BR112022026733A2 - Imunógenos estabilizados de proteína spike (s) de coronavírus e vacinas relacionadas - Google Patents

Imunógenos estabilizados de proteína spike (s) de coronavírus e vacinas relacionadas

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Publication number
BR112022026733A2
BR112022026733A2 BR112022026733A BR112022026733A BR112022026733A2 BR 112022026733 A2 BR112022026733 A2 BR 112022026733A2 BR 112022026733 A BR112022026733 A BR 112022026733A BR 112022026733 A BR112022026733 A BR 112022026733A BR 112022026733 A2 BR112022026733 A2 BR 112022026733A2
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BR
Brazil
Prior art keywords
immunogens
coronavirus
stabilized
vaccines
soluble
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BR112022026733A
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English (en)
Inventor
He Linling
Zhu Jiang
A Wilson Ian
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Scripps Research Inst
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Publication of BR112022026733A2 publication Critical patent/BR112022026733A2/pt

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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • C12N2770/00011—Details
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    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
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Abstract

IMUNÓGENOS ESTABILIZADOS DE PROTEÍNA SPIKE (S) DE CORONAVÍRUS E VACINAS RELACIONADAS. A presente invenção refere-se a imunógenos derivados da proteína S solúvel de coronavírus reprojetados que são estabilizados por meio de modificações específicas nas sequências S solúveis do tipo selvagem. Também são fornecidas na invenção vacinas de nanopartículas que contêm os imunógenos S solúveis reprojetados exibidos em nanopartículas de automontagem. As sequências de polinucleotídeo que codificam os imunógenos reprojetados e as vacinas de nanopartículas também são fornecidas na invenção. A invenção fornece também métodos de uso das composições de vacina em várias aplicações terapêuticas, por exemplo, para prevenir ou tratar infecções por coronavírus.
BR112022026733A 2020-06-29 2020-10-01 Imunógenos estabilizados de proteína spike (s) de coronavírus e vacinas relacionadas BR112022026733A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063045557P 2020-06-29 2020-06-29
US17/019,825 US10906944B2 (en) 2020-06-29 2020-09-14 Stabilized coronavirus spike (S) protein immunogens and related vaccines
PCT/US2020/053714 WO2022005503A1 (en) 2020-06-29 2020-10-01 Stabilized coronavirus spike (s) protein immunogens and related vaccines

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BR112022026733A2 true BR112022026733A2 (pt) 2023-01-24

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US (3) US10906944B2 (pt)
EP (1) EP4171626A1 (pt)
JP (1) JP2023533228A (pt)
CN (2) CN112538105B (pt)
AU (1) AU2020456732A1 (pt)
BR (1) BR112022026733A2 (pt)
CA (1) CA3188348A1 (pt)
IL (1) IL299483A (pt)
MX (1) MX2022016574A (pt)
WO (1) WO2022005503A1 (pt)
ZA (1) ZA202300260B (pt)

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