BRPI0912046B1 - Composições de hibridizaqao e seu uso, bem como metodo de hibridizaqao de sequencias de acido nucleico - Google Patents

Composições de hibridizaqao e seu uso, bem como metodo de hibridizaqao de sequencias de acido nucleico Download PDF

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Publication number
BRPI0912046B1
BRPI0912046B1 BRPI0912046-7A BRPI0912046A BRPI0912046B1 BR PI0912046 B1 BRPI0912046 B1 BR PI0912046B1 BR PI0912046 A BRPI0912046 A BR PI0912046A BR PI0912046 B1 BRPI0912046 B1 BR PI0912046B1
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Brazil
Prior art keywords
hybridization
nucleic acid
polar aprotic
compositions
composition
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BRPI0912046-7A
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English (en)
Portuguese (pt)
Inventor
Charles M. Hansen
Steen Hauge Matthiesen
Kenneth H. Petersen
Tim Svenstrup Poulsen
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Agilent Technologies, Inc
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Application filed by Agilent Technologies, Inc filed Critical Agilent Technologies, Inc
Publication of BRPI0912046A2 publication Critical patent/BRPI0912046A2/pt
Publication of BRPI0912046B1 publication Critical patent/BRPI0912046B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BRPI0912046-7A 2008-05-27 2009-05-27 Composições de hibridizaqao e seu uso, bem como metodo de hibridizaqao de sequencias de acido nucleico BRPI0912046B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US5608908P 2008-05-27 2008-05-27
DKPA200800727 2008-05-27
US61/056,089 2008-05-27
DKPA200800727 2008-05-27
US15568309P 2009-02-26 2009-02-26
US61/155,683 2009-02-26
DKPA200900278 2009-02-27
DKPA200900278 2009-02-27
PCT/IB2009/005893 WO2009144581A1 (en) 2008-05-27 2009-05-27 Hybridization compositions and methods

Publications (2)

Publication Number Publication Date
BRPI0912046A2 BRPI0912046A2 (pt) 2017-06-20
BRPI0912046B1 true BRPI0912046B1 (pt) 2020-11-24

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BRPI0912046-7A BRPI0912046B1 (pt) 2008-05-27 2009-05-27 Composições de hibridizaqao e seu uso, bem como metodo de hibridizaqao de sequencias de acido nucleico

Country Status (9)

Country Link
US (5) US11118214B2 (https=)
EP (8) EP2636756B2 (https=)
JP (2) JP5588970B2 (https=)
CN (3) CN102084004B (https=)
BR (1) BRPI0912046B1 (https=)
CA (2) CA2724638C (https=)
ES (4) ES2595031T5 (https=)
RU (2) RU2618868C2 (https=)
WO (2) WO2009144581A1 (https=)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2636756B2 (en) 2008-05-27 2019-11-20 Dako Denmark A/S Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers
EP2401396B1 (en) * 2009-02-26 2016-11-23 Dako Denmark A/S Methods for performing a stringent wash step in hybridization applications
US20130040294A1 (en) * 2009-12-02 2013-02-14 Steen H. Matthiesen Compositions and methods for performing hybridizations with no denaturation
EP2569624B1 (en) 2010-05-10 2017-03-15 Mayo Foundation for Medical Education and Research Detection of chromosomal abnormalities associated with endometrial cancer
WO2012036329A1 (ko) 2010-09-16 2012-03-22 씨비에스바이오사이언스 주식회사 간암 예후 예측용 조성물 또는 키트, 및 간암 예후 예측 방법
JP2014509189A (ja) 2011-01-25 2014-04-17 アルマック ダイアグノスティックス リミテッド 結腸ガン遺伝子発現シグネチャーおよび使用方法
CN104845992B (zh) * 2011-09-16 2018-09-14 上海长海医院 前列腺癌的生物学标志物、治疗靶点及其用途
WO2013046033A1 (en) 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
EP2768974B1 (en) * 2011-10-21 2017-07-19 Dako Denmark A/S Hybridization compositions and methods
US20130171622A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Compositions and methods for detecting viral infection using direct-label fluorescence in situ hybridization
