BR112016022553A2 - Compostos e métodos para entrega transmembrana de moléculas? - Google Patents

Compostos e métodos para entrega transmembrana de moléculas?

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Publication number
BR112016022553A2
BR112016022553A2 BR112016022553A BR112016022553A BR112016022553A2 BR 112016022553 A2 BR112016022553 A2 BR 112016022553A2 BR 112016022553 A BR112016022553 A BR 112016022553A BR 112016022553 A BR112016022553 A BR 112016022553A BR 112016022553 A2 BR112016022553 A2 BR 112016022553A2
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Brazil
Prior art keywords
compounds
molecules
methods
delivery
transmembrane delivery
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BR112016022553A
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English (en)
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Ziv Ilan
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Aposense Ltd
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Publication date
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Publication of BR112016022553A2 publication Critical patent/BR112016022553A2/pt

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Abstract

COMPOSTOS E MÉTODOS PARA ENTREGA TRANSMEMBRANA DE MOLÉCULAS. A presente invenção provê um novo sistema de entrega para macromoléculas, tais como proteínas e oligonucleotídeos, e, especificamente, siARN, através de membranas biológicas, compreendendo a conjugação da macromolécula a uma porção, que permita o cruzamento efetivo das membranas. Respectivamente, são fornecidos novos compostos e composições farmacêuticas, utilizando tal sistema de entrega. Em um aspecto da invenção, os compostos podem ser utilizados na prática médica, por exemplo, na entrega de siARN ou de oligonucleotídeos anti-sentido através de membranas biológica, para o tratamento de distúrbios médicos.
BR112016022553A 2014-03-28 2015-03-29 Compostos e métodos para entrega transmembrana de moléculas? BR112016022553A2 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201461971548P 2014-03-28 2014-03-28
US201461978903P 2014-04-13 2014-04-13
US201462002870P 2014-05-25 2014-05-25
US201462008509P 2014-06-06 2014-06-06
US201462091551P 2014-12-14 2014-12-14
PCT/IL2015/000019 WO2015145417A1 (en) 2014-03-28 2015-03-29 Compounds and methods for trans-membrane delivery of molecules

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BR112016022553A2 true BR112016022553A2 (pt) 2017-08-15

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US (1) US9687556B2 (pt)
EP (1) EP3125946B1 (pt)
JP (1) JP6669719B2 (pt)
KR (1) KR20160138210A (pt)
CN (1) CN106456804B (pt)
AU (1) AU2015237746B2 (pt)
BR (1) BR112016022553A2 (pt)
CA (1) CA2944141C (pt)
IL (1) IL248067B (pt)
MX (1) MX2016012716A (pt)
RU (1) RU2703416C2 (pt)
WO (1) WO2015145417A1 (pt)

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