CO2021012581A2 - Entrega de biomoléculas a pbmcs para modificar una respuesta inmunitaria - Google Patents
Entrega de biomoléculas a pbmcs para modificar una respuesta inmunitariaInfo
- Publication number
- CO2021012581A2 CO2021012581A2 CONC2021/0012581A CO2021012581A CO2021012581A2 CO 2021012581 A2 CO2021012581 A2 CO 2021012581A2 CO 2021012581 A CO2021012581 A CO 2021012581A CO 2021012581 A2 CO2021012581 A2 CO 2021012581A2
- Authority
- CO
- Colombia
- Prior art keywords
- pbmcs
- immune response
- biomolecules
- modify
- delivery
- Prior art date
Links
- 230000028993 immune response Effects 0.000 title abstract 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 4
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001143 conditioned effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0648—Splenocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/4622—Antigen presenting cells
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- A—HUMAN NECESSITIES
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- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C12N2510/00—Genetically modified cells
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- C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
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- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Immunology (AREA)
- General Health & Medical Sciences (AREA)
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- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente solicitud proporciona células mononucleares de sangre periférica que comprenden un antígeno, métodos de fabricar tales PBMCs, y métodos de usar tales PBMCs, tales como para modular una respuesta inmunitaria en un individuo. En algunas modalidades, las PBMCs se acondicionan incubando las PBMCS en la presencia de un adyuvante.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962812225P | 2019-02-28 | 2019-02-28 | |
EP19161964 | 2019-03-11 | ||
US201962841089P | 2019-04-30 | 2019-04-30 | |
US201962886799P | 2019-08-14 | 2019-08-14 | |
US201962933304P | 2019-11-08 | 2019-11-08 | |
US201962948732P | 2019-12-16 | 2019-12-16 | |
PCT/US2020/020194 WO2020176789A1 (en) | 2019-02-28 | 2020-02-27 | Delivery of biomolecules to pbmcs to modify an immune response |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021012581A2 true CO2021012581A2 (es) | 2022-01-17 |
Family
ID=72238527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0012581A CO2021012581A2 (es) | 2019-02-28 | 2021-09-24 | Entrega de biomoléculas a pbmcs para modificar una respuesta inmunitaria |
Country Status (17)
Country | Link |
---|---|
US (2) | US11692168B2 (es) |
EP (1) | EP3931309A4 (es) |
JP (1) | JP2022522351A (es) |
KR (1) | KR20210134353A (es) |
CN (1) | CN114127267A (es) |
AU (1) | AU2020228648A1 (es) |
BR (1) | BR112021016903A2 (es) |
CA (1) | CA3131701A1 (es) |
CL (1) | CL2021002258A1 (es) |
CO (1) | CO2021012581A2 (es) |
CR (1) | CR20210493A (es) |
IL (1) | IL285809A (es) |
MX (1) | MX2021010320A (es) |
PE (1) | PE20220379A1 (es) |
SG (1) | SG11202109333SA (es) |
TW (1) | TW202045717A (es) |
WO (1) | WO2020176789A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017041051A1 (en) | 2015-09-04 | 2017-03-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
BR112021016903A2 (pt) | 2019-02-28 | 2021-11-03 | Sqz Biotechnologies Co | Administração de biomoléculas a pbmcs para modificação de uma resposta imune |
AU2020271040A1 (en) | 2019-04-08 | 2021-11-18 | Sqz Biotechnologies Company | Cartridge for use in a system for delivery of a payload into a cell |
JP2022533956A (ja) | 2019-05-14 | 2022-07-27 | プロメテウス バイオサイエンシーズ,インク. | Tl1a患者を選択する方法、システム、およびデバイス |
MX2022014134A (es) * | 2020-05-11 | 2022-11-30 | Hoffmann La Roche | Tratamiento conjunto con pbmc modificadas y un inmunoconjugado. |
US20230263879A1 (en) * | 2020-09-02 | 2023-08-24 | Sqz Biotechnologies Company | Methods to stimulate hla-agnostic immune responses to proteins using nucleated cells |
WO2022147017A1 (en) | 2020-12-29 | 2022-07-07 | Sqz Biotechnologies Company | Formulations for cryopreservation of pbmcs |
US20220296691A1 (en) | 2020-12-29 | 2022-09-22 | Sqz Biotechnologies Company | Methods for treating cancer with activating antigen carriers |
US20220233676A1 (en) | 2020-12-29 | 2022-07-28 | Sqz Biotechnologies Company | Formulations of activating antigen carriers |
EP4271711A1 (en) * | 2020-12-29 | 2023-11-08 | SQZ Biotechnologies Company | Methods for treating cancers with modified pbmcs |
