BRPI9915142B8 - novo material farmacêutico no formato de pérolas com liberação controlada, respectivo método de produção e formulação de múltiplas inidades compreendendo o mesmo - Google Patents

novo material farmacêutico no formato de pérolas com liberação controlada, respectivo método de produção e formulação de múltiplas inidades compreendendo o mesmo

Info

Publication number
BRPI9915142B8
BRPI9915142B8 BRPI9915142A BR9915142A BRPI9915142B8 BR PI9915142 B8 BRPI9915142 B8 BR PI9915142B8 BR PI9915142 A BRPI9915142 A BR PI9915142A BR 9915142 A BR9915142 A BR 9915142A BR PI9915142 B8 BRPI9915142 B8 BR PI9915142B8
Authority
BR
Brazil
Prior art keywords
pearls
layer
pharmaceutical material
controlled release
formulation
Prior art date
Application number
BRPI9915142A
Other languages
English (en)
Other versions
BRPI9915142B1 (pt
BR9915142A (pt
Inventor
Torkel Gren
Anders Ringberg
Randy J Wald
Martin Wikberg
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20413266&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI9915142(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/SE1999/001463 external-priority patent/WO2000012069A1/en
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of BR9915142A publication Critical patent/BR9915142A/pt
Publication of BRPI9915142B1 publication Critical patent/BRPI9915142B1/pt
Publication of BRPI9915142B8 publication Critical patent/BRPI9915142B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<b>"novo material farmacêutico no formato de pérolas com liberação controlada, respectivo método de produção e formulação de múltiplas unidades compreendendo o mesmo"<d> a presente invenção se refere a um material farmacêutico no formato de pérolas que compreende: (i) uma unidade de núcleo de um material substancialmente inerte solúvel em água ou expansível em água; (ii) uma primeira camada sobre a unidade de núcleo de um polímero substancialmente insolúvel em água; (iii) uma segunda camada cobrindo a primeira camada e contendo um ingrediente ativo; e (iv) uma terceira camada de polímero sobre a segunda camada efetiva, para liberação controlada do ingrediente ativo, em que a dita primeira camada é adaptada para controlar a penetração de água dentro do núcleo. é também divulgado pela presente invenção um método para produção de um material farmacêutico no formato de pérolas, de liberação controlada.
BRPI9915142A 1998-11-11 1999-11-11 novo material farmacêutico no formato de pérolas com liberação controlada, respectivo método de produção e formulação de múltiplas inidades compreendendo o mesmo BRPI9915142B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9803871A SE9803871D0 (sv) 1998-11-11 1998-11-11 Therapeutic method and formulation
PCT/SE1999/001463 WO2000012069A1 (en) 1998-08-27 1999-08-26 Therapeutic formulation for administering tolterodine with controlled release
PCT/SE1999/002052 WO2000027364A1 (en) 1998-11-11 1999-11-11 New controlled release bead, a method of producing the same and multiple unit formulation comprising it

Publications (3)

Publication Number Publication Date
BR9915142A BR9915142A (pt) 2001-08-07
BRPI9915142B1 BRPI9915142B1 (pt) 2015-08-25
BRPI9915142B8 true BRPI9915142B8 (pt) 2021-05-25

Family

ID=20413266

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9915142A BRPI9915142B8 (pt) 1998-11-11 1999-11-11 novo material farmacêutico no formato de pérolas com liberação controlada, respectivo método de produção e formulação de múltiplas inidades compreendendo o mesmo

Country Status (40)

