BR112015001592B1 - Método para analisar uma amostra - Google Patents

Método para analisar uma amostra Download PDF

Info

Publication number
BR112015001592B1
BR112015001592B1 BR112015001592-1A BR112015001592A BR112015001592B1 BR 112015001592 B1 BR112015001592 B1 BR 112015001592B1 BR 112015001592 A BR112015001592 A BR 112015001592A BR 112015001592 B1 BR112015001592 B1 BR 112015001592B1
Authority
BR
Brazil
Prior art keywords
sample
cells
light
cuvette
cell
Prior art date
Application number
BR112015001592-1A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112015001592A2 (pt
BR112015001592A8 (pt
Inventor
Chinmay Pangarkar
Karan Mohan
James R. Wasson
Original Assignee
Labrador Diagnostics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labrador Diagnostics Llc filed Critical Labrador Diagnostics Llc
Publication of BR112015001592A2 publication Critical patent/BR112015001592A2/pt
Publication of BR112015001592A8 publication Critical patent/BR112015001592A8/pt
Publication of BR112015001592B1 publication Critical patent/BR112015001592B1/pt

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/088—Condensers for both incident illumination and transillumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/12—Condensers affording bright-field illumination
    • G02B21/125—Condensers affording bright-field illumination affording both dark- and bright-field illumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/244—Devices for focusing using image analysis techniques
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/02—Mountings, adjusting means, or light-tight connections, for optical elements for lenses
    • G02B7/04—Mountings, adjusting means, or light-tight connections, for optical elements for lenses with mechanism for focusing or varying magnification
    • G02B7/09—Mountings, adjusting means, or light-tight connections, for optical elements for lenses with mechanism for focusing or varying magnification adapted for automatic focusing or varying magnification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G01N2015/1014—Constitution of reference particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1738—Optionally different kinds of measurements; Method being valid for different kinds of measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70589—CD45
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Multimedia (AREA)
  • Dispersion Chemistry (AREA)
  • Ecology (AREA)
  • Clinical Laboratory Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BR112015001592-1A 2012-07-25 2013-07-25 Método para analisar uma amostra BR112015001592B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261675811P 2012-07-25 2012-07-25
US61/675,811 2012-07-25
US201261676178P 2012-07-26 2012-07-26
US61/676,178 2012-07-26
US201361766116P 2013-02-18 2013-02-18
US61/766,116 2013-02-18
US201361802194P 2013-03-15 2013-03-15
US61/802,194 2013-03-15
PCT/US2013/052141 WO2014018805A2 (en) 2012-07-25 2013-07-25 Image analysis and measurement of biological samples

Publications (3)

Publication Number Publication Date
BR112015001592A2 BR112015001592A2 (pt) 2017-07-04
BR112015001592A8 BR112015001592A8 (pt) 2021-02-17
BR112015001592B1 true BR112015001592B1 (pt) 2022-07-26

Family

ID=48951590

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015001592-1A BR112015001592B1 (pt) 2012-07-25 2013-07-25 Método para analisar uma amostra

Country Status (14)

