BR112015022434A2 - cápsulas de topiramato de liberação estendida - Google Patents

cápsulas de topiramato de liberação estendida

Info

Publication number
BR112015022434A2
BR112015022434A2 BR112015022434A BR112015022434A BR112015022434A2 BR 112015022434 A2 BR112015022434 A2 BR 112015022434A2 BR 112015022434 A BR112015022434 A BR 112015022434A BR 112015022434 A BR112015022434 A BR 112015022434A BR 112015022434 A2 BR112015022434 A2 BR 112015022434A2
Authority
BR
Brazil
Prior art keywords
extended release
core
release topiramate
topiramate
capsules
Prior art date
Application number
BR112015022434A
Other languages
English (en)
Inventor
Srinivas Tantry Jaidev
Marie Patrick Laura
Michelle Betterman Sarah
Original Assignee
Upsher Smith Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50072106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015022434(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upsher Smith Laboratories Inc filed Critical Upsher Smith Laboratories Inc
Publication of BR112015022434A2 publication Critical patent/BR112015022434A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891Coated capsules; Multilayered drug free capsule shells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

resumo cápsulas de topiramato de liberação estendida uma cápsula de topiramato de liberação estendida que inclui um invólucro da cápsula que contém uma população única de partículas revestidas; em que cada partícula revestida inclui um núcleo e um revestimento na mesma; em que cada núcleo da partícula inclui uma mistura homogênea compreendendo topiramato ao longo do seu núcleo; e em que o revestimento inclui um ou mais agente(s) de controle de liberação.
BR112015022434A 2013-03-13 2014-01-06 cápsulas de topiramato de liberação estendida BR112015022434A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361779576P 2013-03-13 2013-03-13
US201361788880P 2013-03-15 2013-03-15
PCT/US2014/010284 WO2014143380A1 (en) 2013-03-13 2014-01-06 Extended-release topiramate capsules

Publications (1)

Publication Number Publication Date
BR112015022434A2 true BR112015022434A2 (pt) 2017-07-18

Family

ID=50072106

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015022434A BR112015022434A2 (pt) 2013-03-13 2014-01-06 cápsulas de topiramato de liberação estendida

Country Status (7)

Country Link
US (5) US8652527B1 (pt)
EP (1) EP2968177A4 (pt)
KR (3) KR101674509B1 (pt)
BR (1) BR112015022434A2 (pt)
CA (1) CA2905011C (pt)
IL (2) IL241053A (pt)
WO (1) WO2014143380A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) * 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
US20220016074A1 (en) 2018-11-21 2022-01-20 Rosemont Pharmaceuticals Limited Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability
CN109602726A (zh) * 2018-12-27 2019-04-12 珠海天翼医药技术开发有限公司 托吡酯缓释剂及制备方法
WO2021033182A1 (en) * 2019-08-16 2021-02-25 Adel Penhasi Adhesive drug delivery film and a microparticle comprising thereof
CN110743507B (zh) * 2019-10-21 2022-08-23 浙江理工大学 一种海藻酸钠-硅胶复合干燥剂及其制备方法

