BR112018012179A2 - adenovírus de grupo b que codifica um anticorpo ou fragmento de complexo anti-tcr - Google Patents

adenovírus de grupo b que codifica um anticorpo ou fragmento de complexo anti-tcr

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Publication number
BR112018012179A2
BR112018012179A2 BR112018012179A BR112018012179A BR112018012179A2 BR 112018012179 A2 BR112018012179 A2 BR 112018012179A2 BR 112018012179 A BR112018012179 A BR 112018012179A BR 112018012179 A BR112018012179 A BR 112018012179A BR 112018012179 A2 BR112018012179 A2 BR 112018012179A2
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BR
Brazil
Prior art keywords
group
antibody
adenovirus encoding
tcr antibody
fragment complex
Prior art date
Application number
BR112018012179A
Other languages
English (en)
Inventor
Claire Noel Bromley Alice
Robert Champion Brian
Original Assignee
Psioxus Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1522334.0A external-priority patent/GB201522334D0/en
Priority claimed from GBGB1607463.5A external-priority patent/GB201607463D0/en
Priority claimed from GBGB1617207.4A external-priority patent/GB201617207D0/en
Priority claimed from GBGB1617206.6A external-priority patent/GB201617206D0/en
Application filed by Psioxus Therapeutics Ltd filed Critical Psioxus Therapeutics Ltd
Publication of BR112018012179A2 publication Critical patent/BR112018012179A2/pt

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    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
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    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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Abstract

a presente revelação refere-se a um vetor viral oncolítico deficiente em replicação ou adenovírus oncolítico de grupo b com capacidade para replicação selecionado a partir do grupo que consiste em ad11 e enadenotucirev, em que o vírus codifica um anticorpo ou um fragmento de ligação do mesmo para expressão sobre a superfície de uma célula cancerígena, em que o dito anticorpo ou fragmento de ligação é específico para uma proteína cd3 de um complexo receptor de célula t (tcr), em que o vírus não codifica uma proteína b7 ou um fragmento ativo da mesma, composições farmacêuticas que compreendem o mesmo e uso de qualquer um dentre os mesmo em tratamento, particularmente, no tratamento contra câncer.
BR112018012179A 2015-12-17 2016-12-19 adenovírus de grupo b que codifica um anticorpo ou fragmento de complexo anti-tcr BR112018012179A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1522334.0A GB201522334D0 (en) 2015-12-17 2015-12-17 Method
GBGB1607463.5A GB201607463D0 (en) 2016-04-29 2016-04-29 Method
GBGB1617207.4A GB201617207D0 (en) 2016-10-10 2016-10-10 Method
GBGB1617206.6A GB201617206D0 (en) 2016-10-10 2016-10-10 Method
PCT/EP2016/081817 WO2017103290A1 (en) 2015-12-17 2016-12-19 Group b adenovirus encoding an anti-tcr-complex antibody or fragment

Publications (1)

Publication Number Publication Date
BR112018012179A2 true BR112018012179A2 (pt) 2018-12-04

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ID=57794239

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112018012179A BR112018012179A2 (pt) 2015-12-17 2016-12-19 adenovírus de grupo b que codifica um anticorpo ou fragmento de complexo anti-tcr
BR112018012180A BR112018012180A2 (pt) 2015-12-17 2016-12-19 vírus de codificação de um anticorpo ou fragmento de complexo anti-tcr

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BR112018012180A BR112018012180A2 (pt) 2015-12-17 2016-12-19 vírus de codificação de um anticorpo ou fragmento de complexo anti-tcr

Country Status (19)

Country Link
US (2) US11970536B2 (pt)
EP (2) EP3389683B8 (pt)
JP (2) JP7064437B2 (pt)
KR (2) KR20180108590A (pt)
CN (2) CN108697746A (pt)
AU (2) AU2016372576A1 (pt)
BR (2) BR112018012179A2 (pt)
CA (1) CA3006859A1 (pt)
CL (1) CL2018001611A1 (pt)
CO (1) CO2018005945A2 (pt)
DK (1) DK3389682T3 (pt)
EA (2) EA201891022A1 (pt)
IL (2) IL260027B (pt)
MX (1) MX2018007249A (pt)
MY (1) MY193281A (pt)
PH (1) PH12018501291A1 (pt)
SG (2) SG11201805136TA (pt)
WO (2) WO2017103291A1 (pt)
ZA (1) ZA201803523B (pt)

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