Country Link
US (8) US9494521B2 (https=)
EP (2) EP2877834B1 (https=)
JP (5) JP6273276B2 (https=)
KR (1) KR102090776B1 (https=)
CN (2) CN104769415B (https=)
AU (2) AU2013295679A1 (https=)
BR (1) BR112015001592B1 (https=)
CA (2) CA3198619A1 (https=)
ES (1) ES2700498T3 (https=)
IL (1) IL236819A0 (https=)
MX (2) MX365089B (https=)
SG (1) SG11201500347SA (https=)
TW (2) TW201831881A (https=)
WO (1) WO2014018805A2 (https=)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
GB201210403D0 (en) * 2012-06-13 2012-07-25 Ffei Ltd Mircoscope colour chart
US9513224B2 (en) 2013-02-18 2016-12-06 Theranos, Inc. Image analysis and measurement of biological samples
AU2013295679A1 (en) 2012-07-25 2015-01-29 Theranos, Inc. Image analysis and measurement of biological samples
AU2014217946A1 (en) * 2013-02-18 2015-08-20 Theranos Ip Company, Llc Image analysis and measurement of biological samples
US9562860B1 (en) 2013-06-19 2017-02-07 Theranos, Inc. Methods and devices for sample analysis
DE102013216124A1 (de) * 2013-08-14 2015-02-19 Carl Zeiss Microscopy Gmbh Hochauflösende 3D-Fluoreszenzmikroskopie
KR20160049001A (ko) 2013-09-06 2016-05-04 테라노스, 인코포레이티드 면봉(swab) 수납용 기기, 시스템, 방법 및 키트
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
US9784670B1 (en) 2014-01-22 2017-10-10 Theranos, Inc. Unified detection system for fluorometry, luminometry and spectrometry
EP3058372B1 (en) 2014-02-06 2023-07-05 Scanogen Inc. Detection units and methods for detecting a target analyte
EP2986891A4 (en) * 2014-04-04 2017-06-14 Bio-rad Laboratories, Inc. Annular illumination structure
US10661268B2 (en) * 2014-06-30 2020-05-26 Beacon Technologies, LLC Pipette tip system, device and method of use
US9574989B2 (en) * 2014-08-08 2017-02-21 Omnivision Technologies, Inc. Lens-free imaging system and method for detecting particles in sample deposited on image sensor
GB201506992D0 (en) * 2014-11-14 2015-06-10 Nplex Pty Ltd A portable in-vitro diagnostic detector
EP3232778A4 (en) 2014-11-24 2018-10-10 Massachusetts Institute of Technology Systems, apparatus, and methods for analyzing blood cell dynamics
TWI566742B (zh) * 2015-02-26 2017-01-21 華邦電子股份有限公司 分析處理裝置
WO2016191004A1 (en) * 2015-05-26 2016-12-01 Becton, Dickinson And Company Methods and systems for high resolution fluorescence microscopy of polymeric dye-labeled samples using polarized light
AU2016321445A1 (en) * 2015-09-13 2018-03-15 Australian Sensing And Identification Systems Pty. Ltd. An analysis instrument, associated systems and methods
WO2017074815A1 (en) 2015-10-26 2017-05-04 Idexx Laboratories, Inc. Hematology test slide
CN105284240B (zh) * 2015-10-30 2017-10-03 山东省农作物种质资源中心 种子籽粒颜色分辨台及分辨方法
EP3390963B1 (en) * 2015-12-18 2021-02-17 Abbott Laboratories Method for determining the identity of histological stains
WO2017117553A1 (en) * 2015-12-31 2017-07-06 Mec Dynamics Micro mechanical methods and systems for performing assays
TWI568464B (zh) * 2016-02-05 2017-02-01 Guo-Zhi Liao Drug release and detection device, method of operation of drug release and detection device, and method for detecting fluorescent substance
WO2017145422A1 (ja) * 2016-02-23 2017-08-31 株式会社島津製作所 顕微分析装置
US10948703B2 (en) * 2016-03-01 2021-03-16 Molecular Devices, Llc Imaging system and method with scattering to reduce source auto-fluorescence and improve uniformity
EP3428263B1 (en) * 2016-03-11 2023-04-19 Nikon Corporation Evaluation device, observation device, and program
US20210217172A1 (en) * 2016-03-15 2021-07-15 Sony Corporation Information processing device, information processing method, program, and information processing system
US10768406B2 (en) * 2016-06-20 2020-09-08 Scanogen Inc. Imaging system
WO2017220249A1 (en) * 2016-06-20 2017-12-28 Plair Sa Device and method for detecting and/or characterizing fluid-borne particles
US20190323939A1 (en) * 2016-06-22 2019-10-24 Kyocera Corporation Fine particle counter
WO2018009384A1 (en) * 2016-07-06 2018-01-11 Advanced Instruments, Llc Cuvette and rotor system for blood plasma separation
US10768105B1 (en) 2016-07-29 2020-09-08 Labrador Diagnostics Llc Image analysis and measurement of biological samples
TWI595372B (zh) 2016-08-31 2017-08-11 義守大學 用以檢測蛋白特徵物之顯微影像檢測系統以及顯微影像檢測方法
EP3521892A4 (en) * 2016-09-29 2020-07-29 Olympus Corporation OBSERVATION DEVICE
EP3521893A1 (en) 2016-09-30 2019-08-07 Olympus Corporation Observation device