KR101938699B1 (ko) 2012-07-23 2019-01-16 삼성전자주식회사 Ｌｒｉｇ１의 항 ｃ―ｍｅｔ 항체 적용 대상 환자 선별을 위한 용도
TWI707038B (zh) 2013-08-05 2020-10-11 美商扭轉生物科技有限公司 重新合成之基因庫
GB201319180D0 (en) * 2013-10-30 2013-12-11 Mast Group Ltd Nucleic acid probe
US10253353B2 (en) * 2013-12-06 2019-04-09 The Broad Institute, Inc. Enhanced methods of ribonucleic acid hybridization
US9587268B2 (en) * 2014-01-29 2017-03-07 Agilent Technologies Inc. Fast hybridization for next generation sequencing target enrichment
US9994912B2 (en) 2014-07-03 2018-06-12 Abbott Molecular Inc. Materials and methods for assessing progression of prostate cancer
DK3201630T3 (en) * 2014-09-29 2019-02-25 Ventana Med Syst Inc Multiplex assay for simultaneous detection of TP53 / CEN17 / B cell gene protein and uniquely specific probes for 19Q12, INSR, ATM, DLEU2, TP53 and 13Q12
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
JP6675758B2 (ja) * 2015-02-20 2020-04-01 国立大学法人名古屋大学 ホスファフルオレセイン化合物若しくはその塩、又はそれを用いた蛍光色素
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
ES2753274T5 (es) * 2015-08-21 2023-05-26 42 Life Sciences Gmbh & Co Kg Composición y procedimiento de hibridación
KR20180050411A (ko) 2015-09-18 2018-05-14 트위스트 바이오사이언스 코포레이션 올리고핵산 변이체 라이브러리 및 그의 합성
KR102794025B1 (ko) 2015-09-22 2025-04-09 트위스트 바이오사이언스 코포레이션 핵산 합성을 위한 가요성 기판
CN108779490A (zh) * 2016-01-08 2018-11-09 雅培分子公司 包含硫氰酸胍的杂交缓冲液
CN105755136B (zh) * 2016-04-13 2017-08-25 武汉康录生物技术有限公司 一种人12号染色体着丝粒探针试剂盒及其制备方法和应用
CN107419001A (zh) * 2016-05-23 2017-12-01 益善生物技术股份有限公司 Brca1、pten基因异常检测试剂盒及检测方法
CN107058565A (zh) * 2016-08-31 2017-08-18 郭军 肢端型黑色素瘤的诊断和治疗
US10417457B2 (en) 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
WO2018093777A1 (en) * 2016-11-15 2018-05-24 The Regents Of The University Of Michigan Centromere analysis
CN110892485B (zh) 2017-02-22 2024-03-22 特韦斯特生物科学公司 基于核酸的数据存储
CN107227359A (zh) * 2017-06-19 2017-10-03 福建万科药业有限公司 一种亚型Ph‑likeALL的检测试剂盒及其检测方法
CN107312838A (zh) * 2017-06-28 2017-11-03 广西大学 细胞荧光原位杂交方法
US20200347455A1 (en) 2017-09-05 2020-11-05 Agency For Science, Technology And Research Clear Cell Renal Cell Carcinoma Biomarkers
CN111565834B (zh) 2017-10-20 2022-08-26 特韦斯特生物科学公司 用于多核苷酸合成的加热的纳米孔
CA3100739A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
EP3830286A1 (en) * 2018-07-27 2021-06-09 F. Hoffmann-La Roche AG Formamide free target enrichment compositions for next-generation sequencing applications
CN108998531B (zh) * 2018-08-31 2021-10-01 昆明医科大学第一附属医院 肺癌下调长链非编码rna标志物及其应用
US20220119870A1 (en) * 2018-11-01 2022-04-21 Advanced Cell Diagnostics, Inc. Methods for digital multiplexing of nucleic acids in situ
US10768173B1 (en) 2019-09-06 2020-09-08 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
US10704094B1 (en) 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
GB2613480B (en) 2018-11-15 2023-11-22 Element Biosciences Inc Methods for generating circular nucleic acid molecules
US12357959B2 (en) 2018-12-26 2025-07-15 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
CN113766930B (zh) 2019-02-26 2025-07-22 特韦斯特生物科学公司 Glp1受体的变异核酸文库
CA3131691A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
CN111781356A (zh) * 2019-04-04 2020-10-16 清华大学 一种胃癌极早期细胞标志和胃癌前病变早期细胞标志及其在诊断试剂盒中的应用
JP7615052B2 (ja) 2019-04-25 2025-01-16 アジレント・テクノロジーズ・インク ハイブリダイゼーション組成物ならびに組成物を調製および使用するための方法
US12313627B2 (en) 2019-05-01 2025-05-27 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
CN110172511A (zh) * 2019-05-10 2019-08-27 广州安必平医药科技股份有限公司 用于检测her-2基因扩增水平的探针组、试剂盒及其应用
CN110257483B (zh) * 2019-07-10 2022-08-05 厦门通灵生物医药科技有限公司 用于原位杂交的杂交液、其制备方法及检测试剂盒
WO2021061842A1 (en) 2019-09-23 2021-04-01 Twist Bioscience Corporation Variant nucleic acid libraries for single domain antibodies
