DE602006013501D1 - Cyclopropylamine als modulatoren des histamin-h3-rezeptors - Google Patents

Cyclopropylamine als modulatoren des histamin-h3-rezeptors

Info

Publication number
DE602006013501D1
DE602006013501D1 DE602006013501T DE602006013501T DE602006013501D1 DE 602006013501 D1 DE602006013501 D1 DE 602006013501D1 DE 602006013501 T DE602006013501 T DE 602006013501T DE 602006013501 T DE602006013501 T DE 602006013501T DE 602006013501 D1 DE602006013501 D1 DE 602006013501D1
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DE
Germany
Prior art keywords
cyclopropylamines
histamine
receptor modulators
modulators
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006013501T
Other languages
English (en)
Inventor
Brett D Allison
Nicholas I Carruthers
Cheryl A Grice
Michael A Letavic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602006013501D1 publication Critical patent/DE602006013501D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Psychology (AREA)
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  • Child & Adolescent Psychology (AREA)
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  • Reproductive Health (AREA)
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  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
DE602006013501T 2005-09-16 2006-09-14 Cyclopropylamine als modulatoren des histamin-h3-rezeptors Active DE602006013501D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71765905P 2005-09-16 2005-09-16
PCT/US2006/035877 WO2007035425A2 (en) 2005-09-16 2006-09-14 Cyclopropyl amines as modulators of the histamine h3 receptor

Publications (1)

Publication Number Publication Date
DE602006013501D1 true DE602006013501D1 (de) 2010-05-20

Family

ID=37889336

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006013501T Active DE602006013501D1 (de) 2005-09-16 2006-09-14 Cyclopropylamine als modulatoren des histamin-h3-rezeptors

Country Status (33)

Country Link
US (3) US7687499B2 (de)
EP (1) EP1948607B1 (de)
JP (1) JP5185120B2 (de)
KR (1) KR101336106B1 (de)
CN (1) CN101321730B (de)
AR (1) AR058670A1 (de)
AT (1) ATE463481T1 (de)
AU (1) AU2006292598B2 (de)
BR (1) BRPI0622428A2 (de)
CA (1) CA2622760C (de)
CR (1) CR9891A (de)
CY (1) CY1110167T1 (de)
DE (1) DE602006013501D1 (de)
DK (1) DK1948607T3 (de)
EA (1) EA014370B1 (de)
EC (1) ECSP088279A (de)
ES (1) ES2342323T3 (de)
HK (1) HK1123291A1 (de)
HR (1) HRP20100263T1 (de)
IL (1) IL190110A (de)
ME (1) ME01181B (de)
MX (1) MX2008003691A (de)
MY (1) MY145305A (de)
NO (1) NO340949B1 (de)
NZ (1) NZ566533A (de)
PL (1) PL1948607T3 (de)
PT (1) PT1948607E (de)
RS (1) RS51311B (de)
SI (1) SI1948607T1 (de)
TW (1) TWI418552B (de)
UA (1) UA96424C2 (de)
WO (1) WO2007035425A2 (de)
ZA (1) ZA200803337B (de)

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CA2706328C (en) 2007-11-20 2016-04-19 Janssen Pharmaceutica N.V. Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor
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US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
AU2011218490B9 (en) * 2010-02-18 2014-12-18 Astrazeneca Ab Solid forms comprising a cyclopropyl amide derivative
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PT2569013T (pt) 2010-05-14 2017-02-08 Univ Leland Stanford Junior Anticorpos monoclonais humanizados e quiméricos para cd47
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
US20130339859A1 (en) 2012-06-15 2013-12-19 Muzik LLC Interactive networked headphones
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
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EP4251148A1 (de) 2020-11-27 2023-10-04 Richter Gedeon Nyrt. Histamin-h3-rezeptorantagonisten/inversagonisten zur behandlung von autismusspektrumsstörungen

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