AU2022314616A1 (en) * | 2021-07-19 | 2024-02-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cellular therapies for cancer by inhibition of monocarboxylate transporter 11 |
WO2023010090A1 (en) | 2021-07-29 | 2023-02-02 | Sqz Biotechnologies Company | Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery |
WO2023087009A1 (en) | 2021-11-11 | 2023-05-19 | Sqz Biotechnologies Company | Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery |
WO2024026492A1 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Methods for treating cancer with enhanced antigen presenting cells |
WO2024026491A2 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Enhanced antigen presenting cell formulations |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2502621C3 (de) | 1975-01-23 | 1978-09-14 | Kernforschungsanlage Juelich Gmbh, 5170 Juelich | Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen |
US4376634A (en) | 1980-05-30 | 1983-03-15 | Mallinckrodt, Inc. | Assay kit having syringe, dilution device and reagents within sealed container |
FR2569477B1 (fr) | 1984-08-24 | 1987-01-02 | Descartes Universite Rene | Appareil et procede pour la determination de la deformabilite des globules rouges du sang |
JP2720161B2 (ja) | 1988-02-01 | 1998-02-25 | 株式会社アドバンス | 細胞変形能測定装置 |
JP2685544B2 (ja) | 1988-11-11 | 1997-12-03 | 株式会社日立製作所 | 血液フィルタおよび血液検査方法並びに血液検査装置 |
JP2532707B2 (ja) | 1990-03-08 | 1996-09-11 | 佑二 菊池 | 血液回路及びこれを用いた血液測定装置及び血液測定方法 |
WO2002067863A2 (en) | 2001-02-22 | 2002-09-06 | The Scepens Eye Research Institute, Inc. | Tolerogenic antigen presenting cells and in treating immune-inflammatory conditions |
ATE411054T1 (de) | 2001-08-17 | 2008-10-15 | Coley Pharm Gmbh | Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung |
WO2003020039A1 (en) | 2001-08-28 | 2003-03-13 | Rush-Presbyterian-St. Luke's Medical Center | Immune tolerance to predetermined antigens |
CN100487456C (zh) | 2002-06-05 | 2009-05-13 | 松下电器产业株式会社 | 细胞外电位测量装置及其制造方法 |
US20060134067A1 (en) | 2003-02-18 | 2006-06-22 | Maxcyte, Inc. | Loading of cells with antigens by electroporation |
EP1699479A1 (en) | 2003-12-24 | 2006-09-13 | Leiden University Medical Center | Synthetic protein as tumor-specific vaccine |
WO2005107712A1 (en) | 2004-05-03 | 2005-11-17 | Hermes Biosciences, Inc. | Liposomes useful for drug delivery |
US7968335B2 (en) | 2004-06-17 | 2011-06-28 | Ken Nakata | Cell culturing method using biomechanical stimulation loading and system therefor |
ES2350895T3 (es) | 2004-08-19 | 2011-01-28 | University College Cardiff Consultants Limited | Preparación de células t gamma delta humanas presentadoras de antígeno y su uso en inmunoterapia. |
US20060134772A1 (en) | 2004-11-18 | 2006-06-22 | The Regents Of The University Of California | System for locating cells and for cellular analysis |
US7704743B2 (en) | 2005-03-30 | 2010-04-27 | Georgia Tech Research Corporation | Electrosonic cell manipulation device and method of use thereof |
NZ581779A (en) | 2005-05-17 | 2011-09-30 | Univ Connecticut | Composition and methods for immunomodulation in an organism comprising interleukin-15 polypeptide and interleukin-15 receptor subunit A polypeptide complex |
WO2007067032A1 (en) | 2005-12-09 | 2007-06-14 | Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
US8293524B2 (en) | 2006-03-31 | 2012-10-23 | Fluxion Biosciences Inc. | Methods and apparatus for the manipulation of particle suspensions and testing thereof |
US20070249038A1 (en) | 2006-04-21 | 2007-10-25 | Andrea Adamo | Microfluidic device for single cell targeted operations |
CA2662826A1 (en) | 2006-08-17 | 2008-02-21 | Massachusetts Institute Of Technology | Method and apparatus for microfluidic injection |
WO2008098094A1 (en) | 2007-02-06 | 2008-08-14 | Network Biosystems, Inc. | Devices and methods for the performance of miniaturized in vitro assays |
US20080311140A1 (en) | 2007-05-29 | 2008-12-18 | Baylor College Of Medicine | Antigen specific immunosuppression by dendritic cell therapy |
FR2919804B1 (fr) | 2007-08-08 | 2010-08-27 | Erytech Pharma | Composition et vaccin therapeutique anti-tumoral |
GB0718160D0 (en) | 2007-09-18 | 2007-10-24 | Medical Res Council | Methods |
WO2009069418A1 (ja) | 2007-11-28 | 2009-06-04 | Konica Minolta Opto, Inc. | 血液流動性計測装置及び血液流動性計測方法 |
US20090280518A1 (en) | 2008-05-12 | 2009-11-12 | Massachusetts Institute Of Technology | System for high throughput measurement of mechanical properties of cells |