US11287422B2 (en) 2019-09-23 2022-03-29 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
JP2022548309A (ja) 2019-09-23 2022-11-17 ツイスト バイオサイエンス コーポレーション Ｃｒｔｈ２のバリアント核酸ライブラリー
GB2617481B (en) 2020-10-30 2025-07-02 Element Biosciences Inc Reagents for massively parallel nucleic acid sequencing
CN112626180A (zh) * 2020-12-30 2021-04-09 北京思尔成生物技术有限公司 一种dna杂交增强液及其制备方法与应用
MA62179B1 (fr) * 2021-02-26 2025-12-31 Elips Diagnostics Inc. Nouveau co-réactif d'électrochimioluminescence et système d'électrochimioluminescence le comprenant
CN114561449B (zh) * 2022-02-28 2022-10-14 深圳大学 一种免预杂交的Northern blot杂交液及其应用
AU2023325064A1 (en) 2022-08-15 2025-03-06 Element Biosciences, Inc. Spatially resolved surface capture of nucleic acids
CN116144780A (zh) * 2023-03-17 2023-05-23 重庆医科大学 一种慢性淋巴细胞白血病的细胞的遗传学检测方法
AU2024335309A1 (en) 2023-08-30 2026-03-19 Foss Analytical A/S Improved hybridization assay with stringency buffer dilution
CN121729506A (zh) 2023-08-30 2026-03-24 福斯分析股份公司 核酸的组合预处理和杂交
CN117247995A (zh) * 2023-09-12 2023-12-19 上海新培晶医学检验所有限公司 一种在g-显带的玻片上进行分子荧光原位杂交处理方法
CN117887813B (zh) * 2023-11-28 2024-07-12 首都医科大学附属北京口腔医院 一种杂交缓冲液与应用
CN118454487B (zh) * 2024-05-20 2024-11-08 上海乐纯生物技术股份有限公司 一种亲水改性聚偏氟乙烯过滤膜的制备方法

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3151405A (en) 1960-12-15 1964-10-06 Ludwig Herbert Ladies' slipper having a plastic bead construction
US4652517A (en) 1984-06-11 1987-03-24 Diagnostic Research Limited Partnership Methods for the in vitro detection and identification of unknown pathogens or genetic entities
US5132207A (en) 1984-07-05 1992-07-21 Gen-Probe Incorporated Accelerated nucleic acid reassociation method
US4888278A (en) 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US6344315B1 (en) 1986-01-16 2002-02-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US6475720B1 (en) * 1986-01-16 2002-11-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
EP0261955A3 (en) 1986-09-26 1989-06-07 E.I. Du Pont De Nemours And Company Process for immobilization of dna
US4886741A (en) 1987-12-09 1989-12-12 Microprobe Corporation Use of volume exclusion agents for the enhancement of in situ hybridization
US4996359A (en) * 1988-03-14 1991-02-26 Arco Chemical Technology, Inc. Process for the preparation of aromatic bis dialkyl ureas
US5869237A (en) 1988-11-15 1999-02-09 Yale University Amplification karyotyping
US6203977B1 (en) 1988-11-15 2001-03-20 Yale University Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization
US5650148A (en) 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5633129A (en) 1989-07-13 1997-05-27 Massachusetts Institute Of Technology Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices
US5106730A (en) 1989-07-24 1992-04-21 Microprobe Corporation Lactam-containing compositions and methods useful for the hybridization of nucleic acids
AU6144590A (en) 1989-07-24 1991-03-11 Microprobe Corporation Lactam-containing compositions and methods useful for the hybridization of nucleic acids
BR9105888A (pt) 1990-08-30 1992-11-10 Tropix Inc 3-(adamant substituido-2'-ilideno) 1,2-dioxetanos quimiluminescentes
WO1992007959A1 (en) 1990-11-05 1992-05-14 Biowhittaker Inc. Homogeneous membrane lytic immunoassay method utilizing contact sensitive liposome formulations
GB9024005D0 (en) 1990-11-05 1990-12-19 British Bio Technology Process for amplifying nucleic acid
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5641625A (en) 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US6228982B1 (en) 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
GB9211979D0 (en) 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