CN108226043B (zh) * 2016-12-22 2024-07-02 赛默飞世尔（上海）仪器有限公司 用于水质监测的测量单元及测量系统
CN106706643B (zh) * 2017-02-23 2019-07-02 马青山 一种肝癌对比切片检测方法
JP6938986B2 (ja) * 2017-03-15 2021-09-22 住友金属鉱山株式会社 粒子形状の評価方法
AU2018254602B2 (en) 2017-04-20 2021-04-01 Biomerieux, Inc. Optical density instrument and systems and methods using the same
JP6911112B2 (ja) 2017-05-29 2021-07-28 オリンパス株式会社 観察装置
EP4292520A3 (en) 2017-10-16 2024-07-10 Massachusetts Institute of Technology Systems, devices and methods for non-invasive hematological measurements
CN109697450B (zh) * 2017-10-20 2023-04-07 曦医生技股份有限公司 细胞分类方法
US20210181085A1 (en) * 2017-10-26 2021-06-17 Essenlix Corporation Rapid measurement of platelets
CN107976439B (zh) * 2017-12-06 2019-02-05 张哲� 一种检测血液和尿液样品的光学检测装置
JP6687656B2 (ja) 2018-03-19 2020-04-28 ファナック株式会社 検査装置およびその検査方法
WO2019209345A1 (en) * 2018-04-27 2019-10-31 Hewlett-Packard Development Company, L.P. Three-dimensional volume imaging
US11371986B2 (en) 2018-05-25 2022-06-28 Scanogen Inc. Detection units and methods for detecting a target analyte
NL2021377B1 (en) * 2018-07-03 2020-01-08 Illumina Inc Interposer with first and second adhesive layers
US20200033260A1 (en) * 2018-07-25 2020-01-30 Pauleologos Cusulos Coagulation and aggregation refracted light indexing device and method
US11263735B2 (en) * 2018-08-01 2022-03-01 Cdx Medical Ip, Inc. Enhanced extended depth of focusing on biological samples
SE542345C2 (en) 2018-08-03 2020-04-14 Redsense Medical Ab Device for measuring a property of a measurement object by luminescence
EP3611695A1 (en) * 2018-08-15 2020-02-19 Koninklijke Philips N.V. Generating annotation data of tissue images
JP7371098B2 (ja) 2018-08-17 2023-10-30 エンリッチ バイオシステムズ インコーポレイテッド 粒子および細胞を選択かつ単離するシステムおよび方法ならびにその使用
CN109084734B (zh) * 2018-08-17 2020-06-16 中国科学院自动化研究所 基于单目显微视觉的微球姿态测量装置及测量方法
CN109100352B (zh) * 2018-08-30 2024-07-23 天津港东科技股份有限公司 显微镜多功能液体测试装置
JP2022001889A (ja) * 2018-09-27 2022-01-06 富士フイルム株式会社 フォーカス位置評価装置、方法及びプログラム、並びに判別器
CN109583470A (zh) * 2018-10-17 2019-04-05 阿里巴巴集团控股有限公司 一种异常检测的解释特征确定方法和装置
CA3112071A1 (en) * 2018-11-02 2020-05-07 Hologic, Inc. Digital imaging system and method
CN113439227B (zh) 2019-01-22 2023-06-09 应用材料公司 放大图像的捕获和存储
US10724956B1 (en) * 2019-02-01 2020-07-28 Essen Instruments, Inc. Spectral unmixing
KR102114135B1 (ko) * 2019-02-28 2020-05-22 서강대학교산학협력단 현미경 장치 및 현미경 장치의 동작방법
CN110057730A (zh) * 2019-03-12 2019-07-26 天津大学 一种人体颗粒物主动吸入浓度测试方法
US11255785B2 (en) 2019-03-14 2022-02-22 Applied Materials, Inc. Identifying fiducial markers in fluorescence microscope images
WO2020186029A1 (en) 2019-03-14 2020-09-17 Applied Materials, Inc. Identifying fiducial markers in microscope images
CN114341619B (zh) 2019-04-05 2025-04-11 上海宜晟生物科技有限公司 测定准确度以及可靠性提高
WO2021007443A1 (en) * 2019-07-09 2021-01-14 The Regents Of The University Of California Automated rapid on-site evaluation machine and stain
WO2021003518A1 (en) * 2019-07-11 2021-01-14 Sensibility Pty Ltd Machine learning based phone imaging system and analysis method
EP4529839A3 (en) 2019-07-24 2025-04-16 Massachusetts Institute of Technology Finger inserts for a nailfold imaging device
WO2021022162A1 (en) 2019-07-31 2021-02-04 Dig Labs Corporation Animal health assessment
US11763920B2 (en) 2019-07-31 2023-09-19 Dig Labs Corporation Mucus analysis for animal health assessments
CN110490882B (zh) * 2019-08-19 2022-12-27 腾讯科技（深圳）有限公司 细胞膜染色图像分析方法、装置及系统
WO2021053649A1 (en) * 2019-09-22 2021-03-25 Ecole Polytechnique Federale De Lausanne (Epfl) Device and method for pre-term birth risk assessment
TWI764287B (zh) * 2019-09-24 2022-05-11 美商應用材料股份有限公司 用於組織分割之機器學習模型的交互式訓練
CN112630197B (zh) * 2019-10-10 2021-10-19 东北农业大学 一种判定蛋白质能否发生液-液相分离的方法
EP4031922A4 (en) * 2019-10-19 2022-12-07 Sequlite Genomics US, Inc. Virtual fiducials
GB2588627B (en) * 2019-10-29 2023-03-29 Oxford Nanoimaging Ltd An optical imaging system
EP3836020B1 (en) * 2019-12-12 2024-08-28 National Cheng Kung University A method for determining cellular nuclear-to-cytoplasmic ratio
US20210182531A1 (en) 2019-12-17 2021-06-17 Applied Materials, Inc. Registration techniques for multiplexed fluorescence in-situ hybridization images
US10823662B1 (en) * 2020-02-18 2020-11-03 Horiba Instruments, Incorporated Special purpose cuvette assembly and method for optical microscopy of nanoparticle colloids
