JP2009530306A - 脊髄性筋萎縮症の治療およびその他用途のための化合物 - Google Patents

脊髄性筋萎縮症の治療およびその他用途のための化合物 Download PDF

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JP2009530306A
JP2009530306A JP2009500525A JP2009500525A JP2009530306A JP 2009530306 A JP2009530306 A JP 2009530306A JP 2009500525 A JP2009500525 A JP 2009500525A JP 2009500525 A JP2009500525 A JP 2009500525A JP 2009530306 A JP2009530306 A JP 2009530306A
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alkoxy
haloalkyl
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ヘームスケルク、ジル
バーンズ、キース、ディー．
マッコール、ジョン、エム．
ジョンソン、グラハム
フェアファックス、デイヴィッド
ジョンソン、マシュー、ロバート
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Government of the United States of America
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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JP2009500525A 2006-03-17 2007-03-16 脊髄性筋萎縮症の治療およびその他用途のための化合物 Pending JP2009530306A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78329206P 2006-03-17 2006-03-17
PCT/US2007/006772 WO2007109211A2 (en) 2006-03-17 2007-03-16 1-oxo-isoindoline compounds for the treatment of spinal muscular atrophy and other uses

Related Child Applications (1)

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JP2013004082A Division JP2013116901A (ja) 2006-03-17 2013-01-11 脊髄性筋萎縮症の治療およびその他用途のための化合物

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JP2009530306A true JP2009530306A (ja) 2009-08-27
JP2009530306A5 JP2009530306A5 (https=) 2010-05-06

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JP2009500525A Pending JP2009530306A (ja) 2006-03-17 2007-03-16 脊髄性筋萎縮症の治療およびその他用途のための化合物
JP2013004082A Abandoned JP2013116901A (ja) 2006-03-17 2013-01-11 脊髄性筋萎縮症の治療およびその他用途のための化合物

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US (2) US8110681B2 (https=)
EP (1) EP2027088A2 (https=)
JP (2) JP2009530306A (https=)
CN (1) CN101500995A (https=)
AU (1) AU2007227398C1 (https=)
BR (1) BRPI0708801A2 (https=)
CA (1) CA2645426A1 (https=)
IL (1) IL194153A0 (https=)
WO (1) WO2007109211A2 (https=)
ZA (1) ZA200807936B (https=)

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JP2013515074A (ja) * 2009-12-22 2013-05-02 バーテックス ファーマシューティカルズ インコーポレイテッド ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター
WO2013062028A1 (ja) * 2011-10-25 2013-05-02 塩野義製薬株式会社 Ｈｉｖ複製阻害剤
JP2013545810A (ja) * 2010-12-16 2013-12-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のビアリールアミドインヒビター
JP2015508075A (ja) * 2012-02-10 2015-03-16 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物
JPWO2014077401A1 (ja) * 2012-11-19 2017-01-05 武田薬品工業株式会社 含窒素複素環化合物
KR102186761B1 (ko) * 2020-06-03 2020-12-04 옙바이오 주식회사 2-(4-(1-하이드록시프로판-2-일)페닐)이소인돌린-1-온 화합물을 포함하는 파킨슨병 예방 또는 치료용 약학적 조성물

