BR0317348A - EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac - Google Patents

EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac

Info

Publication number
BR0317348A
BR0317348A BR0317348-8A BR0317348A BR0317348A BR 0317348 A BR0317348 A BR 0317348A BR 0317348 A BR0317348 A BR 0317348A BR 0317348 A BR0317348 A BR 0317348A
Authority
BR
Brazil
Prior art keywords
acid derivatives
enantiomers
hdac inhibitors
hydroxamic acid
thiophene hydroxamic
Prior art date
Application number
BR0317348-8A
Other languages
English (en)
Inventor
Adelbert Grossmann
Frank Herting
Matthias Koerner
Klaus-Peter Kuenkele
Anja Limberg
Olaf Mundigl
Ulrich Tibes
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0317348A publication Critical patent/BR0317348A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"ENANTIÈMEROS DE DERIVADOS DE áCIDO TIOFENO HIDROXâMICO E SEU USO COMO INIBIDORES DE HDAC". Compostos da fórmula (I) onde Ar, R1 e R2 possuem os significados definidos no relatório descritivo, processo para fabricação desses compostos e medicamentos com atividade inibidora de HDAC contendo tal composto.
BR0317348-8A 2002-12-16 2003-12-15 EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac BR0317348A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02028038 2002-12-16
PCT/EP2003/014235 WO2004054999A1 (en) 2002-12-16 2003-12-15 Enantiomers of thiophene hydroxamic acid derivatives and their use as hdac inhibitors

Publications (1)

Publication Number Publication Date
BR0317348A true BR0317348A (pt) 2005-11-16

Family

ID=32524005

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317348-8A BR0317348A (pt) 2002-12-16 2003-12-15 EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac

Country Status (18)

Country Link
US (1) US7098241B2 (pt)
EP (1) EP1575933A1 (pt)
JP (1) JP2006513181A (pt)
KR (1) KR100781929B1 (pt)
CN (1) CN100391954C (pt)
AR (1) AR042459A1 (pt)
AU (1) AU2003293882A1 (pt)
BR (1) BR0317348A (pt)
CA (1) CA2507629A1 (pt)
CL (1) CL2003002611A1 (pt)
GT (1) GT200300285A (pt)
PA (1) PA8592101A1 (pt)
PE (1) PE20040913A1 (pt)
PL (1) PL377696A1 (pt)
RU (1) RU2348625C2 (pt)
TW (1) TW200418825A (pt)
UY (1) UY28127A1 (pt)
WO (1) WO2004054999A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK288015B6 (sk) * 2001-06-11 2012-11-05 Virochem Pharma Inc. Thiophene derivatives as antiviral agents for flavivirus infection
CN100413861C (zh) 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 用于治疗或预防黄病毒感染的化合物
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
CN1980920A (zh) * 2004-06-14 2007-06-13 霍夫曼-拉罗奇有限公司 噻吩衍生物、它们的制备以及作为药剂的应用
CN1964962A (zh) * 2004-06-14 2007-05-16 霍夫曼-拉罗奇有限公司 噻吩异羟肟酸衍生物以及它们作为hdac抑制剂的应用
WO2005121119A1 (en) * 2004-06-14 2005-12-22 F. Hoffmann-La Roche Ag Hydroxamates, their manufacture and use as pharmaceutical agents
AP2007004245A0 (en) 2005-05-13 2007-12-31 Virochem Pharma Inc Compounds and methods for the treatment or prevention of flavivirus infections
ZA200800901B (en) 2005-07-14 2010-05-26 Takeda San Diego Inc Histone deacetylase inhibitors
GB0518237D0 (en) * 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0522130D0 (en) * 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0603041D0 (en) * 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
NZ576780A (en) 2006-11-15 2011-12-22 Virochem Pharma Inc Thiophene analogues for the treatment or prevention of flavivirus infections
AR074797A1 (es) 2008-10-10 2011-02-16 Japan Tobacco Inc Compuesto de fluoreno , composiciones farmaceuticas , inhibidores de pdhk y pdhk2 , metodos de tratamiento , usos de los mismos y kit comercial
US8546588B2 (en) * 2010-02-26 2013-10-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US20110212969A1 (en) * 2010-02-26 2011-09-01 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
WO2012019772A1 (en) * 2010-08-12 2012-02-16 Institut De Recherche Pour Le Developpement (I.R.D) Method for treating protozoan parasitic diseases
US20140107166A1 (en) * 2011-02-14 2014-04-17 Dana-Farber Cancer Institute, Inc. Histone deacetylase inhibitors and methods of use thereof
WO2013052110A1 (en) * 2011-10-03 2013-04-11 The Trustees Of Columbia University In The City Of New York Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1
PE20151595A1 (es) 2013-03-15 2015-11-24 Japan Tobacco Inc Compuestos de pirazol-amida y sus usos farmaceuticos
CN103159646B (zh) * 2013-03-19 2014-10-22 广东药学院 一种异羟肟酸类化合物及其制备方法和应用
WO2015100363A1 (en) 2013-12-23 2015-07-02 The Trustees Of Columbia University In The City Of New York Selective hdac6 inhibitors
TW202246215A (zh) 2015-12-18 2022-12-01 美商亞德利克斯公司 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物
KR20190036549A (ko) 2016-07-29 2019-04-04 니뽄 다바코 산교 가부시키가이샤 피라졸-아미드 화합물의 제조 방법

