MX2021010320A - Administracion de biomoleculas a celulas mononucleares de sangre periferica (pbmc) para modificar una respuesta inmunitaria. - Google Patents

Administracion de biomoleculas a celulas mononucleares de sangre periferica (pbmc) para modificar una respuesta inmunitaria.

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Publication number
MX2021010320A
MX2021010320A MX2021010320A MX2021010320A MX2021010320A MX 2021010320 A MX2021010320 A MX 2021010320A MX 2021010320 A MX2021010320 A MX 2021010320A MX 2021010320 A MX2021010320 A MX 2021010320A MX 2021010320 A MX2021010320 A MX 2021010320A
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MX
Mexico
Prior art keywords
pbmcs
immune response
biomolecules
modify
delivery
Prior art date
Application number
MX2021010320A
Other languages
English (en)
Inventor
Armon R Sharei
Scott Loughhead
Howard Bernstein
Katarina Blagovic
Kelan Hlavaty
Matthew Booty
Defne Yarar
Emrah Ilker Ozay
Carolyne Kelly Smith
Original Assignee
Sqz Biotechnologies Co
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Publication date
Application filed by Sqz Biotechnologies Co filed Critical Sqz Biotechnologies Co
Publication of MX2021010320A publication Critical patent/MX2021010320A/es

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0648—Splenocytes
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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Abstract

La presente solicitud proporciona células mononucleares de sangre periférica que comprenden un antígeno, métodos para producir estas PBMC y métodos para usar estas PBMC, tal como para modular una respuesta inmune en un individuo. En algunas realizaciones, las PBMC se acondicionan al incubar las PBMC en presencia de un adyuvante.
MX2021010320A 2019-02-28 2020-02-27 Administracion de biomoleculas a celulas mononucleares de sangre periferica (pbmc) para modificar una respuesta inmunitaria. MX2021010320A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962812225P 2019-02-28 2019-02-28
EP19161964 2019-03-11
US201962841089P 2019-04-30 2019-04-30
US201962886799P 2019-08-14 2019-08-14
US201962933304P 2019-11-08 2019-11-08
US201962948732P 2019-12-16 2019-12-16
PCT/US2020/020194 WO2020176789A1 (en) 2019-02-28 2020-02-27 Delivery of biomolecules to pbmcs to modify an immune response

Publications (1)

Publication Number Publication Date
MX2021010320A true MX2021010320A (es) 2021-11-12

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MX2021010320A MX2021010320A (es) 2019-02-28 2020-02-27 Administracion de biomoleculas a celulas mononucleares de sangre periferica (pbmc) para modificar una respuesta inmunitaria.

Country Status (17)

Country Link
US (1) US11692168B2 (es)
EP (1) EP3931309A4 (es)
JP (1) JP2022522351A (es)
KR (1) KR20210134353A (es)
CN (1) CN114127267A (es)
AU (1) AU2020228648A1 (es)
BR (1) BR112021016903A2 (es)
CA (1) CA3131701A1 (es)
CL (1) CL2021002258A1 (es)
CO (1) CO2021012581A2 (es)
CR (1) CR20210493A (es)
IL (1) IL285809A (es)
MX (1) MX2021010320A (es)
PE (1) PE20220379A1 (es)
SG (1) SG11202109333SA (es)
TW (1) TW202045717A (es)
WO (1) WO2020176789A1 (es)

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TW202207975A (zh) * 2020-05-11 2022-03-01 瑞士商赫孚孟拉羅股份公司 使用經修飾之ｐｂｍｃ及免疫結合體之組合療法
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CN116801719A (zh) 2020-12-29 2023-09-22 Sqz生物技术公司 用于pbmc冷冻保存的调配物
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CN116847880A (zh) 2020-12-29 2023-10-03 Sqz生物技术公司 活化抗原载体的调配物
AU2022314616A1 (en) * 2021-07-19 2024-02-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Cellular therapies for cancer by inhibition of monocarboxylate transporter 11
WO2023010090A1 (en) 2021-07-29 2023-02-02 Sqz Biotechnologies Company Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery
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