Family Cites Families (507)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO984B1 (en) 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
US4513006A (en) 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
US5998380A (en) 1995-10-13 1999-12-07 New England Medical Center Hospitals, Inc. Treatment of migraine
US5952187A (en) 1995-12-01 1999-09-14 Oxis International, Inc. Topiramate immunoassay
US5753693A (en) 1996-06-28 1998-05-19 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating manic-depressive bipolar disorder
WO1998000124A1 (en) 1996-06-28 1998-01-08 Ortho Pharmaceutical Corporation Use of topiramate or derivatives thereof for the manufacture of a medicament for the treatment of postischemic neurodegeneration
RU2214241C2 (ru) 1996-06-28 2003-10-20 Орто-Макнейл Фармасьютикал, Инк. Способ лечения ожирения и способ индуцирования потери веса у млекопитающих
SK284266B6 (sk) 1996-06-28 2004-12-01 Ortho-Mcneil Pharmaceutical, Inc. Antikonvulzívne deriváty vhodné na liečbu psoriázy
US5753694A (en) 1996-06-28 1998-05-19 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating amyotrophic lateral sclerosis (ALS)
BR9712503A (pt) 1996-10-08 1999-10-19 Ortho Mcneil Pharm Inc Derivados anticonvulsivos úteis no tratamento de dor neuropática
US6572880B2 (en) 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
CA2216215A1 (en) 1997-04-05 1998-10-05 Isa Odidi Controlled release formulations using intelligent polymers having opposing wettability characteristics of hydrophobicity and hydrophilicity
US20080292700A1 (en) 1997-04-21 2008-11-27 Biovail Laboratories Controlled release formulations using intelligent polymers
ES2248908T7 (es) 1997-06-06 2014-11-24 Depomed, Inc. Formas de dosificación de fármacos por vía oral y retención gástrica para liberación continuada de fármacos altamente solubles
US6635280B2 (en) 1997-06-06 2003-10-21 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
US7744916B2 (en) 1997-06-11 2010-06-29 Umd, Inc. Coated vaginal device for delivery of anti-migraine and anti-nausea drugs
US5760006A (en) 1997-06-23 1998-06-02 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating psoriasis
US5935933A (en) 1997-07-16 1999-08-10 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in treating neuropathic pain
US5760007A (en) 1997-07-16 1998-06-02 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating neuropathic pain
US6622036B1 (en) 2000-02-09 2003-09-16 Cns Response Method for classifying and treating physiologic brain imbalances using quantitative EEG
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
JP2002519373A (ja) 1998-07-02 2002-07-02 エーザイ株式会社 製薬組成物及びそれらの使用
AU8761698A (en) 1998-07-30 2000-02-21 Procter & Gamble Company, The Hair care compositions
US6890951B2 (en) 1998-08-05 2005-05-10 Brookhaven Science Associates Llc Treatment of addiction and addiction-related behavior
US6541520B1 (en) 1998-08-05 2003-04-01 Brookhaven Science Associates Treatment of addiction and addiction-related behavior
NZ511173A (en) 1998-10-20 2003-09-26 Ortho Mcneil Pharm Inc Method for treating alcohol dependency, addiction and abuse using anticonvulsant derivatives (such as 2,3:4,5-bis- O-(1-methylethylidene)-beta-D-fructopyranose sulfamate (topiramate))
US20010055613A1 (en) 1998-10-21 2001-12-27 Beth A. Burnside Oral pulsed dose drug delivery system
EP1002535A1 (en) 1998-10-28 2000-05-24 Hrissanthi Ikonomidou New use of glutamate antagonists for the treatment of cancer
PT1143917E (pt) 1998-11-17 2004-06-30 Ortho Mcneil Pharm Inc Derivados anticonvulsionantes uteis no tratamento da perturbacao de stress pos-traumatico
AU1909700A (en) 1998-12-03 2000-06-19 Ortho-Mcneil Pharmaceutical, Inc. Topiramate and related derivatives for treating Schizophrenia
US7214711B2 (en) 1998-12-23 2007-05-08 Neurotherapeutics Pharma Llc Method of treating migraine headache without aura
IL144406A0 (en) 1999-01-19 2002-05-23 Ortho Mcneil Pharm Inc Anticonvulsant derivatives useful in treating cluster headaches
AR022321A1 (es) 1999-01-21 2002-09-04 Ortho Mcneil Pharm Inc Derivados de anticonvulsivo utiles para el tratamiento de la migrana transformada
WO2000044353A1 (de) * 1999-01-29 2000-08-03 Losan Pharma Gmbh Pharmazeutische zusammensetzungen
HUP0105420A3 (en) 1999-02-01 2003-03-28 Ortho Mcneil Pharm Inc Use of anticonvulsant derivatives for treating bulimia nervosa
DK1152756T3 (da) 1999-02-08 2005-10-10 Ortho Mcneil Pharm Inc Anticonvulsiva til behandling af autisme
DK1158950T3 (da) 1999-02-17 2006-04-24 Ortho Mcneil Pharm Inc antikonvulsive derivater til behandling af essentiel tremor
DK1158973T3 (da) 1999-02-24 2005-05-30 Univ Cincinnati Anvendelse af sulfamatderivater til behandling af impulskontrolafvigelser
US6548529B1 (en) 1999-04-05 2003-04-15 Bristol-Myers Squibb Company Heterocyclic containing biphenyl aP2 inhibitors and method
CA2369093C (en) 1999-04-08 2005-10-18 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in lowering lipids
MXPA01010221A (es) 1999-04-08 2002-03-27 Johnson & Johnson Derivados anticonvulsivos utiles para disminuir la presion sanguinea.
JP2003530300A (ja) 1999-04-08 2003-10-14 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 体重低下を維持することに有用な抗痙攣薬誘導体
NZ514811A (en) 1999-04-08 2005-01-28 Ortho Mcneil Pharm Inc Anticonvulsant derivatives useful in reducing blood glucose levels
WO2000066108A2 (en) 1999-04-30 2000-11-09 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in treating cocaine dependency
AU4307800A (en) 1999-04-30 2000-11-17 Merab Lomia New indication for use of antiepileptic agents and medicines
US6420369B1 (en) 1999-05-24 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in treating dementia
EP1187604A4 (en) 1999-05-28 2004-02-11 Jeffrey Berlant CONNECTIONS AND METHODS FOR TREATING POST-TRAUMATIC STRESS FAILURES
US7056890B2 (en) 1999-06-14 2006-06-06 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US20080255093A1 (en) 1999-06-14 2008-10-16 Tam Peter Y Compositions and methods for treating obesity and related disorders
US7659256B2 (en) 1999-06-14 2010-02-09 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US20080103179A1 (en) 2006-10-27 2008-05-01 Tam Peter Y Combination Therapy
US7674776B2 (en) 1999-06-14 2010-03-09 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
US7553818B2 (en) 1999-06-14 2009-06-30 Vivus, Inc. Combination therapy for effecting weight loss and treating obesity
EP1210118B1 (en) 1999-08-20 2004-12-08 Ortho-McNeil Pharmaceutical, Inc. Composition comprising a tramadol material and an anticonvulsant drug
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
US10179159B2 (en) 1999-10-22 2019-01-15 Scott Wepfer Topical anesthetic formulation
US6479467B1 (en) 1999-12-16 2002-11-12 Eastman Chemical Company Cyclodextrin ethers
MXPA02007254A (es) 2000-02-04 2002-12-09 Depomed Inc Forma de dosis de cubierta-y-nucleo que se aproxima a liberacion de droga de orden cero.
SE0000601D0 (sv) 2000-02-24 2000-02-24 Jan Hedner Sätt att behandla och diagnostisera andningsstörningar i sömnen och medel för att utföra sättet
US6395767B2 (en) 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US20010036943A1 (en) 2000-04-07 2001-11-01 Coe Jotham W. Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines
EP1157682A1 (en) 2000-05-25 2001-11-28 Cilag AG Blister package for topiramate tablets
US20020013334A1 (en) 2000-06-15 2002-01-31 Robl Jeffrey A. HMG-CoA reductase inhibitors and method
US20020028826A1 (en) 2000-06-15 2002-03-07 Robl Jeffrey A. HMG-CoA reductase inhibitors and method
WO2002000221A1 (en) 2000-06-23 2002-01-03 University Of Utah Research Foundation Enhanced brain function by gaba-ergic stimulation
AU2001280486A1 (en) 2000-07-07 2002-01-21 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful for treating and preventing the development of type ii diabetes mellitus and syndrome x
US6191117B1 (en) 2000-07-10 2001-02-20 Walter E. Kozachuk Methods of producing weight loss and treatment of obesity
US6946243B2 (en) 2000-07-20 2005-09-20 Solvay Pharmaceuticals Gmbh Method of identifying compounds suitable for treatment and/or prophylaxis of obesity
CA2417304A1 (en) 2000-08-02 2002-02-07 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful for the treatment of depression
US6395783B1 (en) 2000-10-23 2002-05-28 Brookhaven Science Associates, Llc Treatment of PCP addiction and PCP addiction-related behavior
ATE334718T1 (de) 2000-10-30 2006-08-15 Ortho Mcneil Pharm Inc Kombinationstherapie mit antidiabetischen und antikonvulsiven mitteln
US20050136106A1 (en) 2000-11-20 2005-06-23 Adrian Sandler Therapeutic placebo enhancement of commonly used medications
WO2002043762A2 (en) 2000-11-30 2002-06-06 Pfizer Products Inc. Combination of gaba agonists and sorbitol dehydrogenase inhibitors
EP1337272A2 (en) 2000-11-30 2003-08-27 Pfizer Products Inc. Combination of gaba agonists and aldose reductase inhibitors
RU2317086C2 (ru) 2001-02-02 2008-02-20 Орто-Макнейл Фармасьютикал, Инк. Лечение неврологической дисфункции с применением сульфаматов фруктопиранозы и эритропоэтина
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
US20060198815A1 (en) 2001-03-19 2006-09-07 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained release
JP4499362B2 (ja) 2001-03-28 2010-07-07 バイオジェン・アイデック・エムエイ・インコーポレイテッド ニューロパシーの疼痛を処置するためのニューブラスチンポリペプチドの使用
US20070026440A1 (en) 2001-04-06 2007-02-01 Broderick Patricia A Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using electrodes with microvoltammetry
US8257746B2 (en) 2001-04-10 2012-09-04 Pernix Therapeutics, Llc Tannate compositions, methods of making and methods of use
US8012506B2 (en) 2001-04-10 2011-09-06 Pernix Therapeutics, Llc Tannate compositions, methods of making and methods of use
AU2002254567B2 (en) 2001-04-11 2007-10-11 Bristol-Myers Squibb Company Amino acid complexes of C-aryl glucosides for treatment of diabetes and method
