DE602006013501D1 - Cyclopropylamine als modulatoren des histamin-h3-rezeptors - Google Patents
Cyclopropylamine als modulatoren des histamin-h3-rezeptorsInfo
- Publication number
- DE602006013501D1 DE602006013501D1 DE602006013501T DE602006013501T DE602006013501D1 DE 602006013501 D1 DE602006013501 D1 DE 602006013501D1 DE 602006013501 T DE602006013501 T DE 602006013501T DE 602006013501 T DE602006013501 T DE 602006013501T DE 602006013501 D1 DE602006013501 D1 DE 602006013501D1
- Authority
- DE
- Germany
- Prior art keywords
- cyclopropylamines
- histamine
- receptor modulators
- modulators
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102000004384 Histamine H3 receptors Human genes 0.000 title 1
- 108090000981 Histamine H3 receptors Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71765905P | 2005-09-16 | 2005-09-16 | |
PCT/US2006/035877 WO2007035425A2 (en) | 2005-09-16 | 2006-09-14 | Cyclopropyl amines as modulators of the histamine h3 receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006013501D1 true DE602006013501D1 (de) | 2010-05-20 |
Family
ID=37889336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006013501T Active DE602006013501D1 (de) | 2005-09-16 | 2006-09-14 | Cyclopropylamine als modulatoren des histamin-h3-rezeptors |
Country Status (33)
Country | Link |
---|---|
US (3) | US7687499B2 (de) |
EP (1) | EP1948607B1 (de) |
JP (1) | JP5185120B2 (de) |
KR (1) | KR101336106B1 (de) |
CN (1) | CN101321730B (de) |
AR (1) | AR058670A1 (de) |
AT (1) | ATE463481T1 (de) |
AU (1) | AU2006292598B2 (de) |
BR (1) | BRPI0622428A2 (de) |
CA (1) | CA2622760C (de) |
CR (1) | CR9891A (de) |
CY (1) | CY1110167T1 (de) |
DE (1) | DE602006013501D1 (de) |
DK (1) | DK1948607T3 (de) |
EA (1) | EA014370B1 (de) |
EC (1) | ECSP088279A (de) |
ES (1) | ES2342323T3 (de) |
HK (1) | HK1123291A1 (de) |
HR (1) | HRP20100263T1 (de) |
IL (1) | IL190110A (de) |
ME (1) | ME01181B (de) |
MX (1) | MX2008003691A (de) |
MY (1) | MY145305A (de) |
NO (1) | NO340949B1 (de) |
NZ (1) | NZ566533A (de) |
PL (1) | PL1948607T3 (de) |
PT (1) | PT1948607E (de) |
RS (1) | RS51311B (de) |
SI (1) | SI1948607T1 (de) |
TW (1) | TWI418552B (de) |
UA (1) | UA96424C2 (de) |
WO (1) | WO2007035425A2 (de) |
ZA (1) | ZA200803337B (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7423147B2 (en) * | 2004-03-31 | 2008-09-09 | Janssen Pharmaceutical, N.V. | Pyridine compounds as histamine H3 modulators |
EA014370B1 (ru) * | 2005-09-16 | 2010-10-29 | Янссен Фармацевтика Н.В. | Циклопропиламины в качестве модуляторов рецептора гистамина н |
US7795426B2 (en) * | 2005-10-31 | 2010-09-14 | Janssen Pharmaceutica Nv | Processes for the preparation of cyclopropyl-amide derivatives |
BRPI0618076A2 (pt) * | 2005-10-31 | 2011-08-16 | Janssen Pharmaceutica Nv | processos para a preparação de derivados de ciclopropil-amida |
CA2653940C (en) * | 2006-05-30 | 2015-07-14 | Janssen Pharmaceutica N.V. | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor |
US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
CN103382174A (zh) * | 2006-06-23 | 2013-11-06 | 雅培制药有限公司 | 作为组胺h3受体调节物的环丙胺衍生物 |
AU2007265238A1 (en) * | 2006-06-29 | 2008-01-03 | Janssen Pharmaceutica N.V. | Substituted benzamide modulators of the histamine H3 receptor |
TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
CA2880932A1 (en) * | 2006-12-14 | 2008-06-26 | Janssen Pharmaceutica N.V. | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives |
PT2195293E (pt) | 2007-08-22 | 2014-01-21 | Astrazeneca Ab | Derivados da ciclopropilamida |
CA2706328C (en) | 2007-11-20 | 2016-04-19 | Janssen Pharmaceutica N.V. | Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor |
TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
AU2011218490B9 (en) * | 2010-02-18 | 2014-12-18 | Astrazeneca Ab | Solid forms comprising a cyclopropyl amide derivative |
RU2012136148A (ru) | 2010-02-18 | 2014-03-27 | Астразенека Аб | Новая кристаллическая форма производного циклопропилбензамида |
PT2569013T (pt) | 2010-05-14 | 2017-02-08 | Univ Leland Stanford Junior | Anticorpos monoclonais humanizados e quiméricos para cd47 |
WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
US20130339859A1 (en) | 2012-06-15 | 2013-12-19 | Muzik LLC | Interactive networked headphones |
US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
CN107210950A (zh) | 2014-10-10 | 2017-09-26 | 沐择歌有限责任公司 | 用于共享用户交互的设备 |
EP4251148A1 (de) | 2020-11-27 | 2023-10-04 | Richter Gedeon Nyrt. | Histamin-h3-rezeptorantagonisten/inversagonisten zur behandlung von autismusspektrumsstörungen |
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IL117149A0 (en) | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
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JPH1059954A (ja) | 1996-08-14 | 1998-03-03 | Takeda Chem Ind Ltd | 環状アミン誘導体およびそれを含んでなる医薬 |
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