DK1423525T3 - Rekombinant MVA, der kan eksprimere HCV-strukturantigener - Google Patents
Rekombinant MVA, der kan eksprimere HCV-strukturantigenerInfo
- Publication number
- DK1423525T3 DK1423525T3 DK02797955T DK02797955T DK1423525T3 DK 1423525 T3 DK1423525 T3 DK 1423525T3 DK 02797955 T DK02797955 T DK 02797955T DK 02797955 T DK02797955 T DK 02797955T DK 1423525 T3 DK1423525 T3 DK 1423525T3
- Authority
- DK
- Denmark
- Prior art keywords
- recombinant mva
- recombinant
- structural
- antigens
- producing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24241—Use of virus, viral particle or viral elements as a vector
- C12N2770/24243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10143490A DE10143490C2 (de) | 2001-09-05 | 2001-09-05 | Rekombinantes MVA mit der Fähigkeit zur Expression von HCV Struktur-Antigenen |
PCT/EP2002/009958 WO2003023042A1 (de) | 2001-09-05 | 2002-09-05 | Rekombinantes mva mit der fähigkeit zur expression von hcv struktur-antigenen |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1423525T3 true DK1423525T3 (da) | 2008-12-01 |
Family
ID=7697788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02797955T DK1423525T3 (da) | 2001-09-05 | 2002-09-05 | Rekombinant MVA, der kan eksprimere HCV-strukturantigener |
Country Status (10)
Country | Link |
---|---|
US (4) | US20050019347A1 (da) |
EP (1) | EP1423525B1 (da) |
JP (1) | JP4056472B2 (da) |
CN (1) | CN100375786C (da) |
AT (1) | ATE403007T1 (da) |
DE (2) | DE10143490C2 (da) |
DK (1) | DK1423525T3 (da) |
HK (1) | HK1074643A1 (da) |
RU (1) | RU2270860C2 (da) |
WO (1) | WO2003023042A1 (da) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10143490C2 (de) * | 2001-09-05 | 2003-12-11 | Gsf Forschungszentrum Umwelt | Rekombinantes MVA mit der Fähigkeit zur Expression von HCV Struktur-Antigenen |
EP1518932A1 (en) * | 2003-09-29 | 2005-03-30 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Modified vaccinia virus Ankara (MVA) mutant and use thereof |
CU23496A1 (es) * | 2004-09-03 | 2010-02-23 | Ct Ingenieria Genetica Biotech | Composición vacunal contra el virus de la hepatitis c |
US8058049B2 (en) * | 2006-06-20 | 2011-11-15 | Transgene S.A. | Process for producing poxviruses and poxvirus compositions |
JP5584407B2 (ja) * | 2008-03-07 | 2014-09-03 | 公益財団法人東京都医学総合研究所 | C型肝炎ウイルス遺伝子を有する組換えワクシニアウイルス |
EP2353610A4 (en) * | 2008-11-19 | 2013-12-11 | Avi Mex S A De C V Lab | RECOMBINANT INACTIVATED VIRUS VECTOR VACCINE |
CN103757032B (zh) * | 2014-01-28 | 2017-06-06 | 中国人民解放军第三0二医院 | 一种以流感病毒为载体的hcv嵌合疫苗及其制备方法 |
US11008368B2 (en) * | 2019-07-26 | 2021-05-18 | The Scripps Research Institute | Engineered HCV E2 immunogens and related vaccine compositions |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6297048B1 (en) * | 1992-02-04 | 2001-10-02 | Chiron Corporation | Hepatitis therapeutics |
WO1996004301A2 (en) * | 1994-07-29 | 1996-02-15 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
UA68327C2 (en) * | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
WO2000026385A1 (en) * | 1998-11-05 | 2000-05-11 | Powderject Vaccines, Inc. | Nucleic acid constructs for genetic immunization |
CA2372709C (en) * | 1999-05-28 | 2011-10-25 | Stefan Wintersperger | Vector for integration of heterologous sequences into poxviral genomes |