US6573287B2 (en) 2001-04-12 2003-06-03 Bristo-Myers Squibb Company 2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
US20030109546A1 (en) 2001-04-26 2003-06-12 Fenton Wayne S. Treatment of psychotic disorders comprising co-therapy with anticonvulsant derivatives and atypical antipsychotics
US20020187996A1 (en) 2001-05-14 2002-12-12 Dewey Stephen L. Prevention of addiction in pain management
US6462084B1 (en) 2001-05-14 2002-10-08 Brookhaven Science Associates, Llc Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US6967212B2 (en) 2001-05-30 2005-11-22 Bristol-Myers Squibb Company Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
US7105556B2 (en) 2001-05-30 2006-09-12 Bristol-Myers Squibb Company Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
DE10127134A1 (de) 2001-06-05 2002-12-12 Roehm Gmbh verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß
GB0113663D0 (en) 2001-06-05 2001-07-25 Novartis Ag Use of organic compounds
UA78211C2 (en) 2001-07-09 2007-03-15 Ortho Mcneil Pharm Inc Salts of fructopyranose derivatives as anticonvulsant
WO2003006006A1 (en) 2001-07-09 2003-01-23 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
US7041650B2 (en) 2001-07-09 2006-05-09 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivative salts
EP2275959A3 (en) 2001-07-11 2011-04-06 CNS Response, Inc. Method of screening a therapeutic agent for therapeutic effectiveness
US20030032661A1 (en) 2001-08-02 2003-02-13 Boehringer Ingelheim Pharma Kg Pramipexole as an anticonvulsant
WO2003011271A2 (en) 2001-08-03 2003-02-13 Children's Medical Center Corporation Methods and compositions for modulating brain damage
US20060173064A1 (en) 2001-08-24 2006-08-03 Lippa Arnold S (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders
JP2005502680A (ja) 2001-08-30 2005-01-27 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 抗痙攣剤およびアセチルコリンエステラーゼ阻害剤による痴呆および記憶障害の処置
WO2003020737A1 (en) 2001-09-05 2003-03-13 Bristol-Myers Squibb Company O-pyrazole glucoside sglt2 inhibitors and method of use
EP1429787A1 (en) 2001-09-24 2004-06-23 Ortho-McNeil Pharmaceutical, Inc. Anticonvulsant derivatives useful for the treatment of restless limb syndrome and periodic limb movement disorder
US20030072802A1 (en) 2001-10-11 2003-04-17 R.T. Alamo Ventures, Inc. Sustained release topiramate
US20030091630A1 (en) 2001-10-25 2003-05-15 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data
DE10153078A1 (de) 2001-10-30 2003-05-22 Degussa Verwendung von Granulaten auf Basis von pyrogen hergestelltem Siliciumdioxid in pharmazeutischen Zusammensetzungen
EP1442028A4 (en) 2001-11-06 2009-11-04 Bristol Myers Squibb Co SUBSTITUTED ACID DERIVATIVES, WHICH APPRECIATE AS ANTIDIBILICS AND AGENTS AGAINST OBESITAS, AND METHODS
US8329217B2 (en) * 2001-11-06 2012-12-11 Osmotica Kereskedelmi Es Szolgaltato Kft Dual controlled release dosage form
US20030092636A1 (en) 2001-11-06 2003-05-15 Silberstein Stephen D. Treatment and prevention of paresthesia comprising co-therapy with anticonvulsant derivatives and potassium
MXPA04004572A (es) 2001-11-14 2005-07-05 Ralph Ryback Metodo para el tratamiento de enfermedades autoinmunes.
US6831102B2 (en) 2001-12-07 2004-12-14 Bristol-Myers Squibb Company Phenyl naphthol ligands for thyroid hormone receptor
US20070167853A1 (en) 2002-01-22 2007-07-19 Melker Richard J System and method for monitoring health using exhaled breath
EP1336602A1 (en) 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
US6559293B1 (en) 2002-02-15 2003-05-06 Transform Pharmaceuticals, Inc. Topiramate sodium trihydrate
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7659082B2 (en) 2002-02-19 2010-02-09 Xenon Pharmaceuticals Inc. Methods for identifying analgesic agents
MXPA04008259A (es) 2002-02-26 2005-05-27 Johnson & Johnson Co-terapia para el tratamiento de migrana que comprende derivados de un anticonvulsivo y agentes anti-migrana.
US20030162695A1 (en) 2002-02-27 2003-08-28 Schatzberg Alan F. Glucocorticoid blocking agents for increasing blood-brain barrier permeability
NZ534757A (en) 2002-03-12 2006-07-28 Merck & Co Inc Substituted amides
ES2399880T3 (es) 2002-03-15 2013-04-04 Cypress Bioscience, Inc. Milnaciprán para el tratamiento del síndrome del intestino irritable
US20070021356A1 (en) 2002-03-18 2007-01-25 Cady Roger K Preemptive prophlyaxis of migraine
DE60322371D1 (de) 2002-03-29 2008-09-04 Alza Corp Volumensparende arzneiform zur kontrollierten freisetzung
US20040005358A1 (en) 2002-04-23 2004-01-08 Slugg Peter H. Modified-release vasopeptidase inhibitor formulation, combinations and method
ATE425744T1 (de) 2002-04-29 2009-04-15 Supernus Pharmaceuticals Inc Pharmazeutische formulierungen mit verbesserter bioverfugbarkeit
US7060725B2 (en) 2002-05-13 2006-06-13 Janssen Pharmaceutica N.V. Substituted sulfamate anticonvulsant derivatives
AU2003239455A1 (en) 2002-05-14 2003-12-02 Ralph Ryback Method for treating dermatoses and tissue damage
US7109198B2 (en) 2002-05-17 2006-09-19 Duke University Method for treating obesity
US7057046B2 (en) 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
EP1364649A1 (en) 2002-05-23 2003-11-26 Cilag AG Adduct of topiramate and tramadol hydrochioride and uses thereof
EP1511490A4 (en) 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS
US20040063751A1 (en) 2002-05-31 2004-04-01 Pharmacia Corporation Combination therapy for the treatment of amyotrophic lateral sclerosis (ALS) with cyclooxygenase-2 (COX-2) inhibitor(s) and a second drug
US20030235576A1 (en) 2002-06-15 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of ischaemic conditions
US20070243254A1 (en) 2002-06-26 2007-10-18 David Edgren Novel drug compositions and dosage forms of topiramate
AR039744A1 (es) 2002-06-26 2005-03-09 Alza Corp Metodos y formas de dosificacion para aumentar la solubilidad de las composiciones de farmacos para la administracion controlada
US20040087513A1 (en) 2002-07-04 2004-05-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations based on sodium channel blockers and magnesium salts
EP1531810B1 (en) 2002-07-09 2012-02-01 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
WO2004004665A2 (en) 2002-07-09 2004-01-15 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
AU2003253925A1 (en) 2002-07-18 2004-02-09 Banyu Pharmaceutical Co., Ltd. Combination therapy for the treatment of obesity
JP2006508042A (ja) 2002-07-18 2006-03-09 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体の修飾物質および方法
NZ537543A (en) 2002-07-29 2007-08-31 Alza Corp Formulations and high dose osmotic dosage forms for controlled delivery of topiramate
MXPA05001549A (es) 2002-08-08 2005-05-05 Kissei Pharmaceutical Derivado de pirazol, composicion medicinal que lo contiene, su uso medicinal, e intermediario para su produccion.
JP2004137245A (ja) 2002-08-23 2004-05-13 Kissei Pharmaceut Co Ltd ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体
EP1402924B1 (de) 2002-09-04 2008-12-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung eines Mittel zur Therapie der Herzhypertrophie
WO2004026299A1 (en) 2002-09-17 2004-04-01 Motac Neuroscience Limited Treatment of dyskinesia
AU2003218462A1 (en) 2002-10-01 2004-04-23 Merck And Co., Inc. Treatment of obesity and other disorders associated with excessive food intake
ATE469645T1 (de) 2002-10-23 2010-06-15 Bristol Myers Squibb Co Auf glycinnitril basierende hemmer der dipeptidylpeptidase iv
US20040082543A1 (en) 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
US7196209B2 (en) 2002-10-31 2007-03-27 Ortho-Mcneil Pharmaceutical, Inc. Continuous process for the preparation of fructopyranose sulfamate derivatives
US7098235B2 (en) 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
AU2003297639A1 (en) 2002-12-02 2004-06-23 University Of Florida Treatments for benign tumors, cancers, neoplasias, and/or other inflammatory disorders or diseases
US20040122033A1 (en) 2002-12-10 2004-06-24 Nargund Ravi P. Combination therapy for the treatment of obesity
AU2003296672A1 (en) * 2002-12-13 2004-07-09 Cilag Ag Controlled release preparations comprising tramadol and topiramate
RU2005122035A (ru) * 2002-12-13 2006-01-20 Цилаг Аг (Ch) Стабильные препараты топирамата
ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
EP1585500B8 (en) 2002-12-20 2017-07-26 Auritec Pharmaceuticals Coated particles for sustained-release pharmaceutical administration
WO2004058222A1 (en) 2002-12-20 2004-07-15 St. James Associates Llc/Faber Research Series High pressure compaction for pharmaceutical formulations
EP1587499A1 (en) 2003-01-31 2005-10-26 Elan Pharma International Limited Nanoparticulate topiramate formulations
ATE550022T1 (de) 2003-02-28 2012-04-15 Mcneil Ppc Inc Pharmazeutische mischkristalle von celecoxib- nicotinamid
EP1631260A2 (en) 2003-02-28 2006-03-08 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
UA81657C2 (ru) 2003-03-04 2008-01-25 Орто-Макнейл Фармасьютикел, Инк. Способ получения противосудорожных производных топирамата
US20040204472A1 (en) 2003-03-04 2004-10-14 Pharmacia Corporation Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents
WO2004089965A2 (en) 2003-04-07 2004-10-21 Cipla Ltd Topiramate and processes for the preparation thereof
PT1477166E (pt) 2003-04-28 2006-12-29 Biofrontera Bioscience Gmbh Utilização de riluzole combinado com substâncias auxiliares e aditivos adequados, para o tratamento de doenças caracterizadas por uma hiperproliferação de queratinócitos, especialmente de neurodermite e psoríase
US20040229943A1 (en) 2003-05-16 2004-11-18 Cephalon Inc Analeptic and drug combinations
PL1626721T3 (pl) 2003-05-23 2017-05-31 Otsuka Pharmaceutical Co., Ltd. Pochodne karbostyrylu i stabilizatory nastroju do leczenia zaburzeń nastroju
US20060160776A1 (en) 2003-05-28 2006-07-20 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a cannabinoid agent for the treatment of central nervous system damage
US20060160834A1 (en) 2003-06-06 2006-07-20 Fong Tung M Combination therapy for the treatment of hypertension