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE661226A (fr) 1965-03-17 1965-09-17 Acides arylacethydroxamiques, amides correspondants et procedes de preparation.
NL6406688A (pt) 1964-06-05 1965-12-06
GB1200886A (en) 1966-09-23 1970-08-05 Allen & Hanburys Ltd Phenylaminoethanol derivatives
US4173652A (en) 1976-12-18 1979-11-06 Akzona Incorporated Pharmaceutical hydroxamic acid compositions and uses thereof
NL7614113A (nl) 1976-12-18 1978-06-20 Akzo Nv Hydroxamzuren.
JPS5436229A (en) 1977-08-25 1979-03-16 Hokuriku Pharmaceutical Substituted acetohydroxam derivative
JPS57145838A (en) 1981-03-05 1982-09-09 Hodogaya Chem Co Ltd P-benzyloxybenzoic acid derivative and herbicide containing the same
JPS57149254A (en) 1981-03-10 1982-09-14 Hodogaya Chem Co Ltd M-benzyloxybenzamide derivative and herbicide containing the same
GB8320702D0 (en) 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agents
US4769461A (en) 1986-09-16 1988-09-06 American Home Products Corporation Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents
GB8728051D0 (en) 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
JPH01216961A (ja) 1988-02-25 1989-08-30 Takeda Chem Ind Ltd １２−リポキシゲネース阻害剤
DE3903989A1 (de) 1989-02-10 1990-09-20 Basf Ag Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
US5091533A (en) 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
JPH04217950A (ja) 1990-03-28 1992-08-07 Asahi Chem Ind Co Ltd ヒドロキサム酸誘導体および酵素阻害剤ならびに抗潰瘍剤
JPH03291264A (ja) 1990-04-06 1991-12-20 Japan Tobacco Inc ジメチルアニリン誘導体、その製造方法及びそれを有効成分として含有するガン細胞分化誘導検査試薬及び制癌剤
JPH04187666A (ja) 1990-11-20 1992-07-06 Asahi Chem Ind Co Ltd シクロヘキサンカルボン酸アミド誘導体及び酵素阻害剤ならびに抗潰瘍剤
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
US5700811A (en) 1991-10-04 1997-12-23 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and method of use thereof
EP0544166A3 (en) 1991-11-26 1993-11-03 Hoffmann La Roche Cephalosporinderivatives
CA2139325A1 (en) 1992-07-16 1994-02-03 Stephen E. Bales Thiodiphenol copolycarbonates and their use as components of multilayered polymeric reflective bodies
US5783593A (en) 1993-11-04 1998-07-21 Abbott Laboratories Inhibitors of squalene synthetase and protein farnesyltransferase
US5776983A (en) 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US6008257A (en) 1994-01-28 1999-12-28 Bayer Aktiengesellschaft Hydroxamic-acid derivatives, method of preparing them and their use as fungicides
GB9420557D0 (en) 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
EP0820441B1 (en) 1995-04-10 2002-06-26 Fujisawa Pharmaceutical Co., Ltd. INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS
CA2184783A1 (en) 1995-09-08 1997-03-09 William J. Gill Nonclassical antifolates