WO1994002638A1 (en) * 1992-07-17 1994-02-03 Aprogenex, Inc. Free radical scavengers useful for reducing autofluorescence in fixed cells
US5521061A (en) 1992-07-17 1996-05-28 Aprogenex, Inc. Enhancement of probe signal in nucleic acid-mediated in-situ hybridization studies
AU5355594A (en) 1992-10-09 1994-05-09 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by (in situ) hybridization to fixed tissue
US5432065A (en) 1993-03-30 1995-07-11 United States Biochemical Corporation Cycle sequencing with non-thermostable DNA polymerases
US5382285A (en) 1993-04-06 1995-01-17 Regents Of The University Of California Biofoam
US5527675A (en) 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
US5705333A (en) 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US5582985A (en) 1994-08-05 1996-12-10 The Regents Of The University Of California Detection of mycobacteria
WO1996007668A1 (de) 1994-09-02 1996-03-14 Novartis Ag Funktionelle terpyridin-metallkomplexe, verfahren zu deren herstellung und oligonukleotid-konjugate mit terpyridin-metallkomplexen
US5718915A (en) 1994-10-31 1998-02-17 Burstein Laboratories, Inc. Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme
US20010011131A1 (en) 1997-07-28 2001-08-02 Luyten Frank P. DNA molecules encoding cartilage-derived morphogenetic proteins
US5750340A (en) * 1995-04-07 1998-05-12 University Of New Mexico In situ hybridization solution and process
DE19516399A1 (de) 1995-05-04 1996-11-07 Bayer Ag Verfahren zur Herstellung von Polymeren mit wiederkehrenden Succinyleinheiten
JP2000500341A (ja) 1995-11-13 2000-01-18 ユニバーシティ・オブ・ロチェスター 組換え基質による哺乳類体細胞モザイク現象の生成
US5962227A (en) 1996-07-26 1999-10-05 The Regents Of The University Of California DNA-based diagnostic test for detecting myxobolus, the cause of salmonid whirling disease
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6361940B1 (en) * 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
ATE243761T1 (de) 1996-10-04 2003-07-15 Dako As Sonden zur detektion von mycobakterien
US6329197B2 (en) 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
US5858671A (en) 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
IL131978A0 (en) 1997-03-20 2001-03-19 Univ Washington Solvent for biopolymer synthesis solvent microdots and methods of use
US6716625B1 (en) 1997-04-16 2004-04-06 Claude Selitrennikoff Histidine kinases of Aspergillus and other fungal species, related compositions, and methods of use
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
EP0878552A1 (en) 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
US6107470A (en) 1997-05-29 2000-08-22 Nielsen; Peter E. Histidine-containing peptide nucleic acids
CA2242035C (en) * 1997-07-01 2004-11-23 Transgene S.A. Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy
US6207408B1 (en) 1997-08-20 2001-03-27 University Of Miami High quality, continuous throughput, tissue fixation-dehydration-fat removal-impregnation method
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
AU9063398A (en) 1997-09-12 1999-04-05 Exiqon A/S Oligonucleotide analogues
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US20020192659A1 (en) 1997-09-17 2002-12-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
DE59802413D1 (de) 1997-09-24 2002-01-24 Infineon Technologies Ag o-Amino(thio)phenol-carbonsäuren und deren Herstellung
CN1247780C (zh) 1997-11-26 2006-03-29 津莫吉尼蒂克斯公司 哺乳动物细胞因子样多肽－10
US5972615A (en) 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6043039A (en) 1998-02-17 2000-03-28 Applied Spectral Imaging Method of and composite for in situ fluorescent hybridization
US7396508B1 (en) 2000-07-12 2008-07-08 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6405609B1 (en) 1998-02-27 2002-06-18 Ventana Medical Systems, Inc. System and method of aspirating and dispensing reagent