US20070099884A1 (en) 2003-06-06 2007-05-03 Erondu Ngozi E Combination therapy for the treatment of diabetes
EP1635813A4 (en) 2003-06-06 2009-07-01 Merck & Co Inc COMBINATION THERAPY FOR THE TREATMENT OF DYSLIPIDEMIA
WO2005000294A1 (en) 2003-06-06 2005-01-06 Pharmacia Corporation Selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US7235662B2 (en) 2003-06-11 2007-06-26 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US6949518B1 (en) 2003-06-25 2005-09-27 Pao-Hsien Chu Methods for treating macular degeneration with topiramate
US20090117181A1 (en) * 2003-06-25 2009-05-07 Tomoyuki Uehara Tablet comprising fluvastatin and carmellose calcium
CN1812982B (zh) 2003-06-26 2010-10-27 默沙东公司 苯并二氮杂*cgrp受体拮抗剂
CA2529196A1 (en) 2003-06-26 2005-02-17 Merck & Co., Inc. Benzodiazepine cgrp receptor antagonists
US20070111204A1 (en) 2003-06-27 2007-05-17 Kathleen Delgrosso Methods for detecting nucleic acid variations
WO2005007628A1 (en) 2003-07-11 2005-01-27 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives as cannabinoid receptor modulators
US6995183B2 (en) 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
WO2005016306A2 (en) 2003-08-06 2005-02-24 Alza Corporation Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
US20050031544A1 (en) 2003-08-07 2005-02-10 Njemanze Philip Chidi Receptor mediated nanoscale copolymer assemblies for diagnostic imaging and therapeutic management of hyperlipidemia and infectious diseases
WO2005020957A2 (en) 2003-08-22 2005-03-10 Alza Corporation Stepwise delivery of topiramate over prolonged period of time
EP1673064A1 (en) 2003-08-28 2006-06-28 Sandoz AG Pharmaceutical composition comprising anticonvulsant with taste mask coating
AU2004268661A1 (en) 2003-09-02 2005-03-10 Alza Corporation Novel drug compositions and dosage forms of topiramate
US7611728B2 (en) 2003-09-05 2009-11-03 Supernus Pharmaceuticals, Inc. Osmotic delivery of therapeutic compounds by solubility enhancement
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
WO2005048979A2 (en) 2003-10-06 2005-06-02 Torrent Pharmaceuticals Limited Pharmaceutical composition having casing with multiple micro tablets
US7425410B2 (en) 2003-10-30 2008-09-16 Free State Diagnostics, Llc Methods for diagnosing a bipolar disorder and unipolar disorder
MXPA06005461A (es) 2003-11-13 2006-12-15 Johnson & Johnson Dispersiones de mezclas en estado fundido que comprenden un farmaco de baja solubilidad en agua y un copolimero de bloque de oxido de etileno-oxido de propileno.
EP1684713A1 (en) 2003-11-14 2006-08-02 ALZA Corporation Controlled release of topirimate in liquid dosage forms
WO2005049043A1 (en) 2003-11-18 2005-06-02 Ortho-Mcneil Pharmaceutical, Inc. Combination therapy comprising metformin and anticonvulsant agents
US20050181049A1 (en) 2003-11-19 2005-08-18 Dong Liang C. Composition and method for enhancing bioavailability
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
WO2005063248A1 (en) 2003-12-22 2005-07-14 Sepracor Inc. Modafinil combination therapy for improving sleep quality
WO2005063206A1 (en) 2003-12-23 2005-07-14 Alza Corporation Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
AU2004308962A1 (en) 2003-12-24 2005-07-14 Sepracor Inc. Melatonin combination therapy for improving sleep quality
EP1701708A2 (en) 2003-12-29 2006-09-20 Alza Corporation Novel drug compositions and dosage forms of topiramate
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
KR20060128995A (ko) 2004-01-13 2006-12-14 듀크 유니버시티 체중감량에 영향을 미치는 항경련제와 항정신병 약물의조성물
US7713959B2 (en) 2004-01-13 2010-05-11 Duke University Compositions of an anticonvulsant and mirtazapine to prevent weight gain
US7326728B2 (en) 2004-01-16 2008-02-05 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof
US7273881B2 (en) 2004-01-16 2007-09-25 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7253283B2 (en) 2004-01-16 2007-08-07 Bristol-Myers Squibb Company Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7625921B2 (en) 2004-01-16 2009-12-01 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7569689B2 (en) 2004-01-16 2009-08-04 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7605264B2 (en) 2004-01-16 2009-10-20 Bristol-Myers Squibb Company Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2005082372A1 (en) 2004-01-29 2005-09-09 Pfizer Products Inc. COMBINATION OF γ-AMINOBUTYRIC ACID MODULATORS AND 5-HT 1B RECEPTOR ANTAGONISTS
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US20050182105A1 (en) 2004-02-04 2005-08-18 Nirschl Alexandra A. Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function
ES2241478B1 (es) 2004-02-13 2006-11-16 Lacer S.A. Preparacion farmaceutica para la liberacion sostenida de un principio farmaceuticamente activo.
CA2556214A1 (en) 2004-02-13 2005-09-01 Neuromolecular, Inc. Combination of an nmda receptor antagonist and an anti-epileptic drug for the treatment of epilepsy and other cns disorders
US20050181071A1 (en) 2004-02-18 2005-08-18 Binder Michael R. Method for the treatment of clinical depression
CN1934103B (zh) 2004-03-04 2011-06-01 橘生药品工业株式会社 稠杂环衍生物,包含稠杂环衍生物的药物组合物及其医药用途
US7732596B2 (en) 2004-03-04 2010-06-08 Kissei Pharmaceutical Co., Ltd. Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof
ZA200608029B (en) 2004-03-04 2008-12-31 Kissei Pharmaceutical Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs
US20050203287A1 (en) 2004-03-11 2005-09-15 Chandrasekhar Batchu Process for the preparation of sulfamate derivatives
TWI357901B (en) 2004-03-12 2012-02-11 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivati
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
ES2378071T3 (es) 2004-03-24 2012-04-04 Janssen Pharmaceutica Nv Moduladores de cannabinoides de tetrahidro-indazol
EP1732893A2 (en) 2004-03-29 2006-12-20 Pfizer Japan, Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist
CA2560005A1 (en) 2004-03-31 2005-10-13 Kissei Pharmaceutical Co., Ltd. Phenol derivative, medicinal composition containing the same, and medicinal use thereof
US20050222209A1 (en) 2004-04-01 2005-10-06 Zeldis Jerome B Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
GB0408308D0 (en) 2004-04-14 2004-05-19 Vectura Ltd Pharmaceutical compositions
WO2005110405A1 (en) 2004-05-03 2005-11-24 Duke University Compositions for affecting weight loss
US20050250838A1 (en) * 2004-05-04 2005-11-10 Challapalli Prasad V Formulation for sustained delivery
WO2005113519A1 (en) 2004-05-14 2005-12-01 Irm Llc Compounds and compositions as ppar modulators
WO2005113506A1 (en) 2004-05-14 2005-12-01 Irm Llc Compounds and compositions as ppar modulators
PE20060362A1 (es) 2004-05-24 2006-05-15 Irm Llc Compuestos de oxazol como moduladores de ppar
US20070212428A1 (en) 2004-06-04 2007-09-13 Mood Management Sciences, Inc. Methods and compositions for treating mood disorder
CA2569411A1 (en) 2004-06-04 2005-12-22 Mood Management Sciences, Llc Methods and compositions for treating mood disorder
WO2006007323A2 (en) 2004-06-28 2006-01-19 Alza Corporation Dosage forms for low solubility and/or low dissolution rate free acid pharmaceutical agents
TW200611704A (en) 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
US7829279B1 (en) 2004-07-16 2010-11-09 The Regents Of The University Of California Compositions and methods for diagnosis and treatment of epilepsy
CA2572928A1 (en) 2004-07-22 2006-02-26 Amorepacific Corporation Sustained-release preparations containing topiramate and the producing method thereof
WO2006017524A2 (en) 2004-08-02 2006-02-16 Olney John W Preventing pathological increases in the rate of nerve cell suicide in immature nervous systems
MX2007001563A (es) 2004-08-04 2008-03-05 Johnson & Johnson Composicion para liberacion sostenida de farmaco que demuestra un patron de liberacion ascendente del orden cero, metodos para la elaboracion de dicha composicion.
WO2006015930A1 (en) 2004-08-10 2006-02-16 Nicox S.A. Phenol derivatives
EP1784390A2 (en) 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
DE602004002692T2 (de) 2004-08-19 2007-09-06 Helm Ag Verfahren zur Herstellung von Topiramate
US20060039866A1 (en) 2004-08-20 2006-02-23 Cypress Bioscience, Inc. Method for treating sleep-related breathing disorders
US7696192B2 (en) 2004-09-09 2010-04-13 Merck Sharp & Dohme Corp. Tricyclic anilide spirolactam CGRP receptor antagonists
AU2005285083B2 (en) 2004-09-13 2011-03-10 Merck Sharp & Dohme Corp. Tricyclic anilide spirohydantoin CGRP receptor antagonists
EP1797073B1 (en) 2004-09-13 2010-04-14 Merck Sharp & Dohme Corp. Bicyclic anilide spirolactam cgrp receptor antagonists
US20060058224A1 (en) 2004-09-15 2006-03-16 Yancopoulos George D Methods of treating obesity with combination therapeutics
AR051446A1 (es) 2004-09-23 2007-01-17 Bristol Myers Squibb Co Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
CN101027075A (zh) 2004-09-24 2007-08-29 默克公司 用于治疗肥胖的组合疗法
AU2005295787A1 (en) 2004-10-15 2006-04-27 Janssen Pharmaceutica, N.V. Carbamate compounds for use in treating neurodegenerative disorders
US20060088886A1 (en) 2004-10-25 2006-04-27 Anlong Ouyang Topiramate analogs
US7638291B2 (en) 2004-10-25 2009-12-29 Seradyn, Inc. Immunoassays for topiramate
US8779175B2 (en) 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
US20080200376A1 (en) 2004-10-29 2008-08-21 Maccoss Malcolm Compositions and Methods For the Treatment Of Obesity and Sexual Dysfunction
AU2005307772B2 (en) 2004-11-16 2010-06-10 Limerick Biopharma, Inc. Methods and compositions for treating pain
US20060121112A1 (en) 2004-12-08 2006-06-08 Elan Corporation, Plc Topiramate pharmaceutical composition
EA200701246A1 (ru) * 2004-12-09 2008-06-30 Инсис Терапьютикс, Инк. Стабильные при комнатной температуре составы дронабинола
