CN101500995A - 用于治疗脊髓型肌萎缩和其它用途的1-氧代-异吲哚啉化合物 - Google Patents

用于治疗脊髓型肌萎缩和其它用途的1-氧代-异吲哚啉化合物 Download PDF

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CN101500995A
CN101500995A CNA2007800155890A CN200780015589A CN101500995A CN 101500995 A CN101500995 A CN 101500995A CN A2007800155890 A CNA2007800155890 A CN A2007800155890A CN 200780015589 A CN200780015589 A CN 200780015589A CN 101500995 A CN101500995 A CN 101500995A
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alkyl
group
alkoxy
haloalkyl
alkylamino
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Chinese (zh)
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吉尔·海姆斯凯克
基思·D·巴尔内思
约翰·M·麦考尔
格雷厄姆·约翰逊
大卫·费尔法克斯
马修斯·罗伯特·约翰逊
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Curia Global Inc
US Department of Health and Human Services
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Science Applications International Corp SAIC
Albany Molecular Research Inc
US Department of Health and Human Services
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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CNA2007800155890A 2006-03-17 2007-03-16 用于治疗脊髓型肌萎缩和其它用途的1-氧代-异吲哚啉化合物 Pending CN101500995A (zh)

Applications Claiming Priority (2)

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US78329206P 2006-03-17 2006-03-17
US60/783,292 2006-03-17

Publications (1)

Publication Number Publication Date
CN101500995A true CN101500995A (zh) 2009-08-05

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CNA2007800155890A Pending CN101500995A (zh) 2006-03-17 2007-03-16 用于治疗脊髓型肌萎缩和其它用途的1-氧代-异吲哚啉化合物

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US (2) US8110681B2 (https=)
EP (1) EP2027088A2 (https=)
JP (2) JP2009530306A (https=)
CN (1) CN101500995A (https=)
AU (1) AU2007227398C1 (https=)
BR (1) BRPI0708801A2 (https=)
CA (1) CA2645426A1 (https=)
IL (1) IL194153A0 (https=)
WO (1) WO2007109211A2 (https=)
ZA (1) ZA200807936B (https=)

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CN102762548A (zh) * 2009-12-22 2012-10-31 沃泰克斯药物股份有限公司 磷脂酰肌醇3-激酶的异吲哚啉酮抑制剂
WO2013062028A1 (ja) * 2011-10-25 2013-05-02 塩野義製薬株式会社 Ｈｉｖ複製阻害剤
CN105801556A (zh) * 2014-12-31 2016-07-27 上海药谷药业有限公司 一种2,3-二氢-1,4-苯并二烷-6-羧酸化合物的制备方法
CN107074817A (zh) * 2014-08-29 2017-08-18 Chdi基金会股份有限公司 用于成像亨廷顿蛋白的探针
CN108299314A (zh) * 2012-02-10 2018-07-20 Ptc医疗公司 用于治疗脊髓性肌萎缩的化合物
CN108697709A (zh) * 2015-12-10 2018-10-23 Ptc医疗公司 用于治疗亨廷顿病的方法
CN110121343A (zh) * 2016-09-12 2019-08-13 数值有限公司 用作gpr120调节剂的双环化合物
CN115141097A (zh) * 2022-06-27 2022-10-04 重庆医药高等专科学校 一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的生产线系统
CN115304472A (zh) * 2022-06-27 2022-11-08 重庆医药高等专科学校 一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的合成方法
US11548886B2 (en) 2016-09-12 2023-01-10 Valo Health, Inc. Monocyclic compounds useful as GPR120 modulators
CN117740969A (zh) * 2023-11-30 2024-03-22 杭州志呈科技有限公司 一种吲哚布芬杂质检测方法及其应用
WO2025236852A1 (zh) * 2024-05-17 2025-11-20 北京理工大学 sEH抑制剂化合物、药物组合物及其制备方法和应用

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CN107709311B (zh) * 2015-07-14 2020-09-25 豪夫迈·罗氏有限公司 2-苯基-6-咪唑基-吡啶-4-甲酰胺衍生物及其作为eaat3抑制剂的用途
WO2017066103A1 (en) * 2015-10-16 2017-04-20 Aurimmed Pharma, Inc. Novel compounds advantageous in the treatment of central nervous system diseases and disorders
JP2019535789A (ja) 2016-11-28 2019-12-12 ピーティーシー セラピューティクス，インコーポレーテッド Ｒｎａスプライシングを調節する方法
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CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
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EP4251149A4 (en) * 2020-11-24 2024-10-30 Merck Sharp & Dohme LLC MODIFIED ISOINDOLINONES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
KR102883783B1 (ko) * 2022-12-15 2025-11-12 옙바이오 주식회사 2-(4-(1-하이드록시프로판-2-일)페닐)이소인돌린-1-온 화합물 제조방법
KR102597093B1 (ko) * 2023-06-07 2023-11-03 옙바이오 주식회사 줄기세포 노화 억제 신규 화합물 및 이의 약학적 용도

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