Country Link
US (1) US6911217B1 (pt)
EP (1) EP1128819B1 (pt)
JP (1) JP3616011B2 (pt)
KR (1) KR100467384B1 (pt)
CN (1) CN1169522C (pt)
AP (1) AP1323A (pt)
AR (1) AR027815A1 (pt)
AT (1) ATE247458T1 (pt)
AU (1) AU762410B2 (pt)
BG (1) BG65149B1 (pt)
BR (1) BRPI9915142B8 (pt)
CA (1) CA2350061C (pt)
CZ (1) CZ299582B6 (pt)
DE (1) DE69910604T2 (pt)
DK (1) DK1128819T3 (pt)
EA (1) EA005074B1 (pt)
EE (1) EE05232B1 (pt)
ES (1) ES2204193T3 (pt)
GE (1) GEP20022833B (pt)
HK (1) HK1040917B (pt)
HR (1) HRP20010333B1 (pt)
HU (1) HU226582B1 (pt)
ID (1) ID30039A (pt)
IL (1) IL142809A0 (pt)
IS (1) IS2370B (pt)
MA (1) MA25325A1 (pt)
MY (1) MY122195A (pt)
NO (1) NO331399B1 (pt)
NZ (1) NZ511430A (pt)
OA (1) OA11673A (pt)
PL (1) PL195780B1 (pt)
PT (1) PT1128819E (pt)
RS (1) RS49891B (pt)
SE (1) SE9803871D0 (pt)
SI (1) SI1128819T1 (pt)
SK (1) SK284758B6 (pt)
TW (2) TWI267385B (pt)
UA (1) UA57165C2 (pt)
WO (1) WO2000027364A1 (pt)
ZA (1) ZA200103575B (pt)

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Also Published As

Publication number Publication date
JP3616011B2 (ja) 2005-02-02
BRPI9915142B1 (pt) 2015-08-25
SK6252001A3 (en) 2002-01-07
EA200100538A1 (ru) 2001-10-22
BR9915142A (pt) 2001-08-07
HRP20010333B1 (en) 2004-10-31
AU762410B2 (en) 2003-06-26
HUP0105038A2 (en) 2002-06-29
BG105582A (en) 2001-12-29
KR20010075695A (ko) 2001-08-09
HUP0105038A3 (en) 2006-07-28
DE69910604D1 (de) 2003-09-25
OA11673A (en) 2005-01-12
AP1323A (en) 2004-11-05
MY122195A (en) 2006-03-31
WO2000027364A1 (en) 2000-05-18
HK1040917B (zh) 2005-05-27
MA25325A1 (fr) 2001-12-31
NO331399B1 (no) 2011-12-19
NO20012314L (no) 2001-07-09
EP1128819B1 (en) 2003-08-20
UA57165C2 (uk) 2003-06-16
ID30039A (id) 2001-11-01
IS5936A (is) 2001-05-09
HK1040917A1 (en) 2002-06-28
BG65149B1 (bg) 2007-04-30
IS2370B (is) 2008-06-15
YU33101A (sh) 2003-10-31
CZ20011627A3 (cs) 2001-10-17
ES2204193T3 (es) 2004-04-16
PT1128819E (pt) 2003-12-31
DE69910604T2 (de) 2004-06-24
EE200100254A (et) 2002-12-16
HRP20010333A2 (en) 2003-04-30
TWI267385B (en) 2006-12-01
CN1326339A (zh) 2001-12-12
CA2350061C (en) 2005-05-17
ATE247458T1 (de) 2003-09-15
HU226582B1 (en) 2009-04-28
CZ299582B6 (cs) 2008-09-10
EE05232B1 (et) 2009-12-15
NZ511430A (en) 2003-05-30
IL142809A0 (en) 2002-03-10
CN1169522C (zh) 2004-10-06
PL348612A1 (en) 2002-06-03
AR027815A1 (es) 2003-04-16
KR100467384B1 (ko) 2005-01-24
PL195780B1 (pl) 2007-10-31
SE9803871D0 (sv) 1998-11-11
JP2003517446A (ja) 2003-05-27
NO20012314D0 (no) 2001-05-10
AU1436600A (en) 2000-05-29
SK284758B6 (sk) 2005-11-03
GEP20022833B (en) 2002-11-25
DK1128819T3 (da) 2003-12-01
SI1128819T1 (en) 2003-12-31
AP2001002166A0 (en) 2001-06-30
CA2350061A1 (en) 2000-05-18
RS49891B (sr) 2008-08-07
ZA200103575B (en) 2002-05-03
EA005074B1 (ru) 2004-10-28
US6911217B1 (en) 2005-06-28
EP1128819A1 (en) 2001-09-05
TWI222879B (en) 2004-11-01

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