US20060129324A1 (en) 2004-12-15 2006-06-15 Biogenesys, Inc. Use of quantitative EEG (QEEG) alone and/or other imaging technology and/or in combination with genomics and/or proteomics and/or biochemical analysis and/or other diagnostic modalities, and CART and/or AI and/or statistical and/or other mathematical analysis methods for improved medical and other diagnosis, psychiatric and other disease treatment, and also for veracity verification and/or lie detection applications.
GB0428170D0 (en) 2004-12-23 2005-01-26 Biopartners Ltd Mono and Combination Therapy
US8067217B2 (en) * 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
US7589088B2 (en) 2004-12-29 2009-09-15 Bristol-Myers Squibb Company Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7317024B2 (en) 2005-01-13 2008-01-08 Bristol-Myers Squibb Co. Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7361654B2 (en) 2005-01-13 2008-04-22 Bristol-Myers Squibb Co. Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7411071B2 (en) 2005-01-13 2008-08-12 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
EP1841419A4 (en) 2005-01-19 2009-02-25 Merck Frosst Canada Ltd INHIBITORS OF CATHEPSIN K AND OBESITY
WO2006077492A1 (en) * 2005-01-24 2006-07-27 Ranbaxy Laboratories Limited Sustained release oral dosage forms of gabapentin
WO2006080029A1 (en) 2005-01-27 2006-08-03 Alembic Limited Extended release formulation of levetiracetam
MX2007009356A (es) 2005-02-03 2007-12-07 Irm Llc Compuestos y composiciones como moduladores de ppar.
US20090123563A1 (en) 2005-02-07 2009-05-14 Novo Nordisk A/S Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand
WO2006088305A1 (en) 2005-02-15 2006-08-24 Chong Kun Dang Pharmaceutical Corp. Gastric-retentive controlled release mono-matrix tablet
MX2007010721A (es) 2005-03-01 2007-11-13 Pfizer Ltd Nuevo uso de inhibidores de fosfodiesterasa 7 para el tratamiento de dolor neuropatico.
WO2006096439A2 (en) 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases
IS7748A (is) 2005-03-17 2006-09-18 Actavis Group Samsetning fyrir töflur sem innihalda topiramate
US20060211632A1 (en) 2005-03-17 2006-09-21 Bachmann Kenneth A PXR agonists for cardiovascular disease
AU2005215928A1 (en) 2005-03-18 2006-10-05 Ucl Biomedica Plc Genetic predictor for clinical use of drugs used in the treatment of neurological conditions
WO2006102029A2 (en) 2005-03-21 2006-09-28 Dov Pharmaceutical, Inc. Methods and compositions for the treatment of urinary incontinence
KR101288729B1 (ko) 2005-04-01 2013-07-23 인터자인 테크놀로지스, 인코포레이티드 약물 전달용 중합체성 마이셀
WO2006113095A2 (en) 2005-04-12 2006-10-26 Free State Diagnostics, Llc Methods for diagnosing a bipolar disorder and attention-deficit/hyperactivity disorder
JP5833804B2 (ja) 2005-04-13 2015-12-16 ニューラクソン,インコーポレーテッド Nos阻害活性を有する置換インドール化合物
US20110117070A1 (en) 2005-04-19 2011-05-19 Aurora Sheena K Compositions and methods for treating headache
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
PT2380573E (pt) 2005-05-06 2015-06-11 Bial Portela & Ca Sa Acetato de eslicarbazepina e métodos de utilização
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
AR054045A1 (es) 2005-05-18 2007-05-30 Neuraxon Inc Compuestos benzoimidazol sustituidos con actividad dual no inhibitoria y mu opioide agonista
EP1901733B1 (en) 2005-05-23 2016-04-06 President and Fellows of Harvard College Huperzine for use in the treatment of neuropathic pain
RU2007142346A (ru) 2005-05-31 2009-07-20 Ориксиджен Серапьютикс, Инкорпорэйтд (Сша/Сша) (Us) Способы и составы для контроля психотических нарушений
AU2006262441A1 (en) 2005-06-20 2007-01-04 Schering Corporation Piperidine derivatives useful as histamine H3 antagonists
EP1896453B1 (en) 2005-06-20 2009-12-02 Schering Corporation Carbon-linked substituted piperidines and derivatives thereof useful as histamine h3 antagonists
WO2007001939A1 (en) 2005-06-27 2007-01-04 Janssen Pharmaceutica N.V. Tetrahydro-pyranopyrazole compounds displaying cannabinoid modulating activities
WO2007002872A2 (en) 2005-06-29 2007-01-04 Alza Corporation Semi-permeable compositions providing reduced drying time for osmotic dosage forms
US20070021500A1 (en) 2005-07-12 2007-01-25 Twyman Roy E Methods for neuroprotection
US20070021501A1 (en) 2005-07-12 2007-01-25 Twyman Roy E Methods of treating epileptogenesis
KR20080042092A (ko) 2005-07-27 2008-05-14 오렉시젠 세러퓨틱스 인크. 체중감량 조성물
US8227476B2 (en) 2005-08-03 2012-07-24 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
WO2007026224A2 (en) 2005-08-31 2007-03-08 Pfizer Products Inc. 5-ht1b antagonist composition for depression, anxiety and cognition
US20070276001A1 (en) 2005-09-14 2007-11-29 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
JP2009508854A (ja) 2005-09-16 2009-03-05 セリューサイエンス アーベー 睡眠時呼吸障害の予防及び治療方法及び手段
DE602006013501D1 (de) 2005-09-16 2010-05-20 Janssen Pharmaceutica Nv Cyclopropylamine als modulatoren des histamin-h3-rezeptors
US7332604B2 (en) 2005-09-20 2008-02-19 Schering Corporation 1-[[1-[(2-Amino-6-methyl-4-pyridinyl)methyl]-4-fluoro-4-piperidinyl]carbonyl]-4-[2-(2-pyridinyl)-3H-imidazo[4,5-b]pyridin-3-yl]piperidine
CN101312952B (zh) 2005-09-23 2012-12-26 詹森药业有限公司 四氢-环戊二烯并吡唑大麻素调节剂
US8378117B2 (en) 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
US7825151B2 (en) 2005-09-23 2010-11-02 Janssen Pharmaceutica Nv Hexahydro-cyclooctyl pyrazole cannabinoid modulators
PL1931335T3 (pl) 2005-09-23 2010-07-30 Janssen Pharmaceutica Nv Modulatory heksahydrocyklooktylopirazolokannabinoidowe
US8378096B2 (en) 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
WO2007038610A2 (en) 2005-09-26 2007-04-05 President & Fellows Of Harvard College Use of natural products for treatment of neurological disorders
CA2521272A1 (en) 2005-10-04 2007-04-04 Bernard Charles Sherman Capsules comprising topiramate
WO2007047351A2 (en) 2005-10-13 2007-04-26 Orexigen Therapeutics, Inc. Methods for treating hypertension in overweight and obese individuals
US7378434B2 (en) 2005-10-14 2008-05-27 Mutual Pharmaceutical Company, Inc. Metaxalone products, method of manufacture, and method of use
DE202005016250U1 (de) 2005-10-17 2006-01-26 Helm Ag Topiramat und pharmazeutische Formulierungen davon
JP2009512715A (ja) 2005-10-21 2009-03-26 ノバルティス アクチエンゲゼルシャフト レニン阻害剤と抗異脂肪血症剤および/または抗肥満症剤の組み合わせ
WO2007053819A2 (en) 2005-10-31 2007-05-10 Bristol-Myers Squibb Company Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase iv and methods
EP1951692B1 (en) 2005-11-07 2010-08-18 Irm Llc Oxazole and thiazole ppar modulator
JP2009514974A (ja) 2005-11-07 2009-04-09 アイアールエム・リミテッド・ライアビリティ・カンパニー Pparモジュレーターとしての化合物および組成物
BRPI0618335A2 (pt) 2005-11-07 2011-08-23 Irm Llc compostos e composições como moduladores de ppar
CN101370488B (zh) 2005-11-22 2012-07-18 奥雷西根治疗公司 增加胰岛素敏感性的组合物
WO2007089318A2 (en) 2005-11-23 2007-08-09 Orexigen Therapeutics, Inc. Compositions and methods for reducing food cravings
EP1959947A2 (en) 2005-12-15 2008-08-27 Cytokinetics, Inc. Certain chemical entities, compositions and methods
AR058558A1 (es) 2005-12-21 2008-02-13 Schering Corp Derivados de anilina sustituida utiles como antagonistas de la histamina h3
BRPI0620386A2 (pt) 2005-12-21 2011-12-20 Schering Corp composição compreendendo a combinação de um antagonista de h3/agonista inverso e um supressor de apetite e uso da referida composição
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
AU2006331882A1 (en) 2005-12-21 2007-07-05 Schering Corporation Phenoxypiperidines and analogs thereof useful as histamine H3 antagonists
WO2007084290A2 (en) 2006-01-12 2007-07-26 Orexigen Therapeutics, Inc. Compositions of an anticonvulsant and psychotherapeutic and methods of using the same for reversing weight gain
US7824694B2 (en) 2006-01-12 2010-11-02 Allergan, Inc. Methods for enhancing therapeutic effects of a neurotoxin
JP2009525961A (ja) 2006-01-20 2009-07-16 シェーリング コーポレイション 異常脂質血症の処置のためのニコチン酸受容体アゴニストとしての複素環
WO2007119178A2 (en) 2006-01-23 2007-10-25 Neuren Pharmaceuticals Limited Infusion pump
CA2627692A1 (en) 2006-01-30 2007-08-02 Irm Llc Spiro imidazole derivatives as ppar modulators
WO2007089557A2 (en) 2006-01-30 2007-08-09 Irm Llc Polycyclic 1, 2, 3, 4 -tetrahydro- isoquinoline derivatives and compositions comprising them as ppar modulators
KR20080086529A (ko) 2006-01-30 2008-09-25 아이알엠 엘엘씨 Ppar 조절제로서의 화합물 및 조성물
US20070191371A1 (en) 2006-02-14 2007-08-16 Kalypsys, Inc. Heterocyclic modulators of ppar
LT1988910T (lt) 2006-02-28 2018-01-10 Kodiak Sciences Inc. Akriloiloksietilfosforilcholiną turintys polimero konjugatai ir jų gavimo būdas
WO2007099388A1 (en) 2006-03-01 2007-09-07 Glade Organics Private Limited An improved process for the manufacture of topiramate
WO2007106862A2 (en) 2006-03-14 2007-09-20 Kinemed, Inc. The use of statins to stimulate neurogenesis
WO2007108009A1 (en) 2006-03-17 2007-09-27 Alembic Limited A process for purification of topiramate
US20110263693A1 (en) 2006-03-31 2011-10-27 Dana-Farber Cancer Institute, Inc. Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors
US20070232648A1 (en) 2006-03-31 2007-10-04 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US9561188B2 (en) * 2006-04-03 2017-02-07 Intellipharmaceutics Corporation Controlled release delivery device comprising an organosol coat
DE102006015734A1 (de) 2006-04-04 2007-10-11 Hermann, Holger Lars, Dr. Kombinationspräparate aus Modafinil, Ritalin und Topiramat und deren Derivaten zur Behandlung von Kokainabhängigkeit und/oder Impulskontrollstörung
CN101420958A (zh) 2006-04-06 2009-04-29 挪瓦卡尔迪阿公司 共投与腺苷a1受体拮抗剂和抗惊厥药
US7659281B2 (en) 2006-04-25 2010-02-09 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors
US8945623B2 (en) 2006-05-03 2015-02-03 Warsaw Orthopedic, Inc. Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use
US8840933B2 (en) 2006-05-03 2014-09-23 Warsaw Orthopedic, Inc. Method of treating neuronal injury by administering magnesium chloride and PEG
US8377994B2 (en) 2006-05-10 2013-02-19 Evonik Degussa GmeH Use of roll compacted pyrogenically produced silicon dioxide in pharmaceutical compositions
EP2026790A2 (en) 2006-05-19 2009-02-25 Janssen Pharmaceutica, N.V. Co-therapy for the treatment of epilepsy and related disorders