US6265168B1 (en) 1998-10-06 2001-07-24 Transgenomic, Inc. Apparatus and method for separating and purifying polynucleotides
US6287772B1 (en) 1998-04-29 2001-09-11 Boston Probes, Inc. Methods, kits and compositions for detecting and quantitating target sequences
JP2002513587A (ja) 1998-05-04 2002-05-14 ダコ エー エス 染色体異常を検出するための方法およびプローブ
JP2002531056A (ja) 1998-08-07 2002-09-24 セレイ， エルエルシー 遺伝子分析におけるゲルマイクロドロップ
AU751173B2 (en) 1998-08-24 2002-08-08 Fuso Pharmaceutical Industries, Ltd. Novel collectin
US20080050393A1 (en) * 1998-12-03 2008-02-28 Tang Y Tom Novel nucleic acids and polypeptides
EP1013772A1 (en) 1998-12-21 2000-06-28 Transgene S.A. Method for preparing suspension of stable posiplexes
US6331618B1 (en) * 1999-05-13 2001-12-18 Pe Corporation (Ny) Compositions of solvents and high concentrations of nucleic acid analogs
US6300073B1 (en) 1999-10-01 2001-10-09 Clontech Laboratories, Inc. One step RT-PCR methods, enzyme mixes and kits for use in practicing the same
EP1218547A4 (en) 1999-10-15 2005-04-20 Ventana Med Syst Inc METHOD OF IN-SITU DETECTION OF INDIVIDUAL GENOCOPIES
US8012471B2 (en) 1999-11-19 2011-09-06 Abbott Healthcare Products B.V. Screening and treatment methods using IGS5 enzymes of the metalloprotease family
US20010026919A1 (en) 2000-02-08 2001-10-04 Alex Chenchik Nucleic acid assays employing universal arrays
AU2001243573A1 (en) 2000-03-09 2001-09-17 Protogene Laboratories, Inc. Methods for optimizing hybridization performance of polynucleotide probes and localizing and detecting sequence variations
US6617131B2 (en) 2000-03-21 2003-09-09 Aventis Pharma Deutschland Gmbh Nucleic acid molecule encoding the potassium channel protein, KCNQ5
US6969587B2 (en) 2000-04-04 2005-11-29 Taylor Paul D Detection of nucleic acid heteroduplex molecules by anion-exchange chromatography
US20040048376A1 (en) * 2000-04-10 2004-03-11 Benoit Chabot Methods for modulating splicing and/or alternative splicing, and for identifying alternatively spliced units in genes
AU2001246404A1 (en) 2000-04-14 2001-10-30 Novozymes A/S Polypeptides having haloperoxidase activity
US7482151B2 (en) 2000-05-19 2009-01-27 Aquaria, Inc. Method of using ammonia-oxidizing bacteria
JP2004507230A (ja) 2000-07-03 2004-03-11 アプレラ　コーポレイション ポリヌクレオチド配列アッセイ
US6716829B2 (en) 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
US6942970B2 (en) 2000-09-14 2005-09-13 Zymed Laboratories, Inc. Identifying subjects suitable for topoisomerase II inhibitor treatment
ATE415491T1 (de) 2000-09-15 2008-12-15 Ventana Med Syst Inc Oligonucleotide zur markierung von oligonukleotidsonden und proteine
US20030175852A1 (en) 2000-09-15 2003-09-18 Kalra Krishan L Ehancement of in situ hybridization
US20040030093A1 (en) 2000-09-28 2004-02-12 Yoko Sakurai Metal catalyst for ring-opening polymerization of heterocyclic compound
JP2002112777A (ja) 2000-10-03 2002-04-16 Livestock Improvement Association Of Japan Inc 新規精巣特異的遺伝子
DE10053047A1 (de) 2000-10-13 2002-06-06 Univ Lausanne Epalinges Verwendung von Caveolin-1 oder des Gens desselben zur Behandlung von nichtsteroidabhängigem Karzinom
US7309573B2 (en) 2000-11-21 2007-12-18 Stratagene California Methods for detection of a nucleic acid by sequential amplification
AU3090102A (en) 2000-12-14 2002-06-24 Gen Probe Inc Method and kit for enhancing the association rates of polynucleotides
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
WO2003014398A2 (en) 2001-01-03 2003-02-20 Transgenomic, Inc. Methods and compositions for mutation detection by liquid chromatography
US6656685B2 (en) 2001-01-29 2003-12-02 Ventana Medical Systems, Inc. Hybridization buffers using low molecular weight dextran sulfate and methods for their use