JP5137129B2 (ja) | 2008-07-23 | 2013-02-06 | 国立大学法人山口大学 | 血液細胞の力学的特性測定装置 |
US9115340B2 (en) | 2008-08-08 | 2015-08-25 | Agency For Science Technology & Research | Microfluidic continuous flow device |
WO2011005799A2 (en) | 2009-07-06 | 2011-01-13 | Novartis Ag | Self replicating rna molecules and uses thereof |
US9364831B2 (en) | 2009-08-08 | 2016-06-14 | The Regents Of The University Of California | Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting |
HUE029150T2 (hu) | 2009-10-27 | 2017-02-28 | Erytech Pharma | Készítmény specifikus immuntolerancia indukálására |
WO2011079217A1 (en) | 2009-12-23 | 2011-06-30 | Cytovera, Inc. | A system and method for particle filtration |
WO2011119492A2 (en) | 2010-03-22 | 2011-09-29 | Massachusetts Institute Of Technology | Methods and compositions related to the measurement of material properties |
RU2615460C2 (ru) | 2010-11-25 | 2017-04-04 | Имнейт Сарл | Иммуногенные пептиды для применения в профилактике и/или лечении инфекционных заболеваний, аутоиммунных заболеваний, иммунных ответов на аллогенные факторы, аллергических заболеваний, опухолей, отторжения трансплантата и иммунных ответов против вирусных векторов. используемых для генной терапии или генной вакцинации |
RS59898B1 (sr) | 2011-10-17 | 2020-03-31 | Massachusetts Inst Technology | Intraćelijsko davanje |
WO2013185032A1 (en) | 2012-06-07 | 2013-12-12 | President And Fellows Of Harvard College | Nanotherapeutics for drug targeting |
PT2981607T (pt) | 2013-04-03 | 2020-11-20 | Memorial Sloan Kettering Cancer Center | Geração eficaz de células t direcionadas a tumores, derivadas de células estaminais pluripotentes |
AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
JP6502940B2 (ja) | 2013-08-16 | 2019-04-17 | マサチューセッツ インスティテュート オブ テクノロジー | 細胞への物質の選択的送達 |
SG10201903912XA (en) | 2014-10-31 | 2019-05-30 | Massachusetts Inst Technology | Delivery of biomolecules to immune cells |
CN107002089B (zh) | 2014-11-14 | 2021-09-07 | 麻省理工学院 | 化合物和组合物向细胞中的破坏和场实现的递送 |
WO2016115179A1 (en) | 2015-01-12 | 2016-07-21 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
AU2016289530B2 (en) | 2015-07-09 | 2021-05-06 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
WO2017041051A1 (en) | 2015-09-04 | 2017-03-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
EP3344747B1 (en) | 2015-09-04 | 2022-11-09 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules mediated by a surface with pores |
ES2964746T3 (es) | 2015-12-30 | 2024-04-09 | Celgene Corp | Métodos de producción de linfocitos T y linfocitos T producidos mediante el mismo |
WO2017123663A1 (en) | 2016-01-12 | 2017-07-20 | Sqz Biotechnologies Company | Intracellular delivery of complexes |
CA3023092A1 (en) | 2016-05-03 | 2017-11-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
AU2017259988B2 (en) | 2016-05-03 | 2023-04-27 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
US11422127B2 (en) | 2016-12-07 | 2022-08-23 | Albany Medical College | Ex vivo antigen and adjuvant pulsed peripheral blood mononuclear cells as a screening platform for candidate novel vaccines and candidate antigens |
US20210317187A1 (en) | 2017-12-05 | 2021-10-14 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to modulate antibody production |
KR20200100707A (ko) | 2017-12-20 | 2020-08-26 | 에스큐지 바이오테크놀로지스 컴퍼니 | 페이로드를 세포 내로 전달하기 위한 시스템 |
WO2019178057A1 (en) | 2018-03-12 | 2019-09-19 | Evelo Biosciences, Inc. | Methods of treating cancer using burkholderia |
SG11202008863XA (en) | 2018-03-12 | 2020-10-29 | Sqz Biotechnologies Co | Methods for treating hpv-associated diseases |
CR20200460A (es) | 2018-03-12 | 2020-11-23 | Sqz Biotechnologies Co | Suministro intracelular de biomeléculas para modificar respuestas inmunes |
CA3115245A1 (en) | 2018-10-04 | 2020-04-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to enhance antigen presenting cell function |
CN113614237A (zh) | 2019-01-25 | 2021-11-05 | Sqz生物技术公司 | 无核细胞源性疫苗 |
BR112021016903A2 (pt) | 2019-02-28 | 2021-11-03 | Sqz Biotechnologies Co | Administração de biomoléculas a pbmcs para modificação de uma resposta imune |
AU2020271040A1 (en) | 2019-04-08 | 2021-11-18 | Sqz Biotechnologies Company | Cartridge for use in a system for delivery of a payload into a cell |
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CA3131701A1 (en) | 2020-09-03 |
EP3931309A4 (en) | 2022-12-21 |
IL285809A (en) | 2021-10-31 |
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