BR112022018102A2 (pt) * 2020-03-13 2022-11-22 Advanced Animal Diagnostics Inc Exibição móvel rápida e triagem para infecções e gravidade de infecção
EP3951471A4 (en) * 2020-03-27 2022-06-29 Convergence Technology Co. Ltd. Dark field illuminator for microscopy imaging
US20210301245A1 (en) * 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
EP4134725B1 (en) * 2020-04-08 2025-02-26 BGI Shenzhen Lens-free microscopic imaging system and method, and biochemical substance detection system and method
GB202006259D0 (en) * 2020-04-28 2020-06-10 Leeds Teaching Hospitals Nhs Trust Stain Assessment
US11925456B2 (en) 2020-04-29 2024-03-12 Hyperspectral Corp. Systems and methods for screening asymptomatic virus emitters
EP4157088A4 (en) 2020-05-28 2024-04-24 Leuko Labs, Inc. METHODS FOR DETECTING WHITE BLOOD CELLS AND/OR WHITE BLOOD CELL SUBTYPES FROM NON-INVASIVE CAPILLARY VIDEOS
US12144619B2 (en) 2020-07-06 2024-11-19 Look Tec Co., Ltd Blood measurement device
JP7707277B2 (ja) * 2020-07-24 2025-07-14 生物島実験室 分子を検出する方法及び装置
KR102331711B1 (ko) * 2020-08-21 2021-12-01 동아대학교 산학협력단 현장진료를 위한 미세유체칩 다중 채널 형광측정 장치
US12111257B2 (en) * 2020-08-26 2024-10-08 Honeywell International Inc. Fluid composition sensor device and method of using the same
JP7568212B2 (ja) * 2020-08-27 2024-10-16 リプロバイオ株式会社 精子運動性能評価システム及び精子運動性能評価方法
EP4528353A3 (de) * 2020-09-01 2025-09-17 BMG Labtech GmbH Autofokussystem für eine optische mess- oder mikroskopievorrichtung, verfahren zur fokuseinstellung bei einer optischen mess- oder mikroskopievorrichtung sowie optische mess- oder mikroskopievorrichtung
US20230408534A1 (en) * 2020-10-08 2023-12-21 Essenlix Corporation Assay Error Reduction
US12209964B2 (en) 2020-10-15 2025-01-28 Visera Technologies Company Limited Bio-chip, bio-detection system and bio-detection method
TWI767415B (zh) * 2020-11-18 2022-06-11 中國醫藥大學 自動化血液分析系統及自動化血液分析方法
CN112419295B (zh) * 2020-12-03 2024-08-23 腾讯科技（深圳）有限公司 医学图像处理方法、装置、计算机设备和存储介质
KR102501486B1 (ko) * 2020-12-10 2023-02-17 한국화학연구원 나노 입자 또는 나노 구조체에서 발생된 분광 신호 분석 시스템 및 분석 방법
CN214895849U (zh) 2021-01-28 2021-11-26 贝克曼库尔特生物科技（苏州）有限公司 气泡检测装置和样本处理仪
WO2022246155A1 (en) * 2021-05-20 2022-11-24 Gleghorn Jason P Method for enumeration and physical characterization of nanoparticles
WO2023006372A1 (en) * 2021-07-29 2023-02-02 Technische Universität München Detection of molecular biological objects, cellular biological objects and cell aggregates using quantitative phase-contrast microscopy
WO2023018085A1 (ko) * 2021-08-10 2023-02-16 주식회사 루닛 병리 슬라이드 이미지와 관련된 정보를 출력하는 방법 및 장치
CN113790671B (zh) * 2021-09-03 2022-05-17 苏州天准科技股份有限公司 一种口径可调的落射光源及影像测量仪
EP4453628A1 (en) * 2021-12-23 2024-10-30 Radiometer Medical ApS Biological fluid analyser with adaptive light source assembly
US20250131750A1 (en) * 2021-12-23 2025-04-24 Radiometer Medical Aps Biological fluid analyser with light-setting-based cell classification
TWI813145B (zh) * 2022-01-25 2023-08-21 佛教慈濟醫療財團法人 多重螢光組織影像分析方法及其系統
US20250216394A1 (en) * 2022-01-28 2025-07-03 University Of Southern California Liquid biopsy analytes to define cancer stages
CN116698707A (zh) * 2022-02-24 2023-09-05 杭州迅数科技有限公司 一种双光路双波长的光染色菌落成像装置
WO2023166655A1 (ja) * 2022-03-03 2023-09-07 オリンパス株式会社 照明ユニットおよび撮影システム
CN114895449B (zh) * 2022-03-17 2023-06-23 华东师范大学 一种基于压缩感知的四维高速荧光显微成像装置
JP2023137147A (ja) * 2022-03-17 2023-09-29 シスメックス株式会社 白血球を亜集団に分類する方法
BR102023003038A2 (pt) * 2022-03-17 2024-01-02 Sysmex Corporation Método para classificar glóbulos brancos em subpopulações
TWI798041B (zh) * 2022-03-31 2023-04-01 中原大學 用於執行全內反射散射量測的裝置與方法
KR102537348B1 (ko) * 2022-08-04 2023-05-30 한국기계연구원 디지털 pcr 분석용 기판 및 이의 제작방법
TWI866690B (zh) * 2023-02-07 2024-12-11 邦睿生技股份有限公司 生物樣品檢測裝置
TWI876356B (zh) * 2023-05-30 2025-03-11 天亮醫療器材股份有限公司 檢測管、檢測系統及待測體參數的光學檢測方法
TWI860738B (zh) * 2023-06-05 2024-11-01 崑山科技大學 染色輔助螢光影像偵測現地環境氯苯之方法
CN119394870A (zh) * 2023-07-21 2025-02-07 上海浚真生命科学有限公司 光学成像传感器和生物反应系统
US20250199286A1 (en) * 2023-12-15 2025-06-19 Idexx Laboratories, Inc. Process and systems for autofocusing and measuring tilt of sample plane
WO2025137530A1 (en) * 2023-12-22 2025-06-26 Idexx Laboratories, Inc. Systems and methods for uniform oblique illumination for optical imaging
WO2025145095A1 (en) * 2023-12-29 2025-07-03 Beckman Coulter, Inc. Customized sample handling in biological analysis
KR102832369B1 (ko) * 2025-05-19 2025-07-14 (주)디로펫 정량적 위상 이미징 장치와 이를 이용한 비브리오패혈증 모니터링 방법

