ES2077023T3 - Material de recubrimiento que controla la liberacion de un medicamento para formulaciones de actividad prolongada. - Google Patents

Material de recubrimiento que controla la liberacion de un medicamento para formulaciones de actividad prolongada.

Info

Publication number
ES2077023T3
ES2077023T3 ES90302287T ES90302287T ES2077023T3 ES 2077023 T3 ES2077023 T3 ES 2077023T3 ES 90302287 T ES90302287 T ES 90302287T ES 90302287 T ES90302287 T ES 90302287T ES 2077023 T3 ES2077023 T3 ES 2077023T3
Authority
ES
Spain
Prior art keywords
coating material
formulations
release
drug
controls
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90302287T
Other languages
English (en)
Inventor
Tadayoshi Ohmura
Muneo Fukui
Hiroshi Sugiura
Toshiharu Hosono
Atsushi Kajiyama
Satoru Yoneya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2077023T3 publication Critical patent/ES2077023T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

UN MATERIAL DE CUBIERTA PARA CONTROLAR LA LIBERACION DE DROGA, UTIL PARA FORMULAS ACTUANTES LARGO TIEMPO (POR EJEMPLO PARA ADMINISTRACION UNA VEZ AL DIA), Y UNA COMPOSICION GRANULAR ACTUANTE LARGO TIEMPO QUE COMPRENDE UNA DROGA (ESPECIALMENTE UNA CONVENCIONALMENTE DIFICIL PARA PREPARAR EN LA FORMA ACTUANTE LARGO TIEMPO) CUBIERTA CON EL MATERIAL DE CUBIERTA. ESTA COMPOSICION DEBE SER MEZCLADA CON OTRAS FORMULAS DE DROGAS GRANULARES. EL MATERIAL DE CUBIERTA CONTROLADOR DE LA LIBERACION DE DROGA DEBE COMPRENDER, EN UNA PROPORCION ESPECIFICA, POLIMERO INSOLUBLE EN AGUA ESPECIFICO Y DE PERMEABILIDAD DE AGUA BAJA Y DOS MATERIALES QUE DIFIEREN DE CADA OTRO EN LA DEPENDENCIA PH DE SU SOLUBILIDAD (MATERIALES POLIMEROS DEPENDIENTES DE PH).
ES90302287T 1989-03-10 1990-03-05 Material de recubrimiento que controla la liberacion de un medicamento para formulaciones de actividad prolongada. Expired - Lifetime ES2077023T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5868489 1989-03-10

Publications (1)

Publication Number Publication Date
ES2077023T3 true ES2077023T3 (es) 1995-11-16

Family

ID=13091382

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90302287T Expired - Lifetime ES2077023T3 (es) 1989-03-10 1990-03-05 Material de recubrimiento que controla la liberacion de un medicamento para formulaciones de actividad prolongada.

Country Status (19)

Country Link
US (1) US5028664A (es)
EP (1) EP0386967B1 (es)
JP (1) JPH037238A (es)
KR (1) KR0140985B1 (es)
CN (1) CN1045524A (es)
AT (1) ATE124864T1 (es)
AU (1) AU623233B2 (es)
CA (1) CA2011919A1 (es)
DD (2) DD298205A5 (es)
DE (1) DE69020758T2 (es)
DK (1) DK0386967T3 (es)
ES (1) ES2077023T3 (es)
FI (1) FI97690C (es)
GR (1) GR3017645T3 (es)
HU (1) HU204201B (es)
IE (1) IE68520B1 (es)
NO (1) NO301578B1 (es)
NZ (1) NZ232836A (es)
PT (1) PT93384B (es)

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GEP19971086B (en) * 1991-02-22 1997-12-02 Tillotts Pharma Ag Peroral Pharmaceutically Dispensed Form for Selective Introducing of the Medicine into the Intestine
GB9200607D0 (en) * 1992-01-13 1992-03-11 Ethical Pharma Ltd Pharmaceutical compositions containing nifedipine and process for the preparation thereof
US20030170290A1 (en) * 1993-06-16 2003-09-11 Shug Austin L. Delayed release carnitine
WO1995005168A1 (en) * 1993-08-19 1995-02-23 Shug Austin L Delayed release carnitine
DE9414066U1 (de) * 1994-08-31 1994-11-03 Roehm Gmbh Überzugs- und Bindemittel für Arzneiformen sowie damit hergestellte Arzneiform
NZ270078A (en) * 1994-12-06 1998-05-27 Bernard Charles Sherman Diltiazem hydrochloride formulation comprising beads with immediate, intermediate, and delayed release dissolution profiles
US5567441A (en) * 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
PT784974E (pt) * 1995-07-26 2003-09-30 Kyowa Hakko Kogyo Kk Preparacao de derivados de xantina numa dispersao solida
US6162463A (en) * 1997-05-01 2000-12-19 Dov Pharmaceutical Inc Extended release formulation of diltiazem hydrochloride
US6342611B1 (en) * 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
KR20010040819A (ko) 1998-02-10 2001-05-15 가마꾸라 아끼오 제어방출형 제제
JP2003500348A (ja) * 1999-05-20 2003-01-07 エラン コーポレーシヨン ピーエルシー 多粒子状制御放出選択的セロトニン再吸収阻害剤製剤
EP1064938A1 (en) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmaceutical dosage forms for controlled release producing at least a timed pulse
ATE376414T1 (de) * 1999-09-02 2007-11-15 Nostrum Pharmaceuticals Inc Pellet formulierung mit gesteuerter freisetzung
AR026148A1 (es) * 2000-01-21 2003-01-29 Osmotica Argentina S A Dispositivo osmotico con pasaje preformado que aumenta de tamano
WO2002066004A1 (fr) * 2001-02-23 2002-08-29 Mitsubishi Pharma Corporation Compositions a liberation controlee de medicament
IL161983A0 (en) * 2001-11-21 2005-11-20 Eisai Co Ltd Preparation compositions containing acid-unstable physiologically active compounds, and process for producing the same
RU2401125C2 (ru) 2004-12-27 2010-10-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Способ стабилизации лекарственного средства против деменции
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
US20060246003A1 (en) * 2004-12-27 2006-11-02 Eisai Co. Ltd. Composition containing anti-dementia drug
CN100398122C (zh) * 2005-01-28 2008-07-02 北京北大药业有限公司 一种治疗颈、腰椎病中药的肠溶包衣组合物
BRPI0821985A2 (pt) * 2008-01-10 2015-06-23 Evonik Roehm Gmbh Preparacao farmacêutica ou nutracêutica revestida tendo liberação de substância ativa controlada
ES2715274T3 (es) * 2008-01-10 2019-06-03 Evonik Roehm Gmbh Preparación farmacéutica o nutracéutica recubierta con liberación de sustancias activas mejorada
US9028878B2 (en) 2009-02-03 2015-05-12 Microbion Corporation Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
JP5674684B2 (ja) 2009-02-03 2015-02-25 マイクロビオン コーポレーション 上皮組織、急性および慢性創傷、細菌性バイオフィルムならびに他の適応症のための消毒剤としてのビスマス−チオール
US9408393B2 (en) 2010-02-03 2016-08-09 Microbion Corporation Bismuth-thiols as antiseptics for agricultural, industrial and other uses
JP2021533193A (ja) 2018-07-31 2021-12-02 マイクロビオン コーポレーション ビスマスチオール組成物及び使用方法
CN112788950A (zh) 2018-07-31 2021-05-11 微生物公司 用于治疗伤口的铋-硫醇组合物和方法
WO2022029938A1 (ja) * 2020-08-05 2022-02-10 マルホ株式会社 皮膚用組成物

