BR0113307A - Molécula de proteìna quimérica de núcleo de vìrus de hepatite b recombinante, partìcula imunogênica, vacina ou inóculo, ácido nucleico, molécula de ácido nucleico recombinante, célula hospedeira e método de induzir uma resposta imunológica em um animal hospedeiro inoculado - Google Patents

Molécula de proteìna quimérica de núcleo de vìrus de hepatite b recombinante, partìcula imunogênica, vacina ou inóculo, ácido nucleico, molécula de ácido nucleico recombinante, célula hospedeira e método de induzir uma resposta imunológica em um animal hospedeiro inoculado

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Publication number
BR0113307A
BR0113307A BR0113307-1A BR0113307A BR0113307A BR 0113307 A BR0113307 A BR 0113307A BR 0113307 A BR0113307 A BR 0113307A BR 0113307 A BR0113307 A BR 0113307A
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Brazil
Prior art keywords
nucleic acid
recombinant
molecule
immunogenic
inoculum
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Application number
BR0113307-1A
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English (en)
Inventor
Ashley J Birkett
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Apovia Inc
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Publication date
Application filed by Apovia Inc filed Critical Apovia Inc
Publication of BR0113307A publication Critical patent/BR0113307A/pt

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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
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    • C12N2740/10011—Retroviridae
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  • Health & Medical Sciences (AREA)
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Abstract

"MOLéCULA DE PROTEìNA QUIMéRICA DE NúCLEO DE VìRUS DE HEPATITE B RECOMBINANTE, PARTìCULA IMUNOGêNICA, VACINA OU INóCULO ,áCIDO NUCLEICO, MOLéCULA DE áCIDO NUCLEICO RECOMBINANTE, CéLULA HOSPEDEIRA E MéTODO DE INDUZIR UMA RESPOSTA IMUNOLóGICA EM UM ANIMAL HOSPEDEIRO INOCULADO". Revela-se uma proteína de nucleocapsídeo de vírus de hepatite B (HBc) truncada carbóxi-terminal, quimérica, que é manipulada no sentido de estabilidade incrementada de partículas auto-agrupadas e para apresentar um epítopo imunogênico. A apresentação do epítopo imunogênico é apresentada na alça imunogênica do HBc, enquanto que a estabilidade incrementada de partículas auto-agrupadas é obtida por meio da presença de pelo menos um radical cisteína heterólogo próximo da ponta carbóxi da molécula de quimera. Revela-se também métodos de preparar e usar as quimeras.
BR0113307-1A 2000-08-16 2001-08-16 Molécula de proteìna quimérica de núcleo de vìrus de hepatite b recombinante, partìcula imunogênica, vacina ou inóculo, ácido nucleico, molécula de ácido nucleico recombinante, célula hospedeira e método de induzir uma resposta imunológica em um animal hospedeiro inoculado BR0113307A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22584300P 2000-08-16 2000-08-16
US22686700P 2000-08-22 2000-08-22
US09/930,915 US20030138769A1 (en) 2000-08-16 2001-08-15 Immunogenic HBc chimer particles having enhanced stability
PCT/US2001/041759 WO2002014478A2 (en) 2000-08-16 2001-08-16 IMMUNOGENIC HBc CHIMER PARTICLES HAVING ENHANCED STABILITY

Publications (1)

Publication Number Publication Date
BR0113307A true BR0113307A (pt) 2005-06-28

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BR0113307-1A BR0113307A (pt) 2000-08-16 2001-08-16 Molécula de proteìna quimérica de núcleo de vìrus de hepatite b recombinante, partìcula imunogênica, vacina ou inóculo, ácido nucleico, molécula de ácido nucleico recombinante, célula hospedeira e método de induzir uma resposta imunológica em um animal hospedeiro inoculado

Country Status (12)

Country Link
US (3) US20030138769A1 (pt)
EP (1) EP1333857A4 (pt)
JP (2) JP2005517380A (pt)
KR (1) KR20030084887A (pt)
AP (1) AP2003002752A0 (pt)
AU (2) AU8545201A (pt)
BR (1) BR0113307A (pt)
CA (1) CA2420037A1 (pt)
EA (1) EA006207B1 (pt)
MX (1) MXPA03001338A (pt)
OA (1) OA12366A (pt)
WO (1) WO2002014478A2 (pt)

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MXPA03001338A (es) 2004-01-26
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KR20030084887A (ko) 2003-11-01
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