BRPI0708801A2 - compostos para o tratamento de atrofia muscular espinhal e outros usos - Google Patents

compostos para o tratamento de atrofia muscular espinhal e outros usos Download PDF

Info

Publication number
BRPI0708801A2
BRPI0708801A2 BRPI0708801-9A BRPI0708801A BRPI0708801A2 BR PI0708801 A2 BRPI0708801 A2 BR PI0708801A2 BR PI0708801 A BRPI0708801 A BR PI0708801A BR PI0708801 A2 BRPI0708801 A2 BR PI0708801A2
Authority
BR
Brazil
Prior art keywords
alkyl
group
alkoxy
haloalkyl
compound according
Prior art date
Application number
BRPI0708801-9A
Other languages
English (en)
Portuguese (pt)
Inventor
Jill Heemskerk
Keith D Barnes
John M Mccall
Graham Johnson
David Fairfax
Matthew Robert Johnson
Original Assignee
Us Gov Health & Human Serv
Albany Molecular Res Inc
Science Applic Internat Corp Saic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Albany Molecular Res Inc, Science Applic Internat Corp Saic filed Critical Us Gov Health & Human Serv
Publication of BRPI0708801A2 publication Critical patent/BRPI0708801A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0708801-9A 2006-03-17 2007-03-16 compostos para o tratamento de atrofia muscular espinhal e outros usos BRPI0708801A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78329206P 2006-03-17 2006-03-17
US60/783.292 2006-03-17
PCT/US2007/006772 WO2007109211A2 (en) 2006-03-17 2007-03-16 1-oxo-isoindoline compounds for the treatment of spinal muscular atrophy and other uses

Publications (1)

Publication Number Publication Date
BRPI0708801A2 true BRPI0708801A2 (pt) 2011-06-14

Family

ID=38477008

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0708801-9A BRPI0708801A2 (pt) 2006-03-17 2007-03-16 compostos para o tratamento de atrofia muscular espinhal e outros usos

Country Status (10)