EP1195381A1 (de) * | 2000-09-28 | 2002-04-10 | Immusystems GmbH | CD4+ T-Lymphozyten spezifische Hepatitis C Virus-Epitope |
AR035869A1 (es) * | 2001-04-24 | 2004-07-21 | Innogenetics Nv | Proteinas de la envoltura de hcv glicosiladas en la estructura central, un metodo para producir la proteina de envoltura de hcv aislada, una composicion que la comprende, metodo para detectar la presencia de anticuerpos anti-hcv en una muestra, un kit de diagnostico para detectar la presencia de ant |
DE10143490C2 (de) * | 2001-09-05 | 2003-12-11 | Gsf Forschungszentrum Umwelt | Rekombinantes MVA mit der Fähigkeit zur Expression von HCV Struktur-Antigenen |
DE10144664B4 (de) * | 2001-09-11 | 2005-06-09 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Vacciniavirus MVA-E3L-Knock-Out-Mutanten und Verwendung hiervon |
ATE403005T1 (de) * | 2003-02-18 | 2008-08-15 | Helmholtz Zentrum Muenchen | Rekombinantes mva und verfahren zur erzeugung davon |
EP1518932A1 (en) * | 2003-09-29 | 2005-03-30 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Modified vaccinia virus Ankara (MVA) mutant and use thereof |
US20080286752A1 (en) * | 2005-04-08 | 2008-11-20 | The Trustees Of Columbia University In The City Of New York | Methods for the production of HCV, assaying HCV entry, and screening drugs and cellular receptors for HCV |
-
2001
- 2001-09-05 DE DE10143490A patent/DE10143490C2/de not_active Expired - Fee Related
-
2002
- 2002-09-05 EP EP02797955A patent/EP1423525B1/de not_active Expired - Lifetime
- 2002-09-05 US US10/488,301 patent/US20050019347A1/en not_active Abandoned
- 2002-09-05 RU RU2004106592/13A patent/RU2270860C2/ru not_active IP Right Cessation
- 2002-09-05 CN CNB028222156A patent/CN100375786C/zh not_active Expired - Fee Related
- 2002-09-05 DE DE50212580T patent/DE50212580D1/de not_active Expired - Lifetime
- 2002-09-05 JP JP2003527106A patent/JP4056472B2/ja not_active Expired - Fee Related
- 2002-09-05 DK DK02797955T patent/DK1423525T3/da active
- 2002-09-05 WO PCT/EP2002/009958 patent/WO2003023042A1/de active IP Right Grant
- 2002-09-05 AT AT02797955T patent/ATE403007T1/de active
-
2005
- 2005-08-10 HK HK05106873A patent/HK1074643A1/xx not_active IP Right Cessation
-
2009
- 2009-06-02 US US12/476,696 patent/US20090238843A1/en not_active Abandoned
-
2011
- 2011-05-18 US US13/110,471 patent/US20110293656A1/en not_active Abandoned
-
2012
- 2012-09-21 US US13/624,304 patent/US20130089569A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090238843A1 (en) | 2009-09-24 |
RU2004106592A (ru) | 2005-07-10 |
RU2270860C2 (ru) | 2006-02-27 |
US20130089569A1 (en) | 2013-04-11 |
US20050019347A1 (en) | 2005-01-27 |
DE50212580D1 (de) | 2008-09-11 |
JP4056472B2 (ja) | 2008-03-05 |
WO2003023042A1 (de) | 2003-03-20 |
CN100375786C (zh) | 2008-03-19 |
US20110293656A1 (en) | 2011-12-01 |
DE10143490A1 (de) | 2003-04-24 |
EP1423525A1 (de) | 2004-06-02 |
CN1610748A (zh) | 2005-04-27 |
JP2005502362A (ja) | 2005-01-27 |
WO2003023042A9 (de) | 2003-12-11 |
ATE403007T1 (de) | 2008-08-15 |
EP1423525B1 (de) | 2008-07-30 |
DE10143490C2 (de) | 2003-12-11 |
HK1074643A1 (en) | 2005-11-18 |
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