BRPI0111830B8 - método de produção de partículas semelhantes ao vírus da influenza (vlps), vlps da influenza, vlps quiméricas, composições imunogênica e farmacêutica, e, usos de vlps da influenza e de vlps quiméricas - Google Patents

método de produção de partículas semelhantes ao vírus da influenza (vlps), vlps da influenza, vlps quiméricas, composições imunogênica e farmacêutica, e, usos de vlps da influenza e de vlps quiméricas

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Publication number
BRPI0111830B8
BRPI0111830B8 BRPI0111830A BR0111830A BRPI0111830B8 BR PI0111830 B8 BRPI0111830 B8 BR PI0111830B8 BR PI0111830 A BRPI0111830 A BR PI0111830A BR 0111830 A BR0111830 A BR 0111830A BR PI0111830 B8 BRPI0111830 B8 BR PI0111830B8
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BR
Brazil
Prior art keywords
vlps
influenza
chimeric
particles
immunogenic
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BRPI0111830A
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English (en)
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BR0111830B1 (pt
BR0111830A (pt
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M Galarza Jose
E Latham Theresa
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American Cyanamid Co
Wyeth Corp
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Application filed by American Cyanamid Co, Wyeth Corp filed Critical American Cyanamid Co
Publication of BR0111830A publication Critical patent/BR0111830A/pt
Publication of BR0111830B1 publication Critical patent/BR0111830B1/pt
Publication of BRPI0111830B8 publication Critical patent/BRPI0111830B8/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123—Virus like particles [VLP]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
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  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"método de produção de partículas semelhantes ao vírus da influenza (vlps), vlps da influenza, vlps quiméricas, proteínas da influenza, composições imunogênica e farmacêutica, métodos de imunizar contra a infecção causada pelo vírus da influenza ou por um microorganismo patogênico outro que não o vírus da influenza, método de tratamento, e, célula hospedeira transfectada, infectada ou transformada com uma molécula de dna recombinante". partículas semelhantes ao vírus da influenza (vlps) que compreendem as proteínas estruturais ha, na, m1 e m2 são descritas. as vlps também são geradas contendo somente m1, como o são as vlps com m1 e qualquer um ou dois de ha, na e m2. as vlps com ha de um subtipo da influenza e na de um subtipo diferente da influenza também são descritas, como o são as vlps em que uma parte ou toda de ha ou na são substituídas por uma parte heteróloga não produzida pelo vírus da influenza, de modo a compreender vlps quiméricas.
BRPI0111830A 2000-06-23 2001-06-21 método de produção de partículas semelhantes ao vírus da influenza (vlps), vlps da influenza, vlps quiméricas, composições imunogênica e farmacêutica, e, usos de vlps da influenza e de vlps quiméricas BRPI0111830B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21365600P 2000-06-23 2000-06-23
US60/213656 2000-06-23
US28441101P 2001-04-17 2001-04-17
US60/284411 2001-04-17
PCT/US2001/019890 WO2002000885A2 (en) 2000-06-23 2001-06-21 Assembly of wild-type and chimeric influenza virus-like particles (vlps)

Publications (3)

Publication Number Publication Date
BR0111830A BR0111830A (pt) 2003-03-25
BR0111830B1 BR0111830B1 (pt) 2014-12-02
BRPI0111830B8 true BRPI0111830B8 (pt) 2021-05-25

Family

ID=26908276

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0111830A BRPI0111830B8 (pt) 2000-06-23 2001-06-21 método de produção de partículas semelhantes ao vírus da influenza (vlps), vlps da influenza, vlps quiméricas, composições imunogênica e farmacêutica, e, usos de vlps da influenza e de vlps quiméricas

Country Status (17)

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US (2) US7556940B2 (pt)
EP (1) EP1294892B1 (pt)
JP (1) JP5008244B2 (pt)
KR (1) KR100877019B1 (pt)
CN (1) CN1196788C (pt)
AT (1) ATE376059T1 (pt)
AU (2) AU2001268662A1 (pt)
BR (1) BRPI0111830B8 (pt)
CA (1) CA2410297C (pt)
CY (1) CY1107835T1 (pt)
DE (1) DE60130987T2 (pt)
DK (1) DK1294892T3 (pt)
ES (1) ES2295175T3 (pt)
IL (1) IL153290A0 (pt)
MX (1) MXPA02012254A (pt)
PT (1) PT1294892E (pt)
WO (1) WO2002000885A2 (pt)

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US8859231B2 (en) 2014-10-14
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CA2410297C (en) 2011-03-15
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CN1196788C (zh) 2005-04-13
CA2410297A1 (en) 2002-01-03
PT1294892E (pt) 2008-01-16
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WO2002000885A9 (en) 2002-05-10
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US7556940B2 (en) 2009-07-07

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