WO2009069418A1 - 血液流動性計測装置及び血液流動性計測方法 - Google Patents

血液流動性計測装置及び血液流動性計測方法 Download PDF

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Publication number
WO2009069418A1
WO2009069418A1 PCT/JP2008/069529 JP2008069529W WO2009069418A1 WO 2009069418 A1 WO2009069418 A1 WO 2009069418A1 JP 2008069529 W JP2008069529 W JP 2008069529W WO 2009069418 A1 WO2009069418 A1 WO 2009069418A1
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WO
WIPO (PCT)
Prior art keywords
blood
blood fluidity
fluidity measurement
deformability
measurement apparatus
Prior art date
Application number
PCT/JP2008/069529
Other languages
English (en)
French (fr)
Inventor
Shuji Ichitani
Osamu Toyama
Original Assignee
Konica Minolta Opto, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konica Minolta Opto, Inc. filed Critical Konica Minolta Opto, Inc.
Priority to US12/744,604 priority Critical patent/US20100249621A1/en
Priority to CN2008801176831A priority patent/CN101874201B/zh
Priority to EP08853229.6A priority patent/EP2216639A4/en
Priority to JP2009543726A priority patent/JP5146463B2/ja
Publication of WO2009069418A1 publication Critical patent/WO2009069418A1/ja
Priority to US14/568,972 priority patent/US20150098626A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
    • G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F3/00—Measuring the volume flow of fluids or fluent solid material wherein the fluid passes through the meter in successive and more or less isolated quantities, the meter being driven by the flow
    • G01F3/36—Measuring the volume flow of fluids or fluent solid material wherein the fluid passes through the meter in successive and more or less isolated quantities, the meter being driven by the flow with stationary measuring chambers having constant volume during measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/20—Analysis of motion
    • G06T7/215—Motion-based segmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1027—Determining speed or velocity of a particle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size
    • G01N2015/1495—Deformation of particles
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30101—Blood vessel; Artery; Vein; Vascular
    • G06T2207/30104—Vascular flow; Blood flow; Perfusion

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Ecology (AREA)
  • Multimedia (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Theoretical Computer Science (AREA)
  • Signal Processing (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

　血球の変形能を短時間で定量化することを課題とする。 そのためには、ゲート３０の内部領域Ａ、入口領域Ｂ、及び出口領域Ｃのうちのいずれか２箇所の領域における血液の流れを撮影するＴＶカメラ６と、ＴＶカメラ６によって得られた画像から血液中の血球の速度を算出する画像処理部７と、この速度から、血球の変形能を血液の流動性として算出する変形能算出手段８１とを備える構成とする。
PCT/JP2008/069529 2007-11-28 2008-10-28 血液流動性計測装置及び血液流動性計測方法 WO2009069418A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/744,604 US20100249621A1 (en) 2007-11-28 2008-10-28 Blood fluidity measurement apparatus and blood fluidity measurement method
CN2008801176831A CN101874201B (zh) 2007-11-28 2008-10-28 血液流动性测量装置及血液流动性测量方法
EP08853229.6A EP2216639A4 (en) 2007-11-28 2008-10-28 APPARATUS AND METHOD FOR MEASURING BLOOD FLUIDITY
JP2009543726A JP5146463B2 (ja) 2007-11-28 2008-10-28 血液流動性計測装置及び血液流動性計測方法
US14/568,972 US20150098626A1 (en) 2007-11-28 2014-12-12 Blood fluidity measurement apparatus and blood fluidity measurement method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-306975 2007-11-28
JP2007306975 2007-11-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/744,604 A-371-Of-International US20100249621A1 (en) 2007-11-28 2008-10-28 Blood fluidity measurement apparatus and blood fluidity measurement method
US14/568,972 Division US20150098626A1 (en) 2007-11-28 2014-12-12 Blood fluidity measurement apparatus and blood fluidity measurement method

Publications (1)

Publication Number Publication Date
WO2009069418A1 true WO2009069418A1 (ja) 2009-06-04

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PCT/JP2008/069529 WO2009069418A1 (ja) 2007-11-28 2008-10-28 血液流動性計測装置及び血液流動性計測方法

Country Status (5)