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EP2215074B1 (en) * 2007-09-27 2014-02-19 The United States of America, as Represented by the Secretary, Department of Health and Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
CN101903335A (zh) * 2007-10-19 2010-12-01 詹森药业有限公司 连接有胺的γ-分泌酶调节剂
JP5632612B2 (ja) * 2007-12-05 2014-11-26 あすか製薬株式会社 ラクタム化合物又はその塩及びｐｐａｒ活性化剤
JP5484316B2 (ja) * 2008-02-28 2014-05-07 財団法人乙卯研究所 芳香族アミド誘導体
US10793515B2 (en) 2008-03-19 2020-10-06 Aurimmed Pharma, Inc. Compounds advantageous in the treatment of central nervous system diseases and disorders
US20210130285A1 (en) 2008-03-19 2021-05-06 Aurimmed Pharma, Inc. Novel compounds advantageous in the treatment of central nervous system diseases and disorders
WO2009151546A2 (en) 2008-05-27 2009-12-17 Ptc Therapeutics, Inc. Methods for treating spinal muscular atrophy
WO2010019243A1 (en) 2008-08-13 2010-02-18 Ptc Therapeutics, Inc. Methods for treating viral infections
GB0909672D0 (en) * 2009-06-04 2009-07-22 Xention Discovery Ltd Compounds
GB0909671D0 (en) * 2009-06-04 2009-07-22 Xention Discovery Ltd Compounds
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HK1201455A1 (en) 2012-01-27 2015-09-04 Gilead Sciences Inc Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
US9212209B2 (en) * 2012-07-13 2015-12-15 Indiana University Research And Technology Corporation Screening methods for spinal muscular atrophy
KR20150098675A (ko) * 2012-12-24 2015-08-28 라모트 앳 텔-아비브 유니버시티 리미티드 넌센스 돌연변이로부터 생긴 유전적 질환을 치료하기 위한 물질 및 이를 확인하는 방법
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases
EP3082820B1 (en) 2013-12-19 2022-07-20 PTC Therapeutics, Inc. Methods for modulating the amount of rna transcripts
SI3186241T1 (sl) 2014-08-29 2021-03-31 Chdi Foundation, Inc. Sonde za slikanje Huntingtonovega proteina
CN105801556A (zh) * 2014-12-31 2016-07-27 上海药谷药业有限公司 一种2,3-二氢-1,4-苯并二烷-6-羧酸化合物的制备方法
EP4249472A3 (en) 2015-05-30 2023-12-13 PTC Therapeutics, Inc. Methods for modulating rna splicing
EP3322699B1 (en) * 2015-07-14 2019-05-15 H. Hoffnabb-La Roche Ag 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors
WO2017066103A1 (en) * 2015-10-16 2017-04-20 Aurimmed Pharma, Inc. Novel compounds advantageous in the treatment of central nervous system diseases and disorders
IL294124B2 (en) 2015-12-10 2024-02-01 Ptc Therapeutics Inc Methods for treating huntington's disease
WO2018049328A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Bicyclic compounds useful as gpr120 modulators
JP7086942B2 (ja) 2016-09-12 2022-06-20 インテグラル ヘルス， インコーポレイテッド Ｇｐｒ１２０モジュレーターとして有用な単環式化合物
EA201991309A1 (ru) 2016-11-28 2019-11-29 Способы модуляции сплайсинга рнк
US11407753B2 (en) 2017-06-05 2022-08-09 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
KR20200017476A (ko) 2017-06-14 2020-02-18 피티씨 테라퓨틱스, 인크. Rna 스플라이싱의 변경 방법
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
WO2019005993A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
PL3814357T3 (pl) 2018-06-27 2024-09-16 Ptc Therapeutics, Inc. Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona
EP3814345B8 (en) 2018-06-27 2024-10-30 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
EP3814360B8 (en) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
WO2020231977A1 (en) 2019-05-13 2020-11-19 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
EP4004213A1 (en) 2019-07-25 2022-06-01 Novartis AG Regulatable expression systems
WO2022115301A1 (en) * 2020-11-24 2022-06-02 Merck Sharp & Dohme Corp. Modified isoindolinones as glucosylceramide synthase inhibitors
CN115304472A (zh) * 2022-06-27 2022-11-08 重庆医药高等专科学校 一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的合成方法
CN115141097A (zh) * 2022-06-27 2022-10-04 重庆医药高等专科学校 一种弗雷拉纳中间体4-溴-2-甲基苯甲酸的生产线系统
KR102883783B1 (ko) * 2022-12-15 2025-11-12 옙바이오 주식회사 2-(4-(1-하이드록시프로판-2-일)페닐)이소인돌린-1-온 화합물 제조방법
KR102597093B1 (ko) * 2023-06-07 2023-11-03 옙바이오 주식회사 줄기세포 노화 억제 신규 화합물 및 이의 약학적 용도
CN117740969B (zh) * 2023-11-30 2025-01-10 杭州志呈科技有限公司 一种吲哚布芬杂质检测方法及其应用
CN120965663A (zh) * 2024-05-17 2025-11-18 北京理工大学 sEH抑制剂化合物、药物组合物及其制备方法和应用