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US3236914A (en) * 1959-05-12 1966-02-22 Canadian Ind Method for rendering polymers compatible
US3300429A (en) * 1963-06-17 1967-01-24 Rohm & Haas Aqueous polymeric blends containing ureido monomer
US3369009A (en) * 1964-12-10 1968-02-13 Hercules Inc Azidoformate-containing copolymers
US3641237A (en) * 1970-09-30 1972-02-08 Nat Patent Dev Corp Zero order release constant elution rate drug dosage
US4065523A (en) * 1975-11-24 1977-12-27 Rohm And Haas Company Process for increasing molecular weight of a polymer
US4082705A (en) * 1976-02-05 1978-04-04 Johnson & Johnson Pressure sensitive adhesive compositions
GB2046275A (en) * 1979-03-27 1980-11-12 American Cyanamid Co Granulation and drying aids for polymeric gels
SE8003805L (sv) * 1980-05-21 1981-11-22 Haessle Ab En farmaceutisk beredning med forbettrade utlosningsegenskap
US4539199A (en) * 1981-01-14 1985-09-03 Egyt Gyogyszervegyeszeti Gyar Sustained release pharmaceutical compositions
US4758437A (en) * 1981-12-23 1988-07-19 Yamanouchi Pharmaceutical Co., Ltd. Composition for long acting nicardipine preparation and process of producing the composition
JPS6051106A (ja) * 1983-08-31 1985-03-22 Yamanouchi Pharmaceut Co Ltd 塩酸アモスラロ−ル持続性製剤
JPS60240747A (ja) * 1984-05-15 1985-11-29 Showa Denko Kk 架橋性組成物及びエステル架橋型重合体
JPS62126122A (ja) * 1985-11-27 1987-06-08 Showa Shinyaku Kk 表面コ−テイングされたイブプロフエン顆粒の製法
IL77186A0 (en) * 1985-11-29 1986-04-29 Touitou Elka Pharmaceutical insulin composition
JP2667162B2 (ja) * 1986-11-04 1997-10-27 日本製紙株式会社 インクジエツト記録用シート
SE460946B (sv) * 1987-03-16 1989-12-11 Lejus Medical Ab En multipel-unit-dos komposition av kinidinglukonat

Also Published As

Publication number Publication date
JPH037238A (ja) 1991-01-14
PT93384B (pt) 1996-03-29
NZ232836A (en) 1991-06-25
DK0386967T3 (da) 1995-11-20
EP0386967A3 (en) 1991-04-03
HU901380D0 (en) 1990-05-28
IE68520B1 (en) 1996-06-26
CA2011919A1 (en) 1990-09-10
US5028664A (en) 1991-07-02
NO901116L (no) 1990-09-11
NO301578B1 (no) 1997-11-17
FI97690C (fi) 1997-02-10
EP0386967B1 (en) 1995-07-12
EP0386967A2 (en) 1990-09-12
KR0140985B1 (ko) 1998-06-01
KR900013943A (ko) 1990-10-22
IE900862L (en) 1990-09-10
FI97690B (fi) 1996-10-31
CN1045524A (zh) 1990-09-26
DE69020758T2 (de) 1995-12-07
DD298205A5 (de) 1992-02-13
DD292374A5 (de) 1991-08-01
NO901116D0 (no) 1990-03-09
ATE124864T1 (de) 1995-07-15
AU5122790A (en) 1990-09-13
FI901195A0 (fi) 1990-03-09
AU623233B2 (en) 1992-05-07
HU204201B (en) 1991-12-30
DE69020758D1 (de) 1995-08-17
PT93384A (pt) 1990-11-07
GR3017645T3 (en) 1996-01-31
HUT53813A (en) 1990-12-28

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