Country Link
US (2) US8110681B2 (https=)
EP (1) EP2027088A2 (https=)
JP (2) JP2009530306A (https=)
CN (1) CN101500995A (https=)
AU (1) AU2007227398C1 (https=)
BR (1) BRPI0708801A2 (https=)
CA (1) CA2645426A1 (https=)
IL (1) IL194153A0 (https=)
WO (1) WO2007109211A2 (https=)
ZA (1) ZA200807936B (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2215074B1 (en) * 2007-09-27 2014-02-19 The United States of America, as Represented by the Secretary, Department of Health and Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
CN101903335A (zh) * 2007-10-19 2010-12-01 詹森药业有限公司 连接有胺的γ-分泌酶调节剂
JP5632612B2 (ja) * 2007-12-05 2014-11-26 あすか製薬株式会社 ラクタム化合物又はその塩及びppar活性化剤
JP5484316B2 (ja) * 2008-02-28 2014-05-07 財団法人乙卯研究所 芳香族アミド誘導体
US10793515B2 (en) 2008-03-19 2020-10-06 Aurimmed Pharma, Inc. Compounds advantageous in the treatment of central nervous system diseases and disorders
US20210130285A1 (en) 2008-03-19 2021-05-06 Aurimmed Pharma, Inc. Novel compounds advantageous in the treatment of central nervous system diseases and disorders
WO2009151546A2 (en) 2008-05-27 2009-12-17 Ptc Therapeutics, Inc. Methods for treating spinal muscular atrophy
WO2010019243A1 (en) 2008-08-13 2010-02-18 Ptc Therapeutics, Inc. Methods for treating viral infections
GB0909672D0 (en) * 2009-06-04 2009-07-22 Xention Discovery Ltd Compounds
GB0909671D0 (en) * 2009-06-04 2009-07-22 Xention Discovery Ltd Compounds
KR101758046B1 (ko) * 2009-12-22 2017-07-14 버텍스 파마슈티칼스 인코포레이티드 포스파티딜이노시톨 3-키나제의 이소인돌리논 억제제
JP6097998B2 (ja) * 2010-12-16 2017-03-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のビアリールアミドインヒビター
NO3175985T3 (https=) 2011-07-01 2018-04-28
WO2013062028A1 (ja) * 2011-10-25 2013-05-02 塩野義製薬株式会社 Hiv複製阻害剤
HK1201455A1 (en) 2012-01-27 2015-09-04 Gilead Sciences Inc Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
DK2812004T3 (en) * 2012-02-10 2018-10-15 Ptc Therapeutics Inc COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY
US9212209B2 (en) * 2012-07-13 2015-12-15 Indiana University Research And Technology Corporation Screening methods for spinal muscular atrophy
EP2921480B1 (en) * 2012-11-19 2017-10-11 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound
KR20150098675A (ko) * 2012-12-24 2015-08-28 라모트 앳 텔-아비브 유니버시티 리미티드 넌센스 돌연변이로부터 생긴 유전적 질환을 치료하기 위한 물질 및 이를 확인하는 방법
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases
EP3082820B1 (en) 2013-12-19 2022-07-20 PTC Therapeutics, Inc. Methods for modulating the amount of rna transcripts
SI3186241T1 (sl) 2014-08-29 2021-03-31 Chdi Foundation, Inc. Sonde za slikanje Huntingtonovega proteina
CN105801556A (zh) * 2014-12-31 2016-07-27 上海药谷药业有限公司 一种2,3-二氢-1,4-苯并二烷-6-羧酸化合物的制备方法
EP4249472A3 (en) 2015-05-30 2023-12-13 PTC Therapeutics, Inc. Methods for modulating rna splicing
EP3322699B1 (en) * 2015-07-14 2019-05-15 H. Hoffnabb-La Roche Ag 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors
WO2017066103A1 (en) * 2015-10-16 2017-04-20 Aurimmed Pharma, Inc. Novel compounds advantageous in the treatment of central nervous system diseases and disorders
IL294124B2 (en) 2015-12-10 2024-02-01 Ptc Therapeutics Inc Methods for treating huntington's disease
WO2018049328A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Bicyclic compounds useful as gpr120 modulators
JP7086942B2 (ja) 2016-09-12 2022-06-20 インテグラル ヘルス, インコーポレイテッド Gpr120モジュレーターとして有用な単環式化合物
EA201991309A1 (ru) 2016-11-28 2019-11-29 Способы модуляции сплайсинга рнк
US11407753B2 (en) 2017-06-05 2022-08-09 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
KR20200017476A (ko) 2017-06-14 2020-02-18 피티씨 테라퓨틱스, 인크. Rna 스플라이싱의 변경 방법
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
WO2019005993A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
PL3814357T3 (pl) 2018-06-27 2024-09-16 Ptc Therapeutics, Inc. Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona
EP3814345B8 (en) 2018-06-27 2024-10-30 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
EP3814360B8 (en) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
WO2020231977A1 (en) 2019-05-13 2020-11-19 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
EP4004213A1 (en) 2019-07-25 2022-06-01 Novartis AG Regulatable expression systems
KR102186761B1 (ko) 2020-06-03 2020-12-04 옙바이오 주식회사 2-(4-(1-하이드록시프로판-2-일)페닐)이소인돌린-1-온 화합물을 포함하는 파킨슨병 예방 또는 치료용 약학적 조성물
WO2022115301A1 (en) * 2020-11-24 2022-06-02 Merck Sharp & Dohme Corp. Modified isoindolinones as glucosylceramide synthase inhibitors
