PE20220379A1 - Suministro de biomoleculas a pbmc para modificar una respuesta inmune - Google Patents

Suministro de biomoleculas a pbmc para modificar una respuesta inmune

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Publication number
PE20220379A1
PE20220379A1 PE2021001420A PE2021001420A PE20220379A1 PE 20220379 A1 PE20220379 A1 PE 20220379A1 PE 2021001420 A PE2021001420 A PE 2021001420A PE 2021001420 A PE2021001420 A PE 2021001420A PE 20220379 A1 PE20220379 A1 PE 20220379A1
Authority
PE
Peru
Prior art keywords
pbmc
antigen
modified
biomolecules
modify
Prior art date
Application number
PE2021001420A
Other languages
English (en)
Inventor
Armon R Sharei
Howard Bernstein
Scott Loughhead
Matthew Booty
Katarina Blagovic
Kelan Hlavaty
Defne Yarar
Emrah Ilker Ozay
Carolyne Kelly Smith
Original Assignee
Sqz Biotechnologies Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sqz Biotechnologies Co filed Critical Sqz Biotechnologies Co
Publication of PE20220379A1 publication Critical patent/PE20220379A1/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0648—Splenocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • A61K35/14—Blood; Artificial blood
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46449—Melanoma antigens
    • A61K39/464492—Glycoprotein 100 [Gp100]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
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    • C12N2710/00011—Details
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Abstract

La presente solicitud proporciona una pluralidad de celulas mononucleares de sangre periferica (PBMC) modificadas que comprenden un antigeno exogeno a las PBMC, donde el antigeno es un antigeno de cancer, de una enfermedad infecciosa o uno asociado a una enfermedad viral; y su proceso de preparacion. Tambien refiere una pluralidad acondicionada de PBMC modificada, preparada incubando la pluralidad de PBMC con un adyuvante; donde el adyuvante es un oligodesoxinucleotido CpG (ODN), LPS, IFN-alfa, agonistas de STING, agonistas de RIG-I, entre otros. Una composicion que comprende dicha pluralidad de PBMC modificadas siendo utiles en el tratamiento de un cancer, una enfermedad infecciosa o una enfermedad asociada a virus.
PE2021001420A 2019-02-28 2020-02-27 Suministro de biomoleculas a pbmc para modificar una respuesta inmune PE20220379A1 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962812225P 2019-02-28 2019-02-28
EP19161964 2019-03-11
US201962841089P 2019-04-30 2019-04-30
US201962886799P 2019-08-14 2019-08-14
US201962933304P 2019-11-08 2019-11-08
US201962948732P 2019-12-16 2019-12-16
PCT/US2020/020194 WO2020176789A1 (en) 2019-02-28 2020-02-27 Delivery of biomolecules to pbmcs to modify an immune response

Publications (1)

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PE20220379A1 true PE20220379A1 (es) 2022-03-18

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PE2021001420A PE20220379A1 (es) 2019-02-28 2020-02-27 Suministro de biomoleculas a pbmc para modificar una respuesta inmune

Country Status (17)

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US (2) US11692168B2 (es)
EP (1) EP3931309A4 (es)
JP (1) JP2022522351A (es)
KR (1) KR20210134353A (es)
CN (1) CN114127267A (es)
AU (1) AU2020228648A1 (es)
BR (1) BR112021016903A2 (es)
CA (1) CA3131701A1 (es)
CL (1) CL2021002258A1 (es)
CO (1) CO2021012581A2 (es)
CR (1) CR20210493A (es)
IL (1) IL285809A (es)
MX (1) MX2021010320A (es)
PE (1) PE20220379A1 (es)
SG (1) SG11202109333SA (es)
TW (1) TW202045717A (es)
WO (1) WO2020176789A1 (es)

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BR112021016903A2 (pt) 2019-02-28 2021-11-03 Sqz Biotechnologies Co Administração de biomoléculas a pbmcs para modificação de uma resposta imune
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EP4373500A1 (en) * 2021-07-19 2024-05-29 University of Pittsburgh - of the Commonwealth System of Higher Education Cellular therapies for cancer by inhibition of monocarboxylate transporter 11
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