WO2007137164A2 (en) 2006-05-19 2007-11-29 Janssen Pharmaceutica N.V. Co-therapy for the treatment of epilepsy and related disorders
JP5230613B2 (ja) 2006-05-23 2013-07-10 テラコス・インコーポレイテッド グルコース輸送体阻害剤およびその使用方法
WO2008010231A2 (en) 2006-05-26 2008-01-24 Alembic Limited A process for the purification of topiramate
AU2007256931B2 (en) 2006-05-30 2013-01-24 Janssen Pharmaceutica N.V. Substituted pyridyl amide compounds as modulators of the histamine H3 receptor
CN101511807A (zh) 2006-06-29 2009-08-19 詹森药业有限公司 组胺h3受体的取代的苯甲酰胺调节剂
CA2656075A1 (en) 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Butyl and butynyl benzyl amine compounds
WO2008002818A1 (en) 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Substituted aminomethyl benzamide compounds
AU2007265242A1 (en) 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Substituted benzyl amine compounds
US7795291B2 (en) 2006-07-07 2010-09-14 Bristol-Myers Squibb Company Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
US20080009534A1 (en) 2006-07-07 2008-01-10 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
US20080014252A1 (en) 2006-07-14 2008-01-17 Delprete Keith Topical compositions with long lasting effect
US9744137B2 (en) 2006-08-31 2017-08-29 Supernus Pharmaceuticals, Inc. Topiramate compositions and methods of enhancing its bioavailability
US20090239942A1 (en) 2006-09-15 2009-09-24 Cloyd James C Topiramate Compositions and Methods of Making and Using the Same
US20080078382A1 (en) 2006-09-20 2008-04-03 Lemahieu Edward Methods and Systems of Delivering Medication Via Inhalation
JP2010508997A (ja) 2006-11-09 2010-03-25 オレキシジェン・セラピューティクス・インコーポレーテッド 減量薬を投与するための方法
EP1973528B1 (en) 2006-11-17 2012-11-07 Supernus Pharmaceuticals, Inc. Sustained-release formulations of topiramate
WO2008070670A2 (en) 2006-12-04 2008-06-12 Supernus Pharmaceuticals, Inc. Enhanced immediate release formulations of topiramate
US20080153874A1 (en) * 2006-12-22 2008-06-26 Allergan Inc. Alpha-2b receptor agonist and anticonvulsant compositions for treating chronic pain
EP2150248A4 (en) 2007-01-16 2011-06-29 Univ Johns Hopkins GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE
US20100197610A1 (en) 2007-01-23 2010-08-05 Baylor College Of Medicine Fructose 1, 6 bisphosphate - a novel anticonvulsant drug
WO2008089521A1 (en) 2007-01-25 2008-07-31 Verva Pharmaceuticals Ltd Insulin sensitisers and methods of treatment
US20100119512A1 (en) 2007-01-25 2010-05-13 Joslin Diabetes Center Methods of diagnosing, treating, and preventing increased vascular permeability
CA2677205A1 (en) 2007-01-31 2008-08-07 University Of Virginia Patent Foundation Topiramate plus naltrexone for the treatment of addictive disorders
AU2007346591A1 (en) 2007-02-07 2008-08-14 Gosforth Centre (Holdings) Pty Ltd Treatment of ADHD
US7813811B2 (en) 2007-02-08 2010-10-12 Neuropace, Inc. Refillable reservoir lead systems
WO2008098195A2 (en) 2007-02-09 2008-08-14 Todd Maibach Film comprising nitroglycerin
US20080221161A1 (en) 2007-02-09 2008-09-11 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
WO2008106659A2 (en) 2007-03-01 2008-09-04 Memory Pharmaceuticals Corporation Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith
WO2008109343A1 (en) 2007-03-01 2008-09-12 Memory Pharmaceuticals Corporation Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith with (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate
WO2008115797A1 (en) 2007-03-16 2008-09-25 Pavo, Inc. Therapeutic compositions and methods
WO2008121882A1 (en) 2007-03-29 2008-10-09 Novacardia, Inc. Improved methods of administration of adenosine a1 receptor antagonists
RU2492175C2 (ru) 2007-04-02 2013-09-10 Теракос, Инк. Бензиловые производные гликозидов и способы их применения
ES2438768T3 (es) 2007-04-11 2014-01-20 Omeros Corporation Composiciones y métodos para la profilaxis y el tratamiento de adicciones
US8198305B2 (en) 2007-04-13 2012-06-12 Concert Pharmaceuticals Inc. 1,2-benzisoxazol-3-yl compounds
US8530463B2 (en) 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
WO2008148064A1 (en) 2007-05-23 2008-12-04 Sunesis Pharmaceuticals, Inc. Weight loss treatment
WO2008148023A2 (en) 2007-05-23 2008-12-04 Medical College Of Georgia Research Institute, Inc. Compositions and methods for treating neurological disorders
US8071557B2 (en) 2007-06-13 2011-12-06 Vivus, Inc. Treatment of pulmonary hypertension with carbonic anhydrase inhibitors
US20090004254A1 (en) 2007-06-19 2009-01-01 Todd Maibach Film comprising active drugs
US20120238554A1 (en) * 2007-07-02 2012-09-20 Cowen Neil M Salts of potassium atp channel openers and uses thereof
AU2008279169A1 (en) 2007-07-23 2009-01-29 Biotie Therapies, Inc 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide for the treatment of post-traumatic stress disorder
US20090030403A1 (en) 2007-07-27 2009-01-29 Leyde Kent W Methods and Systems for Attenuating the Tolerance Response to a Drug
US20090082400A1 (en) 2007-07-31 2009-03-26 Ving Lee Soluble pyrone analogs methods and compositions
KR20100051829A (ko) 2007-07-31 2010-05-18 리머릭 바이오파르마 인코오포레이티드 인산화된 피론 유사체 및 방법
EP2185535A1 (en) 2007-08-08 2010-05-19 Janssen Pharmaceutica N.V. Sulfamide derivative useful for the treatment of epilepsy
US7943653B2 (en) 2007-08-13 2011-05-17 Janssen Pharmaceutica N.V. Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators
WO2009026241A1 (en) 2007-08-23 2009-02-26 Kalypsys, Inc. Heterocyclic modulators of tgr5
BRPI0815708B8 (pt) 2007-08-23 2021-05-25 Theracos Sub Llc composto, éster de pró-droga, composição farmacêutica, e, método para tratar uma doença ou condição
CA2697990A1 (en) 2007-08-27 2009-03-05 University Of Virginia Patent Foundation Medication combinations for the treatment of alcoholism and drug addiction
WO2009035473A2 (en) 2007-09-13 2009-03-19 Sanfilippo Louis C Method of treating binge eating disorder, obesity resulting from binge eating behavior and depressive disorders
HUE043897T2 (hu) 2007-09-25 2019-09-30 Solubest Ltd Lipofil hatóanyagot tartalmazó készítmények és eljárás elõállításukra
US20090087483A1 (en) 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
US8846053B2 (en) 2008-09-26 2014-09-30 Sdg, Inc. Orally bioavailable lipid-based constructs
US9145453B2 (en) 2007-09-28 2015-09-29 Sdg, Inc. Orally bioavailable lipid-based constructs
US20120082659A1 (en) 2007-10-02 2012-04-05 Hartmut Land Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
US20120114670A1 (en) 2007-10-02 2012-05-10 University Of Rochester Methods and compositions related to synergistic responses to oncogenic mutations
WO2009045443A2 (en) 2007-10-02 2009-04-09 The University Of Rochester Methods and compositions related to synergistic responses to oncogenic mutations
WO2009054544A1 (en) 2007-10-26 2009-04-30 Eisai R & D Management Co., Ltd. Ampa receptor antagonists for parkinson's disease and movement disorders
JP2011506318A (ja) * 2007-12-06 2011-03-03 デュレクト コーポレーション 経口医薬製剤
EP2227085A4 (en) 2007-12-06 2013-10-09 Berg Pharma Llc INGREDIBLE COMPOSITIONS WITH INCREASED BIOLOGICAL AVAILABILITY
WO2009079521A1 (en) * 2007-12-17 2009-06-25 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US20100317572A1 (en) 2007-12-20 2010-12-16 Neurosearch A/S Pharmaceutical composition comprising tesofensine or its analogue and an anti-obesity compound
CN102015769B (zh) 2008-01-17 2014-12-10 Irm责任有限公司 改进的抗-trkb抗体
KR20100127799A (ko) 2008-02-28 2010-12-06 유니버시티 오브 버지니아 페이턴트 파운데이션 세로토닌 운반체 유전자 및 알콜중독의 치료
US8138169B2 (en) 2008-04-11 2012-03-20 Comgenrx, Inc. Combination therapy for bipolar disorder
WO2009131692A1 (en) 2008-04-23 2009-10-29 The Board Of Trustees Of The University Of Alabama Substrates for delivery of physiologically active agents
US20090270469A1 (en) 2008-04-25 2009-10-29 Auspex Pharmaceuticals, Inc. Substituted oxazolidinones
AU2009242127B2 (en) 2008-04-29 2014-03-27 Pharnext New therapeutic approaches for treating Alzheimer disease and related disorders through a modulation of cell stress response
PT2282778T (pt) 2008-04-29 2017-04-27 Pharnext Novas abordagens terapêuticas no tratamento da doença de alzheimer e doenças relacionadas através de uma modulação da angiogénese
EA024147B1 (ru) 2008-04-29 2016-08-31 Фарнекст Комбинированные композиции для лечения болезни альцгеймера и родственных заболеваний зонизамидом и акампросатом
US20090304789A1 (en) 2008-06-09 2009-12-10 Thomas Najarian Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders
US8580298B2 (en) 2008-06-09 2013-11-12 Vivus, Inc. Low dose topiramate/phentermine composition and methods of use thereof
US8592424B2 (en) 2008-06-30 2013-11-26 Afgin Pharma Llc Topical regional neuro-affective therapy
US20110212944A1 (en) 2008-07-01 2011-09-01 Julie Liu 2-oxo-1-pyrrolidine derivatives
AU2009270849B2 (en) 2008-07-17 2013-11-21 Micell Technologies, Inc. Drug delivery medical device
US9623000B2 (en) 2008-07-31 2017-04-18 Dekel Pharmaceuticals Ltd Compositions and methods for treating inflammatory disorders
US20110207718A1 (en) 2008-08-06 2011-08-25 Gosforth Centre (Holdings) Pty Ltd. Compositions and methods for treating psychiatric disorders
US20100074973A1 (en) 2008-08-27 2010-03-25 Auspex Pharmaceuticals, Inc. Thioxanthene modulators of dopamine d2 receptors
US20100056546A1 (en) 2008-09-04 2010-03-04 Auspex Pharmaceuticals, Inc. Sulfonylurea inhibitors of atp-sensitive potassium channels
US20100190752A1 (en) 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
MX2011002339A (es) 2008-09-05 2011-04-04 Gruenenthal Gmbh Combinacion farmaceutica de 3-(3-dimetilamino-1-etil-2-metil-propi l)-fenol y un antiepileptico.
US20100105755A1 (en) 2008-09-12 2010-04-29 Auspex Pharmaceuticals, Inc. Substituted benzamide modulators of dopamine receptor
US20100119622A1 (en) 2008-09-15 2010-05-13 Auspex Pharmaceuticals, Inc. 3h-benzooxazol-2-one modulators of d2 receptor and/or 5-ht1a receptor