CN115304472A (zh) * 2022-06-27 2022-11-08 重庆医药高等专科学校 一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的合成方法
CN115141097A (zh) * 2022-06-27 2022-10-04 重庆医药高等专科学校 一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的生产线系统
KR102883783B1 (ko) * 2022-12-15 2025-11-12 옙바이오 주식회사 2-(4-(1-하이드록시프로판-2-일)페닐)이소인돌린-1-온 화합물 제조방법
KR102597093B1 (ko) * 2023-06-07 2023-11-03 옙바이오 주식회사 줄기세포 노화 억제 신규 화합물 및 이의 약학적 용도
CN117740969B (zh) * 2023-11-30 2025-01-10 杭州志呈科技有限公司 一种吲哚布芬杂质检测方法及其应用
CN120965663A (zh) * 2024-05-17 2025-11-18 北京理工大学 sEH抑制剂化合物、药物组合物及其制备方法和应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2034240C2 (de) 1968-03-27 1982-12-02 CIBA-GEIGY AG, 4002 Basel Isoindolinderivate, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung
US4126691A (en) 1968-03-27 1978-11-21 Ciba-Geigy Corporation Tertiary aminoacids
US3641040A (en) * 1968-03-27 1972-02-08 Ciba Geigy Corp Tertiary amino phenyl acetic acids
US3542806A (en) 1968-03-29 1970-11-24 Robins Co Inc A H 2-(1-substituted-3-pyrrolidinyl)-isoindolines
DE2046992A1 (en) * 1970-09-24 1972-03-30 Merck Patent Gmbh, 6100 Darmstadt Isoindolinophenyl-alkanoic acid esters and salts - - antiphlogistic, antipyretic and analgesic agents
DE2154525A1 (de) * 1970-11-05 1972-06-15 Carlo Erba S.P.A., Mailand (Italien) Isoindolinderivate und Verfahren zu ihrer Herstellung
FI53702C (fi) * 1971-11-22 1978-07-10 Erba Carlo Spa Foerfarande foer framstaellning av isoindolinderivat
US3890346A (en) * 1972-03-22 1975-06-17 Monsanto Co Process for the preparation of N-arylphthalimidines
GB1413173A (en) * 1972-07-07 1975-11-12 Bp Chem Int Ltd Polymerisation process
US3997669A (en) 1972-12-26 1976-12-14 Ciba-Geigy Corporation Tertiary aminoacids
JPS5233667A (en) * 1975-09-11 1977-03-14 Fuji Kagaku Kogyo Kk Process for preparation of hydrogenated 1-oxo-isoindoline derivatives
IT1113035B (it) * 1979-03-06 1986-01-20 Erba Farmitalia Esteri c alla 3 - c alla 4 aclhilici di 1-oxo-2- aperta par.graffa p aperta par. quadrata (alfa-metil) -carbossimetil chiusa par. quadrata - fenil chiusa par. graffa- isoindolina
JPS5644686A (en) 1979-09-21 1981-04-23 Hodogaya Chem Co Ltd Pressure-sensitive reproducing paper
JPS5645955A (en) 1979-09-21 1981-04-25 Hodogaya Chem Co Ltd 6-(2,3-dihydroisoindol-2-yl)fluoran compound
JPS5750960A (en) * 1980-09-10 1982-03-25 Hisamitsu Pharmaceut Co Inc Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone
JPS5845088A (ja) 1981-09-09 1983-03-16 Sumitomo Chem Co Ltd 記録紙
JPH0262875A (ja) 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
JPH03181478A (ja) 1989-12-08 1991-08-07 Banyu Pharmaceut Co Ltd ピリドンカルボン酸誘導体
US5595872A (en) 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
US5739135A (en) 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5567718A (en) 1994-08-11 1996-10-22 Hoechst Marion Roussel Inc. 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors
WO1998040061A1 (en) * 1997-03-10 1998-09-17 Loma Linda University Medical Center Use of r-nsaid's for the prevention of alzheimer's disease
CA2355886C (en) 1998-12-23 2006-10-31 Schering Corporation Substituted oximes and hydrazones as neurokinin antagonists
US6339093B1 (en) 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives
WO2002046164A1 (en) 2000-12-07 2002-06-13 Astrazeneca Ab Therapeutic compounds
GB0103269D0 (en) 2001-02-09 2001-03-28 Glaxo Group Ltd Napthalene derivatives
US20030027867A1 (en) * 2001-06-29 2003-02-06 Myriad Genetics, Incorporated Use of R-NSAID compounds for anti-HIV treatment
US20040044063A1 (en) 2002-05-31 2004-03-04 Brent Stockwell SMA therapy and cell based assay for identifying therapies
AU2003256755A1 (en) 2002-07-24 2004-02-09 Ptc Therapeutics, Inc. Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations
WO2004036181A2 (en) 2002-10-17 2004-04-29 The Trustees Of The University Of Pennsylvania Method of treating neurological diseases and disorders
WO2004048332A1 (ja) 2002-11-26 2004-06-10 Maruishi Pharmaceutical Co., Ltd. イソインドリン誘導体
US7320992B2 (en) 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
WO2006050451A2 (en) 2004-11-02 2006-05-11 Whitehead Institute For Biomedical Research Methods and compositions to treat motor neuron disease
EA014428B1 (ru) 2006-02-03 2010-12-30 Глэксо Груп Лимитед Производные бензоизоиндола для лечения боли
WO2008045905A1 (en) 2006-10-12 2008-04-17 Novartis Ag Pyrrolydine derivatives as iap inhibitors

