BRPI0819319B8 - análogos de aminoglicosídeo antibacteriano - Google Patents

análogos de aminoglicosídeo antibacteriano

Info

Publication number
BRPI0819319B8
BRPI0819319B8 BRPI0819319A BRPI0819319A BRPI0819319B8 BR PI0819319 B8 BRPI0819319 B8 BR PI0819319B8 BR PI0819319 A BRPI0819319 A BR PI0819319A BR PI0819319 A BRPI0819319 A BR PI0819319A BR PI0819319 B8 BRPI0819319 B8 BR PI0819319B8
Authority
BR
Brazil
Prior art keywords
analogues
compounds
antibacterial aminoglycoside
antibacterial
aminoglycoside
Prior art date
Application number
BRPI0819319A
Other languages
English (en)
Portuguese (pt)
Inventor
Aaron Goldblum Adam
Hildebrandt Darin
Ernst Moser Heinz
Aggen James
Linsell Martin
Gliedt Micah
Dozzo Paola
Original Assignee
Achaogen Inc
Cipla Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achaogen Inc, Cipla Usa Inc filed Critical Achaogen Inc
Publication of BRPI0819319A2 publication Critical patent/BRPI0819319A2/pt
Publication of BRPI0819319B1 publication Critical patent/BRPI0819319B1/pt
Publication of BRPI0819319B8 publication Critical patent/BRPI0819319B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
BRPI0819319A 2007-11-21 2008-11-21 análogos de aminoglicosídeo antibacteriano BRPI0819319B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98964507P 2007-11-21 2007-11-21
PCT/US2008/084399 WO2009067692A1 (en) 2007-11-21 2008-11-21 Antibacterial aminoglycoside analogs

Publications (3)

Publication Number Publication Date
BRPI0819319A2 BRPI0819319A2 (pt) 2015-05-12
BRPI0819319B1 BRPI0819319B1 (pt) 2019-01-15
BRPI0819319B8 true BRPI0819319B8 (pt) 2021-05-25

Family

ID=40512286

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819319A BRPI0819319B8 (pt) 2007-11-21 2008-11-21 análogos de aminoglicosídeo antibacteriano

Country Status (22)

Country Link
US (5) US8383596B2 (US20070167479A1-20070719-C00034.png)
EP (2) EP3150617B1 (US20070167479A1-20070719-C00034.png)
JP (2) JP4986310B2 (US20070167479A1-20070719-C00034.png)
KR (1) KR101296099B1 (US20070167479A1-20070719-C00034.png)
CN (2) CN103360440B (US20070167479A1-20070719-C00034.png)
AU (1) AU2008326297B2 (US20070167479A1-20070719-C00034.png)
BR (1) BRPI0819319B8 (US20070167479A1-20070719-C00034.png)
CA (1) CA2706369C (US20070167479A1-20070719-C00034.png)
CY (1) CY1118915T1 (US20070167479A1-20070719-C00034.png)
DK (1) DK2217610T3 (US20070167479A1-20070719-C00034.png)
EA (1) EA017824B1 (US20070167479A1-20070719-C00034.png)
ES (1) ES2613936T3 (US20070167479A1-20070719-C00034.png)
HR (1) HRP20170154T1 (US20070167479A1-20070719-C00034.png)
HU (1) HUE030523T2 (US20070167479A1-20070719-C00034.png)
IL (1) IL205880A (US20070167479A1-20070719-C00034.png)
LT (1) LT2217610T (US20070167479A1-20070719-C00034.png)
MX (1) MX2010005632A (US20070167479A1-20070719-C00034.png)
PL (1) PL2217610T3 (US20070167479A1-20070719-C00034.png)
PT (1) PT2217610T (US20070167479A1-20070719-C00034.png)
SI (1) SI2217610T1 (US20070167479A1-20070719-C00034.png)
TW (1) TWI425947B (US20070167479A1-20070719-C00034.png)
WO (1) WO2009067692A1 (US20070167479A1-20070719-C00034.png)

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AU2008326297B2 (en) 2007-11-21 2012-11-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
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WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
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WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010147836A1 (en) 2009-06-17 2010-12-23 Achaogen, Inc. Combination therapies using antibacterial aminoglycoside compounds
EP2486044A2 (en) 2009-10-09 2012-08-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
AR083879A1 (es) * 2010-11-17 2013-03-27 Achaogen Inc Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos
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KR101703137B1 (ko) 2014-05-30 2017-02-07 선문대학교 산학협력단 당 부가 아미노글리코사이드 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물
RU2751634C2 (ru) 2015-07-30 2021-07-15 Майкробиал Кемистри Рисерч Фаундейшн Новый эффективный аминогликозидный антибиотик против бактерий с множественной лекарственной резистентностью
CN107987111A (zh) * 2017-07-07 2018-05-04 朱孝云 抗菌性氘代氨基糖苷类衍生物
JP7235741B2 (ja) 2017-10-19 2023-03-08 シプラ ユーエスエイ， インコーポレイテッド 抗菌性アミノグリコシド類似体の合成
CN109900816A (zh) * 2017-12-11 2019-06-18 江苏省食品药品监督检验研究院 一种分析注射用硫酸核糖霉素含量及有关物质的高效液相色谱蒸发光散射检测器法
CN108948107B (zh) * 2018-07-30 2020-05-05 山东大学 一种普拉佐米星抗生素的制备方法
EP3891162B1 (en) 2018-12-05 2024-03-06 AGILeBiotics B.V. Novel derivatives of n-3"-guanidino-2,5-dideoxy-5-fluoro-4,6-disubstituted-streptamine aminoglycoside antibiotics
UA127070C2 (uk) * 2019-05-30 2023-03-29 Чжуохе Фармасьютікал Груп Ко., Лтд Антибактеріальні похідні аміноглікозидів
CN110878108B (zh) * 2019-06-17 2022-11-11 山东安信制药有限公司 一种普拉佐米星的合成方法
CN110885350A (zh) * 2019-08-28 2020-03-17 山东安信制药有限公司 一种普拉佐米星的制备方法
CN110642907B (zh) * 2019-10-12 2020-11-06 上海博璞诺科技发展有限公司 普拉唑米星或其盐的合成方法
CN111004292A (zh) * 2019-12-19 2020-04-14 卓和药业集团有限公司 庆大霉素衍生物及其制备方法
CN116462721B (zh) * 2023-04-18 2024-02-02 江南大学 抗菌性氨基糖苷衍生物

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