AU7392696A (en) 1995-10-04 1997-04-28 Warner-Lambert Company Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins
FR2746098B1 (fr) 1996-03-14 1998-04-30 Composes propynyl biaromatiques
AUPO118896A0 (en) 1996-07-23 1996-08-15 Fujisawa Pharmaceutical Co., Ltd. New use
CA2262682A1 (en) 1996-08-05 1998-02-12 Prolinx, Inc. Boronic compound complexing reagents and highly stable complexes
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
JPH10114654A (ja) 1996-10-09 1998-05-06 Fujisawa Pharmaceut Co Ltd 新規用途
AU743901B2 (en) 1996-10-16 2002-02-07 Wyeth Holdings Corporation Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors
US6392010B1 (en) 1996-12-19 2002-05-21 Aventis Pharmaceuticals Inc. Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
JPH10182583A (ja) 1996-12-25 1998-07-07 Mitsui Chem Inc 新規ヒドロキサム酸誘導体
AU5337498A (en) 1997-01-22 1998-08-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted beta-thiocarboxylic acids
JP2001513771A (ja) 1997-02-27 2001-09-04 アメリカン・サイアナミド・カンパニー マトリクス金属プロテイナーゼ阻害薬としてのｎ−ヒドロキシ−２−（アルキル、アリール、またはヘテロアリールスルファニル、スルフィニルまたはスルホニル）−３−置換アルキル、アリールまたはヘテロアリールアミド
US6696449B2 (en) 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
JPH10259176A (ja) 1997-03-17 1998-09-29 Japan Tobacco Inc 血管新生阻害作用を有する新規アミド誘導体及びその用途
JPH10287634A (ja) 1997-04-11 1998-10-27 Otsuka Pharmaceut Co Ltd ベンゼン誘導体
CA2293433C (en) 1997-06-17 2009-09-29 Schering Corporation Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives as farnesyl protein transferase inhibitors
ATE268750T1 (de) 1997-08-28 2004-06-15 Biovitrum Ab Proteintyrosinphosphatase inhibitoren
JP4125868B2 (ja) 1997-09-09 2008-07-30 塩野義製薬株式会社 ４−置換安息香酸誘導体およびそれを有効成分として含有する制癌剤
ES2200335T3 (es) 1997-10-06 2004-03-01 Wyeth Holdings Corporation Preparacion y utilizacion de acidos orto-sulfonamido(heteroarilo biciclico)hidroxamicos como inhibidores de las metaloproteinasas matriz y del tace.
CA2306343C (en) 1997-10-15 2010-08-03 American Home Products Corporation Novel aryloxy-alkyl-dialkylamines
ID25639A (id) 1998-02-19 2000-10-19 American Cyanamid Co Alkil, aril atau heteroarilamida tersubstitusi n-hidroksi-2-(alkil, aril, atau heteroaril sulfanil, sulfinil atau sulfonil)-3 sebagai inhibitor matriks mataloproteinase
EP0960882A1 (en) * 1998-05-19 1999-12-01 Hoechst Marion Roussel Deutschland GmbH Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
AU783504C (en) 1999-11-23 2006-08-03 Methylgene Inc. Inhibitors of histone deacetylase
CA2404002A1 (en) 2000-03-24 2001-09-27 Methylgene, Inc. Inhibitors of histone deacetylase
US6784173B2 (en) * 2001-06-15 2004-08-31 Hoffmann-La Roche Inc. Aromatic dicarboxylic acid derivatives
AU2002352443A1 (en) * 2001-12-21 2003-07-15 Consejo Superior De Investigaciones Cientificas Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3