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JPN6012047786; Ｌｕｎｎ，　Ｍｉｔｃｈｅｌｌ　Ｒ．；　Ｒｏｏｔ，　Ｄａｖｉｄ　Ｅ．；　Ｍａｒｔｉｎｏ，　Ａｌｌｉｓｏｎ　Ｍ．；　Ｆｌａｈｅｒｔｙ，　Ｓｔｅｐｈｅｎ　Ｐ．；　Ｋｅｌｌｅｙ，　Ｂｒｉａｎ　Ｐ．；　Ｃｏｏｖ: 'Ｉｎｄｏｐｒｏｆｅｎ　Ｕｐｒｅｇｕｌａｔｅｓ　ｔｈｅ　Ｓｕｒｖｉｖａｌ　Ｍｏｔｏｒ　Ｎｅｕｒｏｎ　Ｐｒｏｔｅｉｎ　ｔｈｒｏｕｇｈ　ａ　Ｃｙｃｌｏｏｘｙｇｅｎａｓｅ-Ｉｎｄｅｐｅｎｄｅｎｔ　Ｍｅｃｈａｎ' Ｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｂｉｏｌｏｇｙ １１（１１）, 2004, １４８９-１４９３ *
JPN6012047787; Ｎａｎｎｉｎｉ， Ｇ．； Ｇｉｒａｌｄｉ， Ｐ． Ｎ．； Ｍｏｌｇｏｒａ， Ｇ．； Ｂｉａｓｏｌｉ， Ｇ．； Ｓｐｉｎｅｌｌｉ， Ｆ．； Ｌｏｇｅｍａｎｎ， Ｗ．； Ｄｒａｄｉ， Ｅ．； Ｚａｎｎｉ，: 'Ｎｅｗ ａｎａｌｇｅｓｉｃ-ａｎｔｉｉｎｆｌａｍｍａｔｏｒｙ ｄｒｕｇｓ． １-Ｏｘｏ-２-ｓｕｂｓｔｉｔｕｔｅｄ ｉｓｏｉｎｄｏｌｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ' Ａｒｚｎｅｉｍｉｔｔｅｌ-Ｆｏｒｓｃｈｕｎｇ ２３（８）, 1973, １０９０-１００ *
JPN6012047788; Ｇｏｌｄａｎｉｇａ，　Ｇ．　Ｃ．；　Ｐｉａｎｅｚｚｏｌａ，　Ｅ．；　Ｖａｌｚｅｌｌｉ，　Ｇ．: 'Ａｂｓｏｒｐｔｉｏｎ，　ｅｘｃｒｅｔｉｏｎ，　ａｎｄ　ｍｅｔａｂｏｌｉｓｍ　ｏｆ　ａ　ｎｅｗ　ａｎａｌｇｅｓｉｃ　ａｎｄ　ａｎｔｉｉｎｆｌａｍｍａｔｏｒｙ　ｄｒｕｇ　Ｋ　４２７７　ｉｎ　ｒａｔｓ，　ｇ' Ａｒｚｎｅｉｍｉｔｔｅｌ-Ｆｏｒｓｃｈｕｎｇ ２４（１０）, 1974, １６０３-６ *
JPN6012047789; Ｂｅｎａｃｈｅｎｈｏｕ，　Ｆ．；　Ｍｅｓｌｉ，　Ｍ．　Ａ．；　Ｅｌ　Ｂｏｒａｉ，　Ｍ．；　Ｈａｎｑｕｅｔ，　Ｂ．；　Ｇｕｉｌａｒｄ，　Ｒ．: 'Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ｓｔｒｕｃｔｕｒｅ　ｅｌｕｃｉｄａｔｉｏｎ　ｏｆ　ｔｈｅ　ｃｏｎｄｅｎｓａｔｉｏｎ　ｐｒｏｄｕｃｔｓ　ｂｅｔｗｅｅｎ　ｔｈｉｏｐｈｅｎｅｄｉｃａｒｂｏｘａｌｄｅｈｙｄｅｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ｈｅｔｅｒｏｃｙｃｌｉｃ　Ｃｈｅｍｉｓｔｒｙ ２５（５）, 1988, １５３１-４ *
JPN6012047790; Ａｌｌｅｇｒｅｔｔｉ，　Ｍａｒｃｅｌｌｏ；　Ｂｅｒｔｉｎｉ，　Ｒｉｃｃａｒｄｏ；　Ｃｅｓｔａ，　Ｍａｒｉａ　Ｃａｎｄｉｄａ；　Ｂｉｚｚａｒｒｉ，　Ｃｉｎｚｉａ；　Ｄｉ　Ｂｉｔｏｎｄｏ，　Ｒｏｓａ；　Ｄ: '２-Ａｒｙｌｐｒｏｐｉｏｎｉｃ　ＣＸＣ　Ｃｈｅｍｏｋｉｎｅ　Ｒｅｃｅｐｔｏｒ　１　（ＣＸＣＲ１）　Ｌｉｇａｎｄｓ　ａｓ　Ｎｏｖｅｌ　Ｎｏｎｃｏｍｐｅｔｉｔｉｖｅ　ＣＸＣＬ８　Ｉｎｈｉｂｉｔｏｒｓ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ ４８（１３）, 2005, ４３１２-４３３１ *