US6949368B2 (en) 2001-01-30 2005-09-27 The Trustees Of Princeton University Compositions and methods for enhancing polynucleotide amplification reactions
EP1391519B1 (en) 2001-04-26 2006-10-25 Nof Corporation Nonspecific hybridization inhibitors, clinical diagnostic reagents, and method of clinical analysis
CN1384203A (zh) 2001-04-30 2002-12-11 香港科技创业股份有限公司 具有高度延伸专一性的dna低温循环延伸反应方法
ES2400448T3 (es) 2001-04-30 2013-04-10 Ventana Medical Systems, Inc. Reactivos y métodos para la hibridación automatizada in situ o para microarray
US7297494B2 (en) 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US20030108903A1 (en) 2001-07-19 2003-06-12 Liman Wang Multiple word DNA computing on surfaces
WO2003020932A1 (en) 2001-09-03 2003-03-13 Takeda Chemical Industries, Ltd. Novel secretory proteins and dna thereof
EP1432826B1 (en) 2001-09-24 2012-12-12 Life Technologies Corporation Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid
US20040106109A1 (en) 2001-10-02 2004-06-03 Belly Robert T Detection of ras mutations
US7132236B2 (en) 2001-10-25 2006-11-07 Agilent Technologies, Inc. Composition and method for optimized hybridization using modified solutions
US6783940B2 (en) 2001-10-31 2004-08-31 Applera Corporation Method of reducing non-specific amplification in PCR
DE10154291B4 (de) 2001-11-05 2005-05-19 Hain Lifescience Gmbh Verfahren zum Nachweis von Nukleinsäuren in Form eines Trockenschnelltestes
US20060270595A1 (en) 2001-12-18 2006-11-30 Denis Jullien Nucleic acids encoding compositions of THAP-family chemokine binding domains
US7153390B2 (en) 2001-12-31 2006-12-26 Kimberly-Clark Wordwide, Inc. Process for manufacturing a cellulosic paper product exhibiting reduced malodor
ATE401390T1 (de) 2002-01-18 2008-08-15 Zymogenetics Inc Zytokin (zcytor17-ligand)
US7772383B2 (en) 2002-01-25 2010-08-10 The Trustees Of Princeton University Chemical PCR: Compositions for enhancing polynucleotide amplification reactions
US7456219B2 (en) 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
US20060030541A1 (en) 2002-04-05 2006-02-09 Proskelia Genes involved in osteogenesis, and methods of use
ATE420357T1 (de) 2002-07-02 2009-01-15 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
US20040029184A1 (en) 2002-08-09 2004-02-12 Pickcell Laboratories B.V. Method for antigen retrieval and submersion fluid compositions for use therein
TWI228511B (en) 2002-10-25 2005-03-01 Univ Nat Cheng Kung Genes controlling floral development in orchid
WO2004039966A1 (en) 2002-10-31 2004-05-13 Pfizer Products Inc. Suspension method for producing embryoid bodies, and compositions and methods related thereto
US7517697B2 (en) 2003-02-05 2009-04-14 Applied Biosystems, Llc Compositions and methods for preserving RNA in biological samples
US7601491B2 (en) 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
US20040224343A1 (en) 2003-05-06 2004-11-11 Biochain Inc. Methods and products to enhance interactions among molecules
US7064196B2 (en) 2003-05-20 2006-06-20 E. I. Du Pont De Nemours And Company Genes encoding carotenoid compounds
US20050250094A1 (en) 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US20040241666A1 (en) 2003-05-30 2004-12-02 Amorese Douglas A. Ligand array assays that include an organic fluid wash step and compositions for practicing the same
US20050064472A1 (en) 2003-07-23 2005-03-24 Affymetrix, Inc. Methods of monitoring gene expression
WO2005033333A2 (en) 2003-10-07 2005-04-14 Dako Denmark A/S Methods and compositions for the diagnosis of cancer
CA2482097C (en) † 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methods for isolating nucleic acids
