
| SU (1) | SU719492A3 (nl) |
| ZA (1) | ZA763586B (nl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5255593A (en) * | 1975-10-30 | 1977-05-07 | Ajinomoto Kk | Measuring method of enzyme activity |
| DE2757992A1 (de) * | 1977-12-24 | 1979-06-28 | Boehringer Mannheim Gmbh | Verfahren zur prothrombin-bestimmung |
| DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
| US4289498A (en) * | 1979-01-08 | 1981-09-15 | Ortho Diagnostics, Inc. | One-stage prothrombin assay and compositions useful therein |
| DE3061860D1 (en) * | 1979-04-24 | 1983-03-17 | Marcel Jozefonvicz | Process for the determination of proteases and antiproteases |
| FR2471410A2 (fr) * | 1979-12-17 | 1981-06-19 | Jozefonvicz Marcel | Perfectionnements apportes a un procede de dosage des proteases et des anti-proteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement |
| DE3005540A1 (de) * | 1980-02-14 | 1981-08-20 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma |
| DK155051C (da) * | 1980-05-06 | 1989-07-03 | Pentapharm Ag | Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf |
| JPS5856695A (ja) * | 1981-09-28 | 1983-04-04 | Nitto Boseki Co Ltd | 新規なトロンビン測定用基質 |
| DE3211254A1 (de) * | 1982-03-26 | 1983-09-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
| DK201084A (da) * | 1983-04-28 | 1984-10-29 | Kimberly Clark Co | Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden |
| JPWO2006123789A1 (ja) | 2005-05-20 | 2008-12-25 | 株式会社三菱化学ヤトロン | 酵素分析方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE380257B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser |
| SE380258B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser |
-
1975
- 1975-07-11 SE SE7507975-6A patent/SE407405B/xx not_active IP Right Cessation
-
1976
- 1976-06-16 ZA ZA763586A patent/ZA763586B/xx unknown
- 1976-06-17 IL IL49829A patent/IL49829A/xx unknown
- 1976-06-21 GB GB25580/76A patent/GB1510926A/en not_active Expired
- 1976-06-25 AU AU15305/76A patent/AU497547B2/en not_active Expired
- 1976-06-25 AT AT463976A patent/AT348686B/de not_active IP Right Cessation
- 1976-06-29 DE DE2629195A patent/DE2629195C3/de not_active Expired
- 1976-06-29 NL NLAANVRAGE7607104,A patent/NL188355C/nl not_active IP Right Cessation
- 1976-07-06 CA CA256,417A patent/CA1068261A/en not_active Expired
- 1976-07-08 CS CS764544A patent/CS196314B2/cs unknown
- 1976-07-09 ES ES449739A patent/ES449739A1/es not_active Expired
- 1976-07-09 PL PL1976191068A patent/PL103003B1/pl unknown
- 1976-07-09 DK DK312676A patent/DK145799C/da not_active IP Right Cessation
- 1976-07-09 BE BE168774A patent/BE843970A/xx not_active IP Right Cessation
- 1976-07-09 IT IT50364/76A patent/IT1062605B/it active
- 1976-07-09 FI FI762010A patent/FI56525C/fi not_active IP Right Cessation
- 1976-07-09 CH CH887476A patent/CH622287A5/de not_active IP Right Cessation
- 1976-07-09 NO NO762407A patent/NO142576C/no unknown
- 1976-07-09 SU SU762379659A patent/SU719492A3/ru active
- 1976-07-09 DD DD7600193785A patent/DD128691A5/xx unknown
- 1976-07-09 FR FR7621196A patent/FR2317280A1/fr active Granted
- 1976-07-10 JP JP51082442A patent/JPS5224590A/ja active Granted
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4061625A (en) | Novel chromogenic thrombin substrates | |
| CA1048998A (en) | Chromogenic enzyme substrates | |
| US4214049A (en) | Assay of serine proteases using novel chromogenic enzyme substrates | |
| US3884896A (en) | New substrates for diagnostic use, with high susceptibility to thrombin and other proteolytic | |
| US4440678A (en) | Tripeptide derivatives and their application in assaying enzymes | |
| FI56829C (fi) | Nya diagnostiskt verksamma substrat med hoeg specifitet foer trypsin och andra enzymer av typen peptidylpeptidhydrolaser | |
| SU1277904A3 (ru) | Способ получени трипептидов | |
| US4016042A (en) | Substrate for the quantitative determination of enzymes | |
| US4137225A (en) | Novel chromogenic enzyme substrates | |
| CA1068261A (en) | Chromogenic thrombin substrates | |
| US4247454A (en) | Novel chromogenic thrombin substrates | |
| WO1982000641A1 (en) | Peptide substrates for determination of protease activity | |
| US4428874A (en) | Tripeptide derivatives | |
| US4169015A (en) | Novel chromogenic thrombin substrates | |
| US4216142A (en) | Chromogenic substrates for the proteolytic enzymes | |
| US4244865A (en) | α hydroxy tripeptide substrates | |
| EP0167980B1 (en) | Novel substrates for use in measuring the concentration of kallikrein in urine | |
| US4162941A (en) | Method for determining a proteolytic enzyme | |
| EP0224254B1 (en) | a novel substrate for plasma kallikrein and a method for measuring biological components using the same | |
| US4629695A (en) | Peptide derivatives and use thereof as substrates for quantitatively assaying enzymes | |
| AU602527B2 (en) | Chromogenic compounds, a process for their preparation and their use | |
| US4434096A (en) | Substrates for the quantitative determination of proteolytic enzymes | |
| MAZALEYRAT et al. | Synthesis and enzymic hydrolysis of cyclic peptides containing an anthranilic acid residue | |
| JPS62122599A (ja) | 酵素活性測定用ペプチド誘導体及びその使用法 | |
| JPH0776232B2 (ja) | ペプチド誘導体及びその使用方法 |