JPN6012047791; Ｔａｋａｈａｓｈｉ，　Ｉ．；　Ｎｉｓｈｉｕｃｈｉ，　Ｋ．；　Ｍｉｙａｍｏｔｏ，　Ｒ．；　Ｈａｔａｎａｋａ，　Ｍ．；　Ｕｃｈｉｄａ，　Ｈ．；　Ｉｓａ，　Ｋ．；　Ｓａｋｕｓｈｉｍａ，　Ａ．；　Ｈｏｓｏｉ，: 'Ｒｅａｃｔｉｏｎ　ｓｙｓｔｅｍｓ　ｐｅｒｉｐｈｅｒａｌ　ｔｏ　ｔｈｅ　１：２　Ｍａｎｎｉｃｈ　ｃｏｎｄｅｎｓａｔｉｏｎ　ｒｅａｃｔｉｏｎ　ｂｅｔｗｅｅｎ　ｏ-ｐｈｔｈａｌａｌｄｅｈｙｄｅ　ａｎｄ　ｐｒ' Ｌｅｔｔｅｒｓ　ｉｎ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ ２（１）, 2005, ４０-４３ *
JPN6012047792; Ｊｕ，　Ｙｕｈｏｎｇ；　Ｖａｒｍａ，　Ｒａｊｅｎｄｅｒ　Ｓ．: 'Ａｑｕｅｏｕｓ　Ｎ-Ｈｅｔｅｒｏｃｙｃｌｉｚａｔｉｏｎ　ｏｆ　Ｐｒｉｍａｒｙ　Ａｍｉｎｅｓ　ａｎｄ　Ｈｙｄｒａｚｉｎｅｓ　ｗｉｔｈ　Ｄｉｈａｌｉｄｅｓ：　Ｍｉｃｒｏｗａｖｅ-Ａｓｓｉｓｔｅｄ　Ｓｙｎｔ' Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ ７１（１）, 2006, １３５-１４１ *
JPN6012047793; Ｔｒｚｃｉｏｎｋａ，　Ｊｅｒｏｍｅ；　Ｎｏｉｒｏｔ，　Ａｒｉｅｌｌｅ；　Ｆａｂｒｅ，　Ｐａｕｌ-Ｌｏｕｉｓ；　Ｃｈｏｕｉｎｉ-Ｌａｌａｎｎｅ，　Ｎａｄｉａ: 'Ｃｏｍｐａｒａｔｉｖｅ　ｓｔｕｄｙ　ｏｆ　ｔｈｅ　ｐｈｏｔｏｐｈｙｓｉｃａｌ　ｐｒｏｐｅｒｔｉｅｓ　ｏｆ　ｉｎｄｏｐｒｏｆｅｎ　ｐｈｏｔｏｐｒｏｄｕｃｔｓ　ｉｎ　ｒｅｌａｔｉｏｎ　ｗｉｔｈ　ｔｈｅｉｒ' Ｐｈｏｔｏｃｈｅｍｉｃａｌ　ａｎｄ　Ｐｈｏｔｏｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ ４（３）, 2005, ２９８-３０３ *
JPN6012047794; Ｔｓｕｒｕｔａ，　Ｙａｓｕｔｏ；　Ｔｏｎｏｇａｉｔｏ，　Ｈｉｒｏｓｈｉ；　Ｔａｋａｔａ，　Ｙｏｓｈｉｈｉｓａ；　Ｄａｔｅ，　Ｙｕｕｋｏ；: '４-（２-Ｐｈｔｈａｌｉｍｉｄｙｌ）ｂｅｎｚｏｙｌ　ｃｙａｎｉｄｅ　ａｓ　ｆｌｕｏｒｅｓｃｅｎｔ　ｌａｂｅｌｉｎｇ　ｒｅａｇｅｎｔ　ｆｏｒ　ａｌｃｏｈｏｌｓ　ｉｎ　ｈｉｇｈ-ｐｅｒｆｏｒｍａｎｃｅ　ｌ' Ｃｈｅｍｉｃａｌ　ａｎｄ　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ ４０（６）, 1992, １６２６-８ *
JPN6012047795; Ｋａｍｅｔａｎｉ， Ｔｅｔｓｕｊｉ； Ｋｉｇａｓａｗａ， Ｋａｚｕｏ； Ｈｉｉｒａｇｉ， Ｍｉｎｅｈａｒｕ； Ｗａｇａｔｓｕｍａ， Ｎａｇａｔｏｓｈｉ； Ｋｏｈａｇｉｚａｗａ， Ｔｏｓｈｉｔａｋａ；: 'Ｓｔｕｄｉｅｓ ｏｎ ｔｈｅ ｓｙｎｔｈｅｓｅｓ ｏｆ ｈｅｔｅｒｏｃｙｃｌｉｃ ｃｏｍｐｏｕｎｄｓ． ＤＣＣＣＬＩＩ． Ｓｔｕｄｉｅｓ ｏｎ ｔｈｅ ｓｙｎｔｈｅｓｅｓ ｏｆ ｄｒｕｇ ａｃｔｉ' Ｙａｋｕｇａｋｕ Ｚａｓｓｈｉ １０１（５）, 1981, ４２１-３０ *
JPN6012047796; Ｅｌ-Ｂｏｒａｉ，　Ｍｏｈａｍｅｄ　Ａ．；　Ａｌｙ，　Ｅｌ-Ｓａｉｅｄ　Ａ．；　Ｇｅｒｇｅｓ，　Ｓ．　Ｓ．: 'Ｒｅａｃｔｉｏｎ　ｏｆ　ｔｈｉｏｐｈｅｎｅｄｉｃａｒｂｏｘａｌｄｅｈｙｄｅｓ　ｗｉｔｈ　ｐ-ａｍｉｎｏａｃｅｔｏｐｈｅｎｏｎｅ：　ａ　ｎｅｗ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｈｉｅｎｏｐｙｒｒｏｌｅ　ｄｅ' Ｐｈｏｓｐｈｏｒｕｓ，　Ｓｕｌｆｕｒ　ａｎｄ　Ｓｉｌｉｃｏｎ　ａｎｄ　ｔｈｅ　Ｒｅｌａｔｅｄ　Ｅｌｅｍｅｎｔｓ １０１（１-４）, 1995, ９-１５ *