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066362A (en) * 1968-08-16 1978-01-03 E. I. Du Pont De Nemours And Company Apparatus and method for performing photometric analysis
GB1382081A (en) * 1972-03-14 1975-01-29 Ici Ltd Transmission spectra
US3849654A (en) 1973-10-19 1974-11-19 H Malvin Fluorescence cuvette
US4305816A (en) * 1980-02-11 1981-12-15 Borden, Inc. Apparatus and method for inspecting containers
US5109429A (en) * 1985-11-04 1992-04-28 Cell Analysis Systems,Inc. Apparatus and method for analyses of biological specimens
US4868126A (en) 1985-12-11 1989-09-19 Flow Cytometry Standards Corporation Method of calibrating a fluorescent microscope using fluorescent calibration microbeads simulating stained cells
US4896966A (en) 1986-08-15 1990-01-30 Hamilton-Thorn Research Motility scanner and method
US5289255A (en) * 1991-03-28 1994-02-22 Minnesota Mining And Manufacturing Co. Cuvette for use in making a measurement of a blood parameter and assembly utilizing the same
JPH05240774A (ja) 1992-03-02 1993-09-17 Hitachi Ltd 光学セル及び光学検出装置とこれを用いる試料分離検出装置
US5292484A (en) 1992-07-16 1994-03-08 Spectrum Systems, Inc. Cuvette and cuvette cartridge for a chemical analyzer
US5585246A (en) * 1993-02-17 1996-12-17 Biometric Imaging, Inc. Method for preparing a sample in a scan capillary for immunofluorescent interrogation
DE69425158T2 (de) 1993-02-26 2001-03-15 E-Y Laboratories, Inc. Optisches probe-analysesystem und verfahren
US5374531A (en) * 1993-03-22 1994-12-20 Zynaxis, Inc. Immunoassay for determination of cells
US5534416A (en) * 1993-04-13 1996-07-09 Molecular Probes, Inc. Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes
US5407638A (en) 1993-04-28 1995-04-18 Shell Oil Company Detector-cell adapted for continuous-flow absorption detection
EP0781987A3 (en) 1993-05-28 1997-07-09 FISONS plc Analytical apparatus
US5510621A (en) * 1994-10-03 1996-04-23 Optical Solutions, Inc. Apparatus and method for measuring components in a bag
US5869689A (en) * 1995-10-17 1999-02-09 Molecular Probes, Inc Stains for acidic organelles
WO1997043619A1 (en) * 1996-05-13 1997-11-20 Dhc Analysis, Inc. Sampling device for spectrometric measurements
JP3322579B2 (ja) 1996-10-17 2002-09-09 株式会社エンプラス サイドライト型面光源装置
US7117098B1 (en) 1997-02-27 2006-10-03 Cellomics, Inc. Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm
EP0985142A4 (en) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc SYSTEM AND APPARATUS FOR THE SEQUENTIAL TREATMENT OF ANALYTES
GB2326229A (en) * 1997-06-13 1998-12-16 Robert Jeffrey Geddes Carr Detecting and analysing submicron particles
DE19735119C2 (de) 1997-08-13 2000-05-18 Deutsches Krebsforsch Verfahren zur Fluoreszenzkorrelationsspektroskopie, insbesbesondere zur Mehrfarben-Fluoreszenzkorrelationsspektroskopie und Vorrichtung zur Durchführung des Verfahrens
US20030205681A1 (en) 1998-07-22 2003-11-06 Ljl Biosystems, Inc. Evanescent field illumination devices and methods
DE19801139B4 (de) * 1998-01-14 2016-05-12 Till Photonics Gmbh Punktabtastendes Luminiszenz-Mikroskop
US6529835B1 (en) * 1998-06-25 2003-03-04 Caliper Technologies Corp. High throughput methods, systems and apparatus for performing cell based screening assays
SE9802558D0 (sv) 1998-07-16 1998-07-16 Hanning Instr Ab Device for detection of fluorescent
JP2002525600A (ja) * 1998-09-22 2002-08-13 セロミックス インコーポレイテッド 細胞ベースのスクリーニングのための小型化細胞アレイ方法および装置
US7450229B2 (en) 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US20020019062A1 (en) 1999-06-18 2002-02-14 Peter Lea Assay devices
JP3820806B2 (ja) 1999-07-21 2006-09-13 三菱電機株式会社 レーザ検査装置
WO2001008552A1 (en) 1999-08-03 2001-02-08 Biophysica, Llc Spectroscopic systems and methods for detecting tissue properties
IL131282A (en) 1999-08-05 2009-02-11 Orbotech Ltd Apparatus and methods for inspection of objects
DE10017823B4 (de) 2000-04-10 2004-08-26 Till I.D. Gmbh Mikroskopische Beleuchtungsvorrichtung
WO2003036265A2 (en) 2001-10-26 2003-05-01 Virtual Arrays, Inc. Assay systems with adjustable fluid communication
US20020192763A1 (en) * 2000-04-17 2002-12-19 Jiangchun Xu Compositions and methods for the therapy and diagnosis of prostate cancer
DE10029946A1 (de) 2000-06-17 2001-12-20 Merck Patent Gmbh Integrierte optische Wellenleiter für mikrofluidische Analysensysteme
US6599475B1 (en) * 2000-09-27 2003-07-29 Becton, Dickinson And Company Apparatus for producing thin liquid samples for microscopic analysis