US8436015B2 (en) 2008-09-15 2013-05-07 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US20100119624A1 (en) 2008-09-17 2010-05-13 Auspex Pharmaceuticals, Inc. Benzisoxazole modulators of d2 receptor and/or 5-ht2a receptor
US20110244057A1 (en) 2008-09-25 2011-10-06 Ehrenberg Bruce L Combination therapies with topiramate for seizures, restless legs syndrome, and other neurological conditions
US20100159033A1 (en) 2008-09-29 2010-06-24 Auspex Pharmaceuticals, Inc. Benzisoxazole modulators of d2 receptor, and/or 5-ht2a receptor
US20100266711A1 (en) 2008-09-29 2010-10-21 Auspex Pharmaceuticals, Inc. Thienobenzodiazepine modulators of d1 receptor, d2 receptor, and/or 5-ht2 receptor
CN102186461A (zh) 2008-10-14 2011-09-14 麦克内尔股份公司 多部分口腔内剂型及其用途
WO2010045416A2 (en) 2008-10-16 2010-04-22 Metabolous Pharmaceuticals, Inc. Combination therapies for the treatment of obesity
US20100167988A1 (en) 2008-10-22 2010-07-01 Auspex Pharmaceuticals, Inc. Ethoxyphenylmethyl inhibitors of sglt2
US20100166887A1 (en) 2008-10-22 2010-07-01 Auspex Pharmaceuticals, Inc. DIBENZO[b,e][1,4]DIAZEPINE MODULATORS OF DOPAMINE RECEPTORS, SEROTONIN RECEPTORS, ADRENERGIC RECEPTORS, ACETYLCHOLINE RECEPTORS, AND/OR HISTAMINE RECEPTORS
US20100167989A1 (en) 2008-10-23 2010-07-01 Auspex Pharmaceuticals, Inc. Isopropoxyphenylmethyl inhibitors of sglt2
US20100113432A1 (en) 2008-11-05 2010-05-06 Auspex Pharmaceuticals, Inc. Phenothiazine modulators of d2 receptors and 5-ht2 receptors
US20100120861A1 (en) 2008-11-13 2010-05-13 Auspex Pharmaceuticals, Inc. Benzoic acid inhibitors of atp-sensitive potassium channels
US20100125085A1 (en) 2008-11-17 2010-05-20 Auspex Pharmaceuticals, Inc. Pyridoindole modulators of nmda receptor and acetylcholinesterase
US20100124541A1 (en) 2008-11-19 2010-05-20 Auspex Pharmaceuticals, Inc. Hydroxyadamantyl inhibitors of dipeptidylpeptidase iv
US20100130615A1 (en) 2008-11-21 2010-05-27 Auspex Pharmaceuticals, Inc. Sulfonylurea inhibitors of atp-sensitive potassium channels
US20100129311A1 (en) 2008-11-21 2010-05-27 Auspex Pharmaceuticals, Inc. Phenylalanine amide inhibitors of atp-sensitive potassium channels
US20100130528A1 (en) 2008-11-21 2010-05-27 Auspex Pharmaceuticals, Inc. Adamantane modulators of nmda receptor and/or 5ht3 receptor
US20100130582A1 (en) 2008-11-24 2010-05-27 Auspex Pharmaceuticals, Inc. Indolinone modulators of dopamine receptor
US20100143507A1 (en) 2008-12-09 2010-06-10 Auspex Pharmaceuticals, Inc. Carboxylic acid inhibitors of histone deacetylase, gaba transaminase and sodium channel
WO2010075086A2 (en) 2008-12-15 2010-07-01 Auspex Pharmaceuticals, Inc. Pyrrolidinone inhibitors of pde-4
WO2010071750A1 (en) 2008-12-19 2010-06-24 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds
US20120035105A1 (en) 2009-01-09 2012-02-09 Sdg, Inc. Insulin Therapies for the Treatment of Diabetes, Diabetes Related Ailments, and/or Diseases or Conditions Other Than Diabetes or Diabetes Related Ailments
US20110281795A1 (en) 2009-01-28 2011-11-17 Songnian Lin Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US8324384B2 (en) 2009-02-12 2012-12-04 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
WO2010098948A1 (en) 2009-02-13 2010-09-02 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containin such compounds and methods of use
WO2010098994A1 (en) 2009-02-25 2010-09-02 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2010098888A1 (en) 2009-02-27 2010-09-02 Massachusetts Institute Of Technology Uses of chemicals to modulate gsk-3 signaling for treatment of bipolar disorder and other brain disorders
US20100286762A1 (en) 2009-03-18 2010-11-11 Musc Foundation For Research Development Compositions and Methods for Ameliorating Clinical Electrical Disturbances
EP2414542B1 (en) 2009-03-30 2017-08-30 Tel HaShomer Medical Research Infrastructure and Services Ltd. Methods of predicting clinical course and treating multiple sclerosis
US8778998B2 (en) 2009-04-10 2014-07-15 Auspex Pharmaceuticals, Inc. Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor
MX2011012140A (es) 2009-05-14 2012-02-28 Gilead Sciences Inc Ranolazina para el tratamiento de problemas del snc.
US20100317730A1 (en) 2009-06-12 2010-12-16 Shaya Elias K Treatment for menopausal and perimenopausal vasomotor symptons
WO2010147830A2 (en) 2009-06-15 2010-12-23 Auspex Pharmaceuticals, Inc. Aminothiazole modulators of beta-3-adrenoreceptor
WO2011008298A2 (en) 2009-07-16 2011-01-20 Nectid, Inc. Novel axomadol dosage forms
US20110014296A1 (en) 2009-07-17 2011-01-20 National Chiao Tung University Drug Delivery Nanodevice, its Preparation Method and Uses Thereof
US20110015663A1 (en) 2009-07-17 2011-01-20 Aronne Louis J Combination Therapies for the Treatment of Obesity
US20110257260A1 (en) 2009-07-21 2011-10-20 Auspex Pharmaceuticals, Inc. 3,4-methylenedioxyphenyl inhibitors of gaba aminotransferase and/or gaba reuptake transporter inhibitor
WO2011023392A1 (en) 2009-08-28 2011-03-03 Grünenthal GmbH Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an antiepileptic
EP2477610A1 (en) * 2009-09-17 2012-07-25 Upsher-Smith Laboratories, Inc. A sustained-release product comprising a combination of a non-opioid amine and a non-steroidal anti -inflammatory drug
NO2480669T3 (pt) 2009-09-25 2018-04-07
US20110082407A1 (en) 2009-10-01 2011-04-07 Aronne Louis J Combination Therapies for the Treatment of Obesity
ES2895226T3 (es) 2009-10-16 2022-02-18 Mereo Biopharma 5 Inc Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensivos
WO2011050008A2 (en) 2009-10-19 2011-04-28 Amylin Pharmaceuticals, Inc. Combination therapy comprising administration of an amylinomimetic and a pyy peptidomimetic for effecting weight loss and for treating obesity and related metabolic conditions and disorders
EP2322163A1 (en) 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
WO2011060363A2 (en) 2009-11-16 2011-05-19 Auspex Pharmaceuticals, Inc. Cyclohexyl urea modulators of d2 receptors and/or d3 receptors
US20130109674A1 (en) 2009-12-18 2013-05-02 Achelios Therapeutics Llc Methods and compositions for treating and preventing trigeminal autonomic cephalgias, migraine, and vascular conditions
US20110206780A1 (en) 2010-01-06 2011-08-25 Auspex Pharmaceuticals, Inc. Morphinan modulators of nmda receptors, sigma1 receptors, sigma2 receptors, and/or a3b4 nicotinic receptors
BR112012016799A2 (pt) 2010-01-07 2019-10-08 Vivus Inc tratamento da síndrome de apneia obstrutiva do sono com uma combinação de um inibidor da anidrase carbônica e um agente ativo adicional
WO2011085181A1 (en) 2010-01-08 2011-07-14 Eurand, Inc. Taste masked topiramate composition and an orally disintegrating tablet comprising the same
US8461171B2 (en) 2010-02-09 2013-06-11 QRxPharma Ltd. Hybrid opioid compounds and compositions
US20110200671A1 (en) * 2010-02-17 2011-08-18 Sun Pharma Advanced Research Company Ltd. Method of treating a disease condition susceptible to baclofen therapy
US20110206782A1 (en) 2010-02-24 2011-08-25 Auspex Pharmaceuticals, Inc. Piperidine modulators of dopamine receptor
WO2011107855A2 (en) 2010-03-04 2011-09-09 Torrent Pharmaceuticals Limited Sustained release oral liquid suspension dosage form
GB201003734D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Delayed prolonged drug delivery
GB201003731D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Immediate/delayed drug delivery
GB201003766D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Pulsatile drug release
DK2547679T3 (en) 2010-03-19 2016-01-11 Pfizer 2,3 dihydro-1H-inden-1-yl-2,7-diazaspiro [3.6] nonane derivatives and their use as antagonists or inverse agonists of ghrelin receptor
WO2011120044A1 (en) 2010-03-26 2011-09-29 Duke University Conjugated neuroactive steroid compositions and methods of use
WO2011126910A2 (en) 2010-03-30 2011-10-13 Algynomics Inc. Compositions and methods for the treatment of somatosensory disorders
US9695264B2 (en) 2010-04-01 2017-07-04 Ppg Industries Ohio, Inc. High functionality polyesters and coatings comprising the same
KR101927068B1 (ko) 2010-05-05 2018-12-10 베링거 인겔하임 인터내셔날 게엠베하 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
WO2011143721A1 (en) 2010-05-21 2011-11-24 Gosforth Centre (Holdings) Pty Ltd Compositions and methods for treating neurodegenerative disorders
CN103096895B (zh) 2010-06-24 2016-06-01 塔夫茨大学信托人 烟酸模拟物及其使用的方法
JP5925770B2 (ja) 2010-06-24 2016-05-25 トラスティーズ オブ タフツ カレッジ ナイアシン模倣体、およびその使用方法
US20120003312A1 (en) 2010-06-30 2012-01-05 Aptapharma, Inc. Multilayer Minitablets with Different Release Rates
EP2422787A1 (en) 2010-08-17 2012-02-29 Neurotec Pharma, S.L. Diazoxide for use in the treatment of amyotrophic lateral sclerosis (als)
WO2012033874A1 (en) 2010-09-10 2012-03-15 Chipkin Richard E Method of treating compulsive self-injurious behaviors
WO2012056372A1 (en) 2010-10-29 2012-05-03 Pfizer Inc. N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS
EP2640395A4 (en) 2010-11-08 2014-01-22 Omeros Corp TREATMENT OF DISEASES ASSOCIATED WITH SEARCH AND PULSE CONTROL BY PDE7 INHIBITORS
WO2012074561A2 (en) 2010-11-30 2012-06-07 Columbia Northwest Pharmaceuticals Llc Methods and compositions for the treatment of anxiety disorders, including post traumatic stress disorder (ptsd) and related central nervous system (cns) disorders
EP2479691A1 (en) 2011-01-21 2012-07-25 Johan Cederlund Pharmaceutical product and communication tool
EP2667875A4 (en) 2011-01-24 2014-07-30 Inceptum Res & Therapeutics Inc COMPOSITIONS COMPRISING PROSTAGLANDIN FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES
US20140050728A1 (en) 2011-01-28 2014-02-20 Board Of Regents Of The University Of Nebraska Methods and compositions for inhibiting cyclophilin d for the treatment and prevention of obesity and kidney indications
US20120128683A1 (en) 2011-11-22 2012-05-24 Shantha Totada R Autism treatment
US8652527B1 (en) * 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) * 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