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JP2015101589A (ja) * 2009-12-22 2015-06-04 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター
JP2013545810A (ja) * 2010-12-16 2013-12-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のビアリールアミドインヒビター
US9199959B2 (en) 2011-10-25 2015-12-01 Shionogi & Co., Ltd. HIV replication inhibitor
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JP2015508075A (ja) * 2012-02-10 2015-03-16 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物
JP2017122097A (ja) * 2012-02-10 2017-07-13 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物
JPWO2014077401A1 (ja) * 2012-11-19 2017-01-05 武田薬品工業株式会社 含窒素複素環化合物
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JP2023528499A (ja) * 2020-06-03 2023-07-04 イエプ バイオ カンパニー リミテッド ２－（４－（１－ヒドロキシプロパン－２－イル）フェニル）イソインドリン－１－オンの化合物を含むパーキンソン病の予防または治療用薬学的組成物
JP7492039B2 (ja) 2020-06-03 2024-05-28 イエプ バイオ カンパニー リミテッド ２－（４－（１－ヒドロキシプロパン－２－イル）フェニル）イソインドリン－１－オンの化合物を含むパーキンソン病の予防または治療用薬学的組成物
US12564574B2 (en) 2020-06-03 2026-03-03 Yep Bio Co. Ltd. Pharmaceutical composition for preventing or treating parkinson's disease, comprising 2-(4-(1-hydroxypropane-2-yl)phenyl)isoindoline-1-one compound

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