DE10124055A1 (de) 2001-05-16 2002-11-21 Fisher Rosemount Mfg Gmbh & Co Gerät zur optischen Untersuchung von Gasen
JP2003139687A (ja) * 2001-11-06 2003-05-14 Fuji Photo Film Co Ltd 測定チップ集合体および測定チップ取出し装置
JP3801914B2 (ja) * 2001-12-25 2006-07-26 富士写真フイルム株式会社 測定チップの再使用方法
US7756305B2 (en) * 2002-01-23 2010-07-13 The Regents Of The University Of California Fast 3D cytometry for information in tissue engineering
WO2004048929A2 (en) * 2002-11-22 2004-06-10 Solus Biosystems, Inc. High throughput screening with parallel vibrational spectroscopy
US20050153435A1 (en) 2002-02-14 2005-07-14 Solus Biosystems, Inc. Multiple sample screening using a silicon substrate
DK1493019T3 (da) 2002-04-03 2006-12-18 Univ Jw Goethe Frankfurt Main Infraröd måleindretning, især til spektrometriske vandholdige systemer, fortrinsvis af flerkomponentsystemer
US6723288B2 (en) 2002-04-29 2004-04-20 Dade Behring Inc. Method of providing assay processing in a multi-analyzer system
US7354389B2 (en) * 2002-05-28 2008-04-08 Autogenomics, Inc. Microarray detector and methods
GB0216934D0 (en) * 2002-07-20 2002-08-28 Council Cent Lab Res Councils Optical apparatus
US7122384B2 (en) 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US20110259744A1 (en) * 2003-04-30 2011-10-27 Moyle William R Sensors for biomolecular detection and cell classification
WO2004103563A2 (en) * 2003-05-20 2004-12-02 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
WO2004113886A1 (en) 2003-06-25 2004-12-29 Koninklijke Philips Electronics N.V. Support with a surface structure for sensitive evanescent-field detection
EP1494007B8 (de) 2003-06-30 2014-09-24 Tecan Trading AG Vorrichtung und Verfahren zum Analysieren von Proben
AU2003904237A0 (en) * 2003-08-08 2003-08-21 Garvan Institute Of Medical Research Novel translocation assay
JP3879001B2 (ja) 2003-11-06 2007-02-07 独立行政法人情報通信研究機構 生物試料を高精度に測定する方法
US7804075B2 (en) * 2004-03-11 2010-09-28 The General Hospital Corporation Method and system for tomographic imaging using fluorescent proteins
WO2005090945A1 (en) * 2004-03-16 2005-09-29 Amnis Corporation Method for imaging and differential analysis of cells
JP2005316383A (ja) * 2004-03-29 2005-11-10 Nikon Corp 蛍光顕微鏡
EP1738212B1 (en) 2004-04-16 2010-08-25 Auburn University Microscope illumination device and adapter thereof
EP2752874A1 (en) 2004-06-07 2014-07-09 Fluidigm Corporation Method and apparatus for imaging a device under temperature control
US8313713B2 (en) 2004-06-17 2012-11-20 Ortho-Clinical Diagnostics, Inc. Stabilizing a cuvette during measurement
JP4363649B2 (ja) 2004-09-30 2009-11-11 富士フイルム株式会社 全反射減衰を利用した測定装置及び方法
JP2006162427A (ja) * 2004-12-07 2006-06-22 Toshiba Corp Ｌｅｄチップの検査方法及びｌｅｄチップの検査装置
WO2006062987A2 (en) 2004-12-09 2006-06-15 Inneroptic Technology, Inc. Apparatus, system and method for optically analyzing substrate
US20060166305A1 (en) 2005-01-27 2006-07-27 Genetix Limited Animal cell confluence detection method and apparatus
MX2007009124A (es) * 2005-01-31 2007-10-08 Univ Illinois Metodos y dispositivos para caracterizar particulas en medios transparentes y turbios.
US7344273B2 (en) 2005-03-22 2008-03-18 Binary Works, Inc. Ring light with user manipulable control
KR101931899B1 (ko) 2005-05-09 2018-12-21 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US7817273B2 (en) * 2005-06-30 2010-10-19 Life Technologies Corporation Two-dimensional spectral imaging system
JP2007127449A (ja) 2005-11-01 2007-05-24 Olympus Corp 測定容器
DE102005062439B3 (de) 2005-12-23 2007-05-10 JOMESA Meßsysteme GmbH Verfahren für die Partikelanalyse und Partikelanalysesystem
US8101368B2 (en) * 2006-02-13 2012-01-24 Dvs Sciences Inc. Quantitation of cellular DNA and cell numbers using element labeling
JP2007271360A (ja) * 2006-03-30 2007-10-18 Fujifilm Corp 測定装置及びセンサユニットの保持方法
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
JP2007333497A (ja) * 2006-06-14 2007-12-27 Hitachi High-Technologies Corp 蛍光検出デバイスおよび装置
US8501099B2 (en) 2006-07-11 2013-08-06 The Curators Of The University Of Missouri Photo-acoustic detection device and method
CN101622522A (zh) * 2007-01-26 2010-01-06 贝克顿·迪金森公司 用于细胞计数和分析的方法、系统和组合物
US7936463B2 (en) 2007-02-05 2011-05-03 Palo Alto Research Center Incorporated Containing analyte in optical cavity structures
