RS51311B - Ciklopropil amini kao modulatori histaminskog h3 receptora - Google Patents

Ciklopropil amini kao modulatori histaminskog h3 receptora

Info

Publication number
RS51311B
RS51311B RSP-2010/0263A RSP20100263A RS51311B RS 51311 B RS51311 B RS 51311B RS P20100263 A RSP20100263 A RS P20100263A RS 51311 B RS51311 B RS 51311B
Authority
RS
Serbia
Prior art keywords
cyclopropyl
histamine
modulators
receptor
methanone
Prior art date
Application number
RSP-2010/0263A
Other languages
English (en)
Inventor
Brett D. Allison
Nicholas I. Carruthers
Cheryl A. Grice
Michael A. Letavic
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of RS51311B publication Critical patent/RS51311B/sr

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Jedinjenje koje je izabrano iz grupe koju čine: (4-ciklopropil-piperazin-1-il)-(4-morfolin-4-ilmetil-fenil)-metanon, (4-ciklopropil-piperazin-1-il)-[4-(4-fluoro-piperidin-1-ilmetil)-fenil]-metanon, (4-ciklopropil-piperazin-1-il)-(4-tiomorfolin-4-ilmetil-fenil)metanon i (4-ciklopropil-piperazin-1-il)-[4-(2-hidroksimetil-morfolin-4-ilmetil)-fenil]-metanon i njihovi enantiomeri, hidrati, solvati i farmaceutski prihvatljive soli.Prijava sadrži još 27 zavisnih patentnih zahteva.
RSP-2010/0263A 2005-09-16 2006-09-14 Ciklopropil amini kao modulatori histaminskog h3 receptora RS51311B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71765905P 2005-09-16 2005-09-16
PCT/US2006/035877 WO2007035425A2 (en) 2005-09-16 2006-09-14 Cyclopropyl amines as modulators of the histamine h3 receptor

Publications (1)

Publication Number Publication Date
RS51311B true RS51311B (sr) 2010-12-31

Family

ID=37889336

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2010/0263A RS51311B (sr) 2005-09-16 2006-09-14 Ciklopropil amini kao modulatori histaminskog h3 receptora

Country Status (33)

Country Link
US (3) US7687499B2 (sr)
EP (1) EP1948607B1 (sr)
JP (1) JP5185120B2 (sr)
KR (1) KR101336106B1 (sr)
CN (1) CN101321730B (sr)
AR (1) AR058670A1 (sr)
AT (1) ATE463481T1 (sr)
AU (1) AU2006292598B2 (sr)
BR (1) BRPI0622428A2 (sr)
CA (1) CA2622760C (sr)
CR (1) CR9891A (sr)
CY (1) CY1110167T1 (sr)
DE (1) DE602006013501D1 (sr)
DK (1) DK1948607T3 (sr)
EA (1) EA014370B1 (sr)
EC (1) ECSP088279A (sr)
ES (1) ES2342323T3 (sr)
HK (1) HK1123291A1 (sr)
HR (1) HRP20100263T1 (sr)
IL (1) IL190110A (sr)
ME (1) ME01181B (sr)
MX (1) MX2008003691A (sr)
MY (1) MY145305A (sr)
NO (1) NO340949B1 (sr)
NZ (1) NZ566533A (sr)
PL (1) PL1948607T3 (sr)
PT (1) PT1948607E (sr)
RS (1) RS51311B (sr)
SI (1) SI1948607T1 (sr)
TW (1) TWI418552B (sr)
UA (1) UA96424C2 (sr)
WO (1) WO2007035425A2 (sr)
ZA (1) ZA200803337B (sr)

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JP2009508864A (ja) 2009-03-05
UA96424C2 (ru) 2011-11-10
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CN101321730A (zh) 2008-12-10
AU2006292598A1 (en) 2007-03-29
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AR058670A1 (es) 2008-02-20
CA2622760C (en) 2012-12-04
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