BR122020024443B1 - Composto e composição farmacêutica para modulação da expressão de angptl3 - Google Patents

Composto e composição farmacêutica para modulação da expressão de angptl3 Download PDF

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Publication number
BR122020024443B1
BR122020024443B1 BR122020024443-7A BR122020024443A BR122020024443B1 BR 122020024443 B1 BR122020024443 B1 BR 122020024443B1 BR 122020024443 A BR122020024443 A BR 122020024443A BR 122020024443 B1 BR122020024443 B1 BR 122020024443B1
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BR
Brazil
Prior art keywords
certain embodiments
modified
group
compound
oligonucleotide
Prior art date
Application number
BR122020024443-7A
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English (en)
Portuguese (pt)
Inventor
Thazha P. Prakash
Punit P. Seth
Eric E. Swayze
Susan M. Freier
Mark J. Graham
Rosanne M. Crooke
Original Assignee
Ionis Pharmaceuticals, Inc
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Application filed by Ionis Pharmaceuticals, Inc filed Critical Ionis Pharmaceuticals, Inc
Publication of BR122020024443B1 publication Critical patent/BR122020024443B1/pt

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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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BR122020024443-7A 2014-05-01 2015-05-01 Composto e composição farmacêutica para modulação da expressão de angptl3 BR122020024443B1 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201461987467P 2014-05-01 2014-05-01
US61/987,467 2014-05-01
US201462049230P 2014-09-11 2014-09-11
US62/049,230 2014-09-11
PCT/US2015/028837 WO2015168589A2 (en) 2014-05-01 2015-05-01 Compositions and methods for modulating angiopoietin-like 3 expression
BR112016024850-3A BR112016024850B1 (pt) 2014-05-01 2015-05-01 compostos e composições para modulação da expressão de angptl3 e seus usos

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BR122020024443B1 true BR122020024443B1 (pt) 2022-02-22

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BR122020024443-7A BR122020024443B1 (pt) 2014-05-01 2015-05-01 Composto e composição farmacêutica para modulação da expressão de angptl3
BR112016024850-3A BR112016024850B1 (pt) 2014-05-01 2015-05-01 compostos e composições para modulação da expressão de angptl3 e seus usos

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BR112016024850-3A BR112016024850B1 (pt) 2014-05-01 2015-05-01 compostos e composições para modulação da expressão de angptl3 e seus usos

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US (4) US9382540B2 (https=)
EP (2) EP3137605B1 (https=)
JP (4) JP2017521045A (https=)
KR (1) KR102356388B1 (https=)
CN (2) CN111961669A (https=)
AU (2) AU2015252895B2 (https=)
BR (2) BR122020024443B1 (https=)
CA (1) CA2946003A1 (https=)
DK (1) DK3137605T3 (https=)
ES (1) ES2844593T3 (https=)
HU (1) HUE052931T2 (https=)
IL (1) IL248269B (https=)
MX (2) MX382230B (https=)
PL (1) PL3137605T3 (https=)
PT (1) PT3137605T (https=)
RU (1) RU2734658C2 (https=)
SI (1) SI3137605T1 (https=)
WO (1) WO2015168589A2 (https=)

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