JP5286774B2 (ja) * 2007-04-11 2013-09-11 株式会社ニコン 顕微鏡装置と、これに用いられる蛍光キューブ
US7808641B2 (en) * 2007-04-13 2010-10-05 C Technologies Inc. Interactive variable pathlength device
EP2012110A1 (en) 2007-07-06 2009-01-07 Bp Oil International Limited Optical cell
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
US7952705B2 (en) * 2007-08-24 2011-05-31 Dynamic Throughput Inc. Integrated microfluidic optical device for sub-micro liter liquid sample microspectroscopy
JP5057377B2 (ja) * 2007-08-30 2012-10-24 国立大学法人埼玉大学 生体成分又はその機能の測定方法及び装置
ES2447875T3 (es) 2007-10-02 2014-03-13 Theranos, Inc. Dispositivos modulares para punto de cuidados y usos de los mismos
JP2011503536A (ja) * 2007-11-05 2011-01-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロエレクトロニクスセンサ
CN201156031Y (zh) 2008-02-02 2008-11-26 施慧勇 生化分析仪比色杯
JP5184697B2 (ja) * 2008-03-21 2013-04-17 アボット ポイント オブ ケア インコーポレイテッド 血小板を個々に、及び凝集塊として検出及び計数するための方法及び装置
EP2269038B1 (en) 2008-03-21 2016-07-27 Abbott Point Of Care, Inc. Method for analyzing individual cells or particulates in blood using fluorescence and absorption of a colorant
WO2009142312A1 (ja) * 2008-05-20 2009-11-26 株式会社ニコン 顕微鏡装置
JP2010060854A (ja) * 2008-09-04 2010-03-18 Nikon Corp 顕微鏡装置
JP2010091679A (ja) * 2008-10-06 2010-04-22 Nikon Corp 顕微鏡装置とこれに用いられる蛍光キューブ
JP2010091809A (ja) * 2008-10-08 2010-04-22 Nikon Corp 顕微鏡装置
US8576396B2 (en) 2008-11-19 2013-11-05 Postnova Analytics Gmbh Cell construction for light scatter detectors having self-focusing properties
US8329117B2 (en) 2009-05-14 2012-12-11 Canon U.S. Life Sciences, Inc. Microfluidic chip features for optical and thermal isolation
US8891086B2 (en) * 2009-06-15 2014-11-18 Thermo Scientific Portable Analytical Instruments Inc. Optical scanning systems and methods for measuring a sealed container with a layer for reducing diffusive scattering
JP2011118264A (ja) * 2009-12-07 2011-06-16 Nikon Corp 顕微鏡装置
WO2011072401A1 (en) 2009-12-18 2011-06-23 University Health Network System and method for sub-surface fluorescence imaging
EP2339327A1 (en) * 2009-12-23 2011-06-29 F. Hoffmann-La Roche AG Automatic test for imaging units
JP5344629B2 (ja) * 2010-04-30 2013-11-20 レーザーテック株式会社 検査装置及び検査方法
EP2586041A1 (en) 2010-06-22 2013-05-01 Koninklijke Philips Electronics N.V. Detection of magnetic particles and their clustering
JP5703609B2 (ja) 2010-07-02 2015-04-22 ソニー株式会社 顕微鏡及び領域判定方法
TW201224425A (en) * 2010-12-03 2012-06-16 Microtek Int Inc Carrying device and method of containing specimen within the carrying device
KR20120080056A (ko) * 2011-01-06 2012-07-16 삼성전자주식회사 디스크 및 이를 이용한 검사장치의 보정방법
EP4024029A3 (en) 2011-01-21 2022-09-14 Labrador Diagnostics LLC Systems and methods for sample use maximization
KR20140039175A (ko) 2011-03-07 2014-04-01 더 거버닝 카운실 오브 더 유니버시티 오브 토론토 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템
KR101167649B1 (ko) 2011-04-20 2012-07-20 한국과학기술원 세포 환경 내에서의 단일 분자 수준의 단백질-단백질 상호작용 분석 장치
US8934698B2 (en) 2011-06-22 2015-01-13 The Johns Hopkins University System and device for characterizing cells
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
CN202514348U (zh) 2011-12-23 2012-11-07 鹤山健豪灯饰企业有限公司 具观赏生命成长过程的组合式小夜灯
AU2013295679A1 (en) 2012-07-25 2015-01-29 Theranos, Inc. Image analysis and measurement of biological samples
US9513224B2 (en) 2013-02-18 2016-12-06 Theranos, Inc. Image analysis and measurement of biological samples
US20140193892A1 (en) 2012-07-25 2014-07-10 Theranos, Inc. Image analysis and measurement of biological samples
US9497379B2 (en) 2013-08-22 2016-11-15 California Institute Of Technology Variable-illumination fourier ptychographic imaging devices, systems, and methods
AU2014217946A1 (en) 2013-02-18 2015-08-20 Theranos Ip Company, Llc Image analysis and measurement of biological samples
US20150071541A1 (en) 2013-08-14 2015-03-12 Rice University Automated method for measuring, classifying, and matching the dynamics and information passing of single objects within one or more images
TWI496112B (zh) 2013-09-13 2015-08-11 Univ Nat Cheng Kung 細胞影像分割方法以及核質比評估方法
WO2017110653A1 (ja) 2015-12-22 2017-06-29 オリンパス株式会社 顕微鏡システム
US9930243B2 (en) 2016-05-02 2018-03-27 Mitutoyo Corporation Variable focal length imaging system
US10768406B2 (en) 2016-06-20 2020-09-08 Scanogen Inc. Imaging system
US10768105B1 (en) * 2016-07-29 2020-09-08 Labrador Diagnostics Llc Image analysis and measurement of biological samples

