BR112021016903A2 - Administração de biomoléculas a pbmcs para modificação de uma resposta imune - Google Patents

Administração de biomoléculas a pbmcs para modificação de uma resposta imune

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Publication number
BR112021016903A2
BR112021016903A2 BR112021016903A BR112021016903A BR112021016903A2 BR 112021016903 A2 BR112021016903 A2 BR 112021016903A2 BR 112021016903 A BR112021016903 A BR 112021016903A BR 112021016903 A BR112021016903 A BR 112021016903A BR 112021016903 A2 BR112021016903 A2 BR 112021016903A2
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BR
Brazil
Prior art keywords
pbmcs
immune response
biomolecules
modify
administration
Prior art date
Application number
BR112021016903A
Other languages
English (en)
Inventor
R Sharei Armon
Kelly SMITH Carolyne
Defne Yarar
Ilker OZAY Emrah
Howard Bernstein
Katarina Blagovic
Kelan Hlavaty
Matthew Booty
Scott Loughhead
Original Assignee
Sqz Biotechnologies Co
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Publication date
Application filed by Sqz Biotechnologies Co filed Critical Sqz Biotechnologies Co
Publication of BR112021016903A2 publication Critical patent/BR112021016903A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C12N5/0648—Splenocytes
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    • A61K39/12—Viral antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
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    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
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    • A61K39/4644—Cancer antigens
    • A61K39/46449—Melanoma antigens
    • A61K39/464492—Glycoprotein 100 [Gp100]
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
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    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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Abstract

administração de biomoléculas a pbmcs para modificação de uma resposta imune. a presente invenção refere-se a células mononucleares de sangue periférico compreendendo um antígeno, métodos de fabricação de tais pbmcs e métodos de uso de tais pbmcs, tal como para modulação de uma resposta imune em um indivíduo. em algumas modalidades, as pbmcs são condicionadas pela incubação da pbmc na presença de um adjuvante.
BR112021016903A 2019-02-28 2020-02-27 Administração de biomoléculas a pbmcs para modificação de uma resposta imune BR112021016903A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962812225P 2019-02-28 2019-02-28
EP19161964 2019-03-11
US201962841089P 2019-04-30 2019-04-30
US201962886799P 2019-08-14 2019-08-14
US201962933304P 2019-11-08 2019-11-08
US201962948732P 2019-12-16 2019-12-16
PCT/US2020/020194 WO2020176789A1 (en) 2019-02-28 2020-02-27 Delivery of biomolecules to pbmcs to modify an immune response

Publications (1)

Publication Number Publication Date
BR112021016903A2 true BR112021016903A2 (pt) 2021-11-03

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BR112021016903A BR112021016903A2 (pt) 2019-02-28 2020-02-27 Administração de biomoléculas a pbmcs para modificação de uma resposta imune

Country Status (17)

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US (2) US11692168B2 (pt)
EP (1) EP3931309A4 (pt)
JP (1) JP2022522351A (pt)
KR (1) KR20210134353A (pt)
CN (1) CN114127267A (pt)
AU (1) AU2020228648A1 (pt)
BR (1) BR112021016903A2 (pt)
CA (1) CA3131701A1 (pt)
CL (1) CL2021002258A1 (pt)
CO (1) CO2021012581A2 (pt)
CR (1) CR20210493A (pt)
IL (1) IL285809A (pt)
MX (1) MX2021010320A (pt)
PE (1) PE20220379A1 (pt)
SG (1) SG11202109333SA (pt)
TW (1) TW202045717A (pt)
WO (1) WO2020176789A1 (pt)

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