US20050191657A1 (en) 2003-11-18 2005-09-01 Demorest David M. Stringency modifiers in hybridization assays
JP4745984B2 (ja) 2004-01-08 2011-08-10 ダコ デンマーク アクティーゼルスカブ 生物学的試料を処理するための装置および方法ならびにそのためのレザーバー
JP2005300998A (ja) 2004-04-13 2005-10-27 Tokyo Ohka Kogyo Co Ltd ポジ型レジスト組成物及びレジストパターン形成方法
JP2007532592A (ja) 2004-04-15 2007-11-15 エフ．ホフマン−ラ　ロシュ　アーゲー ピリダジノン化合物の製造方法
US7306916B2 (en) 2004-05-04 2007-12-11 Dako Denmark A/S Methods for detecting chromosome aberrations
US20060024751A1 (en) 2004-06-03 2006-02-02 Fluidigm Corporation Scale-up methods and systems for performing the same
CN1989245A (zh) 2004-06-14 2007-06-27 株式会社嘉尔药物 新型半乳凝素8变体蛋白质以及其用途
CA2574014A1 (en) 2004-07-16 2006-01-26 Oy Jurilab Ltd Method for detecting the risk of and for treatment of type 2 diabetes
US7867443B2 (en) 2004-07-23 2011-01-11 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
WO2006073504A2 (en) 2004-08-04 2006-07-13 President And Fellows Of Harvard College Wobble sequencing
CN101124337B (zh) 2004-08-24 2010-11-17 康乃尔研究基金会有限公司 使用内切核酸酶剪切/连接酶重新密封反应和毛细管电泳或微阵列检测核酸差异
US20060147957A1 (en) 2004-11-12 2006-07-06 Affymetrix, Inc. Methods for high throughput sample preparation for microarray analysis
JP2008524228A (ja) 2004-12-15 2008-07-10 ブリストル−マイヤーズ スクイブ カンパニー Ｘａ因子阻害剤の結晶フォーム
AU2005316449B2 (en) 2004-12-17 2010-10-14 Ventana Medical Systems, Inc. High temperature tissue conditioning with low volatility solutions and applications
US7402654B2 (en) * 2004-12-30 2008-07-22 Ge Healthcare Bio-Sciences Corp. PHI 15 DNA polymerase
US20080318226A1 (en) 2005-02-28 2008-12-25 Eisair & Dmanagement Co., Ltd. Signal Amplification Method
PT103257B (pt) 2005-04-05 2007-05-31 Inst Superior Tecnico Método de produção subcrítica de xerogéis e aerogéis monolíticos híbridos de sílica e látex modificado com grupos alcoxissilano
ATE551433T1 (de) 2005-05-06 2012-04-15 Gen Probe Inc Verfahren und produkte zum erfassen von nukleinsäurezielen
CA2618060A1 (en) 2005-08-05 2007-02-15 Xm Satellite Radio Inc. Broadcast signal interface device and method thereof
WO2007037314A1 (ja) 2005-09-28 2007-04-05 Nec Corporation 信号測定装置
JP4086090B2 (ja) 2005-09-29 2008-05-14 Ｔｏｔｏ株式会社 光電流を用いた被検物質の特異的検出方法、それに用いられる電極、測定用セルおよび測定装置
JP4712814B2 (ja) 2005-11-17 2011-06-29 独立行政法人科学技術振興機構 特定の塩基配列の標的核酸類を検出する方法、及び検出のための核酸類セット
US20070141583A1 (en) 2005-12-20 2007-06-21 Weiwei Li Methods of rapid chromatin immunoprecipitation
US7807354B2 (en) 2005-12-28 2010-10-05 Agilent Technologies, Inc. Low volume hybridization
JP2009530621A (ja) 2006-03-13 2009-08-27 アイコニシス インコーポレーテッド 共有結合フルオロフォアを使用して免疫染色およびｆｉｓｈを組み合わせるための方法。
RU2338787C2 (ru) * 2006-03-15 2008-11-20 Институт белка Российской академии наук Обнаружение молекулярных колоний посредством гибридизации на мембранах с флуоресцентными зондами
US7820883B2 (en) 2006-03-15 2010-10-26 Dow Agrosciences Llc Resistance to auxinic herbicides
BRPI0708949B1 (pt) 2006-03-20 2017-04-04 Novozymes As métodos para degradar ou converter um material celulósico, para produzir uma susbtância, e para produzir um polipeptídeo tendo atividade endoglucanase, e, célula microbiana recombinante
EP2239980B1 (en) 2006-03-29 2012-05-09 Huawei Technologies Co., Ltd. Reducing service interruption of a terminal during packet switched handover in a mobile communication
EP1870411B1 (en) 2006-06-21 2016-03-16 Fidia Farmaceutici S.p.A. Process for the preparation and purification of valgancyclovir
US8568982B2 (en) 2006-08-09 2013-10-29 National University Of Singapore Methods of nucleic acid synthesis using particular crowding agents and concentrations
US7846703B2 (en) 2006-10-02 2010-12-07 Takara Bio Inc. Method for enhancing polymerase activity