Country Link
US (2) US20100249621A1 (ja)
EP (1) EP2216639A4 (ja)
JP (1) JP5146463B2 (ja)
CN (1) CN101874201B (ja)
WO (1) WO2009069418A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010137470A1 (ja) * 2009-05-29 2010-12-02 コニカミノルタオプト株式会社 変形能計測装置及び変形能計測方法
WO2012040067A2 (en) * 2010-09-22 2012-03-29 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
US9151705B2 (en) 2012-10-24 2015-10-06 The Regents Of The University Of California System and method for deforming and analyzing particles
US10252260B2 (en) 2016-04-01 2019-04-09 CytoVale Inc. System and method for deforming particles
US11123734B2 (en) 2019-07-31 2021-09-21 CytoVale Inc. System and method for immune activity determination
US11548003B1 (en) 2022-01-13 2023-01-10 CytoVale Inc. System and method for determining an immune activation state
US11592371B1 (en) 2022-01-13 2023-02-28 CytoVale Inc. System and method for determining an immune activation state
US11964281B2 (en) 2022-02-03 2024-04-23 CytoVale Inc. System and method for correcting patient index

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CN101577845B (zh) 2009-06-01 2012-11-14 中兴通讯股份有限公司 一种倒换控制命令处理的方法及装置
RS59898B1 (sr) * 2011-10-17 2020-03-31 Massachusetts Inst Technology Intraćelijsko davanje
CN102743165B (zh) * 2012-07-31 2013-11-20 刘常春 基于光电容积脉搏波的血液在体流动性测量装置
JP6502940B2 (ja) 2013-08-16 2019-04-17 マサチューセッツ インスティテュート オブ テクノロジー 細胞への物質の選択的送達
SG10201903912XA (en) 2014-10-31 2019-05-30 Massachusetts Inst Technology Delivery of biomolecules to immune cells
CN107002089B (zh) 2014-11-14 2021-09-07 麻省理工学院 化合物和组合物向细胞中的破坏和场实现的递送
WO2016115179A1 (en) 2015-01-12 2016-07-21 Massachusetts Institute Of Technology Gene editing through microfluidic delivery
AU2016289530B2 (en) 2015-07-09 2021-05-06 Massachusetts Institute Of Technology Delivery of materials to anucleate cells
WO2017041051A1 (en) 2015-09-04 2017-03-09 Sqz Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall
BR112021016903A2 (pt) 2019-02-28 2021-11-03 Sqz Biotechnologies Co Administração de biomoléculas a pbmcs para modificação de uma resposta imune
AU2020271040A1 (en) 2019-04-08 2021-11-18 Sqz Biotechnologies Company Cartridge for use in a system for delivery of a payload into a cell

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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010137470A1 (ja) * 2009-05-29 2010-12-02 コニカミノルタオプト株式会社 変形能計測装置及び変形能計測方法
US9897532B2 (en) 2010-09-22 2018-02-20 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
WO2012040067A2 (en) * 2010-09-22 2012-03-29 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
WO2012040067A3 (en) * 2010-09-22 2012-05-31 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
US8935098B2 (en) 2010-09-22 2015-01-13 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
US11169078B2 (en) 2010-09-22 2021-11-09 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
US10107735B2 (en) 2012-10-24 2018-10-23 The Regents Of The University Of California System and method for deforming and analyzing particles
US9638620B2 (en) 2012-10-24 2017-05-02 The Regents Of The University Of California System for deforming and analyzing particles
US9464977B2 (en) 2012-10-24 2016-10-11 The Regents Of The University Of California System and method for deforming, imaging and analyzing particles
US10295455B2 (en) 2012-10-24 2019-05-21 The Regents Of The University Of California System and method for deforming and analyzing particles
US10969327B2 (en) 2012-10-24 2021-04-06 The Regents Of The University Of California System and method for deforming and analyzing particles
US9151705B2 (en) 2012-10-24 2015-10-06 The Regents Of The University Of California System and method for deforming and analyzing particles
US12007321B2 (en) 2012-10-24 2024-06-11 The Regents Of The University Of California System and method for deforming and analyzing particles
US10252260B2 (en) 2016-04-01 2019-04-09 CytoVale Inc. System and method for deforming particles
US11123734B2 (en) 2019-07-31 2021-09-21 CytoVale Inc. System and method for immune activity determination
US11986824B2 (en) 2019-07-31 2024-05-21 CytoVale Inc. System and method for immune activity determination
US11548003B1 (en) 2022-01-13 2023-01-10 CytoVale Inc. System and method for determining an immune activation state
US11592371B1 (en) 2022-01-13 2023-02-28 CytoVale Inc. System and method for determining an immune activation state
US11964281B2 (en) 2022-02-03 2024-04-23 CytoVale Inc. System and method for correcting patient index

Also Published As

Publication number Publication date
CN101874201B (zh) 2012-08-15
US20100249621A1 (en) 2010-09-30
EP2216639A1 (en) 2010-08-11
US20150098626A1 (en) 2015-04-09
EP2216639A4 (en) 2014-01-15
JPWO2009069418A1 (ja) 2011-04-07
JP5146463B2 (ja) 2013-02-20
CN101874201A (zh) 2010-10-27

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