Also Published As

Publication number Publication date
IL250373A0 (en) 2017-03-30
US20200054570A1 (en) 2020-02-20
US20160038426A1 (en) 2016-02-11
IL241053A0 (en) 2015-12-01
KR20160124930A (ko) 2016-10-28
US8889190B2 (en) 2014-11-18
KR101674509B1 (ko) 2016-11-09
EP2968177A4 (en) 2016-08-24
US10363224B2 (en) 2019-07-30
US20180055778A1 (en) 2018-03-01
US20140287037A1 (en) 2014-09-25
KR20200010608A (ko) 2020-01-30
KR20150132838A (ko) 2015-11-26
US8652527B1 (en) 2014-02-18
WO2014143380A1 (en) 2014-09-18
KR102072618B1 (ko) 2020-02-03
CA2905011C (en) 2019-08-27
EP2968177A1 (en) 2016-01-20
IL241053A (en) 2017-02-28
CA2905011A1 (en) 2014-09-18

Similar Documents

Publication Publication Date Title
BR112015022434A2 (pt) cápsulas de topiramato de liberação estendida
EP3642711A4 (en) GENERATION OF SCRIPTS THAT FACILITATE THE EXECUTION OF TASKS IN DIFFERENT EXECUTION ENVIRONMENTS THAT USE DIFFERENT LANGUAGES AND AND DIFFERENT SYNTAXES
BR112018011496A2 (pt) sistema para distribuição de nicotina em pó
PH12018500018A1 (en) Aerosol-generating article having dispersed flavourant
BR112018016369A2 (pt) composições e métodos para uso na descontaminação de superfície
BR112015025235A2 (pt) confinamento de plasma por campo magnético para reator de potência de fusão compacto
BR112016002646A2 (pt) dispositivos e métodos de entrega de fármaco de múltiplas unidades
CR20150515A (es) Derivados de bencimidazolona como inhibidores del bromodominio
BR112015003416A2 (pt) sistema para fornecer acesso temporário a internet a partir de um ambiente de rede de área local restrita
BR112017012363A2 (pt) microcápsulas revestidas
BR112018074352A2 (pt) partículas de nanoalume contendo um agente de dimensionamento
BR112017010239A2 (pt) composições para liberação de agente de benefício
BR112019007459A2 (pt) pós secos antifúngicos
BR112018000935A2 (pt) ?sistema microfluídico, recipiente, e, método?
PH12018501199A1 (en) Nicotine particle capsule
TR201911096T4 (tr) Yumuşak kapsüller için kabuk oluşturma kompozisyonları ve yumuşak kapsüller.
BR112018002036A2 (pt) método para o controle das pragas de um vegetal de algodão e utilização de um ou mais componentes da árvore de ginkgo
BR112018000739A2 (pt) composições farmacêuticas contendo celecoxib e tramadol
CL2019000780A1 (es) Partícula que contiene al menos una sustancia volátil y proceso para su preparación.
ES2812175T8 (es) Polvo compuesto que contiene sal de calcio con partículas microestructuradas
BR112020005849A8 (pt) Partículas sólidas de simeticona e forma de dosagem das mesmas
BR102014016617A8 (pt) montagem de recipiente de medicamentos protegido contra o acesso por crianças, método para montar o mesmo e método para dispensar a um usuário medicamentos contidos em um recipiente de medicamentos protegido contra o acesso por crianças
BR112018072469A2 (pt) sistemas de conexão de elemento tubular e método para conectar elementos tubulares
BR112018069901A2 (pt) aduto de ciclodextrina-panobinostat
BR112018011134A2 (pt) painel de gesso e método para produzir um painel de gesso

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: UPSHER-SMITH LABORATORIES, LLC (US)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2547 DE 29-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.