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US8686129B2 (en) 2007-03-20 2014-04-01 Agilent Technologies, Inc. Methods for the separation of biological molecules using sulfolane
DE602008003922D1 (de) 2007-04-24 2011-01-20 Hoffmann La Roche Verfahren für hcv-proteasehemmerzwischenprodukt
US8841437B2 (en) 2008-06-20 2014-09-23 The Board Of Trustees Of The Leland Stanford Junior University Precursor miRNA loop-modulated target regulation
AU2008298560A1 (en) 2007-09-14 2009-03-19 Ventana Medical Systems, Inc. Prostate cancer biomarkers
EP2235496B1 (en) 2007-12-10 2015-10-14 Dako Denmark A/S A tissue processing apparatus
US9409166B2 (en) 2007-12-10 2016-08-09 The Trustees Of The University Of Pennsylvania Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications
US9261508B2 (en) 2008-04-25 2016-02-16 Istituto Superiore Di Sanita Antisense RNA for treating cancer and inhibition of metastasis and vectors for antisense sequestration
EP2636756B2 (en) 2008-05-27 2019-11-20 Dako Denmark A/S Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers
ITMI20081002A1 (it) 2008-05-30 2009-11-30 Kardia S R L Dispositivo per il trattamento di occlusioni arteriose degli arti inferiori
AU2009257663B2 (en) 2008-06-09 2014-06-26 New York Medical College Compositions comprising cardiac stem cells overexpressing specific microRNA and methods of their use in repairing damaged myocardium
CN102119461B (zh) 2008-06-12 2016-08-03 麻省理工学院 高能量密度氧化还原液流装置
US7750208B2 (en) 2008-07-09 2010-07-06 National Taiwan University Anther-specific expression promoter in plant and application thereof
WO2010088517A1 (en) 2009-01-30 2010-08-05 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Methods and systems for purifying transferring and/or manipulating nucleic acids
EP2401396B1 (en) 2009-02-26 2016-11-23 Dako Denmark A/S Methods for performing a stringent wash step in hybridization applications
BRPI1013410B1 (pt) 2009-03-24 2020-10-06 Asuragen, Inc. Método de analisar se uma sequência de interrupção está presente em pelo menos uma região rica em cgg compreendida por pelo menos um molde em uma amostra
US20130040294A1 (en) 2009-12-02 2013-02-14 Steen H. Matthiesen Compositions and methods for performing hybridizations with no denaturation
ES2470148T3 (es) 2010-05-28 2014-06-23 Syngenta Participations Ag Derivados de pirazolocarboxamida y su uso como microbiocidas
WO2011153354A1 (en) 2010-06-03 2011-12-08 Cellay, Inc. Methods and kits for in situ detection of nucleotide sequences
CN107255584B (zh) 2011-02-28 2021-04-13 安捷伦科技有限公司 用于预处理包埋的生物样本的不混溶两相系统
WO2013046033A1 (en) 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
EP2768974B1 (en) 2011-10-21 2017-07-19 Dako Denmark A/S Hybridization compositions and methods
US9651549B2 (en) 2012-07-13 2017-05-16 Genisphere, Llc Lateral flow assays using DNA dendrimers
EP2914737B1 (en) 2012-10-31 2017-12-06 Cellay, Inc. Methods and kits for performing in situ hybridization
GB201303666D0 (en) 2013-03-01 2013-04-17 Goldsborough Andrew S Sample fixation and stabilisation
WO2014138688A1 (en) 2013-03-07 2014-09-12 Bio-Rad Laboratories, Inc. Repetitive reverse transcription partition assay
AU2014256903B2 (en) 2013-04-25 2020-09-24 Firefly Bioworks, Inc. Multiplexed analysis of target nucleic acids
CN106795550A (zh) 2013-12-30 2017-05-31 促进军事医学的亨利·M·杰克逊基金会公司 与前列腺癌有关的基因组重排和使用所述基因组重排的方法
CN103966321A (zh) 2014-04-24 2014-08-06 哈尔滨工业大学（威海） 一种区域选择性抗生物污染阵列芯片的制备方法
WO2015184144A1 (en) 2014-05-28 2015-12-03 Siemens Healthcare Diagnostics Inc. Rare molecule signal amplification
CN104032033B (zh) 2014-07-07 2015-09-23 玉峰惠仁生物医药科技（北京）有限公司 用于荧光原位杂交检测粪肠球菌和/或其他肠球菌的肽核酸探针组及其试剂盒、使用方法、用途
CN107406877B (zh) 2015-02-04 2021-06-18 博洛尼亚大学 用于加快杂交反应的添加剂

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