Also Published As

Publication number Publication date
KR20050089157A (ko) 2005-09-07
UY28127A1 (es) 2004-06-30
CL2003002611A1 (es) 2005-01-14
US7098241B2 (en) 2006-08-29
RU2005122447A (ru) 2006-05-27
EP1575933A1 (en) 2005-09-21
US20040122079A1 (en) 2004-06-24
PE20040913A1 (es) 2005-01-18
PL377696A1 (pl) 2006-02-06
CN1726204A (zh) 2006-01-25
CN100391954C (zh) 2008-06-04
WO2004054999A1 (en) 2004-07-01
CA2507629A1 (en) 2004-07-01
JP2006513181A (ja) 2006-04-20
AR042459A1 (es) 2005-06-22
KR100781929B1 (ko) 2007-12-04
RU2348625C2 (ru) 2009-03-10
AU2003293882A1 (en) 2004-07-09
PA8592101A1 (es) 2004-11-02
GT200300285A (es) 2004-07-14
TW200418825A (en) 2004-10-01

Similar Documents

Publication Publication Date Title
BR0317348A (pt) EnantiÈmeros de derivados de ácido tiofeno hidroxâmico e seu uso como inibidores de hdac
BR0116402A (pt) Derivados de tetrahidropiridina, sua preparação e sua utilização como inibidores de proliferação celular
BRPI0414111A (pt) inibidores heterocìclicos de mek e métodos de uso dos mesmos
WO2003011851A3 (en) Aromatic hydroxamic acid derivatives useful as hdac inhibitors
BR0209064A (pt) Hidroxamatos de alquila tricìclicos, sua preparaçãoe seu uso como inibidores de proliferação de células
MXPA04007775A (es) Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa.
BRPI0513891B8 (pt) derivados de propenil piperazina substituídos, seu uso como novos inibidores de histona deacetilase, composição farmacêutica, combinação e processo de preparação destes
BR0307606A (pt) Derivados de piperazinila, piperidinila e morfolinila como inibidores de histona desacetilase
EA200500312A1 (ru) Новые спироконденсированные хиназолиноны и их применение в качестве ингибиторов фосфодиэстераз
BRPI0517033A (pt) novos derivados de hidantoìna como inibidores de metaloproteinase
BRPI0407695A (pt) compostos, processo para a preparação de um composto, composições farmacêuticas que compreendem o composto, utilização dos compostos e processo de tratamento para diabetes do tipo 2
GEP20074148B (en) Pyrrolo-triazine aniline compounds useful as kinase inhibitors
BR0307607A (pt) Derivados de carbonilamino como inibidores de histona desacetilase
BR0010716A (pt) Compostos de fenila substituìdos com atividade imunossupressora e composições farmacêuticas
BRPI0517035A (pt) novos compostos
WO2007120379A3 (en) Sulfonanilide analogs as selective aromatase modulators
WO2003007954A3 (en) Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
SE0203303D0 (sv) Novel Compounds
SE0203070D0 (en) Novel compounds
BR0109328A (pt) Inibidores de metaloprotease n-substituìdos, contendo cadeia lateral heterocìclica
SE0301699D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
BR0312593A (pt) Aciluréias substituìdas por uréia e uretano, processo para a sua produção e sua aplicação
BR0109348A (pt) Inibidores de metaloproteases n-substituìdos os quais contêm cadeias laterais carbocìclicas
SE0203300D0 (sv) Novel Compounds
ATE373636T1 (de) Amidderivate als inhibitoren der enzymatischen aktivität von renin

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.