Also Published As

Publication number Publication date
KR20150036757A (ko) 2015-04-07
US12066440B2 (en) 2024-08-20
TWI627393B (zh) 2018-06-21
JP6273276B2 (ja) 2018-01-31
US10345303B2 (en) 2019-07-09
CA2878957A1 (en) 2014-01-30
JP2018031798A (ja) 2018-03-01
US20140030737A1 (en) 2014-01-30
US20170023478A1 (en) 2017-01-26
IL236819A0 (en) 2015-03-31
US10302643B2 (en) 2019-05-28
WO2014018805A2 (en) 2014-01-30
WO2014018805A3 (en) 2014-05-08
JP2015523577A (ja) 2015-08-13
JP2020020805A (ja) 2020-02-06
HK1212440A1 (en) 2016-06-10
BR112015001592A2 (pt) 2017-07-04
CN104769415B (zh) 2020-12-25
EP2877834B1 (en) 2018-09-05
EP3495799A2 (en) 2019-06-12
MX2015001060A (es) 2015-06-04
AU2013295679A1 (en) 2015-01-29
TW201831881A (zh) 2018-09-01
CN104769415A (zh) 2015-07-08
AU2017251721A1 (en) 2017-11-09
BR112015001592A8 (pt) 2021-02-17
JP2021167840A (ja) 2021-10-21
US20150031051A1 (en) 2015-01-29
KR102090776B1 (ko) 2020-03-18
MX365089B (es) 2019-05-22
MX345757B (es) 2017-02-15
EP3495799A3 (en) 2020-11-18
TW201413232A (zh) 2014-04-01
EP3495799B1 (en) 2023-09-06
ES2700498T3 (es) 2019-02-18
US20150204788A1 (en) 2015-07-23
US20170115289A1 (en) 2017-04-27
US20200103406A1 (en) 2020-04-02
JP2022188029A (ja) 2022-12-20
CN112557301A (zh) 2021-03-26
US10823731B2 (en) 2020-11-03
EP2877834A2 (en) 2015-06-03
SG11201500347SA (en) 2015-02-27
US20210148908A1 (en) 2021-05-20
US20140038206A1 (en) 2014-02-06
US9395302B2 (en) 2016-07-19
US9494521B2 (en) 2016-11-15
CA3198619A1 (en) 2014-01-30
US11300564B2 (en) 2022-04-12

Similar Documents

Publication Publication Date Title
US12066440B2 (en) Image analysis and measurement of biological samples
US9513224B2 (en) Image analysis and measurement of biological samples
JP2022078344A (ja) 生物学的サンプルの画像分析および測定
US20210123862A1 (en) Image analysis and measurement of biological samples
HK40009573A (en) A method for measurement of a component in cells
HK40053971A (en) Image analysis and measurement of biological samples
HK1212440B (zh) 生物学样本的图像分析及测量

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: THERANOS IP COMPANY, LLC (US)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B15I Others concerning applications: loss of priority

Free format text: PERDA DAS PRIORIDADES US 61/675,811 DE 25/07/2012, US 61/676,178 DE 26/07/2012, US 61/766,116 DE 18/02/2013 E US 61/802,194 DE 15/03/2013, REIVINDICADAS NO PCT/US2013/052141, POR NAO ENVIO DE DOCUMENTO COMPROBATORIO DE CESSAO DAS MESMAS CONFORME AS DISPOSICOES PREVISTAS NA LEI 9.279 DE 14/05/1996 (LPI) ART. 16 6O, NO ART. 28 DA RESOLUCAO INPI-PR 77/2013 E ART 3O DA IN 179 DE 21/02/2017 UMA VEZ QUE DEPOSITANTE CONSTANTE DA PETICAO DE REQUERIMENTO DO PEDIDO PCT E DISTINTO DAQUELE QUE DEPOSITOU AS PRIORIDADES REIVINDICADAS.

B12F Other appeals [chapter 12.6 patent gazette]

Free format text: RECURSO: 870210030281 - 31/03/2021

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B25F Entry of change of name and/or headquarter and transfer of application, patent and certif. of addition of invention: change of name on requirement

Owner name: THERANOS IP COMPANY, LLC (US)

Free format text: A FIM DE ATENDER A ALTERACAO DE NOME REQUERIDA ATRAVES DA PETICAO 870210077259 DE AA/23/08/2021 E NECESSARIO ANEXAR MAIS UMA GRU 248 REFERENTE A ALTERACAO DE SEDE ANALISADA E ESCLARECER A DIVERGENCIA ENTRE O ENDERECO DO DEPOSITANTE ?LABRADOR DIAGNOSTICS LLC? CONSTANTE NO FORMULARIO E NA DOCUMENTACAO APRESENTADA.

B25D Requested change of name of applicant approved

Owner name: LABRADOR DIAGNOSTICS LLC (US)

B25G Requested change of headquarter approved

Owner name: LABRADOR DIAGNOSTICS LLC (US)

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/07/2013, OBSERVADAS AS CONDICOES LEGAIS

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 11A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2785 DE 21-05-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.