Also Published As

Publication number Publication date
US20120083495A1 (en) 2012-04-05
US20090312323A1 (en) 2009-12-17
JP2013116901A (ja) 2013-06-13
AU2007227398C1 (en) 2013-05-30
WO2007109211A2 (en) 2007-09-27
AU2007227398A8 (en) 2008-11-27
JP2009530306A (ja) 2009-08-27
AU2007227398A1 (en) 2007-09-27
ZA200807936B (en) 2009-12-30
AU2007227398B2 (en) 2012-09-27
WO2007109211A3 (en) 2007-12-13
CA2645426A1 (en) 2007-09-27
CN101500995A (zh) 2009-08-05
US8110681B2 (en) 2012-02-07
IL194153A0 (en) 2009-08-03
WO2007109211A8 (en) 2009-02-12
EP2027088A2 (en) 2009-02-25

Similar Documents

Publication Publication Date Title
BRPI0708801A2 (pt) compostos para o tratamento de atrofia muscular espinhal e outros usos
US6992096B2 (en) 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
DE602004011358T2 (de) (4-hydroxyphenyl)-1h-indol-3-carbaldehydoxim-derivative als östrogenagentien
CN101861151B (zh) 使用组蛋白脱乙酰基酶hdac1、hdac2和/或hdac3的选择性抑制剂和微管稳定剂的癌症组合治疗
JP5009151B2 (ja) Bcrp/abcg2阻害剤
US7763656B2 (en) Use of Acetylamino benzoic acid compounds for nonsense suppression and the treatment of disease
HUT68642A (en) N-sulphonyl-2-oxoindole derivatives having affinity for vasopressin and/or ocytocin receptors
EP2068871B1 (en) Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression
JPH11512750A (ja) 2―(2―オキソ―エチリデン)―イミダゾリジン―4―オンの誘導体およびファルネシル蛋白質トランスフェラーゼ阻害物質としてのそれらの使用法
EP0636609A1 (fr) Dérivés du 1-benzyl-1,3-dihydro-indol-2-one, leur préparation, les compositions pharmaceutiques en contenant
WO2004031118A1 (ja) Lpa受容体拮抗剤
WO2003103657A1 (ja) 神経変性疾患治療剤
JP2013525470A (ja) 癌治療に用いるためのコンブレタスタチン類似体
FR2927625A1 (fr) Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
ES2953704T3 (es) Derivado de tiofeno y uso del mismo
FR2837824A1 (fr) Nouveaux derives de la podophyllotoxine, leur preparation et leur application en therapeutique
JP2004525958A (ja) テロメラーゼ阻害剤としてのオーロン
HUP0400546A2 (hu) Antiangiogén hatású triciklusos indolszármazékok és ezeket tartalmazó gyógyszerkészítmények
CN104244934A (zh) 用于治疗白血病的化合物和方法
KR102776660B1 (ko) 벤조다이옥세인 유도체 화합물 및 이의 의약 용도
HK1120258B (en) Bcrp/abcg2 inhibitor
JP2018533600A (ja) 7−アザインドリン−2−オン誘導体又はその薬学的に許容される塩を有効成分として含有する医薬組成物
HK1093979B (en) 1,2,4-oxadiazole benzoic acid compounds
HU230808B1 (hu) Dihidro-2,3-benzodiazepin optikai izomerjei és ezek sztereoszelektív szintézise

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: ALBANY MOLECULAR RESEARCH, INC. (US) , GOVERNMENT

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2307 DE 24/03/2015.